基本信息
王可品  男  硕导  中国科学院广州生物医药与健康研究院
电子邮件: wang_kepin@gibh.ac.cn
通信地址: 广州市黄埔区开源大道190号
邮政编码:

招生信息

   
招生专业
071008-发育生物学
071010-生物化学与分子生物学
0710J6-再生医学
招生方向
基因修饰大动物模型的构建与应用

教育背景

2011-09--2016-07   中国科学院大学   理学博士
2007-09--2011-07   安徽大学   工学学士

工作经历

   
工作简历
2018-01~现在, 中国科学院广州生物医药与健康研究院, 副研究员
2016-07~2017-12,中国科学院广州生物医药与健康研究院, 助理研究员
社会兼职
2018-01-01-2022-12-31,广东省遗传学会, 理事,副秘书长

专利与奖励

   
专利成果
[1] 赖良学, 王可品, 葛维凯, 刘琪帅, 谢精科. 一种重度免疫缺陷猪模型及其构建方法和应用. CN: CN109777834A, 2019-05-21.

出版信息

   
发表论文
[1] Li, Nan, Gou, Shixue, Wang, Jiaowei, Zhang, Quanjun, Huang, Xingyun, Xie, Jingke, Li, Li, Jin, Qin, Ouyang, Zhen, Chen, Fangbing, Ge, Weikai, Shi, Hui, Liang, Yanhui, Zhuang, Zhenpeng, Zhao, Xiaozhu, Lian, Meng, Ye, Yinghua, Quan, Longquan, Wu, Han, Lai, Liangxue, Wang, Kepin. CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I. MOLECULAR THERAPY[J]. 2021, 29(3): 1001-1015, http://dx.doi.org/10.1016/j.ymthe.2020.11.023.
[2] Meng Lian, Fangbing Chen, Xingyun Huang, Xiaozhu Zhao, Shixue Gou, Nan Li, Qin Jin, Hui Shi, Yanhui Liang, Jingke Xie, Weikai Ge, Zhenpeng Zhuang, Jiaowei Wang, Yinghua Ye, Yi Yang, Kepin Wang, Liangxue Lai, Han Wu. Improving Cpf1-mediated base editing system by combining dCas9/ dead sgRNA with human APOBEC3A variants. Journal of Genetics and Genomics[J]. 2021, http://dx.doi.org/10.1016/j.jgg.2020.07.010.
[3] Li, Wenjing, Shi, Lei, Zhuang, Zhenpeng, Wu, Han, Lian, Meng, Chen, Yihui, Li, Lei, Ge, Weikai, Jin, Qin, Zhang, Quanjun, Zhao, Yu, Liu, Zhaoming, Ouyang, Zhen, Ye, Yinghua, Li, Yingying, Wang, Hai, Liao, Yuan, Quan, Longquan, Xiao, Lei, Lai, Liangxue, Meng, Guangxun, Wang, Kepin. Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses. JOURNAL OF IMMUNOLOGY[J]. 2020, 205(9): 2532-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000581921400019.
[4] Xie, Jingke, Huang, Xingyun, Wang, Xia, Gou, Shixue, Liang, Yanhui, Chen, Fangbing, Li, Nan, Ouyang, Zhen, Zhang, Quanjun, Ge, Weikai, Jin, Qin, Shi, Hui, Zhuang, Zhenpeng, Zhao, Xiaozhu, Lian, Meng, Wang, Jiaowei, Ye, Yinghua, Quan, Longquan, Wu, Han, Wang, Kepin, Lai, Liangxue. ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems. BMC BIOLOGY[J]. 2020, 18(1): http://dx.doi.org/10.1186/s12915-020-00866-5.
[5] Jingke Xie, Weikai Ge, Nan Li, Qishuai Liu, Fangbing Chen, Xiaoyu Yang, Xingyun Huang, Zhen Ouyang, Quanjun Zhang, Yu Zhao, Zhaoming Liu, Shixue Gou, Han Wu, Chengdan Lai, Nana Fan, Qin Jin, Hui Shi, Yanhui Liang, Ting Lan, Longquan Quan, Xiaoping Li, Kepin Wang, Liangxue Lai. Efficient base editing for multiple genes and loci in pigs using base editors. Nature Communications[J]. 2019, 10(1): 1-13, http://dx.doi.org/10.1038/s41467-019-10421-8.
[6] Ruan, Degong, Peng, Jiangyun, Wang, Xiaoshan, Ouyang, Zhen, Zou, Qingjian, Yang, Yi, Chen, Fangbing, Ge, Weikai, Wu, Han, Liu, Zhaoming, Zhao, Yu, Zhao, Bentian, Zhang, Quanjun, Lai, Chengdan, Fan, Nana, Zhou, Zhiwei, Liu, Qishuai, Li, Nan, Jin, Qin, Shi, Hui, Xie, Jingke, Song, Hong, Yang, Xiaoyu, Chen, Jiekai, Wang, Kepin, Li, Xiaoping, Lai, Liangxue. XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer. STEM CELL REPORTS[J]. 2018, 10(2): 494-508, http://dx.doi.org/10.1016/j.stemcr.2017.12.015.
