基本信息
张刚 男 硕导 中国科学院微生物研究所
电子邮件: zhanggang@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号A715
邮政编码:
电子邮件: zhanggang@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号A715
邮政编码:
招生信息
招生专业
071005-微生物学
招生方向
病原菌耐药与噬菌体防御机制
教育背景
2008-09--2011-06 中国农业大学 博士2005-09--2008-06 石河子大学 硕士2001-09--2005-06 石河子大学 学士
工作经历
工作简历
2018-10~现在, 中国科学院微生物研究所, 副研究员2011-07~2018-10,中国科学院微生物研究所, 助理研究员2008-09~2011-06,中国农业大学, 博士2005-09~2008-06,石河子大学, 硕士2001-09~2005-06,石河子大学, 学士
专利与奖励
专利成果
( 1 ) β-内酰胺酶及其编码基因以及它们的应用, 2019, 第 4 作者, 专利号: CN110157699A
出版信息
发表论文
(1) Harnessing the Native Type I-F CRISPR-Cas System of Acinetobacter baumannii for Genome Editing and Gene Repression, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2023, 第 6 作者 通讯作者(2) Systematic Discovery of a New Catalogue of Tyrosine-Type Integrases in Bacterial Genomic Islands, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2023, 第 1 作者(3) IS26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics (vol 13, e03340-21, 2022), MBIO, 2022, 第 4 作者(4) In vivo evolution of carbapenem resistance in hypervirulent Klebsiella pneumoniae in a patient undergoing long-term treatment, Journal of Antimicrobial Chemotherapy, 2022, 第 6 作者(5) An urban soil environmental E. coli ST354 isolate co-harbouring mcr-1 and bla NDM-9, Journal of Global Antimicrobial Resistance, 2022, 第 4 作者(6) Amplification of bla(NDM-1) mediated by ISCR1 confers hyperresistance to carbapenem, JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2022, 第 4 作者(7) The integrase of genomic island GIsul2 mediates the mobilization of GIsul2 and ISCR-related element CR2-sul2 unit through site-specific recombination, FRONTIERS IN MICROBIOLOGY, 2022, 第 1 作者(8) IS 26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics, MBIO, 2022, 第 4 作者(9) Efficient Suppression of Natural Plasmid-Borne Gene Expression in Carbapenem-Resistant Klebsiella pneumoniae Using a Compact CRISPR Interference System, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2022, 第 7 作者 通讯作者(10) Streptococcus sputorum , a Novel Member of Streptococcus with Multidrug Resistance, Exhibits Cytotoxicity, ANTIBIOTICS, 2021, 第 6 作者(11) The Shared Resistome of Human and Pig Microbiota Is Mobilized by Distinct Genetic Elements, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2021, 第 4 作者(12) Systematic analysis of supervised machine learning as an effective approach to predicate beta-lactam resistance phenotype in Streptococcus pneumoniae, BRIEFINGS IN BIOINFORMATICS, 2020, 第 5 作者(13) A new intrinsic aminoglycoside 6 '-N-acetyltransferase subclass, AAC(6 ')-III, in Burkholderia pseudomallei, Burkholderia mallei and Burkholderia oklahomensis, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2020, 第 1 作者(14) Co-existence of the carbapenem resistance genes blaKPC-2 and blaNDM-1 in a Raoultella planticola isolate in China, JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2020, 第 7 作者(15) A novel family of intrinsic chloramphenicol acetyltransferase CATC in Vibrio parahaemolyticus: naturally occurring variants reveal diverse resistance levels against chloramphenicol, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2019, 第 1 作者(16) Real time monitoring of Aeromonas salmonicida evolution in response to successive antibiotic therapies in a commercial fish farm, ENVIRONMENTAL MICROBIOLOGY, 2019, 第 6 作者(17) 细菌中基因组岛的转移与调控机制研究进展, Regulation, excision and horizontal transfer of genomic islands in bacteria, 微生物学通报, 2018, 第 2 作者(18) Five novel carbapenem-hydrolysing OXA-type beta-lactamase groups are intrinsic in Acinetobacter spp., JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2018, 第 2 作者(19) A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3")-II, is horizontally transferred among Acinetobacter spp. by homologous recombination, PLOS GENETICS, 2017, 第 1 作者(20) Iscr2 is associated with the dissemination of multiple resistance genes among vibrio spp. and pseudoalteromonas spp. isolated from farmed fish, ARCHIVES OF MICROBIOLOGY, 2017, 第 3 作者(21) 细菌固有耐药的研究进展, The intrinsic resistance of bacteria, 遗传, 2016, 第 1 作者(22) Identification of Novel Cryptic Aminoglycoside Phosphotransferases in Pseudomonas aeruginosa, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 第 1 作者(23) Insights into the evolutionary trajectories of fluoroquinolone resistance in Streptococcus pneumoniae, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2015, 第 1 作者(24) Functional characterization and phylogenetic analysis of acquired and intrinsic macrolide phosphotransferases in the Bacillus cereus group, ENVIRONMENTAL MICROBIOLOGY, 2015, 第 4 作者(25) Mechanism for transfer of transposon Tn2010 carrying macrolide resistance genes in Streptococcus pneumoniae and its effects on genome evolution, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 第 3 作者(26) Characterization of a Multiresistant Mosaic Plasmid from a Fish Farm Sediment Exiguobacterium sp. Isolate Reveals Aggregation of Functional Clinic-Associated Antibiotic Resistance Genes, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2014, 第 5 作者(27) 肺炎链球菌对氟喹诺酮类抗生素耐药研究进展, Research progress in Streptococcus Pneumoniae resistance to fluoroquinolone antibiotics, 中国实用内科杂志, 2014, 第 1 作者(28) Identification of a novel resistance mutation in parE that confers high-level resistance to moxifloxacin in Streptococcus pneumoniae, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2012, 第 1 作者
科研活动
科研项目
( 1 ) 多重耐药食源性病原菌溯源及其耐药基因传播预警, 负责人, 国家任务, 2022-12--2025-11( 2 ) 重组酶Iscr2和ResG协同介导耐药元件iscr2-sul2的移动机制研究, 负责人, 国家任务, 2021-01--2024-12( 3 ) 病原细菌中转移酶固有耐药组的发现及其进化研究, 负责人, 国家任务, 2016-01--2018-12