基本信息
李幸 男 博导 中国科学院动物研究所
电子邮件: li@ioz.ac.cn
通信地址: 北京市朝阳区北辰西路1号院
邮政编码: 100101
电子邮件: li@ioz.ac.cn
通信地址: 北京市朝阳区北辰西路1号院
邮政编码: 100101
研究领域
RNA成像、传感与调控技术
CRISPR合成生物学
小分子药物与探针
招生信息
欢迎生命科学、化学生物学、药学等背景考生报考!
招生专业
071010-生物化学与分子生物学0703Z1-化学生物学071009-细胞生物学
招生方向
RNA成像、传感和调控基因编辑小分子药物和探针
工作经历
专利与奖励
出版信息
发表论文
[1] Zhongxuan Zhang, Xiaoxiao Rong, Tianjin Xie, Zehao Li, Haozhi Song, Shujun Zhen, Haifeng Wang, Jiahui Wu, Samie R Jaffrey, Xing Li. Fluorogenic CRISPR for genomic DNA imaging. NATURE COMMUNICATIONS[J]. 2024, 第 10 作者 通讯作者 15: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10831063/.[2] 李幸. Structural mechanisms for binding and activation of a contact-quenched fluorophore by RhoBAST. Nature Communications[J]. 2024, 第 1 作者[3] Nature Communications. 2024, 第 10 作者[4] SCIENTIA SINICA Vitae. 2024, 通讯作者 [5] Nature Communications. 2024, 第 9 作者[6] Chen, Wei, Zhao, Xiaoying, Yang, Nanyang, Li, Xing. Single mRNA Imaging with Fluorogenic RNA Aptamers and Small-molecule Fluorophores. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2023, 第 4 作者 通讯作者 [7] Passalacqua, L. F. M, Banco, M. T., Jared D Moon, Xing Li, JAFFREY, SAMIE R, Adrian R. Ferré-D’Amaré. Intricate 3D architecture of a DNA mimic of green fluorescent protein. Nature[J]. 2023, 第 4 作者[8] Chen, Zhenyin, Duan, Hongtao, Li, Xing. In vivo single-molecule RNA structural profiling. TRENDS IN BIOCHEMICAL SCIENCES[J]. 2023, 第 3 作者 通讯作者 48(3): 211-212, http://dx.doi.org/10.1016/j.tibs.2023.01.001.[9] Zhenyin Chen, 李幸. Genetically encoded RNA-based sensors with Pepper fluorogenic aptamer. Nucleic Acids Research[J]. 2023, 第 11 作者[10] Jiahui Wu, Nina Svensen, Wenjiao Song, Hyaeyeong Kim, Sulei Zhang, Xing Li, Samie R. Jaffrey. Self-Assembly of Intracellular Multivalent RNA Complexes Using Dimeric Corn and Beetroot Aptamers. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 第 6 作者[11] Lynda Truong, Hamed Kooshapur, Sourav Kumar Dey, Xing Li, Nico Tjandra, Samie R. Jaffrey, Adrian R. Ferré-D’Amaré. The fluorescent aptamer Squash extensively repurposes the adenine riboswitch fold. Nature Chemical Biology[J]. 2022, 第 4 作者[12] Jared D Moon, Jiahui Wu, Sourav K Dey, Jacob L Litke, Xing Li, Hyaeyeong Kim, Samie R Jaffrey. Naturally occurring three-way junctions can be repurposed as genetically encoded RNA-based sensors. CELL CHEMICAL BIOLOGY[J]. 2021, 第 5 作者28(11): 1569-1580.e4, [13] Xing Li, Jiahui Wu, Samie R. Jaffrey. Engineering Fluorophore Recycling in a Fluorogenic RNA Aptamer. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 第 1 作者 通讯作者 60(45): 24153-24161, http://dx.doi.org/10.1002/anie.202108338.[14] Ke Ma, Xing Li, Bin Xu, Wenjing Tian. Label-free bioassay with graphene oxide-based fluorescent aptasensors: A review. Analytica Chimica Acta[J]. 2021, 第 2 作者 通讯作者 [15] Ashley E Modell, Sachini U Siriwardena, Veronika M Shoba, Xing Li, Amit Choudhary. Chemical and optical control of CRISPR-associated nucleases. CURRENT OPINION IN CHEMICAL BIOLOGY[J]. 2021, 第 4 作者60: 113-121, http://dx.doi.org/10.1016/j.cbpa.2020.10.003.[16] Xing Li, Hyaeyeong Kim, Jacob L. Litke, Jiahui Wu, Samie R. Jaffrey. Fluorophore-promoted RNA folding and photostability enable imaging of single Broccoli-tagged mRNAs in live mammalian cells. Angewandte Chemie International Edition[J]. 2020, 第 1 作者[17] Xing Li, Mo, Liuting, Litke, Jacob L, Dey, Sourav Kumar, Suter, Scott R, Jaffrey, Samie R. Imaging Intracellular S-Adenosyl Methionine Dynamics in Live Mammalian Cells with a Genetically Encoded Red Fluorescent RNA-Based Sensor. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 第 1 作者142(33): 14117-14124, https://www.webofscience.com/wos/woscc/full-record/WOS:000563079000015.[18] Grozhik, Anya V, OlarerinGeorge, Anthony O, Sindelar, Miriam, Li, Xing, Gross, Steven S, Jaffrey, Samie R. Antibody cross-reactivity accounts for widespread appearance of m(1)A in 5 ' UTRs. NATURE COMMUNICATIONS[J]. 2019, 第 4 作者10(1): http://dx.doi.org/10.1038/s41467-019-13146-w.
科研活动
指导学生
现指导学生
陈振寅 博士研究生 071007-遗传学
高万锴 硕士研究生 071010-生物化学与分子生物学
蒋浩东 博士研究生 071010-生物化学与分子生物学