基本信息
和耀喜  男  硕导  中国科学院昆明动物研究所
电子邮件: heyaoxi@mail.kiz.ac.cn
通信地址: 云南省昆明市盘龙区龙欣路17号
邮政编码: 650201

研究领域

人类适应性进化,基因组多样性

招生信息

欢迎每一个热爱科学,对人类进化具有好奇和探索之心的人。


招生专业
071007-遗传学
招生方向
人类适应性进化

教育背景

2014-09--2019-06   中国科学院大学   博士研究生/理学博士
2010-09--2014-07   云南大学   本科/理学学士

出版信息

   
发表论文
[1] Yaoxi He, Chaoying Cui, Yongbo Guo, Wangshan Zheng, Tian Yue, Hui Zhang, Ouzhuluobu, Tianyi Wu, Xuebin Qi, Bing Su. High Arterial Oxygen Saturation in the Acclimatized Lowlanders Living at High Altitude. 表型组学(英文). 2023, 第 1 作者3(4): 329-332, http://lib.cqvip.com/Qikan/Article/Detail?id=7110265269.
[2] Wangshan Zheng, Yaoxi He, Yongbo Guo, Tian Yue, Hui Zhang, Jun Li, Bin Zhou, Xuerui Zeng, Liya Li, Bin Wang, Jingxin Cao, Li Chen, Chunxia Li, Hongyan Li, Chaoying Cui, Caijuan Bai, Baimakangzhuo, Xuebin Qi, Ouzhuluobu, Bing Su. Large-scale genome sequencing redefines the genetic footprints of high-altitude adaptation in Tibetans. GENOME BIOLOGY[J]. 2023, 第 2 作者24(1): 1-25, https://doaj.org/article/163b08b919484e2da7faba233901d414.
[3] He, Yaoxi, Zheng, Wangshan, Guo, Yongbo, Yue, Tian, Cui, Chaoying, Ouzhuluobu, Hui, Zhang, Hui, Liu, Kai, Yang, Zhaohui, Wu, Tianyi, Qu, Jia, Jin, ZiBing, Yang, Jian, Lu, Fan, Qi, Xuebin, Su, Bing. Deep phenotyping of 11,880 highlanders reveals novel adaptive traits in native Tibetans. ISCIENCE[J]. 2023, 第 1 作者  通讯作者  26(9): http://dx.doi.org/10.1016/j.isci.2023.107677.
[4] He, Yaoxi, Guo, Yongbo, Zheng, Wangshan, Yue, Tian, Zhang, Hui, Wang, Bin, Feng, Zhanying, Cui, Chaoying, Liu, Kai, Zhou, Bin, Zeng, Xuerui, Li, Liya, Wang, Tianyun, Wang, Yong, Zhang, Chao, Xu, Shuhua, Qi, Xuebin, Su, Bing. Polygenic adaptation leads to a higher reproductive fitness of native Tibetans at high altitude. CURRENT BIOLOGY[J]. 2023, 第 1 作者  通讯作者  33(19): 4037-+, http://dx.doi.org/10.1016/j.cub.2023.08.021.
[5] Yaoxi He, Yafei Mao. Exploring the primate genome: Unraveling the mysteries of evolution and human disease. THE INNOVATION. 2023, 第 1 作者4(4): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328975/.
[6] Feng, Zhanying, Duren, Zhana, Xin, Jingxue, Yuan, Qiuyue, He, Yaoxi, Su, Bing, Wong, Wing Hung, Wang, Yong. Heritability enrichment in context-specific regulatory networks improves phenotype-relevant tissue identification. ELIFE[J]. 2022, 第 5 作者11: http://dx.doi.org/10.7554/eLife.82535.
[7] Yang, Zhaohui, Bai, Caijuan, Pu, Youwei, Kong, Qinghong, Guo, Yongbo, Ouzhuluobu, Gengdeng, Liu, Xuyang, Zhao, Qi, Qiu, Zhichao, Zheng, Wangshan, He, Yaoxi, Lin, Yihan, Deng, Lian, Zhang, Chao, Xu, Shuhua, Peng, Yi, Xiang, Kun, Zhang, Xiaoming, Baimayangji, Cirenyangji, Cui, Chaoying, Baimakangzhuo, Gonggalanzi, Bianba, Pan, Yongyue, Xin, Jingxue, Wang, Yong, Liu, Shiming, Wang, Liangbang, Guo, Hengliang, Feng, Zhenzhen, Wang, Shaobo, Shi, Hong, Jiang, Binghua, Wu, Tianyi, Qi, Xuebin, Su, Bing. Genetic adaptation of skin pigmentation in highland Tibetans. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2022, 第 12 作者119(40): http://dx.doi.org/10.1073/pnas.2200421119.
