1. 研究微纳米材料的表面物理化学电子结构与目标分子相互作用原理
2. 设计和制备高性能微纳米材料 SERS 生物探针
3. 循环肿瘤细胞等肿瘤标志物的光谱学精准诊断

   

080501-材料物理与化学
0702J1-纳米科学与技术
070302-分析化学

材料表面增强拉曼光谱
生物肿瘤检测与微区成像
表界面电荷转移效应

2013-09--2018-07   北京航空航天大学   博士学位
2009-09--2013-07   东北师范大学   学士学位

   

2023-12~现在, 中国科学院宁波材料技术与工程研究所, 研究员
2020-12~2023-12,中国科学院宁波材料技术与工程研究所, 副研究员
2018-07~2020-12,中国科学院宁波材料技术与工程研究所, 博士后(助理研究员）

2024-02-01-2029-01-31,全国卫生产业企业管理协会健康医学, 理事
2023-11-16-2025-11-15,中国抗癌协会诊疗一体会专委会, 委员
2023-04-30-2025-04-29,Smartmat期刊, 青年编委

   

（1） 第二届医工青年论坛优秀报告, 一等奖, 研究所（学校）, 2020
（2） 北航校长科研创新团队, 一等奖, 研究所（学校）, 2018
（3） 北航卓越博士研究生学术基金, 特等奖, 研究所（学校）, 2016

（ 1 ） 一种多功能性复合生物探针及其制备方法和应用, 发明专利, 2023, 第 2 作者, 专利号: CN116429746A

（ 2 ） 一种纯半导体复合纳米材料、其制备方法和检测癌细胞的方法, 发明专利, 2022, 第 2 作者, 专利号: CN114994016A

（ 3 ） ROC曲线用于协助SERS识别CTC、识别方法及应用, 发明专利, 2023, 第 2 作者, 专利号: CN116642870A

（ 4 ） 一种氧化银或含氧化银的复合材料在制备肿瘤近红外二区光热治疗制剂中的应用, 发明专利, 2023, 第 1 作者, 专利号: CN115869400A

（ 5 ） 一种铋系纳米异质结材料及其制备方法和应用, 发明专利, 2021, 第 4 作者, 专利号: CN112891536A

（ 6 ） 一种金属有机框架复合纳米材料及其制备方法与应用, 发明专利, 2022, 第 3 作者, 专利号: CN114230803A

（ 7 ） 一种杂化有机-金属框架磁性材料作为核磁共振造影剂的应用, 发明专利, 2022, 第 4 作者, 专利号: CN114225054A

（ 8 ） 一种复合材料及其制备方法与应用, 发明专利, 2022, 第 1 作者, 专利号: CN114113029A

（ 9 ） 一种复合变价金属氧化物粒子及其制备方法与应用, 发明专利, 2022, 第 1 作者, 专利号: CN114105103A

（ 10 ） 一种复合变价金属氧化物粒子作为表面增强拉曼光谱基底的应用, 2023, 第 1 作者, 专利号: CN114105103B

（ 11 ） 混合晶态半导体纳米粒子作为表面增强激光拉曼光谱的基底的应用, 发明专利, 2022, 第 1 作者, 专利号: CN114113028A

（ 12 ） 一种循环肿瘤细胞筛选分离装置及方法和应用, 发明专利, 2020, 第 1 作者, 专利号: CN111733072A

（ 13 ） 一种超低温增强拉曼光谱信号的检测方法及应用, 发明专利, 2020, 第 1 作者, 专利号: CN111579543A

（ 14 ） 一种复合纳米材料、其制备方法和应用, 发明专利, 2020, 第 1 作者, 专利号: CN111504973A

（ 15 ） 一种复合结构半导体纳米粒子、其制备方法及其应用, 发明专利, 2021, 第 1 作者, 专利号: CN112694120A

   

