基本信息
李幸  男  博导  中国科学院动物研究所
电子邮件: li@ioz.ac.cn
通信地址: 北京市朝阳区北辰西路1号院
邮政编码: 100101

研究领域

  1. RNA成像、传感与调控技术

  2. CRISPR合成生物学

  3. 小分子药物与探针


招生信息

欢迎生命科学、化学生物学、药学等背景考生报考!

招生专业
071010-生物化学与分子生物学
0703Z1-化学生物学
071009-细胞生物学
招生方向
RNA成像、传感和调控
基因编辑
小分子药物和探针

工作经历

   

专利与奖励

   

出版信息

   
发表论文
[1] Zhongxuan Zhang, Xiaoxiao Rong, Tianjin Xie, Zehao Li, Haozhi Song, Shujun Zhen, Haifeng Wang, Jiahui Wu, Samie R Jaffrey, Xing Li. Fluorogenic CRISPR for genomic DNA imaging. NATURE COMMUNICATIONS[J]. 2024, 第 10 作者  通讯作者  15: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10831063/.
[2] 李幸. Structural mechanisms for binding and activation of a contact-quenched fluorophore by RhoBAST. Nature Communications[J]. 2024, 第 1 作者
[3] Nature Communications. 2024, 第 10 作者
[4] SCIENTIA SINICA Vitae. 2024,   通讯作者  
[5] Nature Communications. 2024, 第 9 作者
[6] Chen, Wei, Zhao, Xiaoying, Yang, Nanyang, Li, Xing. Single mRNA Imaging with Fluorogenic RNA Aptamers and Small-molecule Fluorophores. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2023, 第 4 作者  通讯作者  
[7] Passalacqua, L. F. M, Banco, M. T., Jared D Moon, Xing Li, JAFFREY, SAMIE R, Adrian R. Ferré-D’Amaré. Intricate 3D architecture of a DNA mimic of green fluorescent protein. Nature[J]. 2023, 第 4 作者
[8] Chen, Zhenyin, Duan, Hongtao, Li, Xing. In vivo single-molecule RNA structural profiling. TRENDS IN BIOCHEMICAL SCIENCES[J]. 2023, 第 3 作者  通讯作者  48(3): 211-212, http://dx.doi.org/10.1016/j.tibs.2023.01.001.
[9] Zhenyin Chen, 李幸. Genetically encoded RNA-based sensors with Pepper fluorogenic aptamer. Nucleic Acids Research[J]. 2023, 第 11 作者
[10] Jiahui Wu, Nina Svensen, Wenjiao Song, Hyaeyeong Kim, Sulei Zhang, Xing Li, Samie R. Jaffrey. Self-Assembly of Intracellular Multivalent RNA Complexes Using Dimeric Corn and Beetroot Aptamers. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 第 6 作者
[11] Lynda Truong, Hamed Kooshapur, Sourav Kumar Dey, Xing Li, Nico Tjandra, Samie R. Jaffrey, Adrian R. Ferré-D’Amaré. The fluorescent aptamer Squash extensively repurposes the adenine riboswitch fold. Nature Chemical Biology[J]. 2022, 第 4 作者
[12] Jared D Moon, Jiahui Wu, Sourav K Dey, Jacob L Litke, Xing Li, Hyaeyeong Kim, Samie R Jaffrey. Naturally occurring three-way junctions can be repurposed as genetically encoded RNA-based sensors. CELL CHEMICAL BIOLOGY[J]. 2021, 第 5 作者28(11): 1569-1580.e4, 
[13] Xing Li, Jiahui Wu, Samie R. Jaffrey. Engineering Fluorophore Recycling in a Fluorogenic RNA Aptamer. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 第 1 作者  通讯作者  60(45): 24153-24161, http://dx.doi.org/10.1002/anie.202108338.
[14] Ke Ma, Xing Li, Bin Xu, Wenjing Tian. Label-free bioassay with graphene oxide-based fluorescent aptasensors: A review. Analytica Chimica Acta[J]. 2021, 第 2 作者  通讯作者  
[15] Ashley E Modell, Sachini U Siriwardena, Veronika M Shoba, Xing Li, Amit Choudhary. Chemical and optical control of CRISPR-associated nucleases. CURRENT OPINION IN CHEMICAL BIOLOGY[J]. 2021, 第 4 作者60: 113-121, http://dx.doi.org/10.1016/j.cbpa.2020.10.003.
[16] Xing Li, Hyaeyeong Kim, Jacob L. Litke, Jiahui Wu, Samie R. Jaffrey. Fluorophore-promoted RNA folding and photostability enable imaging of single Broccoli-tagged mRNAs in live mammalian cells. Angewandte Chemie International Edition[J]. 2020, 第 1 作者
[17] Xing Li, Mo, Liuting, Litke, Jacob L, Dey, Sourav Kumar, Suter, Scott R, Jaffrey, Samie R. Imaging Intracellular S-Adenosyl Methionine Dynamics in Live Mammalian Cells with a Genetically Encoded Red Fluorescent RNA-Based Sensor. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 第 1 作者142(33): 14117-14124, https://www.webofscience.com/wos/woscc/full-record/WOS:000563079000015.
[18] Grozhik, Anya V, OlarerinGeorge, Anthony O, Sindelar, Miriam, Li, Xing, Gross, Steven S, Jaffrey, Samie R. Antibody cross-reactivity accounts for widespread appearance of m(1)A in 5 ' UTRs. NATURE COMMUNICATIONS[J]. 2019, 第 4 作者10(1): http://dx.doi.org/10.1038/s41467-019-13146-w.

科研活动

   

指导学生

现指导学生

陈振寅  博士研究生  071007-遗传学  

高万锴  硕士研究生  071010-生物化学与分子生物学  

蒋浩东  博士研究生  071010-生物化学与分子生物学