基本信息
孙毅  女  博导  深圳理工大学
电子邮件: sunyi@siat.ac.cn
通信地址: 深圳西丽深圳大学城学苑大道1068
邮政编码:

教育背景

1990-06--1995-12   凯斯西储大学   研究生/博士
1987-09--1989-06   中国科学院细胞生物学研究所   研究生
1983-09--1987-06   复旦大学   本科/学士

工作经历

   
工作简历
2022-08~现在, 中国科学院深圳先进技术研究院, 研究员
2022-08~现在, 深圳理工大学(筹), 讲席教授
2011-07~2020-06,加州大学洛杉矶分校医学院,精神病学与生物行为科学系、分子医药系, 教授
2007-07~2011-06,加州大学洛杉矶分校医学院,精神病学与生物行为科学系、分子医药系, 副教授
2001-05~2007-06,加州大学洛杉矶分校医学院,精神病学与生物行为科学系、分子医药系, 助理教授
1996-01~2001-04,哈佛医学院, 博士后
1990-06~1995-12,凯斯西储大学, 研究生/博士
1987-09~1989-06,中国科学院细胞生物学研究所, 研究生
1983-09~1987-06,复旦大学, 本科/学士
社会兼职
2023-04-23-今,中国干细胞再生医学专业委员会, 常务委员
2022-11-15-今,中国干细胞产业联盟理事会专家委员会, 委员
2022-11-14-今,中国整形美容协会干细胞研究与应用分会, 常务理事
2016-12-31-今,美国华人生物科学家学会(SCBA)项目委员会, 委员
2016-06-11-今,戈登会议(GRC)分子细胞神经生物学会议(MCN), 主席
2014-06-28-今,戈登会议(GRC)分子细胞神经生物学会议(MCN), 副主席
2009-12-30-2011-12-29,华人生物学家协会, 理事
2007-12-31-2010-12-30,全球神经生物学会(SFN)WIN(女性神经生物学家)分会, 理事

教授课程

干细胞与转化医学
干细胞与临床转化
M252A/B (stem cell section)
Neuro215
UCLA PHARM291
UCLA NS M201
Molecular Biology 298 (current topics in molecular biology)
NS193
UCLA Neuroscience Seminar Course
PHARM295

专利与奖励

   
奖励信息
(1) 上海自然科学奖, 一等奖, 省级, 2023
(2) 上海市科学技术-国际合作奖, 一等奖, 省级, 2017
(3) 上海市科学技术奖, 一等奖, 省级, 2014
(4) 上海医学科技奖, 一等奖, 省级, 2013
专利成果
( 1 ) 一种复合生物材料及其制备方法和用途, 2023, 第 2 作者, 专利号: ZL202210435069.1