[1] Qianlan Fang, Chengyuan Hong, Zhusheng Liu, Yuning Pan, Jie Lin, Jianjun Zheng, Jingfeng Zhang, Tianxiang Chen, Xuehua Ma, Aiguo Wu. Oxygen vacancy defect enhanced NIR-II photothermal performance of BiOxCl nanosheets for combined phototherapy of cancer guided by multimodal imaging. Advanced Healthcare Materials[J]. 2024, 第 5 作者13: 2303200, 
[2] Jie Lin, Zhang, Dinghu, Jian Yu, Ting Pan, Xiaoxia Wu, Tianxiang Chen, Gao Changyong, Chao Chen, Xiaotian Wang, Wu, Aiguo. Amorphous Nitrogen-Doped Carbon Nanocages with Excellent SERS Sensitivity and Stability for Accurate Identification of Tumor Cells. Analtical Chemistry[J]. 2023, 第 1 作者
[3] Awiaz, Gul, Wu, Xiaoxia, Zhang, Chenguang, Pan, Ting, Xu, Xiawei, Lin, Jie, Wu, Aiguo. Au@Ag-Au core@double shell SERS bioprobes for high-resolution tumor cells imaging. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2023, 第 6 作者  通讯作者  51(1): http://dx.doi.org/10.1016/j.cjac.2022.100204.
[4] Xu, Yanping, Lin, Jie, Wu, Xiaoxia, Xu, Xiawei, Zhang, Dinghu, Xie, Yujiao, Pan, Ting, He, Yiwei, Wu, Aiguo, Shao, Guoliang. A TiO2-based bioprobe enabling excellent SERS activity in the detection of diverse circulating tumor cells. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2022, 第 2 作者  通讯作者  10(20): 3808-3816, http://dx.doi.org/10.1039/d2tb00464j.
[5] Xu, Yanping, Zhang, Dinghu, Lin, Jie, Wu, Xiaoxia, Xu, Xiawei, Akakuru, Ozioma Udochukwu, Zhang, Hao, Zhang, Zhewei, Xie, Yujiao, Wu, Aiguo, Shao, Guoliang. Ultrahigh SERS activity of the TiO2@Ag nanostructure leveraged for accurately detecting CTCs in peripheral blood. BIOMATERIALS SCIENCE[J]. 2022, 第 3 作者  通讯作者  10(7): 1812-1820, http://dx.doi.org/10.1039/d1bm01821c.
[6] Xu, Xiawei, Lin, Jie, Guo, Yanhong, Wu, Xiaoxia, Xu, Yanping, Zhang, Dinghu, Zhang, Xiangzhi, Yujiao, Xie, Wang, Jing, Yao, Chengyang, Yao, Junlie, Xing, Jie, Cao, Yi, Li, Yanying, Ren, Wenzhi, Chen, Tianxiang, Ren, Yong, Wu, Aiguo. TiO2-based Surface-Enhanced Raman Scattering bio-probe for efficient circulating tumor cell detection on microfilter. BIOSENSORS & BIOELECTRONICS[J]. 2022, 第 2 作者  通讯作者  210: http://dx.doi.org/10.1016/j.bios.2022.114305.
[7] Lin Jie, Ma, xuehua, Li, Anran Li, Akakuru, Ozioma udochukwu, Pan, Chunshu, He, Meng, Yao, Chenyang, Ren, Wenzhi, Li, Yanying, Zhang, Dinghu, Cao, Yi, Chen, Tianxiang, Wu, Aiguo. Multiple Valence States of Fe Boosting SERS Activity of Fe3O4 Nanoparticles and Enabling Effective SERS-MRI Bimodal Cancer Imaging. Fundmental Research[J]. 2022, 第 1 作者  通讯作者  
[8] Chen, Jia, Chen, Tianxiang, Fang, Qianlan, Pan, Chunshu, Akakuru, Ozioma udochukwu, Ren, Wenzhi, Lin, Jie, Sheng, Aizhu, Ma, Xuehua, Wu, Aiguo. Gd2O3/b-TiO2 composite nanoprobes with ultra-high photoconversion efficiency for MR image-guided NIR-II photothermal therapy. Exploration[J]. 2022, 第 7 作者https://onlinelibrary.wiley.com/doi/10.1002/EXP.20220014.
[9] Yu, Jian, Chen, Chao, Lin, Jie, Meng, Xiangyu, Qiu, Lin, Wang, Xiaotian. Amorphous Co(OH)(2) nanocages achieving efficient photo-induced charge transfer for significant SERS activity. JOURNAL OF MATERIALS CHEMISTRY C[J]. 2022, 第 3 作者  通讯作者  10(5): 1632-1637, 
[10] Jie Lin, Ozioma Udochukwu Akakuru, Aiguo Wu. Advances in surface‐enhanced Raman scattering bioprobes for cancer imaging. VIEW[J]. 2021, 第 1 作者2(4): n/a-n/a, https://doaj.org/article/a832d6dc2b7749a69e8d7dc58a9899d1.
