基本信息
徐智圣 男 硕导 中国科学院武汉病毒研究所
电子邮件: zsxu@wh.iov.cn
通信地址: 湖北省武汉市武昌区小洪山中区44号
邮政编码:
电子邮件: zsxu@wh.iov.cn
通信地址: 湖北省武汉市武昌区小洪山中区44号
邮政编码:
招生信息
招生专业
100102-免疫学100103-病原生物学
招生方向
炎症反应宿主与病毒互作
教育背景
2012-09--2015-06 武汉大学 博士2006-09--2009-06 武汉大学 硕士2002-09--2006-06 武汉大学 学士
工作经历
工作简历
2021-03~现在, 中国科学院武汉病毒研究所, 副研究员2020-09~2021-02,中国科学院武汉病毒研究所, 助理研究员2015-07~2020-08,广州市妇女儿童医疗中心/中国科学院武汉病毒研究所, 博士后2012-09~2015-06,武汉大学, 博士2009-07~2011-06,武汉大学生命科学学院, 科研助理2006-09~2009-06,武汉大学, 硕士2002-09~2006-06,武汉大学, 学士
出版信息
发表论文
(1) LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus, Cell Research, 2024, 第 1 作者(2) SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5, VIROLOGICA SINICA, 2021, 第 5 作者(3) FAM177A1 Inhibits IL-1�����Induced Signaling by Impairing TRAF6���Ubc13 Association, JOURNAL OF IMMUNOLOGY, 2021, 第 11 作者(4) SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response, SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response, CELLULAR & MOLECULAR IMMUNOLOGY, 2021, 第 6 作者(5) SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication, Cell Discovery, 2021, 第 3 作者(6) RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization, EMBO REPORTS, 2020, 第 2 作者(7) Temporal profiling of plasma cytokines,chemokines and growth factors from mild,severe and fatal COVID-19 patients, Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 第 1 作者(8) USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA, PLoS Pathogens, 2020, 第 3 作者(9) Ubiquitination of TLR3 by TRIM3 signals its ESCRT-mediated trafficking to the endolysosomes for innate antiviral response, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 第 11 作者(10) YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING Trafficking, JOURNAL OF IMMUNOLOGY, 2019, 第 3 作者(11) FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 第 1 作者(12) TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis, NATURE COMMUNICATIONS, 2018, 第 2 作者(13) March3 attenuates il-1 beta-triggered inflammation by mediating k48-linked polyubiquitination and degradation of il-1ri, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 第 11 作者(14) PASD1 promotes STAT3 activity and tumor growth by inhibiting TC45-mediated dephosphorylation of STAT3 in the nucleus, JOURNAL OF MOLECULAR CELL BIOLOGY, 2016, 第 1 作者(15) Foot-and-mouth disease virus non-structural protein 3A inhibits the interferon-beta signaling pathway, SCIENTIFIC REPORTS, 2016, 第 3 作者(16) MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes, JOURNAL OF IMMUNOLOGY, 2016, 第 3 作者(17) 家蚕抗菌肽CD高效表达及其抗BmNPV感染作用, High-level Expression of Silkworm Antimicrobial Peptide and Its Anti-infection to BmNPV, 中国病毒学, 2006, 第 6 作者
科研活动
科研项目
( 1 ) 高致病性出血热病毒互作网络与致病机制, 参与, 国家任务, 2022-12--2025-11( 2 ) FAM64A调控IL-6-STAT3信号通路的分子机制及其在炎症-癌症转化中的功能, 负责人, 国家任务, 2018-01--2020-12( 3 ) DNA病毒逃逸宿主天然免疫的机制研究, 负责人, 中国科学院计划, 2016-08--2020-12