基本信息

常宏 男 博导 中国科学院昆明动物研究所
电子邮件: changhong@mail.kiz.ac.cn
通信地址: 云南省昆明市盘龙区龙欣路17号昆明动物研究所主楼928室
邮政编码:
电子邮件: changhong@mail.kiz.ac.cn
通信地址: 云南省昆明市盘龙区龙欣路17号昆明动物研究所主楼928室
邮政编码:
招生信息
招生专业
071006-神经生物学
招生方向
精神疾病功能基因组解析
教育背景
2008-09--2011-06 中国科学院大学 理学博士
2005-09--2008-06 云南大学 理学硕士
2001-09--2005-06 云南大学 理学学士
2005-09--2008-06 云南大学 理学硕士
2001-09--2005-06 云南大学 理学学士
工作经历
工作简历
2022-01~2022-06,昆明动物研究所, 研究员
2017-01~2021-12,昆明动物研究所, 副研究员
2016-07~2017-01,昆明动物研究所, 助理研究员
2014-01~2016-06,美国南阿拉巴马大学Mitchell肿瘤研究所, 博士后
2012-07~2013-09,昆明动物研究所, 助理研究员
2011-07~2012-06,昆明动物研究所, 研究实习员
2008-09~2011-06,中国科学院大学, 理学博士
2005-09~2008-06,云南大学, 理学硕士
2001-09~2005-06,云南大学, 理学学士
2017-01~2021-12,昆明动物研究所, 副研究员
2016-07~2017-01,昆明动物研究所, 助理研究员
2014-01~2016-06,美国南阿拉巴马大学Mitchell肿瘤研究所, 博士后
2012-07~2013-09,昆明动物研究所, 助理研究员
2011-07~2012-06,昆明动物研究所, 研究实习员
2008-09~2011-06,中国科学院大学, 理学博士
2005-09~2008-06,云南大学, 理学硕士
2001-09~2005-06,云南大学, 理学学士
出版信息
发表论文
(1) Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice, BMC Medicine, 2023,
(2) Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function, BMC Medicine, 2023,
(3) Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants, GENOME MEDICINE, 2022, 第 11 作者
(4) A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MT(d2d3) and Mushroom Dendritic Spine Density, SCHIZOPHRENIA BULLETIN, 2021, 第 11 作者
(5) Independent replications and integrative analyses confirmTRANK1as a susceptibility gene for bipolar disorder, NEUROPSYCHOPHARMACOLOGY, 2021, 第 11 作者
(6) Functional Genomics Identify a Regulatory Risk Variation rs4420550 in the 16p11.2 Schizophrenia-Associated Locus, BIOLOGICAL PSYCHIATRY, 2021, 第 1 作者
(7) Regulation of TRANK1 by GSK-3 in the brain: unexpected interactions, MOLECULAR PSYCHIATRY, 2021, 第 1 作者
(8) Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder, NEUROPSYCHOPHARMACOLOGY, 2019, 第 2 作者
(9) Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder, JOURNAL OF PSYCHIATRIC RESEARCH, 2019, 第 3 作者
(10) The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders, MOLECULAR PSYCHIATRY, 2018,
(11) Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population, TRANSLATIONAL PSYCHIATRY, 2018, 第 2 作者
(12) Rare and common variants at 16p11.2 are associated with schizophrenia, SCHIZOPHRENIA RESEARCH, 2017, 第 1 作者
(13) The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions, MOLECULAR PSYCHIATRY, 2017,
(14) Evaluation of European Schizophrenia GWAS Loci in Asian Populations via Comprehensive Meta-Analyses, MOLECULAR NEUROBIOLOGY, 2017, 第 3 作者
(15) Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1, MOLECULAR NEUROBIOLOGY, 2017, 第 1 作者
(16) Replication analyses of four chromosomal deletions with schizophrenia via independent large-scale meta-analyses, AM J MED GENET B NEUROPSYCHIATR GENET, 2016,
(17) CRISPR/cas9, a novel genomic tool to knock down microRNA in vitro and in vivo, SCIENTIFIC REPORTS, 2016, 第 1 作者
(18) Expression and distribution of symplekin regulates the assembly and function of the epithelial tight junction, HISTOCHEMISTRY AND CELL BIOLOGY, 2012, 第 1 作者
(19) Methylation of tumor associated genes in tissue and plasma samples from liver disease patients, EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2008, 第 1 作者