[11] Yu, Jian, Lin, Jie, Chen, Mo, Meng, Xiangyu, Qiu, Lin, Wu, Jin, Xi, Guangcheng, Wang, Xiaotian. Amorphous Ni(OH)(2 )nanocages as efficient SERS substrates for selective recognition in mixtures. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2021, 第 2 作者  通讯作者  631: http://dx.doi.org/10.1016/j.colsurfa.2021.127652.
[12] Pan, Chunshu, Lin, Junjie, Zheng, Jianjun, Liu, Chuang, Yuan, Bo, Akakuru, Ozioma Udochukwu, Zubair Iqbal, M, Fang, Qianlan, Hu, Jiapeng, Chen, Jia, Lin, Jie, Dai, Qi, Guo, Xiuyu, Li, Zihou, Zhang, Tao, Xu, Chen, Ma, Xuehua, Chen, Tianxiang, Wu, Aiguo, Jin, Yinhua. An intelligent T-1-T-2 switchable MRI contrast agent for the non-invasive identification of vulnerable atherosclerotic plaques. NANOSCALE[J]. 2021, 第 11 作者13(13): 6461-6474, http://dx.doi.org/10.1039/d0nr08039j.
[13] Lin Jie. Octahedral Silver Oxide Nanoparticles Enabling Remarkable SERS Activity for Circulating Tumor Cells Detection. SCIENCE CHINA Life Science. 2021, 第 1 作者  通讯作者  
[14] Pan, Chunshu, Lin, Junjie, Zheng, Jianjun, Liu, Chuang, Yuan, Bo, Akakuru, Ozioma Udochukwu, Zubair Iqbal, M, Fang, Qianlan, Hu, Jiapeng, Chen, Jia, Lin, Jie, Dai, Qi, Guo, Xiuyu, Li, Zihou, Zhang, Tao, Xu, Chen, Ma, Xuehua, Chen, Tianxiang, Wu, Aiguo, Jin, Yinhua. An intelligent T-1-T-2 switchable MRI contrast agent for the non-invasive identification of vulnerable atherosclerotic plaques dagger. NANOSCALE[J]. 2021, 第 11 作者13(13): 6461-6474, http://dx.doi.org/10.1039/d0nr08039j.
[15] Lin, Jie, Ren, Wenzhi, Li, Anran, Yao, Chenyang, Chen, Tianxiang, Ma, Xuehua, Wang, Xiaotian, Wu, Aiguo. Crystal-Amorphous Core-Shell Structure Synergistically Enabling TiO2 Nanoparticles' Remarkable SERS Sensitivity for Cancer Cell Imaging. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 第 1 作者12(4): 4204-4211, http://dx.doi.org/10.1021/acsami.9b17150.
[16] Lin, Jie, Zheng, Jianping, Wu, Aiguo. An efficient strategy for circulating tumor cell detection: surface-enhanced Raman spectroscopy. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2020, 第 1 作者8(16): 3316-3326, https://www.webofscience.com/wos/woscc/full-record/WOS:000548186500007.
[17] Li, Anran, Yu, Jian, Lin, Jie, Chen, Mo, Wang, Xiaotian, Guo, Lin. Increased O 2p State Density Enabling Significant Photoinduced Charge Transfer for Surface-Enhanced Raman Scattering of Amorphous Zn(OH)(2). JOURNAL OF PHYSICAL CHEMISTRY LETTERS[J]. 2020, 第 3 作者11(5): 1859-1866, https://www.webofscience.com/wos/woscc/full-record/WOS:000518706000037.
[18] Lin, Jie, Yu, Jian, Akakuru, Ozioma Udochukwu, Wang, Xiaotian, Yuan, Bo, Chen, Tianxiang, Guo, Lin, Wu, Aiguo. Low temperature-boosted high efficiency photo-induced charge transfer for remarkable SERS activity of ZnO nanosheets. CHEMICAL SCIENCE[J]. 2020, 第 1 作者11(35): 9414-9420, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162034/.
[19] Lin Jie. Crystal-amorphous Core-shell Structure synergistically Enabling TiO2 Nanoparticles Remarkable SERS Sensitivity for Cancer Cells Imaging. ACS Applied Materials & Interfaces. 2020, 第 1 作者
[20] Yang, Jie, Yang, Yun, Li, Anran, Wang, Zicheng, Wang, Hua, Yu, Dandan, Hu, Pengfei, Qian, Mengmeng, Lin, Jie, Guo, Lin. Sustainable treatment of dye wastewater for high-performance rechargeable battery cathodes. ENERGY STORAGE MATERIALS[J]. 2019, 第 9 作者17: 334-340, http://dx.doi.org/10.1016/j.ensm.2018.06.030.
[21] Wang, Xiaotian, Shi, Wenxiong, Wang, Shaoxiong, Zhao, Hewei, Lin, Jie, Yang, Zhao, Chen, Mo, Guo, Lin. Two-Dimensional Amorphous TiO2 Nanosheets Enabling High-Efficiency Photoinduced Charge Transfer for Excellent SERS Activity. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 第 5 作者141(14): 5856-5862, 
