100701-药物化学

抗肿瘤和代谢性疾病的创新药物研发

2009-09--2014-07   中国科学院上海药物研究所   博士
2005-09--2009-07   武汉大学   大学本科

   

2022-06~现在, 中国科学院上海药物研究所, 研究员
2018-12~2022-04,美国德克萨斯大学, 博士后
2016-08~2018-11,上海药明康德新药研发有限公司, 项目主管
2014-07~2016-07,中国科学院上海药物研究所, 博士后
2009-09~2014-07,中国科学院上海药物研究所, 博士
2005-09~2009-07,武汉大学, 大学本科

   

（ 1 ） 一种含季碳手性1,2,5-噻唑啉酮-1,1-二氧化物和2,3-二氢-1,2,5-噻二唑-1,1-二氧化物的合成方法, 2017, 第 2 作者, 专利号: CN106608859A

（ 2 ） 高光学纯度含手性叔丁基亚磺酰基的α-芳基氨基酸酯类化合物、其制备方法及用途, 2013, 第 2 作者, 专利号: CN102993065A

   

（1） Discovery, X-ray Crystallography, and Anti-Inflammatory Activity of Bromodomain-Containing Protein 4 (BRD4) Inhibitors Targeting a Distinct New Binding Site, JOURNAL OF MEDICINAL CHEMISTRY, 2022, 第 1 作者
（2） Target-Based Small Molecule Drug Discovery towards Novel Therapeutics for Inflammatory Bowel Diseases, INFLAMMATORY BOWEL DISEASES, 2021, 第 1 作者
（3） Applications of Asymmetric Petasis Reaction in the Synthesis of Chiral Amines, ACTA CHIMICA SINICA, 2021, 第 1 作者
（4） Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives, ORGANIC LETTERS, 2021, 第 2 作者
（5） Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives, ORGANIC LETTERS, 2021, 第 2 作者
（6） Discovery of Phenanthridine Analogues as Novel Chemical Probes Disrupting the Binding of DNA to ��FosB Homodimers and ��FosB/JunD Heterodimers, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 第 1 作者
（7） Rhodium-Catalyzed Enantioselective Alkenylation of Cyclic Ketimines: Synthesis of Multifunctional Chiral alpha,alpha-Disubstituted Allylic Amine Derivatives, ORGANIC LETTERS, 2018, 第 1 作者
（8） Rhodium-Catalyzed Enantioselective Alkenylation of Cyclic Ketimines: Synthesis of Multifunctional Chiral alpha,alpha-Disubstituted Allylic Amine Derivatives, ORGANIC LETTERS, 2018, 第 1 作者
（9） Simple Open-Chain Phosphite-Olefin as Ligand for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Enantioselective Access to gem-Diaryl alpha-Amino Acid Derivatives, ACS CATALYSIS, 2016, 第 1 作者
（10） Simple Open-Chain Phosphite-Olefin as Ligand for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Enantioselective Access to gem-Diaryl alpha-Amino Acid Derivatives, ACS CATALYSIS, 2016, 第 1 作者
（11） Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol, ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 第 3 作者
（12） A highly diastereoselective Friedel-Crafts reaction of indoles with isatin-derived N-sulfinyl ketimines towards the efficient synthesis of chiral tetrasubstituted 3-indolyl-3-aminooxindoles, ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 第 3 作者
（13） Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol, ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 第 3 作者
（14） A highly diastereoselective Friedel-Crafts reaction of indoles with isatin-derived N-sulfinyl ketimines towards the efficient synthesis of chiral tetrasubstituted 3-indolyl-3-aminooxindoles, ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 第 3 作者
（15） Rhodium-Catalyzed Asymmetric Tandem Cyclization for Efficient and Rapid Access to Underexplored Heterocyclic Tertiary Allylic Alcohols Containing a Tetrasubstituted Olefin, ORGANIC LETTERS, 2014, 第 1 作者
（16） Simple sulfur-olefins as new promising chiral ligands for asymmetric catalysis, CHEMICAL COMMUNICATIONS, 2014, 第 1 作者
（17） Rhodium-Catalyzed Highly Enantioselective Arylation of Cyclic Diketimines: Efficient Synthesis of Chiral Tetrasubstituted 1,2,5-Thiadiazoline 1,1-Dioxides, ORGANIC LETTERS, 2014, 第 2 作者
（18） Rhodium-Catalyzed Asymmetric Tandem Cyclization for Efficient and Rapid Access to Underexplored Heterocyclic Tertiary Allylic Alcohols Containing a Tetrasubstituted Olefin, ORGANIC LETTERS, 2014, 第 1 作者
（19） Simple sulfur-olefins as new promising chiral ligands for asymmetric catalysis, CHEMICAL COMMUNICATIONS, 2014, 第 1 作者
（20） Rhodium-Catalyzed Highly Enantioselective Arylation of Cyclic Diketimines: Efficient Synthesis of Chiral Tetrasubstituted 1,2,5-Thiadiazoline 1,1-Dioxides, ORGANIC LETTERS, 2014, 第 2 作者
（21） Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: Binding mode, inhibitory mechanism and biological action, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 第 2 作者
（22） A new versatile approach to synthesise enantioenriched 3-hydroxyoxindoles, 1,3-dihydroisobenzofuran and 3-isochromanone derivatives by a rhodium-catalyzed asymmetric arylation-cyclization sequence, CHEMICAL COMMUNICATIONS, 2013, 第 1 作者
（23） Lewis-Acid-Catalyzed Intramolecular Aza-Friedel-Crafts Reaction of N-tert-Butanesulfinyl Imines: Efficient Synthesis of Optically Active 9-Aminofluorene Derivatives, ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 第 1 作者
（24） Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: Binding mode, inhibitory mechanism and biological action, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 第 2 作者
（25） A new versatile approach to synthesise enantioenriched 3-hydroxyoxindoles, 1,3-dihydroisobenzofuran and 3-isochromanone derivatives by a rhodium-catalyzed asymmetric arylation-cyclization sequence, CHEMICAL COMMUNICATIONS, 2013, 第 1 作者
（26） Lewis-Acid-Catalyzed Intramolecular Aza-Friedel-Crafts Reaction of N-tert-Butanesulfinyl Imines: Efficient Synthesis of Optically Active 9-Aminofluorene Derivatives, ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 第 1 作者
（27） Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids, ORGANIC LETTERS, 2012, 第 1 作者
（28） Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids, ORGANIC LETTERS, 2012, 第 1 作者
（29） Highly diastereoselective Friedel-Crafts reaction of arenes with N-tert-butanesulfinylimino ester towards the efficient synthesis of alpha-arylglycines, ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 第 1 作者
（30） Highly diastereoselective Friedel-Crafts reaction of arenes with N-tert-butanesulfinylimino ester towards the efficient synthesis of alpha-arylglycines, ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 第 1 作者
（31） One-pot synthesis of furocoumarins via sequential Pd/Cu-catalyzed alkynylation and intramolecular hydroalkoxylation, ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 第 2 作者
（32） One-pot synthesis of furocoumarins via sequential Pd/Cu-catalyzed alkynylation and intramolecular hydroalkoxylation, ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 第 2 作者

   

（ 1 ） 基于协同靶向策略的抗糖尿病候选化合物发现研究, 负责人, 地方任务, 2023-10--2025-09