(2) Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function, BMC Medicine, 2023,
(3) Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants, GENOME MEDICINE, 2022, 第 11 作者
(4) A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MT(d2d3) and Mushroom Dendritic Spine Density, SCHIZOPHRENIA BULLETIN, 2021, 第 11 作者
(5) Independent replications and integrative analyses confirmTRANK1as a susceptibility gene for bipolar disorder, NEUROPSYCHOPHARMACOLOGY, 2021, 第 11 作者
(6) Functional Genomics Identify a Regulatory Risk Variation rs4420550 in the 16p11.2 Schizophrenia-Associated Locus, BIOLOGICAL PSYCHIATRY, 2021, 第 1 作者
(7) Regulation of TRANK1 by GSK-3 in the brain: unexpected interactions, MOLECULAR PSYCHIATRY, 2021, 第 1 作者
(8) Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder, NEUROPSYCHOPHARMACOLOGY, 2019, 第 2 作者
(9) Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder, JOURNAL OF PSYCHIATRIC RESEARCH, 2019, 第 3 作者
(10) The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders, MOLECULAR PSYCHIATRY, 2018,
(11) Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population, TRANSLATIONAL PSYCHIATRY, 2018, 第 2 作者
(12) Rare and common variants at 16p11.2 are associated with schizophrenia, SCHIZOPHRENIA RESEARCH, 2017, 第 1 作者
(13) The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions, MOLECULAR PSYCHIATRY, 2017,
(14) Evaluation of European Schizophrenia GWAS Loci in Asian Populations via Comprehensive Meta-Analyses, MOLECULAR NEUROBIOLOGY, 2017, 第 3 作者
(15) Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1, MOLECULAR NEUROBIOLOGY, 2017, 第 1 作者
(16) Replication analyses of four chromosomal deletions with schizophrenia via independent large-scale meta-analyses, AM J MED GENET B NEUROPSYCHIATR GENET, 2016,
(17) CRISPR/cas9, a novel genomic tool to knock down microRNA in vitro and in vivo, SCIENTIFIC REPORTS, 2016, 第 1 作者
(18) Expression and distribution of symplekin regulates the assembly and function of the epithelial tight junction, HISTOCHEMISTRY AND CELL BIOLOGY, 2012, 第 1 作者
(19) Methylation of tumor associated genes in tissue and plasma samples from liver disease patients, EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2008, 第 1 作者
科研活动
科研项目
( 1 ) 云南省灵长类脑类器官与精神疾病探索创新团队, 负责人, 地方任务, 2024-01--2026-12
( 2 ) 精神分裂症易感变异rs4420550影响神经发育的分子机制解析, 负责人, 地方任务, 2023-06--2026-05
( 3 ) SETD1A c.4582-2delAG>-变异影响神经发育参与精神分裂症发生的机制探索, 负责人, 国家任务, 2023-01--2026-12
( 4 ) 双相情感障碍易感基因Trank1的功能研究, 负责人, 国家任务, 2021-01--2024-12
( 5 ) 遗传风险基因Trank1参与双相情感障碍发病的机制研究, 负责人, 地方任务, 2020-02--2024-12
( 6 ) 组蛋白去乙酰化酶HDAC8调节原肌球蛋白TPM3巴豆酰化修饰对血管舒张的作用及机制研究, 参与, 国家任务, 2020-01--2023-12
( 7 ) 遗传风险基因PCDH17参与心境障碍发病的机制研究, 负责人, 国家任务, 2019-01--2022-12
( 8 ) 硫化舒林酸诱导Snail蛋白降解进而抑制肠癌细胞转移的分子机制, 负责人, 地方任务, 2018-06--2021-05
( 2 ) 精神分裂症易感变异rs4420550影响神经发育的分子机制解析, 负责人, 地方任务, 2023-06--2026-05
( 3 ) SETD1A c.4582-2delAG>-变异影响神经发育参与精神分裂症发生的机制探索, 负责人, 国家任务, 2023-01--2026-12
( 4 ) 双相情感障碍易感基因Trank1的功能研究, 负责人, 国家任务, 2021-01--2024-12
( 5 ) 遗传风险基因Trank1参与双相情感障碍发病的机制研究, 负责人, 地方任务, 2020-02--2024-12
( 6 ) 组蛋白去乙酰化酶HDAC8调节原肌球蛋白TPM3巴豆酰化修饰对血管舒张的作用及机制研究, 参与, 国家任务, 2020-01--2023-12
( 7 ) 遗传风险基因PCDH17参与心境障碍发病的机制研究, 负责人, 国家任务, 2019-01--2022-12
( 8 ) 硫化舒林酸诱导Snail蛋白降解进而抑制肠癌细胞转移的分子机制, 负责人, 地方任务, 2018-06--2021-05