[22] Lin, Jie, Hao, Wei, Shang, Yang, Wang, Xiaotian, Qiu, Dengli, Ma, Guanshui, Chen, Chao, Li, Shuzhou, Guo, Lin. Direct Experimental Observation of Facet-Dependent SERS of Cu2O Polyhedra. SMALL[J]. 2018, 第 1 作者14(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000425744600013.
[23] Li, Xiaoxia, Shang, Yang, Lin, Jie, Li, Anran, Wang, Xiaotian, Li, Bin, Guo, Lin. Temperature-Induced Stacking to Create Cu2O Concave Sphere for Light Trapping Capable of Ultrasensitive Single-Particle Surface-Enhanced Raman Scattering. ADVANCED FUNCTIONAL MATERIALS[J]. 2018, 第 3 作者28(33): https://www.webofscience.com/wos/woscc/full-record/WOS:000445192400018.
[24] Li, Anran, Lin, Jie, Huang, Zhongning, Wang, Xiaotian, Guo, Lin. Surface-Enhanced Raman Spectroscopy on Amorphous Semiconducting Rhodium Sulfide Microbowl Substrates. ISCIENCE[J]. 2018, 第 2 作者10: 1-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000454331700001.
[25] Wang, Xiaotian, Ma, Guanshui, Li, Anran, Yu, Jian, Yang, Zhao, Lin, Jie, Li, Ang, Han, Xiaodong, Guo, Lin. Composition-adjustable Ag-Au substitutional alloy microcages enabling tunable plasmon resonance for ultrasensitive SERS. CHEMICAL SCIENCE[J]. 2018, 第 6 作者9(16): 4009-4015, https://www.webofscience.com/wos/woscc/full-record/WOS:000435858300015.
[26] Lin, Jie, Shang, Yang, Li, Xiaoxia, Yu, Jian, Wang, Xiaotian, Guo, Lin. Ultrasensitive SERS Detection by Defect Engineering on Single Cu2O Superstructure Particle. ADVANCED MATERIALS[J]. 2017, 第 1 作者29(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000396142100029.
[27] Wang, Xiaotian, Shi, Wenxiong, Jin, Zhao, Huang, Weifeng, Lin, Jie, Ma, Guanshui, Li, Shuzhou, Guo, Lin. Remarkable SERS Activity Observed from Amorphous ZnO Nanocages. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 第 5 作者56(33): 9851-9855, https://www.webofscience.com/wos/woscc/full-record/WOS:000406798700036.
[28] Hu, Pengfei, Wang, Hua, Yang, Yun, Yang, Jie, Lin, Jie, Guo, Lin. Renewable-Biomolecule-Based Full Lithium-Ion Batteries. ADVANCED MATERIALS[J]. 2016, 第 5 作者28(18): 3486-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000376250600007.
[29] Huang, Fengqin, Ma, Guanshui, Liu, Juzhe, Lin, Jie, Wang, Xiaotian, Guo, Lin. High-Yield Synthesis of Hollow Octahedral Silver Nanocages with Controllable Pack Density and Their High-Performance Sers Application. SMALL[J]. 2016, 第 4 作者12(39): 5442-5448, https://www.webofscience.com/wos/woscc/full-record/WOS:000389264500008.
[30] Zhao, Kunyu, Lin, Jie, Guo, Lin. ZnO/Ag porous nanosheets used as substrate for surface-enhanced Raman scattering to detect organic pollutant. RSC ADVANCES[J]. 2015, 第 2 作者5(66): 53524-53528, https://www.webofscience.com/wos/woscc/full-record/WOS:000356801300045.
[31] Hao, Rui, Lin, Jie, Wang, Hua, Li, Bo, Li, Fengshi, Guo, Lin. A fast self-cleaning SERS-active substrate based on an inorganic-organic hybrid nanobelt film. PHYSICAL CHEMISTRY CHEMICAL PHYSICS[J]. 2015, 第 2 作者17(32): 20840-20845, http://dx.doi.org/10.1039/c5cp02286j.
[32] Jie Lin, Xuehua Ma, Anran Li, Ozioma Udochukwu Akakuru, Chunshu Pan, Meng He, Chenyang Yao, Wenzhi Ren, Yanying Li, Dinghu Zhang, Yi Cao, Tianxiang Chen, Aiguo Wu. Multiple Valence States of Fe Boosting SERS Activity of Fe3O4 Nanoparticles and Enabling Effective SERS-MRI Bimodal Cancer Imaging. FUNDAMENTAL RESEARCH. 第 1 作者  通讯作者  

