基本信息
侍骏超 男 博导 中国科学院北京基因组研究所(国家生物信息中心)
电子邮件: shijc@big.ac.cn
通信地址: 北京市朝阳区北辰西路1号院104号楼
邮政编码: 100101
电子邮件: shijc@big.ac.cn
通信地址: 北京市朝阳区北辰西路1号院104号楼
邮政编码: 100101
招生信息
招生专业
0710J3-生物信息学071010-生物化学与分子生物学0710Z1-基因组学
招生方向
非编码RNA组学表观遗传早期胚胎发育
教育背景
2019-01--2021-06 美国加州大学河滨分校 遗传学、基因组学与生物信息学博士学位2016-08--2019-01 美国内华达大学里诺分校 攻读细胞与分子生物学博士学位2013-09--2016-07 中国科学院大学 发育生物学专业理学硕士学位2008-09--2012-06 吉林大学 生物技术(动物)专业理学学士学位
工作经历
工作简历
2023-04~2023-07,美国犹他大学, 博士后研究员2021-08~2023-03,美国加州大学河滨分校, 博士后研究员2012-06~2013-09,中国科学院动物研究所, 研究助理
出版信息
发表论文
[1] Cell & Bioscience. 2023, 第 7 作者[2] Hernandez, Rebecca, Shi, Junchao, Liu, Jingwei, Li, Xiuchun, Wu, Jake, Zhao, Linlin, Zhou, Tong, Chen, Qi, Zhou, Changcheng. PANDORA-Seq unveils the hidden small noncoding RNA landscape in atherosclerosis of LDL receptor-deficient mice. JOURNAL OF LIPID RESEARCH[J]. 2023, 64(4): http://dx.doi.org/10.1016/j.jlr.2023.100352.[3] Jingwei Liu, Junchao Shi, Rebecca Hernandez, Xiuchun Li, Pranav Konchadi, Yuma Miyake, Qi Chen, Tong Zhou, Changcheng Zhou. Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice. ENVIRONMENT INTERNATIONAL[J]. 2023, 172: 107769, http://dx.doi.org/10.1016/j.envint.2023.107769.[4] Shi, Junchao, Zhou, Tong, Chen, Qi. Exploring the expanding universe of small RNAs. NATURE CELL BIOLOGY[J]. 2022, 24(4): 415-423, http://dx.doi.org/10.1038/s41556-022-00880-5.[5] Cable, Jennifer, Heard, Edith, Hirose, Tetsuro, Prasanth, Kannanganattu, V, Chen, LingLing, Henninger, Jonathan E, Quinodoz, Sofia A, Spector, David L, Diermeier, Sarah D, Porman, Allison M, Kumar, Dhiraj, Feinberg, Mark W, Shen, Xiaohua, Unfried, Juan Pablo, Johnson, Rory, Chen, ChunKan, Wilusz, Jeremy E, Lempradl, Adelheid, McGeary, Sean E, Wahba, Lamia, Pyle, Anna Marie, Hargrove, Amanda E, Simon, Matthew D, Marcia, Marco, Przanowska, Roza K, Chang, Howard Y, Jaffrey, Samie R, Contreras, Lydia M, Chen, Qi, Shi, Junchao, Mendell, Joshua T, He, Lin, Song, Erwei, Rinn, John L, Lalwani, Mukesh Kumar, Kalem, Murat Can, Chuong, Edward B, Maquat, Lynne E, Liu, Xuhang. Noncoding RNAs: biology and applications-a Keystone Symposia report. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES[J]. 2021, 1506(1): 118-141, http://dx.doi.org/10.1111/nyas.14713.[6] Yongcun Qu, Qi Chen, Shanshan Guo, Chiyuan Ma, Yonggang Lu, Junchao Shi, Shichao Liu, Tong Zhou, Taichi Noda, Jingjing Qian, Liwen Zhang, Xili Zhu, Xiaohua Lei, Yujing Cao, Wei Li, Wei Li, Nicolas Plachta, Martin MMatzuk, Masahito Ikawa, Enkui Duan, Ying Zhang, Hongmei Wang. Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization. Protein & Cell[J]. 2021, 12(10): 810-817, https://academic.oup.com/proteincell/article/12/10/810/6746920.[7] Chen, Qi, Zhang, Xudong, Shi, Junchao, Yan, Menghong, Zhou, Tong. Origins and evolving functionalities of tRNA-derived small RNAs. TRENDS IN BIOCHEMICAL SCIENCES. 2021, 46(10): 790-804, http://dx.doi.org/10.1016/j.tibs.2021.05.001.