071006-神经生物学

DNA损伤应答，神经发育与神经退行，衰老，神经再生

2005-09--2008-06   兰州大学   博士

   

2019-02~现在, 中国科学院动物研究所, 副研
2010-10~2019-02,中国科学院动物研究所, 助研
2008-09~2010-08,德国于利希研究中心, 博士后
2005-09~2008-06,兰州大学, 博士

2024-04-01-2025-03-31,副研究员,

   

（1） 甘肃省技术发明奖, 一等奖, 省级, 2012
（2） 甘肃省科学技术进步奖, 二等奖, 省级, 2012
（3） 甘肃省药学发展奖, 一等奖, 省级, 2010

（ 1 ） CPE在制备促进原位神经发生及治疗衰老相关神经退行性疾病药物中的应用, 2021, 第 3 作者, 专利号: 202111352889.6

（ 2 ） C末端修饰的内吗啡肽1, 2008, 第 3 作者, 专利号: CN100378126C

（ 3 ） C末端修饰的内吗啡肽2, 2008, 第 3 作者, 专利号: CN101139383A

（ 4 ） 组合化学修饰的内吗啡肽－1及其制备方法, 2008, 第 2 作者, 专利号: CN101134774A

   

（1） Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer���s disease, TRANSLATIONAL NEURODEGENERATION, 2024, 第 2 作者  通讯作者
（2） Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration, CELL & BIOSCIENCE, 2023, 第 5 作者  通讯作者
（3） Restoring carboxypeptidase E rescues BDNF maturation and neurogenesis in aged brains, Life Medicine, 2023, 第 1 作者
（4） ER Ca 2+ overload activates the IRE1�� signaling and promotes cell survival, CELL & BIOSCIENCE, 2023, 第 8 作者  通讯作者
（5） Ca2+ maintained by TMCO1 underlies corpus callosum development via ERK signaling, Cell Death and Disease, 2022, 第 11 作者  通讯作者
（6） Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases, FRONTIERS IN CELLULAR NEUROSCIENCE, 2022, 第 6 作者  通讯作者
（7） Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation, MOLECULAR CELL, 2022, 第 4 作者
（8） BMP4 Exerts Anti-Neurogenic Effect via Inducing Id3 during Aging, BIOMEDICINES, 2022, 第 2 作者
（9） Miro2 supplies a platform for Parkin translocation to damaged mitochondria, SCIENCE BULLETIN, 2019, 第 11 作者
（10） Epigenetic profiles in polyglutamine disorders, EPIGENOMICS, 2018, 第 1 作者  通讯作者
（11） Parkin Regulates Translesion DNA Synthesis in Response to UV Radiation, ONCOTARGET, 2017, 第 5 作者
（12） RBM45 competes with HDAC1 for binding to FUS in response to DNA damage, NUCLEIC ACIDS RESEARCH, 2017, 第 5 作者
（13） Ataxin-3 promotes genome integrity by stabilizing Chk1., NUCLEIC ACIDS RESEARCH, 2017, 第 2 作者
（14） Pol�� O-GlcNAcylation Governs Genome Integrity During Translesion DNA Synthesis, NATURE COMMUNICATIONS, 2017, 第 2 作者
（15） The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53., PLOS BIOLOGY, 2016, 第 1 作者
（16） Toward therapeutic targets for SCA3: Insight into the role of Machado���Joseph disease protein ataxin-3 in misfolded proteins clearance, PROGRESS IN NEUROBIOLOGY, 2015, 第 2 作者
（17） Transcriptomic Analyses of Neurotoxic Effects in Mouse Brain After Intermittent Neonatal Administration of Thimerosal, TOXICOLOGICAL SCIENCES, 2014, 第 5 作者
（18） Mismatch Repair Protein MSH2 Regulates Translesion DNA Synthesis Following Exposure of Cells to UV Radiation, NUCLEIC ACIDS RESEARCH, 2013, 第 6 作者
（19） Structure���activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling, BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 第 6 作者
（20） Type 1 Diabetes attenuates the modulatory effects of endomorphins on mouse colonic motility, NEUROPEPTIDES, 2008, 
（21） Differential cardiovascular effects of synthetic peptides derived from endomorphin-1 in anesthetized rats, PEPTIDES, 2008, 第 1 作者
（22） In vitro and in vivo characterization of opioid activities of endomorphins analogs with novel constrained C-terminus: Evidence for the important role of proper spatial disposition of the third aromatic ring, PEPTIDES, 2007, 第 4 作者
（23） Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: Design, synthesis, and pharmacological characterization, BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 第 1 作者
（24） Utilization of combined chemical modifications to enhance the blood-brain barrier permeability and pharmacological activity of endomorphin-1, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2006, 第 1 作者
（25） C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats, PEPTIDES, 2006, 
（26） Cardiovascular effects of endomorphins in alloxan-induced diabetic rats, PEPTIDES, 2005, 

   

（ 1 ） 雷特综合症致病蛋白MeCP2在DNA损伤修复中的功能及分子机制研究, 负责人, 国家任务, 2021-01--2024-12