100706-药理学

肿瘤药理

2006-09--2011-06   浙江大学   博士研究生
2002-09--2006-06   浙江大学   学士学位

   

2017-11~现在, 中国科学院上海药物研究所, 副研究员
2017-04~2017-10,中国科学院上海药物研究所, 助理研究员
2013-07~2017-03,华东师范大学, 助理研究员
2011-10~2013-06,美国密西根大学, 博士后
2006-09~2011-06,浙江大学, 博士研究生
2002-09~2006-06,浙江大学, 学士学位

   

（ 1 ） 一种应用于靶向给药系统的新的支链连接体, 2018, 第 4 作者, 专利号: ZL201510005869.X

（ 2 ） 一种葡萄糖基化近红外染料及其制备方法和应用, 2017, 第 3 作者, 专利号: ZL201610111482.7

   

（1） Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition, ACTA PHARMACOLOGICA SINICA, 2023, 第 9 作者
（2） PI3K�� inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 3 作者
（3） Design, Synthesis, and Biological Evaluation of HSP90 Inhibitor-SN38 Conjugates for Targeted Drug Accumulation, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 5 作者
（4） AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition, AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition, ACTA PHARMACOLOGICA SINICA, 2019, 第 3 作者
（5） NEK2 promotes proliferation, migration and tumor growth of gastric cancer cells via regulating KDM5B/H3K4me3, AMERICAN JOURNAL OF CANCER RESEARCH, 2019, 第 6 作者
（6） Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression, CANCER RESEARCH, 2019, 第 5 作者
（7） ES2 enhances the efficacy of chemotherapeutic agents in ABCB1-overexpressing cancer cells in vitro and in vivo, PHARMACOLOGICAL RESEARCH, 2018, 第 1 作者
（8） Characterization of a near-infrared fluorescent DCPO-tagged glucose analogue for cancer cell imaging, JOURNAL OF PHOTOCHEMISTRY & PHOTOBIOLOGY, B: BIOLOGY, 2017, 第 1 作者
（9） Structure-based design and synthesis of imidazo1,2-apyridine derivatives as novel and potent Nek2 inhibitors with invitro and invivo antitumor activities, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 第 2 作者
（10） Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis, FRONTIERS IN PHARMACOLOGY, 2017, 第 6 作者
（11） Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity, ONCOTARGET, 2016, 第 1 作者
（12） Targeting NEK2 as a promising therapeutic approach for cancer treatment, CELL CYCLE, 2016, 第 1 作者
（13） Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases, JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH : CR, 2016, 第 7 作者
（14） NIR fluorescent DCPO glucose analogues and their application in cancer cell imaging, RSC ADVANCES, 2016, 第 2 作者

   

（ 1 ） 二代肝癌类器官模型构建及在肝癌临床治疗药物作用机制研究 中的应用, 负责人, 地方任务, 2021-06--2024-06