100102-免疫学

病毒免疫
新病原
病毒宿主相互作用

2012-09--2015-06   中国科学院大学   理学博士学位
2003-09--2006-06   兰州大学   理学硕士学位
1999-09--2003-06   兰州大学   理学学士学位

   

2021-01~现在, 中国科学院昆明动物研究所, 副研究员
2015-07~2020-12,中国科学院昆明动物研究所, 助理研究员
2012-09~2015-06,中国科学院大学, 理学博士学位
2009-02~2012-08,中国科学院上海巴斯德研究所, 助理研究员
2006-08~2009-01,中国科学院武汉病毒研究所, 研究实习员/助理研究员
2003-09~2006-06,兰州大学, 理学硕士学位
1999-09~2003-06,兰州大学, 理学学士学位

2022-08-01-2026-07-31,中国医药生物技术协会生物安全专业委员会第三届委员会委员, 委员
2021-10-20-2025-10-19,中华中医药学会防治艾滋病分会第五届委员会委员,

   

（ 1 ） 一种北平顶猴T细胞的体外扩增方法, 2020, 第 6 作者, 专利号: CN111607565A

（ 2 ） 毛蕊异黄酮-7-氧-β-D-吡喃葡萄糖苷或其盐在抗艾滋病中的应用, 2009, 第 6 作者, 专利号: CN101590072

（ 3 ） 治疗艾滋病的药物组合物,其制备方法及其用途, 2007, 第 5 作者, 专利号: CN1931151

   

（1） Bromodomain and Extra-Terminal Inhibitor BMS-986158 Reverses Latent HIV-1 Infection In Vitro and Ex Vivo by Increasing CDK9 Phosphorylation and Recruitment, PHARMACEUTICALS, 2022, 第 2 作者
（2） Glucose Metabolism Disorder Induces Spermatogenic Dysfunction in Northern Pig-Tailed Macaques (Macaca leonina) With Long-Term SIVmac239 Infection, FRONTIERS IN ENDOCRINOLOGY, 2021, 第 6 作者
（3） Exploration of a Sequential Gp140-Gp145 Immunization Regimen with Heterologous Envs to Induce a Protective Cross-Reactive HIV Neutralizing Antibody Response In Non-human Primates, Exploration of a Sequential Gp140-Gp145 Immunization Regimen with Heterologous Envs to Induce a Protective Cross-Reactive HIV Neutralizing Antibody Response In Non-human Primates, VIROLOGICA SINICA, 2021, 第 9 作者
（4） Northern pig-tailed macaques(Macaca leonina)infected with SARS-CoV-2 show rapid viral clearance and persistent immune response, Northern pig-tailed macaques (Macaca leonina) infected with SARS-CoV-2 show rapid viral clearance and persistent immune response, ZOOLOGICAL RESEARCH, 2021, 第 9 作者
（5） Lower respiratory tract samples are reliable for severe acute respiratory syndrome coronavirus 2 nucleic acid diagnosis and animal model study, Lower respiratory tract samples are reliable for severe acute respiratory syndrome coronavirus 2 nucleic acid diagnosis and animal model study, ZOOLOGICAL RESEARCH, 2021, 第 1 作者
（6） Inherited OKT4 epitope deficiency in a Chinese rhesus macaque, JOURNAL OF MEDICAL PRIMATOLOGY, 2021, 通讯作者
（7） Successful implementation of intestinal resection and anastomosis in non-human primates suggests the possibility of longitudinal intestinal research, Successful implementation of intestinal resection and anastomosis in non-human primates suggests the possibility of longitudinal intestinal research, ZOOLOGICAL RESEARCH, 2020, 第 4 作者
（8） Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques, Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques, ZOOLOGICAL RESEARCH, 2020, 第 8 作者
（9） CD24Fc protects against viral pneumonia in simian immunodeficiency virus-infected Chinese rhesus monkeys, CD24Fc protects against viral pneumonia in simian immunodeficiency virus-infected Chinese rhesus monkeys, CELLULAR & MOLECULAR IMMUNOLOGY, 2020, 第 1 作者
（10） Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19, Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 第 4 作者
（11） CD24 and Fc fusion protein protects SIVmac239-infected Chinese rhesus macaque against progression to AIDS, ANTIVIRAL RESEARCH, 2018, 第 1 作者
（12） Northern pig-tailed macaques (Macaca leonina) maintain superior CD4 + T-cell homeostasis during SIVmac239 infection, EUROPEAN JOURNAL OF IMMUNOLOGY, 2018, 第 9 作者
（13） Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence, SCIENTIFIC REPORTS, 2017, 第 7 作者
（14） Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in rhesus macaque brain, GENOME RESEARCH, 2017, 第 5 作者
（15） HIV-1 can infect northern pig-tailed macaques (Macaca leonina) and form viral reservoirs in vivo, SCIENCE BULLETIN, 2017, 第11作者
（16） Translocation of microbes and changes of immunocytes in the gut of rapid- and slow-progressor Chinese rhesus macaques infected with SIVmac239, IMMUNOLOGY, 2016, 第 2 作者
（17） Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque, JOURNAL OF IMMUNOLOGY RESEARCH, 2015, 第 6 作者
（18） High immune activation and abnormal expression of cytokines contribute to death of SHIV89.6-infected Chinese rhesus macaques, ARCHIVES OF VIROLOGY, 2015, 第 1 作者
（19） Replication potentials of HIV-1/HSIV in PBMCs from northern pigtailed macaque (Macaca leonina), ZOOLOGICAL RESEARCH, 2014, 第 3 作者
（20） Independent Birth of a Novel TRIMCyp in Tupaia belangeri with a Divergent Function from Its Paralog TRIM5, MOLECULAR BIOLOGY AND EVOLUTION, 2014, 第 5 作者
（21） IFN-λ inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral production, ANTIVIRAL RESEARCH, 2012, 第 1 作者
（22） Translation of Pur-α is targeted by cellular miRNAs to modulate the differentiation-dependent susceptibility of monocytes to HIV-1 infection, FASEB J, 2012, 
（23） Penicillium marneffei-Stimulated Dendritic Cells Enhance HIV-1 Trans-Infection and Promote Viral Infection by Activating Primary CD4(+) T Cells, PLOS ONE, 2011, 第 4 作者
（24） Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora, ARCHIVES OF PHARMACAL RESEARCH, 2010, 第 4 作者
（25） Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia, PHYTOCHEMISTRY, 2008, 第 2 作者
（26） Pestalotheols A-D, bioactive metabolites from the plant endophytic fungus Pestalotiopsis theae, JOURNAL OF NATURAL PRODUCTS, 2008, 第 2 作者
（27） Pestaloficiols A-E, bioactive cyclopropane derivatives from the plant endophytic fungus Pestalotiopsis fici, BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 第 2 作者
（28） A new anti-HIV lupane acid from Gleditsia sinensis Lam., JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2007, 
（29） 天然来源的人类免疫缺陷病毒1整合酶抑制剂, 中国药学杂志, 2006, 第 1 作者
（30） Triterpenoids from Schisandra lancifolia with anti-HIV-1 activity, JOURNAL OF NATURAL PRODUCTS, 2006, 

   

（ 1 ） 基于AIDS非人灵长类模型研究CD39/CD73-腺苷-腺苷受体轴在病毒库建立 与维持中的作用, 负责人, 国家任务, 2021-01--2024-12
（ 2 ） SARS-CoV-2 I型干扰素诱导逃逸研究, 负责人, 地方任务, 2021-04--2024-03
（ 3 ） 灵长目生态圈病原体广域调查与全链条挖掘, 参与, 国家任务, 2021-12--2024-11