基本信息
李媛媛  女  博导  中国科学院上海药物研究所
电子邮件: liyuanyuan@simm.ac.cn
通信地址: 广东省中山市翠亨新区和清路10号中山生命科学园
邮政编码:

招生信息

   
招生专业
100706-药理学
招生方向
代谢性疾病、非酒精性脂肪肝、肝纤维化

教育背景

2004-09--2010-01   中国科学院上海药物研究所   药理学,理学博士
2000-09--2004-06   华中科技大学   药学,理学学士

工作经历

   
工作简历
2020-08~现在, 中国科学院上海药物研究所, 研究员,课题组长
2019-10~2020-06,美国贝勒医学院, 博士后
2012-09~2018-04,美国东北俄亥俄医科大学, 博士后
2010-09~2012-08,美国约翰霍普金斯大学, 博士后
2004-09~2010-01,中国科学院上海药物研究所, 药理学,理学博士
2000-09~2004-06,华中科技大学, 药学,理学学士

专利与奖励

   
奖励信息
(1) 上海浦江人才, 市地级, 2021

出版信息

   
发表论文
(1) Charting new paradigms for CAR-T cell therapy beyond current Achilles heels, Frontiers in Immunology, 2024, 第 1 作者  通讯作者
(2) Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways, BIOMOLECULES, 2023, 第 5 作者  通讯作者
(3) Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism, NATURE METABOLISM, 2021, 第 1 作者
(4) Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice, AMERICAN JOURNAL OF PHYSIOLOGY - GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2020, 第 6 作者
(5) Hepatic forkhead box protein A3 regulates ApoA-I expression, cholesterol efflux and atherogenesis, ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, 2019, 第 1 作者
(6) Lipocalin���2 Protects Against Diet���Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes, HEPATOLOGY COMMUNICATIONS, 2019, 第 4 作者
(7) Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR, MOLECULAR METABOLISM, 2018, 第 4 作者
(8) Carboxylesterase 2 Prevents Liver Steatosis by Modulating Lipolysis, ER stress and Lipogenesis and is regulated by Hepatocyte Nuclear Factor 4 Alpha in Mice, Hepatology, 2016, 第 1 作者
(9) Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4�� and Protects Against Alcohol- and MCD diet-induced Liver Injury, SCIENTIFIC REPORTS, 2016, 第 3 作者
(10) A Metabolic Stress-inducible miR-34a-HNF4�� Pathway Regulates Lipid and Lipoprotein Metabolism, NATURE COMMUNICATIONS, 2015, 第 4 作者
(11) Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes, CELL METABOLISM, 2015, 第 7 作者
(12) Increasing ��-Cell Mass Requires Additional Stimulation for Adaptation to Secretory Demand, MOLECULAR ENDOCRINOLOGY, 2014, 第 3 作者
(13) Tsc2 Is a Molecular Checkpoint Controlling Osteoblast Development and Glucose Homeostasis, MOLECULAR AND CELLULAR BIOLOGY, 2014, 第 5 作者
(14) Hepatic Carboxylesterase 1 Is Induced by Glucose and Regulates Postprandial Glucose Levels, PLOS ONE, 2014, 第 4 作者
(15) Hepatic Carboxylesterase 1 Is Essential for Both Normal and Farnesoid X Receptor-Controlled Lipid Homeostasis, HEPATOLOGY, 2014, 第 2 作者
(16) Design and Synthesis of 4-(2,4,5-Trifluorophenyl)butane-1,3-diamines as Dipeptidyl PeptidaseIV Inhibitors, CHEMMEDCHEM, 2013, 第 2 作者
(17) Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice, PLOS ONE, 2013, 第 5 作者
(18) Novel Small-Molecule PGC-1 alpha Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice, DIABETES, 2013, 第 4 作者
(19) Development of Novel Alkene Oxindole Derivatives AsOrally Efficacious AMP-Activated Protein Kinase Activators, ACS MEDICINAL CHEMISTRY LETTERS, 2013, 第 2 作者
(20) Pancreatic ��-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A, DIABETES, 2013, 第 3 作者
(21) Bile acid receptors in non-alcoholic fatty liver disease, BIOCHEMICAL PHARMACOLOGY, 2013, 第 1 作者
(22) Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice, TOXICOLOGY AND APPLIED PHARMACOLOGY, 2013, 第 1 作者
(23) 8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models, BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 第 7 作者
(24) Discovery of novel PTP1B inhibitors with antihyperglycemic activity, ACTA PHARMACOLOGICA SINICA, 2010, 第 3 作者
(25) High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice, DIABETES, 2010, 第 3 作者
(26) Synthesis of (S)-, (R)-, and (rac)-2-amino-3,3-bis(4-fluorophenyl)propanoic acids and an evaluation of the DPP IV inhibitory activity of Denagliptin diastereomers, TETRAHEDRON, 2008, 第 3 作者

科研活动

   
科研项目
( 1 ) 羧酸酯酶CES2调控肝星状细胞活化治疗非酒精性脂肪肝病与肝纤维化的机制研究与原创新药开发, 负责人, 地方任务, 2022-03--2024-12
( 2 ) FOXA3抑制非酒精性脂肪肝炎(NASH)炎症与纤维化的机制研究与靶标验证, 负责人, 国家任务, 2022-01--2024-12
( 3 ) 代谢性疾病的新机制研究与新靶标发现, 负责人, 中国科学院计划, 2022-01--2024-12
( 4 ) 非酒精性脂肪肝病的致病新机制发现、原创靶点鉴定与新药研发, 负责人, 研究所自主部署, 2020-08--2025-08
参与会议
(1)Carboxylesterase 2 Prevents Liver Steatosis by Modulating Lipolysis, ER stress and Lipogenesis and is regulated by Hepatocyte Nuclear Factor 4 Alpha in Mice   美国肝脏协会2016年大会   2016-11-11
(2)Hippo Signaling Pathway Regulates Mouse Pancreas Development   2011年大西洋中部糖尿病研究 讨论会   2011-09-23