基本信息
王广川 男 博导 中国科学院分子细胞科学卓越创新中心
电子邮件: guangchuan.wang@sibcb.ac.cn
通信地址: 上海市岳阳路320号新生化楼1303室
邮政编码:
电子邮件: guangchuan.wang@sibcb.ac.cn
通信地址: 上海市岳阳路320号新生化楼1303室
邮政编码:
招生信息
招生专业
071010-生物化学与分子生物学071009-细胞生物学100102-免疫学
招生方向
肿瘤免疫学免疫治疗肿瘤微环境
教育背景
2007-09--2013-06 浙江大学 博士2003-09--2007-06 浙江工业大学 学士
工作经历
工作简历
2021-01~现在, 中科院分子细胞科学卓越创新中心, 研究员2016-05~2021-01,耶鲁大学医学院, 博士后&副研究员2013-09~2016-05,浙江大学, 讲师2007-09~2013-06,浙江大学, 博士2003-09~2007-06,浙江工业大学, 学士
专利与奖励
奖励信息
(1) CRI-Irvington Postdoctoral Fellowship, 研究所(学校), 2017
专利成果
( 1 ) Compositions and Methods Comprising Viral Vector Systems for Multiplexed Activation of Endogenous Genes as Immunotherapy and Viral-based Immune-Gene Therapy, 2020, 第 2 作者, 专利号: PCT/US2020/057113( 2 ) COMPOSITIONS AND METHODS FOR MULTIPLEXED TUMOR VACCINATION WITH ENDOGENOUS GENE ACTIVATION, 2019, 第 3 作者, 专利号: PCT/US20 19/027956( 3 ) 一种基因工程热稳定疫苗及其制备方法, 2017, 第 1 作者, 专利号: ZL 2013 1 0278495.X( 4 ) 一种制备热稳定疫苗的方法, 2014, 第 1 作者, 专利号: ZL 2012 1 0282409.8
出版信息
发表论文
(1) CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade, CANCER DISCOVERY, 2020, 第 1 作者(2) Convergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity InVivo, CELL SYSTEMS, 2019, 第 3 作者(3) In vivo profiling of metastatic double knockouts through CRISPR-Cpf1 screens, NATURE METHODS, 2019, 第 2 作者(4) Systematic identification of immunotherapy targets using genome-scale in vivo CRISPR screens in CD8+ cytotoxic T cells., Cell, 2019, 第 1 作者(5) Multiplexed activation of endogenous genes by CRISPRa elicits potent anti-tumor immunity, NATURE IMMUNOLOGY, 2019, 第 1 作者(6) Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR���mediated direct in vivo screening, SCIENCE ADVANCES, 2018, 第 1 作者(7) AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma (vol 20, pg 1329, 2017), NATURE NEUROSCIENCE, 2017, 第 3 作者(8) Robust vaccine formulation produced by assembling a hybrid coating of polyethyleneimine-silica, CHEMICAL SCIENCE, 2016, 第 1 作者(9) Hydrated Silica Exterior Produced by Biomimetic Silicification Confers Viral Vaccine Heat-Resistance, ACS NANO, 2015, 第 1 作者(10) Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 第 1 作者(11) Eggshell-Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 第 1 作者(12) Extracellular Silica Nanocoat Confers Thermotolerance on Individual Cells: A Case Study of Material-Based Functionalization of Living Cells, CHEMBIOCHEM, 2010, 第 1 作者
科研活动
科研项目
( 1 ) 肝癌肝移植免疫稳态维持的精准策略及选择性区域免疫耐受新靶点研究, 负责人, 国家任务, 2023-01--2025-12( 2 ) CRISPR高通量筛选解析CD8+T细胞中介导MDSCs免疫抑制功能的关键基因, 负责人, 国家任务, 2022-01--2025-12( 3 ) CRISPR技术解析肿瘤微环境中决定T细胞疗效的关键基因, 负责人, 地方任务, 2021-10--2023-09
参与会议
(1)CRISPR SCREENING TO IDENTIFY THE KEY MODULATORS DURING THE CANCER-IMMUNE INTERACTIONS FOR EFFECTIVE IMMUNOTHERAPY Guangchuan Wang, Ryan Chow, Zhigang Bai, Lupeng Ye, and Sidi Chen 2021-04-20(2)Mapping the genetic features of immune checkpoint responsiveness using AAV-CRISPR mediated in vivo screen Guangchuan Wang, Ryan Chow, Zhigang Bai, Lupeng Ye, and Sidi Chen 2018-09-30