基本信息
李淑芬 女 硕导 中国科学院武汉病毒研究所
电子邮件: lishufen@wh.iov.cn
通信地址: 湖北省武汉市武昌区小洪山中区44号
邮政编码:
电子邮件: lishufen@wh.iov.cn
通信地址: 湖北省武汉市武昌区小洪山中区44号
邮政编码:
招生信息
招生专业
071010-生物化学与分子生物学
招生方向
病毒与宿主相互作用,炎症反应,抗炎药物
教育背景
2009-09--2015-06 中国科学院武汉病毒研究所 博士2005-09--2009-06 南昌大学 学士
工作经历
工作简历
2021-10~现在, 中国科学院武汉病毒研究所, 副研究员2017-07~2021-10,中国科学院武汉病毒研究所, 助理研究员2015-07~2017-06,广东出入境检验检疫局, 博士后2009-09~2015-06,中国科学院武汉病毒研究所, 博士2005-09~2009-06,南昌大学, 学士
专利与奖励
专利成果
( 1 ) 组合物在制备抗布尼亚病毒或者SARS-CoV-2病毒药物中的用途, 2022, 第 2 作者, 专利号: CN113350361B( 2 ) 贝尼地平在制备预防和/或治疗布尼亚病毒感染性疾病药物中的应用, 2021, 第 2 作者, 专利号: CN110237074B( 3 ) 一种组合物在制备预防和/或治疗发热伴血小板减少综合征病毒的药物中的应用, 2021, 第 4 作者, 专利号: CN110279693B
出版信息
发表论文
(1) SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses, CELL RESEARCH, 2023, 第 1 作者(2) Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19, Proceedings of the National Academy of Sciences of the United States of America, 2023, 第 2 作者(3) ACE2-independent infection of T lymphocytes by SARS-CoV-2, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2022, 第 5 作者(4) Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 4 作者(5) High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against Arenaviruses and SARS-CoV-2, ACS INFECTIOUS DISEASES, 2021, 第 3 作者(6) Screening of a Small Molecule Compound Library Identifies Toosendanin as an Inhibitor Against Bunyavirus and SARS-CoV-2, FRONTIERS IN PHARMACOLOGY, 2021, 第 1 作者(7) Viral dynamics and antibody responses in people with asymptomatic SARS-CoV-2 infection, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 6 作者(8) SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation, SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 第 1 作者(9) Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension, CELL DISCOVERY, 2020, 第 8 作者(10) SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation, CELL REPORTS, 2020, 第 1 作者(11) Host factor heat-shock protein 90 contributes to baculovirus budded virus morphogenesis via facilitating nuclear actin polymerization, VIROLOGY, 2019, 第 1 作者(12) Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality, CELL RESEARCH, 2019, 第 3 作者(13) NSs Filament Formation Is Important but Not Sufficient for RVFV Virulence In Vivo, VIRUSES-BASEL, 2019, 第 1 作者(14) Patient-derived avian influenza A (H5N6) virus is highly pathogenic in mice but can be effectively treated by anti-influenza polyclonal antibodies, EMERGING MICROBES & INFECTIONS, 2018, 第 0 作者(15) Morphologic and Molecular Characterization of a Strain of Zika Virus Imported into Guangdong, China, PLOS ONE, 2017, 第 1 作者(16) Isolation and phylogenetic study of Rift Valley fever virus from the first imported case to China, VIROLOGICA SINICA, 2017, 第 5 作者(17) Mutational and functional analysis of N-linked glycosylation of envelope fusion protein F of Helicoverpa armigera nucleopolyhedrovirus, JOURNAL OF GENERAL VIROLOGY, 2016, 第 4 作者(18) The FP25K Acts as a Negative Factor for the Infectivity of AcMNPV Budded Virus, PLOS ONE, 2015, 第 1 作者(19) 搭建流行病探测网络, 环球科学, 2014, 第 3 作者(20) Genetic Modification of Baculovirus Expression Vectors, Genetic Modification of Baculovirus Expression Vectors, 中国病毒学:英文版, 2012, 第 1 作者
科研活动
科研项目
( 1 ) RVFV关键毒力因子NSs抑制坏死性凋亡拮抗宿主免疫防 御的机制研究, 负责人, 国家任务, 2024-01--2027-12( 2 ) 潜在虫媒新病毒的传播和致病机制研究, 参与, 国家任务, 2023-12--2026-11( 3 ) 裂谷热病毒诱发重度炎症机制及抗炎药物研究, 负责人, 中国科学院计划, 2022-01--2023-12
参与会议
(1)新冠病毒感染激活Caspase-8诱发炎症反应和细胞死亡 第四届全国病毒学青年学者学术研讨会 2020-12-14(2)SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation 2020-11-02