[8] Shi, Junchao, Zhang, Yunfang, Tan, Dongmei, Zhang, Xudong, Yan, Menghong, Zhang, Ying, Franklin, Reuben, Shahbazi, Marta, Mackinlay, Kirsty, Liu, Shichao, Kuhle, Bernhard, James, Emma R, Zhang, Liwen, Qu, Yongcun, Zhai, Qiwei, Zhao, Wenxin, Zhao, Linlin, Zhou, Changcheng, Gu, Weifeng, Murn, Jernej, Guo, Jingtao, Carrell, Douglas T, Wang, Yinsheng, Chen, Xuemei, Cairns, Bradley R, Yang, Xianglei, Schimmel, Paul, ZernickaGoetz, Magdalena, Cheloufi, Sihem, Zhang, Ying, Zhou, Tong, Chen, Qi. PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications. NATURE CELL BIOLOGY[J]. 2021, 23(4): 424-+, http://dx.doi.org/10.1038/s41556-021-00652-7.[9] Wang, Jun, Xie, Xueying, Shi, Junchao, He, Wenjun, Chen, Qi, Chen, Liang, Gu, Wanjun, Zhou, Tong. Denoising Autoencoder, A Deep Learning Algorithm, Aids the Identification of A Novel Molecular Signature of Lung Adenocarcinoma. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2020, 18(4): 468-480, http://lib.cqvip.com/Qikan/Article/Detail?id=00002HUHLL7G7JP0MPDO5JP16PR.[10] Lei, Xiaohua, Cao, Yujing, Ma, Baohua, Zhang, Yunfang, Ning, Lina, Qian, Jingjing, Zhang, Liwen, Qu, Yongcun, Zhang, Tao, Li, Dehong, Chen, Qi, Shi, Junchao, Zhang, Xudong, Ma, Chiyuan, Zhang, Ying, Duan, Enkui. Development of mouse preimplantation embryos in space. NATIONAL SCIENCE REVIEW[J]. 2020, 7(9): 1437-1446, http://dx.doi.org/10.1093/nsr/nwaa062.[11] Gu, Wanjun, Shi, Junchao, Liu, Hui, Zhang, Xudong, Zhou, Jin J, Li, Musheng, Zhou, Dandan, Li, Rui, Lv, Jingzhu, Wen, Guoxia, Zhu, Shanshan, Qi, Ting, Li, Wei, Wang, Xiaojing, Wang, Zhaohua, Zhu, Hua, Zhou, Changcheng, Knox, Kenneth S, Wang, Ting, Chen, Qi, Qian, Zhongqing, Zhou, Tong. Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer. MOLECULAR CANCER[J]. 2020, 19(1): http://dx.doi.org/10.1186/s12943-020-01280-9.[12] Zhang, Xudong, Trebak, Fatima, Souza, Lucas A C, Shi, Junchao, Zhou, Tong, Kehoe, Patrick G, Chen, Qi, Earley, Yumei Feng. Small RNA modifications in Alzheimer's disease. NEUROBIOLOGY OF DISEASE[J]. 2020, 145: 105058-105058, http://dx.doi.org/10.1016/j.nbd.2020.105058.[13] Shi, Junchao, Zhang, Yunfang, Zhou, Tong, Chen, Qi. tsRNAs: The Swiss Army Knife for Translational Regulation. TRENDS IN BIOCHEMICAL SCIENCES. 2019, 44(3): 185-189, http://dx.doi.org/10.1016/j.tibs.2018.09.007.[14] Zhang, Yunfang, Shi, Junchao, Rassoulzadegan, Minoo, Tuorto, Francesca, Chen, Qi. Sperm RNA code programmes the metabolic health of offspring. NATURE REVIEWS ENDOCRINOLOGY[J]. 2019, 15(8): 489-498, http://dx.doi.org/10.1038/s41574-019-0226-2.[15] Wang, Jiaqiang, Wang, Leyun, Feng, Guihai, Wang, Yukai, Li, Yufei, Li, Xin, Liu, Chao, Jiao, Guanyi, Huang, Cheng, Shi, Junchao, Zhou, Tong, Chen, Qi, Liu, Zhonghua, Li, Wei, Zhou, Qi. Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos. CELL[J]. 2018, 175(7): 1887-1901.e18, http://dx.doi.org/10.1016/j.cell.2018.11.039.[16] Qian, Zhongqing, Liu, Hui, Li, Musheng, Shi, Junchao, Li, Na, Zhang, Yao, Zhang, Xiaojie, Lv, Jingzhu, Xie, Xueying, Bai, Yunfei, Ge, Qinyu, Ko, EunA, Tang, Haiyang, Wang, Ting, Wang, Xiaojing, Wang, Zhaohua, Zhou, Tong, Gu, Wanjun. Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. EBIOMEDICINE[J]. 