[7] 刘琪帅, 李小平, 王可品, 葛维凯, 赖良学. 异种移植相关功能蛋白人源化基因修饰猪模型的建立. 实用器官移植电子杂志. 2018, 6(5): 344-348, http://lib.cqvip.com/Qikan/Article/Detail?id=676491202.
[8] 金琴, 王可品, 赖良学. 利用人工核酸酶构建基因编辑猪的研究进展. 生命科学[J]. 2018, 30(9): 955-966, http://lib.cqvip.com/Qikan/Article/Detail?id=676565580.
[9] Wu, Han, Liu, Qishuai, Shi, Hui, Xie, Jingke, Zhang, Quanjun, Ouyang, Zhen, Li, Nan, Yang, Yi, Liu, Zhaoming, Zhao, Yu, Lai, Chengdan, Ruan, Degong, Peng, Jiangyun, Ge, Weikai, Chen, Fangbing, Fan, Nana, Jin, Qin, Liang, Yanhui, Lan, Ting, Yang, Xiaoyu, Wang, Xiaoshan, Lei, Zhiyong, Doevendans, Pieter A, Sluijter, Joost P G, Wang, Kepin, Li, Xiaoping, Lai, Liangxue. Engineering CRISPR/Cpf1 with tRNA promotes genome editing capability in mammalian systems. CELLULAR AND MOLECULAR LIFE SCIENCES[J]. 2018, 75(19): 3593-3607, http://www.corc.org.cn/handle/1471x/2202255.
[10] 李小平, 王可品, 刘琪帅, 赖良学. 基因修饰工具猪模型的建立及应用. 中国实验动物学报[J]. 2017, 25(3): 329-335, http://lib.cqvip.com/Qikan/Article/Detail?id=672706813.
[11] Wang, Kepin, Jin, Qin, Ruan, Degong, Yang, Yi, Liu, Qishuai, Wu, Han, Zhou, Zhiwei, Ouyang, Zhen, Liu, Zhaoming, Zhao, Yu, Zhao, Bentian, Zhang, Quanjun, Peng, Jiangyun, Lai, Chengdan, Fan, Nana, Liang, Yanhui, Lan, Ting, Li, Nan, Wang, Xiaoshan, Wang, Xinlu, Fan, Yong, Doevendans, Pieter A, Sluijter, Joost P G, Liu, Pentao, Li, Xiaoping, Lai, Liangxue. Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing. GENOME RESEARCH[J]. 2017, 27(12): 2061-2071, https://www.webofscience.com/wos/woscc/full-record/WOS:000417047600009.
[12] Han, Kai, Liang, Liuping, Li, Li, Ouyang, Zhen, Zhao, Bentian, Wang, Qi, Liu, Zhaoming, Zhao, Yu, Ren, Xiaoshuai, Jiang, Fei, Lai, Chengdan, Wang, Kepin, Yan, Sen, Huang, Liang, Guo, Lin, Zeng, Kang, Lai, Liangxue, Fan, Nana. Generation of Hoxc13 knockout pigs recapitulates human ectodermal dysplasia-9. HUMAN MOLECULAR GENETICS[J]. 2017, 26(1): 184-191, https://www.webofscience.com/wos/woscc/full-record/WOS:000397064600015.
[13] Yang, Yi, Wang, Kepin, Wu, Han, Jin, Qin, Ruan, Degong, Ouyang, Zhen, Zhao, Bentian, Liu, Zhaoming, Zhao, Yu, Zhang, Quanjun, Fan, Nana, Liu, Qishuai, Guo, Shimei, Bu, Lei, Fan, Yong, Sun, Xiaofang, Li, Xiaoping, Lai, Liangxue. Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering. JOURNAL OF MOLECULAR CELL BIOLOGYnull. 2016, 8(2): 174-177, http://ir.gibh.ac.cn/handle/344009/868.
[14] Zou, Qingjian, Yan, Quanmei, Zhong, Juan, Wang, Kepin, Sun, Haitao, Yi, Xiaoling, Lai, Liangxue. Direct Conversion of Human Fibroblasts into Neuronal Restricted Progenitors*. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2014, 289(8): 5250-5260, http://dx.doi.org/10.1074/jbc.M113.516112.

科研活动

   
科研项目
( 1 ) 利用单碱基编辑工具构建儿童早衰症猪模型, 负责人, 国家任务, 2020-01--2022-12
( 2 ) 利用CRISPR/Cpf1对杜氏肌营养不良症(DMD)猪模型进行基因治疗研究, 负责人, 国家任务, 2018-01--2020-12
( 3 ) 条件性基因敲除与恢复系统的建立及其应用, 负责人, 地方任务, 2020-04--2023-03
( 4 ) 基于条件性表达Cas9系统构建谱系示踪工具猪模型, 负责人, 国家任务, 2022-01--2025-12
( 5 ) β地中海贫血五指山猪模型构建及其基因治疗研究, 负责人, 地方任务, 2021-09--2023-09
( 6 ) 基因修饰猪模型资源库建设, 负责人, 中国科学院计划, 2020-01--2021-12
( 7 ) 代谢紊乱条件性敲除猪模型的建立及发病机理研究, 负责人, 国家任务, 2022-01--2026-12