071006-神经生物学
071009-细胞生物学

神经退行性疾病
神经免疫

2013-10--2017-08   慕尼黑大学   博士
2011-09--2013-09   比利时鲁汶大学   硕士

   

2017-09~2020-08,慕尼黑大学, 博士后

   

[1] 赵俊伊, 赵月, 刘思雨, 陈雪贞, 朱凯川, 项贤媛, 祝心舟. 一种胶质瘤体外共培养模型及其构建方法和应用. CN: CN115125206A, 2022-09-30.

   

[1] Dai Shi, Jaime K Y Wong, Kaichuan Zhu, Peter G Noakes, Gerhard Rammes, Yuzuru Imai. The Anaesthetics Isoflurane and Xenon Reverse the Synaptotoxic Effects of Aβ 1–42 on Megf10-Dependent Astrocytic Synapse Elimination and Spine Density in Ex Vivo Hippocampal Brain Slices. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023, 第 3 作者24(2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861496/.
[2] Chen, Xuezhen, Zhao, Yue, Huang, Yimin, Zhu, Kaichuan, Zeng, Fan, Zhao, Junyi, Zhang, Huaqiu, Zhu, Xinzhou, Kettenmann, Helmut, Xiang, Xianyuan. TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages. GLIA. 2023, 第 4 作者http://dx.doi.org/10.1002/glia.24456.
[3] Schmid, Sebastian, Rammes, Gerhard, Blobner, Manfred, Kellermann, Kristine, Bratke, Sebastian, Fendl, Diana, Zhu, Kaichuan, Schneider, Gerhard, Jungwirth, Bettina. Cognitive decline in Tg2576 mice shows sex-specific differences and correlates with cerebral amyloid-beta. BEHAVIOURAL BRAIN RESEARCH[J]. 2019, 第 7 作者359: 408-417, http://dx.doi.org/10.1016/j.bbr.2018.11.022.
[4] Zhu, Kaichuan, Xiang, Xianyuan, Filser, Severin, Marinkovic, Petar, Dorostkar, Mario M, Crux, Sophie, Neumann, Ulf, Shimshek, Derya R, Rammes, Gerhard, Haass, Christian, Lichtenthaler, Stefan F, Gunnersen, Jenny M, Herms, Jochen. Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6. BIOLOGICAL PSYCHIATRY[J]. 2018, 第 1 作者83(5): 428-437, http://dx.doi.org/10.1016/j.biopsych.2016.12.023.
[5] Xiang, Xianyuan, Piers, Thomas M, Wefers, Benedikt, Zhu, Kaichuan, Mallach, Anna, Brunner, Bettina, Kleinberger, Gernot, Song, Wilbur, Colonna, Marco, Herms, Jochen, Wurst, Wolfgang, Pocock, Jennifer M, Haass, Christian. The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans. MOLECULAR NEURODEGENERATION[J]. 2018, 第 4 作者13(1): http://dx.doi.org/10.1186/s13024-018-0280-6.
[6] Gerhard Rammes, Franziska Seeser, Korinna Mattusch, Kaichuan Zhu, Laura Haas, Markus Kummer, Michael Heneka, Jochen Herms, Chris G Parsons. The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (Aβ) species on long-term potentiation (LTP). NEUROPHARMACOLOGY. 2018, 第 4 作者140: 184-192, http://dx.doi.org/10.1016/j.neuropharm.2018.07.021.
[7] Zhu, Kaichuan, Peters, Finn, Filser, Severin, Herms, Jochen. Consequences of Pharmacological BACE Inhibition on Synaptic Structure and Function. BIOLOGICAL PSYCHIATRY. 2018, 第 1 作者84(7): 478-487, http://dx.doi.org/10.1016/j.biopsych.2018.04.022.
[8] Gerhard Rammes, Corinna Mattusch, Matthias Wulff, Franziska Seeser, Matthias Kreuzer, Kaichuan Zhu, Jan M. Deussing, Jochen Herms, Chris G. Parsons. Involvement of GluN2B subunit containing N-methyl-d-aspartate (NMDA) receptors in mediating the acute and chronic synaptotoxic effects of oligomeric amyloid-beta (Aβ) in murine models of Alzheimer's disease (AD). NEUROPHARMACOLOGY. 2017, 第 6 作者123: 100-115, http://dx.doi.org/10.1016/j.neuropharm.2017.02.003.
[9] Zou, Chengyu, Crux, Sophie, Marinesco, Stephane, Montagna, Elena, Sgobio, Carmelo, Shi, Yuan, Shi, Song, Zhu, Kaichuan, Dorostkar, Mario M, Mueller, Ulrike C, Herms, Jochen. Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis. EMBO JOURNAL[J]. 2016, 第 8 作者35(20): 2213-2222, https://www.webofscience.com/wos/woscc/full-record/WOS:000385708000005.

   

（ 1 ） 2021年度院优秀青年创新基金B档资助, 负责人, 其他任务, 2022-03--2023-12
（ 2 ） 专2022N061 儿童发育性疾病肠道营养感知特征数据库的建立与应用, 负责人, 地方任务, 2022-04--2024-12