100701-药物化学
1007Z1-药物设计学

药物化学基础研究和新药发现
开发新型合成方法学，合成生物活性天然产物
交叉科学（纳米药物）

2016-02--2020-01   美国斯克里普斯研究所（The Scripps Research Institute）   博士后（研究助理）
2009-09--2015-01   中国科学院大学   研究生/理学博士
2005-09--2009-07   四川大学化学学院   大学生/理学学士

   

2015-06~2016-01,上海合全药业股份有限公司, 高级研究员I级
2015-01~2015-05,中国科学院上海有机化学研究所, 研究助理

   

[1] Huang, Jindi, Chen, Liye, Wu, Jiangxia, Ai, Daiqiao, Zhang, JiQuan, Chen, TieGen, Wang, Ling. Targeting the PI3K/AKT/mTOR Signaling Pathway in the Treatment of Human Diseases: Current Status, Trends, and Solutions. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 65(24): 16033-16061, [2] Chen, TieGen, Mele, Lucas, Jentzer, Olivier, Delbrayelle, Dominique, Echeverria, PierreGeorges, Vantourout, Julien C, Baran, Phil S. Convergent synthesis of (R)-silodosin via decarboxylative cross-coupling. TETRAHEDRON LETTERS[J]. 2021, 79: http://dx.doi.org/10.1016/j.tetlet.2021.153290.
[3] Chen, TieGen, Zhang, Haolin, Mykhailiuk, Pavel K, Merchant, Rohan R, Smith, Courtney A, Qin, Tian, Baran, Phil S. Quaternary Centers by Nickel-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(8): 2454-2458, http://dx.doi.org/10.1002/anie.201814524.
[4] Chen, TieGen, Barton, Lisa M, Lin, Yutong, Tsien, Jet, Kossler, David, Bastida, Inaki, Asai, Shota, Bi, Cheng, Chen, Jason S, Shan, Mingde, Fang, Hui, Fang, Francis G, Choi, HyeongWook, Hawkins, Lynn, Qin, Tian, Baran, Phil S. Building C(sp(3))-rich complexity by combining cycloaddition and C-C cross-coupling reactions. NATURE[J]. 2018, 560(7718): 350-+, http://dx.doi.org/10.1038/s41586-018-0391-9.
[5] Wang, Jie, Qin, Tian, Chen, TieGen, Wimmer, Laurin, Edwards, Jacob T, Cornella, Josep, Vokits, Benjamin, Shaw, Scott A, Baran, Phil S. Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 55(33): 9676-9679, https://search.proquest.com/docview/1967855414.
[6] Toriyama, Fumihiko, Cornella, Josep, Wimmer, Laurin, Chen, TieGen, Dixon, Darryl D, Creech, Gardner, Baran, Phil S. Redox-Active Esters in Fe-Catalyzed C-C Coupling. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2016, 138(35): 11132-11135, https://www.webofscience.com/wos/woscc/full-record/WOS:000382901800017.
[7] Chen, TieGen, Fang, Ping, Hou, XueLong, Dai, LiXin. Palladium-Catalyzed Asymmetric Allylic Alkylation Reaction of 2-Monosubstituted Indolin-3-ones. SYNTHESIS-STUTTGART[J]. 2015, 47(1): 134-140, https://www.webofscience.com/wos/woscc/full-record/WOS:000347380200017.
[8] Chen Tiegen. Pd-catalyzed highly regio-, diastereo-, and enantioselective allylic alkylation of a-fluorophosphonates. Chemical Communications. 2014, 

   

（ 1 ） 核苷类似物小分子库的构建, 主持, 省级, 2021-07--2024-06