基本信息
李金娥 女 博导 中国科学院微生物研究所
电子邮件: lijine@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码:
电子邮件: lijine@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码:
招生信息
招生专业
071007-遗传学071005-微生物学
招生方向
微生物遗传药物研发
教育背景
2005-09--2011-07 中国科学院研究生院 博士2001-09--2005-07 哈尔滨工业大学 学士
工作经历
工作简历
2019-05~2021-08,美国北卡大学教堂山分校, 助理教授2016-06~2019-04,美国北卡大学教堂山分校, 博士后2016-01~2016-05,美国宾夕法尼亚州立大学, 博士后2011-07~2016-01,中国科学院微生物研究所, 助理研究员2005-09~2011-07,中国科学院研究生院, 博士2001-09~2005-07,哈尔滨工业大学, 学士
专利与奖励
专利成果
( 1 ) 菌株及其在制备泰乐菌素A中的应用, 2023, 第 1 作者, 专利号: 2023103454217( 2 ) 菌株及其在发酵产泰乐菌素中的应用, 2023, 第 1 作者, 专利号: 2023103443903( 3 ) 利用昆虫细胞杆状病毒表达系统表达硫酸软骨素修饰酶的方法及应用, 2023, 第 1 作者, 专利号: 2023103067394( 4 ) 利用昆虫细胞杆状病毒表达系统表达软骨素6-O-硫酸转移酶的方法及应用, 2023, 第 1 作者, 专利号: 2023103067375( 5 ) 农用抗生素多氧霉素P及其生物合成方法与应用, 2012, 第 2 作者, 专利号: CN102532277A( 6 ) 重组圈卷产色链霉菌及其制备方法与应用, 2009, 第 3 作者, 专利号: CN101591635A
出版信息
发表论文
(1) An efficient method for targeted cloning of large DNA fragments from Streptomyces, Appl Microbiol Biotechnol, 2023, (2) Chemoenzymatic Synthesis of Homogeneous Heparan Sulfate and Chondroitin Sulfate Chimeras, ACS CHEMICAL BIOLOGY, 2022, 第 4 作者(3) A visualization reporter system for characterizing antibiotic biosynthetic gene clusters expression with high-sensitivity, COMMUNICATIONS BIOLOGY, 2022, 第 2 作者(4) Chemical, Molecular, and Single-nucleus Analysis Reveal Chondroitin Sulfate Proteoglycan Aberrancy in Fibrolamellar Carcinoma, CANCER RESEARCH COMMUNICATIONS, 2022, 第 2 作者(5) Molecular mechanism of mureidomycin biosynthesis activated by introduction of an exogenous regulatory gene ssa A into Streptomyces roseosporus, Molecular mechanism of mureidomycin biosynthesis activated by introduction of an exogenous regulatory gene ssaA into Streptomyces roseosporus, SCIENCE CHINA-LIFE SCIENCES, 2021, 第 7 作者(6) Characterization of a 3-hydroxyanthranilic acid 6-hydroxylase involved in paulomycin biosynthesis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 第 3 作者(7) Construction of an Alternative NAD(+) De Novo Biosynthesis Pathway, ADVANCED SCIENCE, 2021, 第 6 作者(8) Enzymatic Synthesis of Chondroitin Sulfate E to AttenuateBacteria Lipopolysaccharide-Induced Organ Damage, ACS CENTRAL SCIENCE, 2020, 第 1 作者(9) Using heparin molecules to manage COVID���2019, RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, 2020, 第 2 作者(10) 通过保罗酸的加成提高保罗霉素的稳定性, Improvement of Paulomycin Stability by Addition of Paulic Acid, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 第 4 作者(11) Discovery of pentangular polyphenols hexaricins A-C from marine Streptosporangium sp CGMCC 4.7309 by genome mining, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2016, 第 5 作者(12) 链丝菌素类抗生素的研究进展, Progress in streptothricin antibiotics - A review, 微生物学报, 2016, 第 1 作者(13) Involvement of an octose ketoreductase and two acyltransferases in the biosynthesis of paulomycins, SCIENTIFIC REPORTS, 2016, 第 1 作者(14) Biosynthesis of the Carbamoylated D-Gulosamine Moiety of Streptothricins: Involvement of a Guanidino-N-glycosyltransferase and an N-Acetyl-D-gulosamine Deacetylase, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 第 2 作者(15) Identification and Analysis of the Paulomycin Biosynthetic GeneCluster and Titer Improvement of the Paulomycins in Streptomycespaulus NRRL 8115, PLOS ONE, 2015, 第 1 作者(16) An efficient blue-white screening based gene inactivation system for Streptomyces, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2015, 第 2 作者(17) 尼可霉素生物合成基因簇的改造及其异源表达, Engineering and heterologous expression of a nikkomycin biosynthetic gene cluster, 微生物学报, 2015, 第 3 作者(18) Mining of a streptothricin gene cluster from Streptomyces sp.TP-A0356 genome via heterologous expression, SCIENCE CHINA-LIFE SCIENCES, 2013, 第 1 作者(19) Novel polyoxins generated by heterologously expressing polyoxin biosynthetic gene cluster in the sanN inactivated mutant of Streptomyces ansochromogenes, MICROBIAL CELL FACTORIES, 2012, 第 1 作者(20) Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties, METABOLIC ENGINEERING, 2011, 第 1 作者(21) Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production, MICROBIAL CELL FACTORIES, 2010, 第 2 作者(22) Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes, MICROBIAL CELL FACTORIES, 2009, 第 2 作者(23) sanN encoding a dehydrogenase is essential for nikkomycin biosynthesis in Streptomyces ansochromogenes, JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2008, 第 3 作者
发表著作
Comprehensive glycosciences 2nd edition, Elisevier, 2021-06, 第 其他 作者
科研活动
科研项目
( 1 ) 微生物酶法合成功能性硫酸软骨素寡糖, 负责人, 国家任务, 2023-01--2026-12( 2 ) 重要医用多糖绿色生物制造关键技术及产业化示范, 负责人, 国家任务, 2022-01--2025-12