基本信息
李翼  男  硕导  中国科学院上海药物研究所
电子邮件: liyi@simm.ac.cn
通信地址: 广东翠亨新区中瑞(欧)工业园健康医药示范区
邮政编码:

招生信息

   
招生专业
100701-药物化学
招生方向
抗肿瘤药物研发

教育背景

2009-09--2014-07   中国科学院上海药物研究所   博士
2005-09--2009-07   武汉大学   大学本科

工作经历

   
工作简历
2022-06~现在, 中国科学院上海药物研究所, 研究员
2018-12~2022-04,美国德克萨斯大学, 博士后
2016-08~2018-11,上海药明康德新药研发有限公司, 项目主管
2014-07~2016-07,中国科学院上海药物研究所, 博士后
2009-09~2014-07,中国科学院上海药物研究所, 博士
2005-09~2009-07,武汉大学, 大学本科

专利与奖励

   
专利成果
( 1 ) 一种含季碳手性1,2,5-噻唑啉酮-1,1-二氧化物和2,3-二氢-1,2,5-噻二唑-1,1-二氧化物的合成方法, 2017, 第 2 作者, 专利号: CN106608859A

( 2 ) 高光学纯度含手性叔丁基亚磺酰基的α-芳基氨基酸酯类化合物、其制备方法及用途, 2013, 第 2 作者, 专利号: CN102993065A

出版信息

   
发表论文
(1) Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives, ORGANIC LETTERS, 2021, 第 2 作者
(2) Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives, ORGANIC LETTERS, 2021, 第 2 作者
(3) Rhodium-Catalyzed Enantioselective Alkenylation of Cyclic Ketimines: Synthesis of Multifunctional Chiral alpha,alpha-Disubstituted Allylic Amine Derivatives, ORGANIC LETTERS, 2018, 第 1 作者
(4) Rhodium-Catalyzed Enantioselective Alkenylation of Cyclic Ketimines: Synthesis of Multifunctional Chiral alpha,alpha-Disubstituted Allylic Amine Derivatives, ORGANIC LETTERS, 2018, 第 1 作者
(5) Simple Open-Chain Phosphite-Olefin as Ligand for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Enantioselective Access to gem-Diaryl alpha-Amino Acid Derivatives, ACS CATALYSIS, 2016, 第 1 作者
(6) Simple Open-Chain Phosphite-Olefin as Ligand for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Enantioselective Access to gem-Diaryl alpha-Amino Acid Derivatives, ACS CATALYSIS, 2016, 第 1 作者
(7) Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol, ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 第 3 作者
(8) A highly diastereoselective Friedel-Crafts reaction of indoles with isatin-derived N-sulfinyl ketimines towards the efficient synthesis of chiral tetrasubstituted 3-indolyl-3-aminooxindoles, ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 第 3 作者
(9) Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol, ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 第 3 作者
(10) A highly diastereoselective Friedel-Crafts reaction of indoles with isatin-derived N-sulfinyl ketimines towards the efficient synthesis of chiral tetrasubstituted 3-indolyl-3-aminooxindoles, ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 第 3 作者
(11) Rhodium-Catalyzed Asymmetric Tandem Cyclization for Efficient and Rapid Access to Underexplored Heterocyclic Tertiary Allylic Alcohols Containing a Tetrasubstituted Olefin, ORGANIC LETTERS, 2014, 第 1 作者
(12) Simple sulfur-olefins as new promising chiral ligands for asymmetric catalysis, CHEMICAL COMMUNICATIONS, 2014, 第 1 作者
(13) Rhodium-Catalyzed Highly Enantioselective Arylation of Cyclic Diketimines: Efficient Synthesis of Chiral Tetrasubstituted 1,2,5-Thiadiazoline 1,1-Dioxides, ORGANIC LETTERS, 2014, 第 2 作者
(14) Rhodium-Catalyzed Asymmetric Tandem Cyclization for Efficient and Rapid Access to Underexplored Heterocyclic Tertiary Allylic Alcohols Containing a Tetrasubstituted Olefin, ORGANIC LETTERS, 2014, 第 1 作者
(15) Simple sulfur-olefins as new promising chiral ligands for asymmetric catalysis, CHEMICAL COMMUNICATIONS, 2014, 第 1 作者
(16) Rhodium-Catalyzed Highly Enantioselective Arylation of Cyclic Diketimines: Efficient Synthesis of Chiral Tetrasubstituted 1,2,5-Thiadiazoline 1,1-Dioxides, ORGANIC LETTERS, 2014, 第 2 作者
(17) Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: Binding mode, inhibitory mechanism and biological action, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 第 2 作者
(18) A new versatile approach to synthesise enantioenriched 3-hydroxyoxindoles, 1,3-dihydroisobenzofuran and 3-isochromanone derivatives by a rhodium-catalyzed asymmetric arylation-cyclization sequence, CHEMICAL COMMUNICATIONS, 2013, 第 1 作者
(19) Lewis-Acid-Catalyzed Intramolecular Aza-Friedel-Crafts Reaction of N-tert-Butanesulfinyl Imines: Efficient Synthesis of Optically Active 9-Aminofluorene Derivatives, ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 第 1 作者
(20) Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: Binding mode, inhibitory mechanism and biological action, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 第 2 作者
(21) A new versatile approach to synthesise enantioenriched 3-hydroxyoxindoles, 1,3-dihydroisobenzofuran and 3-isochromanone derivatives by a rhodium-catalyzed asymmetric arylation-cyclization sequence, CHEMICAL COMMUNICATIONS, 2013, 第 1 作者
(22) Lewis-Acid-Catalyzed Intramolecular Aza-Friedel-Crafts Reaction of N-tert-Butanesulfinyl Imines: Efficient Synthesis of Optically Active 9-Aminofluorene Derivatives, ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 第 1 作者
(23) Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids, ORGANIC LETTERS, 2012, 第 1 作者
(24) Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids, ORGANIC LETTERS, 2012, 第 1 作者
(25) Highly diastereoselective Friedel-Crafts reaction of arenes with N-tert-butanesulfinylimino ester towards the efficient synthesis of alpha-arylglycines, ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 第 1 作者
(26) Highly diastereoselective Friedel-Crafts reaction of arenes with N-tert-butanesulfinylimino ester towards the efficient synthesis of alpha-arylglycines, ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 第 1 作者
(27) One-pot synthesis of furocoumarins via sequential Pd/Cu-catalyzed alkynylation and intramolecular hydroalkoxylation, ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 第 2 作者
(28) One-pot synthesis of furocoumarins via sequential Pd/Cu-catalyzed alkynylation and intramolecular hydroalkoxylation, ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 第 2 作者