洞穴生境具有终年无光、相对封闭、缺少植物的光合作用、食物匮乏等特征，生物在洞穴中生存需要依靠它们独特的适应能力和资源利用策略。我们利用进化发育生物学的实验手段，以斑马鱼和金线鲃为模式动物对洞穴鱼类多组织、器官适应洞穴环境的分子机制进行研究，揭示洞穴生物适应性演化机制、促进洞穴鱼类物种多样性的保护。

071008-发育生物学

发育生物学
进化发育生物学

2003-09--2008-07   清华大学   博士学位
2000-09--2003-07   吉林大学生命科学学院   硕士学历
1994-09--1998-07   吉林大学生命科学学院   学士学位

2016-12~2021-07,中国科学院动物研究所, 副研究员
2012-06~2016-12,中国科学院动物研究所, 助理研究员
2008-07~2012-06,中国科学院动物研究所, 博士后

   

[1] Lam, Sin Man, Li, Jie, Sun, Huan, Mao, Weining, Lu, Zongmin, Zhao, Qingshuo, Han, Chao, Gong, Xia, Jiang, Binhua, Chua, Gek Huey, Zhao, Zhenwen, Meng, Fanwei, Shui, Guanghou. Quantitative Lipidomics and Spatial MS-Imaging Uncovered Neurological and Systemic Lipid Metabolic Pathways Underlying Troglomorphic Adaptations in Cave-Dwelling Fish. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2022, 第 12 作者  通讯作者  39(4): http://dx.doi.org/10.1093/molbev/msac050.
[2] Molecular Biology and Evolution. 2022,   通讯作者  
[3] Zhao, Yahui, Huang, Zushi, Huang, Jinqing, Zhang, Chunguang, Meng, Fanwei. Phylogenetic analysis and expression differences of eye-related genes in cavefish genusSinocyclocheilus. INTEGRATIVE ZOOLOGY[J]. 2021, 第 5 作者  通讯作者  16(3): 354-367, https://www.webofscience.com/wos/woscc/full-record/WOS:000555409600001.
[4] Integrative Zoology. 2020,   通讯作者  
[5] Journal of Molecular Evolution. 2019,   通讯作者  
[6] Huang, Zushi, Titus, Tom, Postlethwait, John H, Meng, Fanwei. Eye Degeneration and Loss of otx5b Expression in the Cavefish Sinocyclocheilus tileihornes. JOURNAL OF MOLECULAR EVOLUTION[J]. 2019, 第 4 作者  通讯作者  87(7-8): 199-208, https://www.webofscience.com/wos/woscc/full-record/WOS:000483687000001.
[7] Meng, Fanwei, Zhao, Yahui, Titus, Tom, Zhang, Chunguang, Postlethwait, John H. Brain of the blind: transcriptomics of the golden-line cavefish brain. CURRENT ZOOLOGY[J]. 2018, 第 1 作者  通讯作者  64(6): 765-773, http://lib.cqvip.com/Qikan/Article/Detail?id=6100089448.
[8] Meng, Fanwei, Braasch, Ingo, Phillips, Jennifer B, Lin, Xiwen, Titus, Tom, Zhang, Chunguang, Postlethwait, John H. Evolution of the Eye Transcriptome under Constant Darkness in Sinocyclocheilus Cavefish. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2013, 第 1 作者30(7): 1527-1543, http://dx.doi.org/10.1093/molbev/mst079.
[9] Meng, Fanwei, Zhao, Yahui, Postlethwait, John H, Zhang, Chunguang. Differentially-expressed opsin genes identified in Sinocyclocheilus cavefish endemic to China. CURRENT ZOOLOGY[J]. 2013, 第 1 作者59(2): 170-174, https://doaj.org/article/a9a1d7bb6757442aa67802477082be16.
[10] Li, Fangfei, Lan, Yu, Wang, Youliang, Wang, Jun, Yang, Guan, Meng, Fanwei, Han, Hua, Meng, Anming, Wang, Yaping, Yang, Xiao. Endothelial Smad4 Maintains Cerebrovascular Integrity by Activating N-Cadherin through Cooperation with Notch. DEVELOPMENTAL CELL[J]. 2011, 第 6 作者20(3): 291-302, http://www.corc.org.cn/handle/1471x/2301215.
[11] Meng Fanwei, Meng Anming. Dapper family members modulate distinct signaling pathways in vertebrate development. Trends in Developmental Biology[J]. 2008, 第 1 作者1(3): 61-69, 
[12] Fanwei Meng, Xuan Cheng, Leilei Yang, Hou, Ning, Yang Xiao, Anming Meng. Accelerated re-epithelialization in Dpr2-deficient mice is associated with enhanced response to TGF beta signaling. JOURNAL OF CELL SCIENCE[J]. 2008, 第 1 作者121(17): 2904-2912, 
[13] Su, Ying, Zhang, Long, Gao, Xia, Meng, Fanwei, Wen, Jun, Zhou, Hu, Meng, Anming, Chen, YeGuang. The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling. FASEB JOURNAL[J]. 2007, 第 4 作者21(3): 682-690, https://www.webofscience.com/wos/woscc/full-record/WOS:000244686400007.
[14] Meng, Fanwei, Shi, Ling, Cheng, Xuan, Hou, Ning, Wang, Yongliang, Teng, Yan, Meng, Anming, Yang, Xiao. Surfactant protein A promoter directs the expression of Cre recombinase in brain microvascular endothelial cells of transgenic mice. MATRIX BIOLOGY[J]. 2007, 第 1 作者26(1): 54-57, http://dx.doi.org/10.1016/j.matbio.2006.09.003.
[15] 孟凡伟, 郭慧云, 周仁平, 张成岗. β-Netrin mRNA在成年大鼠脑内的表达及其分布. 中国神经科学杂志[J]. 2004, 第 1 作者20(4): 286-289, http://lib.cqvip.com/Qikan/Article/Detail?id=10371014.
[16] Zhang, CG, Meng, FW, Wang, CL, Guo, HY, Fan, M, Liu, SJ, Zhou, RP, He, FH. Identification of a novel alternative splicing form of human netrin-4 and analyzing the expression patterns in adult rat brain. MOLECULAR BRAIN RESEARCH[J]. 2004, 130(1-2): 68-80, http://dx.doi.org/10.1016/j.molbrainres.2004.07.009.
[17] 孟凡伟, 郭慧云, 周仁平, 张成岗. Hetrin基因在大鼠脑发育过程中表达的初步研究. 神经解剖学杂志[J]. 2004, 第 1 作者20(1): 21-26, http://lib.cqvip.com/Qikan/Article/Detail?id=9518135.
[18] 孟凡伟, 郭慧云, 张成岗. 轴突生长诱向因子（Netrin）基因家族研究进展. 神经解剖学杂志[J]. 2003, 第 1 作者19(1): 89-93, http://lib.cqvip.com/Qikan/Article/Detail?id=9545208.

   

（ 1 ） 利用斑马鱼和金线对洞穴鱼眼睛退化机制和眼睛发育调控网络的研究, 主持, 国家级, 2019-01--2022-12
（ 2 ） 中国特有洞穴金线鲃属鱼类眼睛形态特征适应性演化及其与眼睛基因相关性的研究, 主持, 国家级, 2014-01--2017-12