083100-生物医学工程

生物医用水凝胶
新型抗菌药物开发
活性药物递送

2008-09--2013-06   南京大学   博士
2004-09--2008-06   中国药科大学   学士

   

2014-05~2015-04,韩国蔚山国立科技大学, 博士后
2014-01~2017-11,南京大学, 博士后
2008-09~2013-06,南京大学, 博士
2004-09~2008-06,中国药科大学, 学士

   

（ 1 ） 一种酰胺类化合物及其制备方法, 2022, 第 1 作者, 专利号: 202210056304.4

   

（1） tructure���Activity relationship (SAR) of 18��-glycyrrhetinic acid derivatives on their antitumor activity through the PPAR�� receptor and caspase-3 pathway, Journal Of Saudi Chemical Society, 2024, 
（2） Target identification, and optimization of dioxygenated amide derivatives as potent antibacterial agents with FabH inhibitory activity, European Journal of Medicinal Chemistry, 2024, 
（3） Design, Synthesis and Molecular Docking of 1,3,4-Oxadiazole-2(3H)-thione Derivatives Containing 1,4-Benzodioxane Skeleton as Potential FabH Inhibitors, CHEMISTRY & BIODIVERSITY, 2023, 第 6 作者  通讯作者
（4） Design, Synthesis and Antitumor Activity of FAK/PLK1 Dual Inhibitors with Quinazolinone as the Skeleton, CHEMISTRY & BIODIVERSITY, 2023, 第 7 作者  通讯作者
（5） Co2+-Mediated Hydrogels with Enhanced Mechanical Properties for Flexible Sensing, ACS APPLIED POLYMER MATERIALS, 2022, 第 8 作者  通讯作者
（6） A mechanically adaptive "all-sugar" hydrogel for cell-laden injection, EUROPEAN POLYMER JOURNAL, 2022, 第 4 作者
（7） Thiazolidinedione: A provikeged scaffold for the design of anticancer agents, Curr. Top. Med. Chem., 2021, 第 5 作者  通讯作者
（8） Ultrastretchable, highly transparent, self-adhesive, and 3D-printable ionic hydrogel for multimode tactical sensing, Chemistry of Materials, 2021, 第 6 作者
（9） Gold complexes of bis-indazole-derived N-Heterocyclic carbene: Synthesis, structural characterizations, and catalysis, JOURNAL OF MOLECULAR STRUCTURE, 2021, 第 6 作者  通讯作者
（10） Three-Dimensional-Printable Thermo/Photo-Cross-Linked Methacrylated Chitosan-Gelatin Hydrogel Composites for Tissue Engineering, ACS APPLIED MATERIALS & INTERFACES, 2021, 第 4 作者
（11） Reinforced macromolecular micelle-crosslinked hyaluronate gels induced by water/DMSO binary solvent, SOFT MATTER, 2020, 第 6 作者  通讯作者
（12） Understanding of Growth Mechanism and Structure of Multilayer Thin Films via Layer-by-Layer Hydrogen Bonded Assembly from Polymer Brushes-Grafted Surface, NANOSCIENCE AND NANOTECHNOLOGY LETTERS, 2020, 第 3 作者  通讯作者
（13） Mechano-Responsive, Tough, and Antibacterial Zwitterionic Hydrogels with Controllable Drug Release for Wound Healing Applications, ACS APPLIED MATERIALS & INTERFACES, 2020, 第 7 作者
（14） Stretchable, self-healing and tissue-adhesive zwitterionic hydrogels as strain sensors for wireless monitoring of organ motions, MATERIALS HORIZONS, 2020, 第 3 作者
（15） Biomimetic epidermal sensors assembled from polydopamine-modified reduced graphene oxide/polyvinyl alcohol hydrogels for the real-time monitoring of human motions, JOURNAL OF MATERIALS CHEMISTRY B, 2020, 
（16） Direct 3D Printed Biomimetic Scaffolds Based on Hydrogel Microparticles for Cell Spheroid Growth, ADVANCED FUNCTIONAL MATERIALS, 2020, 第 4 作者
（17） Effect of solvent-matrix interactions on structures and mechanical properties of micelle-crosslinked gels, JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 2019, 第 7 作者
（18） A quinoxalinone-derivated fluorescence sensor with optimized solubility for cysteine detection and biological imaging, DYES AND PIGMENTS, 2019, 第 4 作者  通讯作者
（19） Flexible and wearable strain sensors based on tough and self-adhesive ion conducting hydrogels, JOURNAL OF MATERIALS CHEMISTRY B, 2019, 第 5 作者
（20） Development of novel chromeno4,3-cpyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3K alpha, BIOORGANIC CHEMISTRY, 2019, 第 2 作者
（21） Development of novel chromeno4,3-cpyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3K��, BIOORGANIC CHEMISTRY, 2019, 第 2 作者
（22） Tough, Adhesive, Self-Healable, and Transparent Ionically Conductive Zwitterionic Nanocomposite Hydrogels as Skin Strain Sensors, ACS APPLIED MATERIALS & INTERFACES, 2019, 第 3 作者
（23） Synergistic pH and Temperature-Driven Actuation of Poly(NIPAM-co-DMAPMA)/Clay Nanocomposite Hydrogel Bilayers, ACS OMEGA, 2018, 第 5 作者

   

（ 1 ） 基于β-酮酰-ACP缩合酶的多靶点硫内酯霉素结构修饰与抗菌活性研究, 负责人, 国家任务, 2021-01--2023-12
（ 2 ） 基于β-酮酰-ACP缩合酶的新型多靶点抗菌药物开发, 负责人, 地方任务, 2020-09--2023-08
（ 3 ） 骨诱导及抗菌型超高分子量聚乙烯-多孔钛涂层人工关节关键技术研究, 参与, 其他国际合作项目, 2020-01--2021-12
（ 4 ） 新型硫脲-醚甜菜碱两性离子水凝胶的合成、力学性能、自愈性能及抗粘附性研究, 负责人, 地方任务, 2019-01--2021-12