[8] Zhang, Xiaoming, Ji, Xueping, Li, Chunmei, Yang, Tingyu, Huang, Jiahui, Zhao, Yinhui, Wu, Yun, Ma, Shiwu, Pang, Yuhong, Huang, Yanyi, He, Yaoxi, Su, Bing. A Late Pleistocene human genome from Southwest China. CURRENT BIOLOGY[J]. 2022, 第 11 作者  通讯作者  32(14): 3095-+, http://dx.doi.org/10.1016/j.cub.2022.06.016.
[9] 和耀喜. Seasonality and Sex‑Biased Fluctuation of Birth Weight in Tibetan Populations. Phenomics[J]. 2021, 第 1 作者
[10] Jingxue Xin, Hui Zhang, Yaoxi He, Zhana Duren, Caijuan Bai, Lang Chen, Xin Luo, DongSheng Yan, Chaoyu Zhang, Xiang Zhu, Qiuyue Yuan, Zhanying Feng, Chaoying Cui, Xuebin Qi, Ouzhuluobu, Wing Hung Wong, Yong Wang, Bing Su. Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation. NATURE COMMUNICATIONS[J]. 2020, 第 3 作者11(1): http://dx.doi.org/10.1038/s41467-020-18638-8.
[11] 次旺拉姆, 和耀喜, 宿兵, 欧珠罗布. 基因组结构变异与藏族高原适应表型的遗传相关性初探. 高原科学研究[J]. 2020, 第 2 作者4(1): 70-78, http://lib.cqvip.com/Qikan/Article/Detail?id=7101570949.
[12] 和耀喜. 藏族人群高原低氧适应的表型与遗传机制研究. 2019, 第 1 作者
[13] He, Yaoxi, Luo, Xin, Zhou, Bin, Hu, Ting, Meng, Xiaoyu, Audano, Peter A, Kronenberg, Zev N, Eichler, Evan E, Jin, Jie, Guo, Yongbo, Yang, Yanan, Qi, Xuebin, Su, Bing. Long-read assembly of the Chinese rhesus macaque genome and identification of ape-specific structural variants. NATURE COMMUNICATIONS[J]. 2019, 第 1 作者10(1): 
[14] Qi, Xuebin, Zhang, Qu, He, Yaoxi, Yang, Lixin, Zhang, Xiaoming, Shi, Peng, Yang, Linping, Liu, Zhengheng, Zhang, Fuheng, Liu, Fengyun, Liu, Shiming, Wu, Tianyi, Cui, Chaoying, Ouzhuluobu, Bai, Caijuan, Baimakangzhuo, Han, Jianlin, Zhao, Shengguo, Liang, Chunnian, Su, Bing. The Transcriptomic Landscape of Yaks Reveals Molecular Pathways for High Altitude Adaptation. GENOME BIOLOGY AND EVOLUTION[J]. 2019, 第 3 作者11(1): 72-85, https://www.webofscience.com/wos/woscc/full-record/WOS:000462712200007.
[15] Luo, Xin, He, Yaoxi, Zhang, Chao, He, Xiechao, Yan, Lanzhen, Li, Min, Hu, Ting, Hu, Yan, Jiang, Jin, Meng, Xiaoyu, Ji, Weizhi, Zhao, Xudong, Zheng, Ping, Xu, Shuhua, Su, Bing. Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys. NATURE COMMUNICATIONS[J]. 2019, 第 2 作者10(1): http://dx.doi.org/10.1038/s41467-019-13481-y.
[16] He, Yaoxi, Qi, Xuebin, Ouzhuluobu, Liu, Shiming, Li, Jun, Zhang, Hui, Baimakangzhuo, Bai, Caijuan, Zheng, Wangshan, Guo, Yongbo, Duojizhuoma, Baimayangji, Dejiquzong, Bianba, Gonggalanzi, Pan, Yongyue, Qula, Kangmin, Cirenyangji, Guo, Wei, Yangla, Peng, Yi, Zhang, Xiaoming, Xiang, Kun, Yang, Zhaohui, Wang, Liangbang, Gengdeng, Zhang, Yanfeng, Wu, Tianyi, Su, Bing, Cui, Chaoying. Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia. NATIONAL SCIENCE REVIEW[J]. 2018, 第 1 作者5(4): 516-529, http://lib.cqvip.com/Qikan/Article/Detail?id=6100230367.