2018, 27(C): 18-26, https://doaj.org/article/787176c295c944cd9f1933e1d7d09ad6.[17] Zhang, Yunfang, Zhang, Xudong, Shi, Junchao, Tuorto, Francesca, Li, Xin, Liu, Yusheng, Liebers, Reinhard, Zhang, Liwen, Qu, Yongcun, Qian, Jingjing, Pahima, Maya, Liu, Ying, Yan, Menghong, Cao, Zhonghong, Lei, Xiaohua, Cao, Yujing, Peng, Hongying, Liu, Shichao, Wang, Yue, Zheng, Huili, Woolsey, Rebekah, Quilici, David, Zhai, Qiwei, Li, Lei, Zhou, Tong, Yan, Wei, Lyko, Frank, Zhang, Ying, Zhou, Qi, Duan, Enkui, Chen, Qi. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. NATURE CELL BIOLOGY[J]. 2018, 20(5): 535-+, http://dx.doi.org/10.1038/s41556-018-0087-2.[18] Chen, Qi, Shi, Junchao, Tao, Yi, ZernickaGoetz, Magdalena. Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/34f4ad89145e450a8f654040cd5bc6eb.[19] Zhou, Tong, Xie, Xueying, Li, Musheng, Shi, Junchao, Zhou, Jin J, Knox, Kenneth S, Wang, Ting, Chen, Qi, Gu, Wanjun. Rat BodyMap transcriptomes reveal unique circular RNA features across tissue types and developmental stages. RNA[J]. 2018, 24(11): 1443-1456, http://dx.doi.org/10.1261/rna.067132.118.[20] Qian, Jingjing, Zhang, Yunfang, Qu, Yongcun, Zhang, Liwen, Shi, Junchao, Zhang, Xudong, Liu, Shichao, Kim, Bo Hyun, Hwang, Sung Jin, Zhou, Tong, Chen, Qi, Ward, Sean M, Duan, Enkui, Zhang, Ying. Caffeine consumption during early pregnancy impairs oviductal embryo transport, embryonic development and uterine receptivity in mice. BIOLOGY OF REPRODUCTION[J]. 2018, 99(6): 1266-1275, http://dx.doi.org/10.1093/biolre/ioy155.[21] Shi, Junchao, Ko, EunA, Sanders, Kenton M, Chen, Qi, Zhou, Tong. SPORTS1.0: A Tool for Annotating and Profiling Non-coding RNAs Optimized for rRNA- and tRNA-derived Small RNAs. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2018, 16(2): 144-151, http://lib.cqvip.com/Qikan/Article/Detail?id=675426156.[22] Shi, Junchao, Zhang, Xudong, Liu, Ying, Chen, Qi. Epigenetic information in gametes: Gaming from before fertilization Comment on "Epigenetic game theory: How to compute the epigenetic control of maternal-to-zygotic transition" by Qian Wang et al.. PHYSICS OF LIFE REVIEWS. 2017, 20: 146-149, http://dx.doi.org/10.1016/j.plrev.2017.01.001.[23] Wenbo Liu, Fengchao Wang, Qianhua Xu, Junchao Shi, Xiaoxin Zhang, Xukun Lu, ZhenAo Zhao, Zheng Gao, Huaixiao Ma, Enkui Duan, Fei Gao, Shaorong Gao, Zhaohong Yi, Lei Li. BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/318f4f53fb5a48d5adc1879ed3272619.[24] Zhang, Yunfang, Shi, Junchao, Chen, Qi. tsRNAs: new players in mammalian retrotransposon control. CELL RESEARCH[J]. 2017, 27(11): 1307-1308, http://lib.cqvip.com/Qikan/Article/Detail?id=673788622.[25] 陈琦, 侍骏超, 段恩奎. 配子介导的哺乳动物获得性性状的跨代遗传. 生命科学[J]. 2017, 第 2 作者29(1): 8-14, [26] Liu, Yusheng, Lu, Xukun, Shi, Junchao, Yu, Xingjiang, Zhang, Xiaoxin, Zhu, Kai, Yi, Zhaohong, Duan, Enkui, Li, Lei. BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2016, 8(4): 366-368, https://www.webofscience.com/wos/woscc/full-record/WOS:000384849900009.