基本信息
侯春晖 男 博导 中国科学院昆明动物研究所
电子邮件: houchunhui@mail.kiz.ac.cn
通信地址: 云南省昆明市龙欣路17号
邮政编码:
电子邮件: houchunhui@mail.kiz.ac.cn
通信地址: 云南省昆明市龙欣路17号
邮政编码:
招生信息
招生专业
071007-遗传学0710Z1-基因组学071008-发育生物学
招生方向
基因调控表观遗传调控三维基因组学
教育背景
1997-09--2004-06 中国科学院上海生物化学与细胞生物学研究所 理学博士1993-09--1997-06 复旦大学 理学学士
工作经历
工作简历
2022-09~现在, 中国科学院昆明动物研究所, 研究员2013-08~2022-08,南方科技大学, 副教授2009-12~2013-08,美国埃默里大学, 博士后2004-11~2009-11,美国国立卫生研究院, 访问学者博士后2004-07~2004-11,中国科学院上海生物化学与细胞生物学研究所, 研究助理1997-09~2004-06,中国科学院上海生物化学与细胞生物学研究所, 理学博士1993-09~1997-06,复旦大学, 理学学士
教授课程
表观遗传学免疫学
出版信息
发表论文
(1) EpiMCI: Predicting Multi-Way Chromatin Interactions from Epigenomic Signals, BIOLOGY-BASEL, 2023, 第 6 作者 通讯作者(2) Genome-wide enhancer identification by massively parallel reporter assay in Arabidopsis, PLANT JOURNAL, 2023, 第 9 作者 通讯作者(3) High-throughput Pore-C reveals the single-allele topology and cell type-specificity of 3D genome folding, NATURE COMMUNICATIONS, 2023, 第 7 作者 通讯作者(4) Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis, CELL REPORTS, 2023, 第 12 作者(5) Genome-wide identification of functional enhancers and their potential roles in pig breeding, Genome-wide identification of functional enhancers and their potential roles in pig breeding, JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, 2022, 第 9 作者(6) Integration of Count Difference and Curve Similarity in Negative Regulatory Element Detection, FRONTIERS IN GENETICS, 2022, 第 6 作者 通讯作者(7) Extensive Chromatin Structure-Function Associations Revealed by Accurate 3D Compartmentalization Characterization, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 第 5 作者(8) The dynamic proteome in Arabidopsis thaliana early embryogenesis, DEVELOPMENT, 2022, 第 3 作者(9) Interrogating global chromatin interaction network by high-throughput chromosome conformation capture (Hi-C) in plants, Methods Mol Biol., 2022, 第 3 作者 通讯作者(10) Original PKC inhibitors regulate stem cell self-renewal by regulating H3K27me3 and H3K9me3, AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2022, 第 5 作者 通讯作者(11) Nucleosome remodeling and deacetylation complex and MBD3 influence mouse embryonic stem cell na��ve pluripotency under inhibition of protein kinase C, CELL DEATH DISCOVERY, 2022, 第 5 作者(12) Three-dimensional folding dynamics of the Xenopus tropicalis genome, NATURE GENETICS, 2021, 第 17 作者 通讯作者(13) De novo genome assembly and Hi-C analysis reveal an association between chromatin architecture alterations and sex differentiation in the woody plant Jatropha curcas, GIGASCIENCE, 2020, 第 9 作者 通讯作者(14) An extracellular matrix protein promotes anillin-dependent processes in the Caenorhabditis elegans germline, LIFE SCIENCE ALLIANCE, 2019, 第 9 作者(15) Global Quantitative Mapping of Enhancers in Rice by STARR-seq, GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 第 8 作者 通讯作者(16) Amplification-free library preparation with SAFE Hi-C uses ligation products for deep sequencing to improve traditional Hi-C analysis, COMMUNICATIONS BIOLOGY, 2019, 第 12 作者 通讯作者(17) Modeling human point mutation diseases in Xenopus tropicalis with a modified CRISPR/Cas9 system, FASEB JOURNAL, 2019, 第 12 作者(18) RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions, CELLSTEMCELL, 2017, 第 15 作者(19) Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening, CELL RESEARCH, 2017, 第 10 作者(20) Radical aryl migration enables diversity-oriented synthesis of structurally diverse medium/macroor bridged-rings, NATURE COMMUNICATIONS, 2016, 第 10 作者(21) Widespread Rearrangement of 3D Chromatin Organization Underlies Polycomb-Mediated Stress-Induced Silencing, MOLECULAR CELL, 2015, 第 3 作者(22) Throwing transcription for a loop: expression of the genome in the 3D nucleus, CHROMOSOMA, 2012, 第 1 作者(23) Gene Density, Transcription, and Insulators Contribute to the Partition of the Drosophila Genome into Physical Domains, MOLECULAR CELL, 2012, 第 1 作者(24) CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the beta-globin locus, NUCLEIC ACIDS RESEARCH, 2012, 第 3 作者(25) Distinct Ldb1/NLI complexes orchestrate gamma-globin repression and reactivation through ETO2 in human adult erythroid cells, BLOOD, 2011, 第 3 作者(26) Insulators and imprinting from flies to mammals, BMC BIOLOGY, 2010, 第 1 作者(27) Cell type specificity of chromatin organization mediated by CTCF and cohesin, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 第 1 作者(28) Nups Take Leave of the Nuclear Envelope to Regulate Transcription, CELL, 2010, 第 1 作者(29) Involvement of Sp1/Sp3 in the activation of the GATA-1 erythroid promoter in K562 cells, CELL RESEARCH, 2008, 第 1 作者(30) Epigenetics of beta-globin gene regulation, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2008, 第 2 作者(31) CTCF-dependent enhancer-blocking by alternative chromatin loop formation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 第 1 作者(32) A positive role for NLI/Ldb1 in long-range beta-globin locus control region function, MOLECULAR CELL, 2007, 第 2 作者(33) Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells, EUROPEAN JOURNAL OF PHARMACOLOGY, 2007, 第 2 作者(34) Functional analysis of multiple transcription factor sites in a regulatory element of human epsilon-globin gene, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2004, (35) Effects of Huangqi (Hex) on Inducing Cell Differentiation and Cell Death in K562 and HEL Cells��, Acta Biochimica et Biophysica Sinica, 2004, 第 2 作者(36) The in vitro reconstitution of nucleosome and its binding patterns with HMG1/2 and HMG14/17 proteins, CELL RESEARCH, 2003, (37) Screening of genes related to the expression of human epsilon-globin gene by using yeast one-hybrid system, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2001, (38) CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the {\beta}-globin locus, 第 3 作者
科研活动
科研项目
( 1 ) 染色质多位点相互作用与多个基因转录协同的调控机制研究, 负责人, 国家任务, 2024-01--2027-12( 2 ) 乳腺和大脑新皮层的协同进化起源的遗传机制, 参与, 国家任务, 2024-01--2028-12( 3 ) 院择优支持项目, 负责人, 中国科学院计划, 2024-01--2027-12( 4 ) 新学科组启动经费-侯春晖, 负责人, 研究所自主部署, 2022-05--2027-12