070304-物理化学

核酸疫苗，疫苗载体，脂质纳米颗粒

2012-09--2017-06   美国东北大学   博士
2008-09--2012-07   北京化工大学   学士学位

   

2017-08~2020-11,麻省理工学院, 博士后
2012-09~2017-06,美国东北大学, 博士
2008-09~2012-07,北京化工大学, 学士学位

   

（1） 麻省理工科技评论35岁以下科技创新35人中国, 国家级, 2021

   

（1） All���Trans���Retinoic Acid���Adjuvanted mRNA Vaccine Induces Mucosal Anti���Tumor Immune Responses for Treating Colorectal Cancer, Advanced Science, 2024, 
（2） Advances in Pulmonary Protein Delivery Systems, Adv. Nanobiomed. Res., 2024, 
（3） 7-Oxa-2, 3-Diazanorbornene: A One-Step Accessible Monomer for Living Ring-Opening Metathesis Polymerization to Produce Backbone-Biodegradable Polymers, CCS Chemistry, 2024, 
（4） Increase Nebulization Stability of Lipid Nanoparticles by Integrating a DNA Supramolecular Hydrogel, ACS Macro Lett, 2023, 第 12 作者
（5） A fluorinated ionizable lipid improves the mRNA delivery efficiency of lipid nanoparticles, J. Mater. Chem. B., 2023, 
（6） A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges, Advanced Materials, 2023, 
（7） Pulmonary delivery of immune checkpoint inhibitors using a responsive polyethylene glycol nanogel for treating lung metastasis, Nano Today, 2023, 
（8） Fullerene-based nanocomplex assists pulmonary delivery of siRNA for treating metastatic lung cancer, Nano Today, 2023, 第 12 作者
（9） Micromolding of thermoplastic polymers for direct fabrication of discrete, multilayered microparticles, Small Methods, 2022, 第 2 作者
（10） Doxorubicin and CpG loaded liposomal spherical nucleic acid for enhanced Cancer treatment, J. Nanobiotechnol., 2022, 
（11） Two-pronged intracellular co-delivery of antigen and adjuvant for synergistic cancer immunotherapy, Advanced Materials, 2022, 
（12） Polymeric PD-L1 blockade nanoparticles for cancer photothermal-immunotherapy, Biomaterials, 2022, 第 12 作者
（13） Mild acidosis-directed signal amplification in tumor microenviroment via spatioselective recruitment of DNA amplifiers, Angew. Chem. Int. Ed., 2022, 第 2 作者
（14） Advanced materials for the delivery of vaccines for infectious diseases, Biosafety and Health, 2022, 
（15） Bottlebrush polymer-conjugated melittin exhibits enhanced antitumor activity and better safety profile, ACS Appl. Mater. Interfaces, 2021, 
（16） Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy, Science Translational Medicine, 2020, 第 1 作者
（17） DNA-mediated Step-growth Polymerization of Bottlebrush Macro-monomers, J. Am. Chem. Soc., 2020, 第 1 作者
（18） Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo, Science Advances, 2019, 
（19） PEGylation of therapeutic oligonucleotides: from linear to highly branched PEG architectures, Nano Research, 2018, 第 1 作者
（20） Effective antisense gene regulation via noncationic, polyethylene glycol brushes, J. Am. Chem. Soc., 2016, 第 1 作者
（21） Providing oligonucleotides with steric selectivity by brush polymer-assisted compaction, J. Am. Chem. Soc., 2015, 第 1 作者
（22） Polycondensation of polymer brushes via DNA hybridization, J. Am. Chem. Soc., 2014, 第 1 作者

   

（ 1 ） 单次注射疫苗递送系 统, 负责人, 中国科学院计划, 2024-01--2026-12
（ 2 ） 可激活肠道黏膜免疫应答的新型mRNA疫苗, 负责人, 研究所自主部署, 2023-01--2025-12
（ 3 ） 可激活肠道黏膜免疫应答纳米疫苗的构建及其应用于结 直肠癌治疗的研究, 负责人, 国家任务, 2022-01--2025-12
（ 4 ） 新型阳性脂质分子及药物递送技术开发, 负责人, 其他, 2021-09--2024-08