( 2 ) 靶向ATF5的小干扰RNA及其用途, 2021, 第 2 作者, 专利号: CN112877328A

( 3 ) ATF5在筛选用于治疗线粒体基因3243位点突变相关疾病的药物中的用途, 2021, 第 2 作者, 专利号: CN112680511A

( 4 ) 一种人脐带间充质干 细胞的储存液, 2020, 第 3 作者, 专利号: ZL201710746062.0

( 5 ) 细胞生产GMP车间单向移动控制门锁, 2017, 第 1 作者, 专利号: CN206722571U

( 6 ) 用于富集特定细胞的血液过滤装置, 2017, 第 3 作者, 专利号: CN206467237U

( 7 ) 用于免疫治疗检测用的离心管, 2017, 第 2 作者, 专利号: CN206404811U

( 8 ) 用于多通道移液器的连接器, 2016, 第 3 作者, 专利号: CN205199537U

出版信息

   
发表论文
(1) A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment, Cell Reports Medicine, 2023, 
(2) Sophisticated Magneto-Mechanical Actuation Promotes In Situ Stem Cell Assembly and Chondrogenesis for Treating Osteoarthritis, ACS Nano, 2023, 
(3) Exploring the shared molecular mechanisms between systemic lupus erythematosus and primary Sj��gren���s syndrome based on integrated bioinformatics and single-cell RNA-seq analysis, Frontiers in Immunology, 2023, 
(4) Proper wiring of newborn neurons to control bladder function after complete spinal cord injury, BIOMATERIALS, 2023, 
(5) Immune pathway activation in neurons triggers neural damage after stroke, Cell Reports, 2023, 
(6) Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis, NATURECOMMUNICATIONS, 2022, 
(7) Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury, Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2022, 
(8) Bio-C (Modified Hyaluronic Acid-Coated-Collagen Tube) Implants Enable Functional Recovery after Complete Spinal Cord Injury, PHARMACEUTICS, 2022, 
(9) A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer's disease pathologies, BRAIN, 2021, 
(10) Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines, CELL DISCOVERY, 2021, 
(11) Single-cell RNA-seq analysis revealed long-lasting adverse effects of tamoxifen on neurogenesis in prenatal and adult brains, PROCEEDINGSOFTHENATIONALACADEMYOFSCIENCESOFTHEUNITEDSTATESOFAMERICA, 2020, 
(12) Graded and pan-neural disease phenotypes of Rett Syndrome linked with dosage of functional MeCP2, PROTEIN & CELL, 2020, 
(13) Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity (vol 9, pg 298, 2018), PROTEIN & CELL, 2019, 
(14) NT3-chitosan enables de novo regeneration and functional recovery in monkeys after spinal cord injury., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 
(15) Unbiased transcriptomic analyses reveal distinct effects of immune deficiency in CNS function with and without injury, PROTEIN & CELL, 2018, 
(16) MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 
(17) Single-cell transcriptomics reveals gene signatures and alterations associated with aging in distinct neural stem/progenitor cell subpopulations, PROTEIN & CELL, 2017, 
(18) Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys, CELL, 2017, 
(19) Coupled electrophysiological recording and single cell transcriptome analyses revealed molecular mechanisms underlying neuronal maturation, PROTEIN & CELL, 2016, 
(20) NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 
(21) Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 
(22) Single-Cell Transcriptome Analyses Reveal Signals to Activate Dormant Neural Stem Cells, CELL, 2015, 
(23) Extended Cocaine Access Results in a Distinct Epigenetic Alterations to the Homer2 Gene in the Dorsal Medial Prefrontal Cortex, FASEB JOURNAL, 2015, 第 5 作者
(24) Prolonged Access to Cocaine Results in Distinct Epigenetic Changes in the Prefrontal Cortex, FASEB JOURNAL, 2014, 第 6 作者
(25) The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory, NATURE NEUROSCIENCE, 2011, 
(26) Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells, NATURE, 2011, 
(27) Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes, SCIENCE, 2010, 
(28) Epigenetic Mechanisms Associated with the Extinction of Conditioned Fear, BIOLOGICAL PSYCHIATRY, 2009, 第 4 作者
(29) CD133 + neural stem cells in the ependyma of mammalian postnatal forebrain, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 
(30) Copy number variant analysis of human embryonic stem cells, STEM CELLS, 2008, 第 16 作者
(31) 从人胚胎干细胞畸胎瘤中有效获取间充质干细胞和神经前体细胞, Efficient Derivation of Mesenchymal Stem Cells and Neural Precursor Cells From Human Embryonic Stem Cells Through Teratoma Formation, 生物化学与生物物理进展, 2008, 
(32) Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 

科研活动

   
科研项目
( 1 ) 深圳市神经系统疾病干预策略概念验证中心, 负责人, 地方任务, 2023-01--2025-12
( 2 ) 2022年度广东省“银龄专家”, 负责人, 地方任务, 2022-07--2024-12
( 3 ) 鹏程孔雀特聘A岗, 负责人, 地方任务, 2021-12--2025-11
( 4 ) 单细胞转录组解析神经-免疫-血脑屏障互作的分子病理机制, 负责人, 国家任务, 2021-01--2025-12
参与会议
(1)Wide-Spread Molecular and Cellular Pathological Manifestations Mirroring Rett Syndrome in MeCP2-T158M Monkeys   2024-05-29
(2)Neuroinflammation from periphery to central and converse   2023年“神经-免疫-内分泌-代谢网络相互调控”会议   2023-05-29
(3)自体年轻化细胞治疗ALS   第三届生命·健康论坛   2023-04-21
(4)脊髓损伤再生的分子机理及临床转化过程中需要解决的重大基础问题   “中枢神经再生与临床转化研究”科学与技术前沿论坛   2020-10-24
(5)Immune Pathway activated in neurons triggers neural damage after stroke   神经科学研究Zoom讲座   2020-04-28
(6)Modeling Rett Syndrome using TALEN-edited MECP2 Mutant Cynomolgus Monkeys   2019-03-21
(7)Applications of transcriptomic analyses with single cell resolution to neural injury and repair research   2018-07-26