（1） TiO2 Nanoparticles Applications in Nanobiotechnology and Nanomedicine-Surface-Enhanced Raman Spectrum of TiO2 Nanoparticle for Biosensing (TiO2 Nanoparticle Served as SERS Sensing Substrate), WILEY-VCH, 2019-11, 第 1 作者
（2） NANOMATERIALS IN DIAGNOSTIC TOOLS AND DEVICES-SERS methods based on nanomaterials as a diagnostic tool of cancer, ELSEVIER, 2021-06, 第 1 作者

   

（ 1 ） 表面增强拉曼光谱（SERS）生物探针, 负责人, 地方任务, 2024-06--2026-05
（ 2 ） 半导体纳米片锚定贵金属（Au、Ag、Cu）单原子SERS生物探针的可控制备和增强机制研究, 负责人, 国家任务, 2024-01--2027-12
（ 3 ） 基于微纳米材料SERS探针的恶性肿瘤（肝癌和乳腺癌）诊疗试剂的研发, 负责人, 地方任务, 2023-05--2026-04
（ 4 ） 表面增强拉曼光谱(SERS)生物探针, 负责人, 中国科学院计划, 2023-01--2026-12

（1）半导体纳米生物探针   第二届全国高灵敏快速响应探针研究开发与应用论坛   2024-04-20
（2）SERS生物探针   2023全国生命医学高效探针与生物传感技术论坛   2023-07-22
（3）半导体SERS探针   半山肿瘤介入高峰论坛   2022-10-28
（4）分子影像探针   第一届医药产业技术发展前言论坛   2020-08-23
（5）循环肿瘤细胞检测新策略-表面增强拉曼光谱   生物医药科技成果推荐会   2020-06-23

现指导学生

刘奥驰  硕士研究生  083100-生物医学工程