070303-有机化学

1、 有机及药物合成，不对称催化

2001-09--2004-06   四川大学   理学硕士
1990-09--1994-06   哈尔滨工业大学   工学学士

   

2004-07~现在, 中科院成都有机化学研究所, 副研究员
2001-09~2004-06,四川大学, 理学硕士
1994-07~2001-08,成都航天工业总公司中心实验室, 工程师
1990-09~1994-06,哈尔滨工业大学, 工学学士

   

（ 1 ） 手性螺3,2'-吡咯烷氧化吲哚骨架化合物、制备方法及用途、中间体及制备方法, 2020, 第 3 作者, 专利号: 202010066989.1

（ 2 ） 芳基甲酰甲酸盐及酸的制备方法, 2019, 第 3 作者, 专利号: 201910345001.2

   

（1） Enantioselective Benzylation and Allylation of a Crucial Synthon of 3-Amino Oxindole Schiff Base Promoted by a Cinchonidinium Phase Transfer Catalyst to Enable the Effective Preparation of Chiral Quaternary 3-Amino Oxindoles, Journal Of Organic Chemistry, 2023, 
（2） Novel preparation of chiral 3,2���-pyrrolidinyl spirooxindole from an enantioselective Michael addition between 3-(diphenylmethylene)-amino-oxindole and acrolein catalyzed by a cinchona alkaloid, Tetrahedron Letters, 2022, 
（3） （s）-3-（3，4-二甲氧基苯基）-2-甲基丙氨酸衍生的手性咪唑啉酮催比剂合成新方法, 合成化学, 2021, 第 11 作者
（4） 3-Amino Oxindole Schiff Base as Synthon for Enantioselective Preparation of Spirooxindol-3,2 '-pyrrol from a Michael/Cyclization Reaction Catalyzed by a Bifunctional Cinchona, ORGANIC LETTERS, 2021, 
（5） Base Catalyzed Abnormal [3 + 2]-Cycloaddition between Isatin N,N���-Cyclic Azomethine Imine 1,3-Dipole and 3-Methyleneoxindole for the One-Step Construction of Tetracyclic Bispirooxindoles, J. Org. Chem. 2020, 85, 3921-3928, 2020, 
（6） A base-catalyzed domino reaction between isoindigos and alpha-alkylidene succinimides-convenient preparation of highly steric bispirooxindoles, ORGANIC & BIOMOLECULAR CHEMISTRY, 2020, 
（7） Organocatalytic and enantioselective 4+2 cyclization between hydroxymaleimides and ortho-hydroxyphenyl para-quinone methide-selective preparation of chiral hemiketals, CHEMICAL COMMUNICATIONS, 2020, 
（8） Substituted (E)-2-Methylene-3,4-cyclohexenones through Direct and Convenient Synthesis from Cyclohexenone-MBH Alcohol in the Presence of DMAP, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2019, 
（9） Effective and diastereoselective preparation of dispirocyclopent-3'-enebisoxindoles via novel 3+2 annulation of isoindigos and MBH carbonates, ORGANIC & BIOMOLECULAR CHEMISTRY, 2018, 
（10） Isatin N,N '-Cyclic Azomethine Imine 1,3-Dipole and Abnormal 3+2-Cycloaddition with Maleimide in the Presence of 1,4-Diazabicyclo2.2.2octane, ORGANIC LETTERS, 2017, 
（11） A cinchona alkaloid catalyzed enantioselective sulfa-Michael/aldol cascade reaction of isoindigos: construction of chiral bispirooxindole tetrahydrothiophenes with vicinal quaternary spirocenters, ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 
（12） Asymmetric Double Michael Reaction Catalyzed by Simple Primary Amine Catalysts: A Straightforward Approach to Construct Spirocyclic Oxindoles, Asymmetric Double Michael Reaction Catalyzed by Simple Primary Amine Catalysts: A Straightforward Approach to Construct Spirocyclic Oxindoles, 中国化学：英文版, 2012, 

   

（ 1 ） 生物制造体系过程集成、优化与产业化示范, 负责人, 国家任务, 2021-07--2025-06
（ 2 ） 甲萘酚氧化制备甲萘醌工艺研究, 参与, 境内委托项目, 2020-09--2025-08
（ 3 ） 阿托伐他汀新工艺路线研究, 负责人, 境内委托项目, 2020-04--2021-04
（ 4 ） 二氧化氯缓释剂研制及分析检测方法的建立, 负责人, 研究所自主部署, 2020-04--2022-10
（ 5 ） 草胺磷绿色制造关键工艺突破与系统集成应用, 参与, 国家任务, 2019-10--2022-10