[17] Zheng, WangShan, He, YaoXi, Cui, ChaoYing, Ouzhuluobu, Dejiquzong, Peng, Yi, Bai, CaiJuan, Duojizhuoma, Gonggalanzi, Bianba, Baimakangzhuo, Pan, YongYue, Qula, Kangmin, Cirenyangji, Baimayangji, Guo, Wei, Yangla, Zhang, Hui, Zhang, XiaoMing, Guo, YongBo, Xu, ShuHua, Chen, Hua, Zhao, ShengGuo, Cai, Yuan, Liu, ShiMing, Wu, TianYi, Qi, XueBin, Su, Bing. EP300 contributes to high-altitude adaptation in Tibetans by regulating nitric oxide production. ZOOLOGICAL RESEARCH[J]. 2017, 第 2 作者38(3): 163-170, http://159.226.149.26:8080/handle/152453/11737.
[18] Guo, YongBo, He, YaoXi, Cui, ChaoYing, Ouzhuluobu, Baimakangzhuo, Duojizhuoma, Dejiquzong, Bianba, Peng, Yi, Bai, Caijuan, Gonggalanzi, Pan, YongYue, Qula, Kangmin, Cirenyangji, Baimayangji, Guo, Wei, Yangla, Zhang, Hui, Zhang, XiaoMing, Zheng, WangShan, Xu, ShuHua, Chen, Hua, Zhao, ShengGuo, Gai, Yuan, Liu, ShiMing, Wu, TiariYi, Qi, XueBin, Su, Bing. GCH1 plays a role in the high-altitude adaptation of Tibetans. ZOOLOGICAL RESEARCH[J]. 2017, 第 2 作者38(3): 155-162, http://159.226.149.26:8080/handle/152453/11736.
[19] Peng Yi, Cui Chaoying, He Yaoxi, Ouzhuluobu, Zhang Hui, Yang Deying, Zhang Qu, Bianbazhuoma, Yang Lixin, He Yibo, Xiang Kun, Zhang Xiaoming, Bhandari Sushil, Shi Peng, Yangla, Dejiquzong, Baimakangzhuo, Duojizhuoma, Pan Yongyue, Cirenyangji, Baimayangji, Gonggalanzi, Bai Caijuan, Bianba, Basang, Ciwangsangbu, Xu Shuhua, Chen Hua, Liu Shiming, Wu Tianyi, Qi Xuebin, Su Bing, 陈华. Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2017, 第 3 作者34(4): 818-830, http://www.irgrid.ac.cn/handle/1471x/1149185.
[20] Zhang, Hui, He, Yaoxi, Cui, Chaoying, Ouzhuluobu, Baimakangzhuo, Duojizhuoma, Dejiquzong, Bianba, Gonggalanzi, Pan, Yongyue, Qula, Kangmin, Cirenyangji, Baimayangji, Bai, Caijuan, Guo, Wei, Yangla, Peng, Yi, Zhang, Xiaoming, Xiang, Kun, Yang, Zhaohui, Liu, Shiming, Tao, Xiang, Gengdeng, Zheng, Wangshan, Guo, Yongbo, Wu, Tianyi, Qi, Xuebin, Su, Bing. Cross-altitude analysis suggests a turning point at the elevation of 4,500 m for polycythemia prevalence in Tibetans. AMERICAN JOURNAL OF HEMATOLOGY. 2017, 第 2 作者92(9): E552-E554, http://159.226.149.26:8080/handle/152453/11744.
[21] Yang, Deying, Peng, Yi, Ouzhuluobu, Bianbazhuoma, Cui, Chaoying, Bianba, Wang, Liangbang, Xiang, Kun, He, Yaoxi, Zhang, Hui, Zhang, Xiaoming, Liu, Jiewei, Shi, Hong, Pan, Yongyue, Duojizhuoma, Dejiquzong, Cirenyangji, Baimakangzhuo, Gonggalanzi, Liu, Shimin, Gengdeng, Wu, Tianyi, Chen, Hua, Qi, Xuebin, Su, Bing. HMOX2 Functions as a Modifier Gene for High-Altitude Adaptation in Tibetans. HUMAN MUTATION[J]. 2016, 第 9 作者37(2): 216-223, http://www.irgrid.ac.cn/handle/1471x/1149141.

科研活动

   
科研项目
( 1 ) 藏族人群高原适应关键生理表型的变化模式及其分子调控机制的研究, 主持, 国家级, 2021-01--2023-12
( 2 ) 藏族人群新生儿适合度的评估和遗传分析, 主持, 研究所(学校), 2020-01--2022-12
( 3 ) 中国科学院青年创新促进会项目, 主持, 研究所(学校), 2020-01--2023-12