100102-免疫学

感染与免疫

2009-09--2014-07   华中农业大学   学士
2009-09--2015-01   中国科学院大学   博士

   

2018-01~现在, 中国科学院昆明动物研究所, 副研究员
2015-01~2017-12,中国科学院昆明动物研究所, 助理研究员
2009-09~2014-07,华中农业大学, 学士
2009-09~2015-01,中国科学院大学, 博士

   

（1） 中国免疫学会第七届青年学者奖, 一等奖, 其他, 2017

   

（1） A combination vaccine against SARS-CoV-2 and H1N1 influenza based on receptor binding domain trimerized by six-helix bundle fusion core, EBIOMEDICINE, 2022, 第 3 作者
（2） Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice, EBIOMEDICINE, 2022, 第 4 作者
（3） Tupaia guanylate-binding protein 1 interacts with vesicular stomatitis virus phosphoprotein and represses primary transcription of the viral genome, CYTOKINE, 2021, 第 3 作者
（4） Lower respiratory tract samples are reliable for severe acute respiratory syndrome coronavirus 2 nucleic acid diagnosis and animal model study, Lower respiratory tract samples are reliable for severe acute respiratory syndrome coronavirus 2 nucleic acid diagnosis and animal model study, ZOOLOGICAL RESEARCH, 2021, 第 10 作者
（5） Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models, Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models, CELL RESEARCH, 2021, 第 9 作者
（6） COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2, COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2, ZOOLOGICAL RESEARCH, 2020, 第 1 作者
（7） Tupaia OASL1 Promotes Cellular Antiviral Immune Responses by Recruiting MDA5 to MAVS, JOURNAL OF IMMUNOLOGY, 2020, 第 3 作者
（8） An Alternative Splicing of Tupaia STING Modulated Anti-RNA Virus Responses by Targeting MDA5-LGP2 and IRF3, JOURNAL OF IMMUNOLOGY, 2020, 第 1 作者
（9） Tupaia MAVS is a dual target during HCV infection for innate immune evasion and viral replication via NF-κB, The Journal of Immunology, 2020, 第 1 作者
（10） Tupaia MAVS Is a Dual Target during Hepatitis C Virus Infection for Innate Immune Evasion and Viral Replication via NF-kappa B, JOURNAL OF IMMUNOLOGY, 2020, 第 1 作者
（11） Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models, CIRCULATION, 2020, 第 9 作者
（12） The 3′UTR of human MAVS mRNA contains multiple regulatory elements for the control of protein expression and subcellular localization, BBA - GENE REGULATORY MECHANISMS, 2019, 第 1 作者
（13） Establishment and characterization of an immortalized renal cell line of the Chinese tree shrew (Tupaia belangeri chinesis), APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2019, 第 4 作者
（14） Evolutionary selection on MDA5 and LGP2 in the chicken preserves antiviral competence in the absence of RIG-I, Evolutionary selection on MDA5 and LGP2 in the chicken preserves antiviral competence in the absence of RIG-I, JOURNAL OF GENETICS AND GENOMICS, 2019, 第 1 作者
（15） Molecular identification and antiviral function of the guanylate-binding protein (GBP) genes in the Chinese tree shrew (Tupaia belangeri chinesis), DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2019, 通讯作者
（16） The 3 ' UTR of human MAVS mRNA contains multiple regulatory elements for the control of protein expression and subcellular localization, BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2019, 第 1 作者
（17） Native musk and synthetic musk ketone strongly induced the growth repression and the apoptosis of cancer cells, BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2016, 第 1 作者
（18） Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 第 1 作者
（19） Characterization of a MAVS ortholog from the Chinese tree shrew (Tupaia belangeri chinensis), DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2015, 第 1 作者
（20） Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina, GENE, 2015, 第 3 作者
（21） IDH1 p.R132 mutations may not be actively involved in the carcinogenesis of hepatocellular carcinoma, MEDICAL SCIENCE MONITOR, 2014, 第 3 作者
（22） 树鼩进化分类地位的分子证据, 动物学研究, 2013, 第 1 作者
（23） GENETIC ENGINEERING NEURAL STEM CELL MODIFIED BY LENTIVIRUS FOR REPAIR OF SPINAL CORD INJURY IN RATS, GENETIC ENGINEERING NEURAL STEM CELL MODIFIED BY LENTIVIRUS FOR REPAIR OF SPINAL CORD INJURY IN RATS, 中国医学科学杂志：英文版, 2006, 第 6 作者

   

（ 1 ） hACE2转基因树鼩创制和SARS-CoV-2感染模型建立, 负责人, 国家任务, 2021-01--2024-12
（ 2 ） 树鼩 GBP 家族基因影响 HCV 复制的机制研究, 负责人, 国家任务, 2018-01--2020-12
（ 3 ） 云南省高层次人才培养支持计划“青年拔尖人才”专项, 负责人, 地方任务, 2021-01--2025-12

（1）树鼩抗病毒天然免疫通路基因的挖掘与功能鉴定   第十二届全国免疫学学术大会   2017-10-28