070302-分析化学

新型抗肿瘤药物及靶向载药体系的设计和应用

   

2017-03~现在, 中国科学院化学研究所, 副研究员
2009-11~2017-03,中国科学院化学研究所, 助理研究员
2005-07~2009-11,中国科学院化学研究所, 研究实习员

2022-06-01-2025-05-31,江西省高性能医疗器械产业科技创新联合体,

   

（1） 北京市科学技术奖, 二等奖, 省级, 2015
（2） 中国药学会科学技术奖, 三等奖, 部委级, 2012
（3） 中国分析测试协会科学技术奖, 一等奖, 省级, 2009

   

（1） Novel fluorescence strategy based on G-quadruplex structureswitching aptamer for enrofloxacin detection in food and environmental samples, Food Chemistry, 2024, 
（2） Advances and prospects of natural dietary polyphenols as G-quadruplex stabilizers in biomedical applications, International Journal of Biological Macromolecules, 2024, 
（3） New insights into the effect of molecular crowding environment induced by dimethyl sulfoxide on the conformation and stability of G-quadruplex, Chinese Chemical Letters, 2023, 
（4） An inner salt derivative of Thioflavin T designed for live-cell imaging of mitochondrial G-quadruplexes, Sensors & Actuators: B. Chemical, 2023, 第 5 作者
（5） A label-free G-quadruplex aptamer fluorescent aptasensor for visual and real-time kanamycin detection in lake and human samples, Analyst, 2022, 
（6） Direct detection of potassium and lead (II) ions based on assemblydisassembly of a chiral cyanine dye /TBA complex, Talanta, 2019, 
（7） Ultrasensitive and high specific detection of non-small-cell lung cancer cells in human serum and clinical pleural effusion by aptamer-based fluorescence spectroscopy, Talanta, 2018, 
（8） Thrombin Ultrasensitive Detection Based on Chiral Supramolecular Assembly Signal-Amplified Strategy Induced by Thrombin Binding Aptamer, Analytical Chemistry, 2017, 
（9） Stabilizing G-Quadruplex DNA by a Scissors-Shaped Binaphthyl Derivative through the Entangling Mode: Cooperation of Binaphthylene and the Ethoxy Chain, Biochemistry, 2010, 第 1 作者

（ 1 ） 化学生物学丛书, 华东理工大学出版社, 2021-12, 第 3 作者

   

（ 1 ） 复合抗凝血涂层的研究开发及应用, 负责人, 地方任务, 2023-06--2026-05
（ 2 ） 仿生活性纳米颗粒时序靶向人工血管促进血管再生与相关机制探究, 负责人, 地方任务, 2022-10--2025-09