081703-生物化工

长效重组蛋白质药物
亚单位疫苗及佐剂递送

   

（ 1 ） 一种寨卡病毒E蛋白结合疫苗及其制备方法, 2022, 第 3 作者, 专利号: CN111514286B

（ 2 ） 一种基于分子内交联和聚乙二醇修饰的尿酸氧化酶及其制备方法, 2021, 第 2 作者, 专利号: CN112852772A

（ 3 ） 一种寨卡病毒E蛋白结合疫苗及其制备方法, 2020, 第 3 作者, 专利号: CN111514286A

（ 4 ） 一种基于双重化学修饰的血红蛋白氧载体及其制备方法和应用, 2020, 第 3 作者, 专利号: CN111499732A

（ 5 ） 一种基于抗原蛋白多聚体的结核分枝杆菌亚单位疫苗及其制备方法, 2017, 第 2 作者, 专利号: CN107096019A

（ 6 ） 一种基于菊粉-壳聚糖修饰的结核分枝杆菌亚单位疫苗及其制备方法, 2016, 第 2 作者, 专利号: CN105944094A

（ 7 ） 一种基于阿拉伯半乳聚糖-聚肌苷酸胞苷酸修饰的结核分枝杆菌亚单位疫苗及其制备方法, 2016, 第 2 作者, 专利号: CN105903009A

   

（1） A mucosal SARS-CoV-2 nanoparticle vaccine based on mucosal adjuvants and its immune effectiveness by intranasal administration, Acs Applied Materials & Interfaces, 2023, 第 3 作者
（2） Mucosal SARS-CoV-2 Nanoparticle Vaccine Based on Mucosal Adjuvants and Its Immune Effectiveness by Intranasal Administration, ACS APPLIED MATERIALS & INTERFACES, 2023, 第 2 作者
（3） Conjugation with loxoribine and mannan improves the immunogenicity of Mycobacterium tuberculosis CFP10-TB10.4 fusion protein, EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2022, 第 1 作者
（4） Conjugation with loxoribine and mannan improves the immunogenicity of Mycobacterium tuberculosis CFP10-TB10.4 fusion protein, EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2022, 第 1 作者
（5） Conjugation with 8-arm PEG and CRM197 enhances the immunogenicity of SARS-CoV-2 ORF8 protein, INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 第 2 作者
（6） Purification and characterization of the receptor-binding domain of SARS-CoV-2 spike protein from Escherichia coli, ENGINEERING IN LIFE SCIENCES, 2021, 第 5 作者  通讯作者
（7） Conjugation of Hemoglobin and Mannan Markedly Improves the Immunogenicity of Domain III of the Zika Virus E Protein: Structural and Immunological Study, BIOCONJUGATE CHEMISTRY, 2021, 第 4 作者
（8） Conjugation of beta-Glucan with the Hydrazone and Disulfide Linkers Markedly Improves the Immunogenicity of Zika Virus E Protein, MOLECULAR PHARMACEUTICS, 2020, 第 3 作者
（9） A triply modified human adult hemoglobin with low oxygen affinity, rapid autoxidation and high tetramer stability, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 第 3 作者
（10） Self-conjugated protective antigen elicits strong and durable protective antibody response against anthrax, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 第 2 作者
（11） An effective immobilized haloalkane dehalogenase DhaA from Rhodococcus rhodochrous by adsorption, crosslink and PEGylation on meso-cellular foam, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 第 2 作者
（12） Conjugation of staphylokinase with the arabinogalactan-PEG conjugate: Study on the immunogenicity, in vitro bioactivity and pharmacokinetics, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 第 5 作者  通讯作者
（13） 板蓝根多糖IIP-A-1和IIP-2作为疫苗佐剂的免疫原性, Immunogenicity of polysaccharides IIP-A-1 and IIP-2 from Isatis indigotica as vaccine adjuvants, 中国药理学与毒理学杂志, 2019, 第 4 作者
（14） Conjugation with 20kDa dextran decreases the autoxidation rate of bovine hemoglobin, ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2018, 第 6 作者
（15） In vitro and in vivo investigation of the novel dex-bhb as oxygen carriers, ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2018, 第 7 作者
（16） Conjugation with Eight-Arm PEG Markedly Improves the In Vitro Activity and Prolongs the Blood Circulation of Staphylokinase, BIOCONJUGATE CHEMISTRY, 2018, 第 3 作者  通讯作者
（17） The phenyl linker markedly increases the immunogenicity of the pneumococcal polysaccharide conjugate vaccine, BIOTECHNOLOGY LETTERS, 2018, 第 2 作者
（18） Conjugation of the CRM197-inulin conjugate significantly increases the immunogenicity of Mycobacterium tuberculosis CFP10-TB10.4 fusion protein, BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 第 2 作者
（19） PEGylation with the thiosuccinimido butylamine linker significantly increases the stability of haloalkane dehalogenase DhaA, JOURNAL OF BIOTECHNOLOGY, 2017, 第 2 作者
（20） A PEGylated bovine hemoglobin as a potent hemoglobin-based oxygen carrier, BIOTECHNOLOGY PROGRESS, 2017, 第 3 作者
（21） Effect of protein immunogenicity and PEG size and branching on the anti-PEG immune response to PEGylated proteins, PROCESS BIOCHEMISTRY, 2017, 第 3 作者
（22） Structural, functional and physiochemical properties of dextran-bovine hemoglobin conjugate as a hemoglobin-based oxygen carrier, PROCESS BIOCHEMISTRY, 2017, 第 4 作者
（23） Conjugation of PEG-hexadecane markedly increases the immunogenicity crossMark of pneumococcal polysaccharide conjugate vaccine, VACCINE, 2017, 第 2 作者
（24） Conjugation Reaction with 8-Arm PEG Markedly Improves the Immunogenicity of Mycobacterium tuberculosis CFP10-TB10.4 Fusion Protein, BIOCONJUGATE CHEMISTRY, 2017, 第 2 作者
（25） Potent Antigen-Adjuvant Delivery System by Conjugation of Mycobacterium tuberculosis Ag85B-HspX Fusion Protein with Arabinogalactan-Poly(I:C) Conjugate, BIOCONJUGATE CHEMISTRY, 2016, 第 2 作者
（26） Conjugation with an Inulin-Chitosan Adjuvant Markedly Improves the Immunogenicity of Mycobacterium tuberculosis CFP10-TB10.4 Fusion Protein, MOLECULAR PHARMACEUTICS, 2016, 第 1 作者
（27） Moderate PEGylation of the carrier protein improves the polysaccharide-specific immunogenicity of meningococcal group A polysaccharide conjugate vaccine, VACCINE, 2015, 第 2 作者
（28） PEGylated recombinant human interferon-omega as a long-acting antiviral agent: Structure, antiviral activity and pharmacokinetics, ANTIVIRAL RESEARCH, 2014, 第 1 作者

   

（ 1 ） 以佐剂为基质的新冠病毒纳米颗粒二价疫苗及其鼻内接 种的免疫效力与机制研究, 负责人, 国家任务, 2023-01--2026-12
（ 2 ） 一种基于共价组装的寨卡病毒仿生疫苗及其免疫机制的研究, 参与, 国家任务, 2020-01--2023-12