[27] Chen Qi, Yan Menghong, Cao Zhonghong, Li Xin, Zhang Yunfang, Shi Junchao, Feng Guihai, Peng Hongying, Zhang Xudong, Zhang Ying, Qian Jingjing, Duan Enkui, Zhou Qi, Zhou Qi. Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. SCIENCE[J]. 2016, 351(6271): 397-400, https://www.webofscience.com/wos/woscc/full-record/WOS:000368440500043.[28] 侍骏超, 张云芳, 陈琦. Molecular Carriers of Acquired Inheritance: Absence of Evidence Is Not Evidence of Absence. ENVIRONMENTAL EPIGENETICS[J]. 2016, 第 1 作者2(2): Article No. dvw014, http://ir.ioz.ac.cn/handle/000000/12023.[29] Shi Junchao, Chen Qi, Li Xin, Zheng Xiudeng, Zhang Ying, Qiao Jie, Tang Fuchou, Tao Yi, Zhou Qi, Duan Enkui. Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq. DEVELOPMENT[J]. 2015, 142(20): 3468-3477, [30] Liu, Shuang, Wang, Xinyue, Zhao, Qian, Liu, Shu, Zhang, Huishan, Shi, Junchao, Li, Na, Lei, Xiaohua, Zhao, Huashan, Deng, Zhili, Cao, Yujing, Ning, Lina, Xia, Guoliang, Duan, Enkui. Senescence of human skin-derived precursors regulated by Akt-FOXO3-p27(KIP1)/p15(INK4b) signaling. CELLULAR AND MOLECULAR LIFE SCIENCES[J]. 2015, 72(15): 2949-2960, https://www.webofscience.com/wos/woscc/full-record/WOS:000358088600013.[31] Zhang, Shuang, Kong, Shuangbo, Wang, Bingyan, Cheng, Xiaohong, Chen, Yongjie, Wu, Weiwei, Wang, Qiang, Shi, Junchao, Zhang, Ying, Wang, Shumin, Lu, Jinhua, Lydon, John P, DeMayo, Francesco, Pear, Warren S, Han, Hua, Lin, Haiyan, Li, Lei, Wang, Hongmei, Wang, YanLing, Li, Bing, Chen, Qi, Duan, Enkui, Wang, Haibin. Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. CELL RESEARCH[J]. 2014, 24(8): 925-942, https://www.webofscience.com/wos/woscc/full-record/WOS:000343133700008.[32] Zhang, Yunfang, Zhang, Ying, Shi, Junchao, Zhang, He, Cao, Zhonghong, Gao, Xuan, Ren, Wanhua, Ning, Yunna, Ning, Lina, Cao, Yujing, Chen, Yongchang, Ji, Weizhi, Chen, Zijiang, Chen, Qi, Duan, Enkui. Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2014, 6(2): 172-174, http://lib.cqvip.com/Qikan/Article/Detail?id=50281934.[33] He Zhang, Ying Zhang, Huashan Zhao, Yunfang Zhang, Qi Chen, Hongying Peng, Li Lei, Jingqiao Qiao, Junchao Shi, Zhonghong Cao, Enkui Duan, Yaping Jin. Hormonal Regulation of Ovarian Bursa Fluid in Mice and Involvement of Aquaporins. PLOS ONE[J]. 2013, 8(5): https://doaj.org/article/fffa3fa82a6a47e688164736cb68bbd4.[34] Peng, Hongying, Shi, Junchao, Zhang, Ying, Zhang, He, Liao, Shangying, Li, Wei, Lei, Li, Han, Chunsheng, Ning, Lina, Cao, Yujing, Zhou, Qi, Chen, Qi, Duan, Enkui. A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm. CELL RESEARCH[J]. 2012, 22(11): 1609-1612, https://www.webofscience.com/wos/woscc/full-record/WOS:000310789500014.
科研活动
科研项目
( 1 ) 运用PANDORA-seq技术绘制衰老过程中精子非编码小RNA 动态表达谱及其功能研究, 负责人, 国家任务, 2024-01--2027-12
参与会议
(1)PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications 2023-05-25(2)SPORTS1.1: A Tool for Annotating and ProfilingNon-Coding RNAs Optimized for rRNA-and tRNA-Derived Small RNAs 2021-05-13
指导学生
现指导学生
谢乐凡 硕士研究生 0710J3-生物信息学
黄奥 硕士研究生 0710J3-生物信息学
奉泽荣 博士研究生 0710J3-生物信息学
刘鑫鑫 博士研究生 0710Z1-基因组学