100104-病理学与病理生理学

细胞异质性，细胞命运决定

2006-09--2011-06   北京师范大学   博士

   

2020-07~现在, 中科院动物研究所, 细胞异质性与命运决定研究组组长
2016-10~2020-06,西奈山医院Lunenfeld-Tanenbaum研究所, 博士后
2011-09~2016-06,宾夕法尼亚大学, 博士后
2006-09~2011-06,北京师范大学, 博士

   

（1） Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma, Developmental Cell, 2025, 
（2） Immune checkpoint inhibitor related myositis: an observational, retrospective, pharmacovigilance study, EXPERT OPINION ON DRUG SAFETY, 2024, 
（3） Tacrolimus Related Acute Pancreatitis: An Observational, Retrospective, Pharmacovigilance Study, CLINICAL THERAPEUTICS, 2024, 
（4） Identification of IRAK1BP1 as a candidate prognostic factor in lung adenocarcinoma, FRONTIERS IN ONCOLOGY, 2023, 
（5） Wip1 inhibits neutrophil extracellular traps to promote abscess formation in mice by directly dephosphorylating Coronin-1a, Wip1 inhibits neutrophil extracellular traps to promote abscess formation in mice by directly dephosphorylating Coronin-1a, CELLULAR & MOLECULAR IMMUNOLOGY, 2023, 
（6） Distinct genomic features between osteosarcomas firstly metastasing to bone and to lung, HELIYON, 2023, 
（7） Asymmetric Cell Division and Tumor Heterogeneity, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 
（8） Tn5转座子及其在生物技术领域的应用, Tn5 transposon and its applications in biotechnology, 中国实验动物学报, 2022, 第 4 作者
（9） TGF-�� Signali ng and Resistance to Cancer Therapy, Front Cell Dev Biol ., 2021, 第 5 作者  通讯作者
（10） PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas, NATURE, 2017, 
（11） Oncogenica BRAF-induced invadopodia formation and melanoma invasion., Cell Reports, 2016, 第 1 作者
（12） Exo70 isoform switching 3 Resume of Hezhe Lu| The Lunenfeld-Tanenbaum Research Institute upon Epithelial-Mesenchymal transition mediates cancer cell invasion, Dev Cell, 2013, 第 1 作者
（13） Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation, ONCOGENE, 2012, 
（14） MicroRNA-9 up-regulates E-cadherin through inhibition of NF- kB1-snail1 pathway in melanoma, Journal of Pathology, 2012, 第 1 作者
（15） An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition, EMBO JOURNAL, 2010, 
（16） Cyr61 Is Up-Regulated in Prostate Cancer and Associated With the p53 Gene Status, JOURNAL OF CELLULAR BIOCHEMISTRY, 2009, 

   

（ 1 ） 单细胞谱系示踪解析乳腺癌多药耐药分子机制, 负责人, 国家任务, 2024-01--2027-12
（ 2 ） 绘制不同来源血细胞类群的时空动态图谱, 参与, 国家任务, 2024-01--2028-01
（ 3 ） 优秀青年科学基金（海外）, 负责人, 国家任务, 2022-06--2025-06
（ 4 ） 中国科学院稳定支持基础研究领域青年团队计划, 参与, 中国科学院计划, 2021-07--2025-07
（ 5 ） 率先行动人才择优支持, 负责人, 中国科学院计划, 2021-06--2025-06
（ 6 ） 率先行动人才启动计划, 负责人, 中国科学院计划, 2020-07--2025-07