基本信息
周海波 男 博导 中国科学院脑科学与智能技术卓越创新中心
电子邮件: hbzhou@ion.ac.cn
通信地址: 上海市徐汇区岳阳路320号
邮政编码:
电子邮件: hbzhou@ion.ac.cn
通信地址: 上海市徐汇区岳阳路320号
邮政编码:
招生信息
招生专业
071006-神经生物学071009-细胞生物学
招生方向
基因编辑技术开发和神经系统疾病治疗
教育背景
2012-09--2014-11 荷兰鹿特丹伊拉斯谟斯大学 博士2010-09--2012-08 荷兰鹿特丹伊拉斯谟斯大学 硕士2005-09--2009-07 吉林大学 学士
工作经历
工作简历
2020-06~现在, 中国科学院脑科学与智能技术卓越创新中心, 研究员2015-04~2020-05,中国科学院脑科学与智能技术卓越创新中心, 博士后2012-09~2014-11,荷兰鹿特丹伊拉斯谟斯大学, 博士2010-09~2012-08,荷兰鹿特丹伊拉斯谟斯大学, 硕士2005-09~2009-07,吉林大学, 学士
教授课程
Gene editing in neuroscienceGene editingAlzheimer’s Disease and Parkinson’s Disease
出版信息
发表论文
(1) Generation of rat forebrain tissues in mice, Cell, 2024, (2) Engineered Extracellular Vesicle���Delivered CRISPR/CasRx as a Novel RNA Editing Tool, Advanced Science, 2023, (3) Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice, Nature Metabolism, 2023, (4) Engineered Extracellular Vesicle���Delivered CRISPR/CasRx as a Novel RNA Editing Tool, Advanced Science, 2023, (5) Endogenous promoter-driven sgRNA for monitoring the expression of low-abundance transcripts and lncRNAs, NATURE CELL BIOLOGY, 2021, 第 18 作者 通讯作者(6) Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos, Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos, PROTEIN & CELL, 2021, 第 7 作者(7) Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice, CELL, 2020, 第 1 作者 通讯作者(8) CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration, CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration, NATIONAL SCIENCE REVIEW, 2020, 第 11 作者(9) Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis, NATURE, 2019, 第 12 作者 通讯作者(10) In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice, NATURE NEUROSCIENCE, 2018, 第 1 作者(11) Homology-mediated end joining-based targeted integration using crispr/cas9, CELL RESEARCH, 2017, 第 6 作者(12) Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2 -deficient mice, NATURE COMMUNICATIONS, 2016, 第 6 作者(13) Differential Purkinje cell simple spike activity and pausing behavior related to cerebellar modules, JOURNAL OF NEUROPHYSIOLOGY, 2015, 第 1 作者(14) Cerebellar modules operate at different frequencies, ELIFE, 2014, 第 1 作者(15) Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis, JOURNAL OF CLINICAL INVESTIGATION, 2014, 第 8 作者
科研活动
科研项目
( 1 ) 极紧凑型CRISPR-Cas基因编辑蛋白挖掘, 负责人, 地方任务, 2023-04--2026-03( 2 ) 基因表达时空精准操控技术研究, 参与, 国家任务, 2022-11--2027-10( 3 ) 非人灵长类动物模型平台, 参与, 国家任务, 2021-12--2026-11