100701-药物化学
0703Z1-化学生物学

疾病靶向诊治的探针与药物分子开发

2015-09--2020-06   华东理工大学   工学博士
2011-09--2015-06   山东理工大学   工学学士

   

2020-07~2022-06,华东理工大学, 博士后

2022-04-01-今,《Frontier in Chemistry》, 评审编辑

   

（ 1 ） 二噻吩乙烯类化合物及其制备方法和用途, 发明专利, 2019, 第 3 作者, 专利号: CN110105413A

   

（1） Fluorescent probes for the imaging of lipid droplets in live cells, COORDINATION CHEMISTRY REVIEWS, 2021, 第 3 作者
（2） A long-wavelength fluorescent probe with a large Stokes shift for lysosome-targeted imaging of Cys and GSH, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2021, 第 2 作者
（3） In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics, CHEMICAL COMMUNICATIONS, 2021, 第 3 作者
（4） Deferasirox (ExJade): An FDA-Approved AIEgen Platform with Unique Photophysical Properties, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, 第 6 作者
（5） A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters †, Chemical Science, 2021, 第 3 作者
（6） Long-Wavelength AIE-Based Fluorescent Probes for Mitochondria-Targeted Imaging and Photodynamic Therapy of Hepatoma Cells, ACS APPLIED BIO MATERIALS, 2021, 第 2 作者
（7） Small-molecule fluorescence-based probes for interrogating major organ diseases, CHEMICAL SOCIETY REVIEWS, 2021, 第 1 作者
（8） Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications, CHEMICAL SCIENCE, 2020, 第 2 作者
（9） Protein encapsulation: a new approach for improving the capability of small-molecule fluorogenic probes, CHEMICAL SCIENCE, 2020, 第 1 作者
（10） Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 第 2 作者
（11） Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging, CHEMISTRY-A EUROPEAN JOURNAL, 2020, 第 4 作者
（12） Protein Encapsulation: A Nanocarrier Approach to the Fluorescence Imaging of an Enzyme-Based Biomarker, FRONTIERS IN CHEMISTRY, 2020, 第 2 作者
（13） Self-Assembled Thin-Layer Glycomaterials With a Proper Shell Thickness for Targeted and Activatable Cell Imaging, FRONTIERS IN CHEMISTRY, 2019, 第 3 作者
（14） Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2019, 第 2 作者
（15） Peroxynitrite Activated Drug Conjugate Systems Based on a Coumarin Scaffold Toward the Application of Theranostics, FRONTIERS IN CHEMISTRY, 2019, 第 2 作者
（16） Glypican-3-targeted precision diagnosis of hepatocellular carcinoma on clinical sections with a supramolecular 2D imaging probe, THERANOSTICS, 2018, 第 1 作者
（17） The development of a novel AND logic based fluorescence probe for the detection of peroxynitrite and GSH, CHEMICAL SCIENCE, 2018, 第 2 作者
（18） Photocontrolled Fluorescence "Double-Check" Bioimaging Enabled by a Glycoprobe-Protein Hybrid, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 2 作者
（19） Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes, NATURE COMMUNICATIONS, 2017, 第 3 作者
（20） Sialylglycan-Assembled Supra-Dots for Ratiometric Probing and Blocking of Human-Infecting Influenza Viruses, ACS APPLIED MATERIALS & INTERFACES, 2017, 第 2 作者
（21） Supramolecular core-glycoshell polythiophene nanodots for targeted imaging and photodynamic therapy, CHEMICAL COMMUNICATIONS, 2017, 第 1 作者
（22） Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite, CHEMICAL COMMUNICATIONS, 2017, 第 2 作者

   

（ 1 ） 肝星状细胞活化中脂质代谢过程的原位与动态荧光可视化研究, 负责人, 国家任务, 2022-01--2024-12