深圳市后备级人才。2012年加入深圳先进院，2017年9月开始在中国科学院大学攻读博士学位，在博士期间获得中科院院长优秀奖、研究生国家奖学金、朱李月华奖学金，北京市普通高等学校及中国科学院大学“优秀毕业生”。2020年荣获深圳市科学技术奖自然科学奖一等奖，入选深圳市后备级人才。以第一及通讯作者（含共同）发表于Cell Reports Physical Science, Trends in Biotechnology, Advanced Functional Materials, ACS Nano, Biomaterials, Theranostics, Small Structures等期刊上，发表论文共计40余篇。申请国家发明专利20多项，国际PCT专利8项；主持国家自然科学基金面上项目和青年基金项目、广东省自然科学自由申请项目、以及深圳市重点项目和自由探索项目，并作为核心成员参与科技部国家重点研发计划，参与多项国家、省、市级科研项目；担任国家自然科学基金、广东省基础与应用基础研究基金项目评审专家；担任ACS NANO, ACS Applied Materials & Interfaces等期刊审稿人。

研究方向：微纳仿生药物递送、基因治疗及抗肿瘤光免疫调控

每年拟招收博士/硕士研究生1-2名。

071010-生物化学与分子生物学
0710J1-纳米科学与技术
071009-细胞生物学

纳米医学，微纳仿生药物递送，肿瘤免疫，基因治疗
仿生微纳机器人
肿瘤学

2017-09--2020-06   中国科学院大学   博士学位

研究生

博士

2012.07-今 中国科学院深圳先进技术研究院

2020-01~现在, 中国科学院深圳先进技术研究院, 副研究员
2017-01~2019-12,中国科学院深圳先进技术研究院, 助理研究员
2012-07~2016-12,中国科学院深圳先进技术研究院, 研究员助理

2020-08-01-今,广东省基础与应用基础研究基金项目评审专家,
2019-03-12-今,ACS NANO, ACS Applied Materials & Interfaces期刊审稿人,

生物技术前沿

   

（1） 优秀员工, 研究所（学校）, 2021
（2） 深圳市自然科学奖, 一等奖, 市地级, 2020
（3） 中国科学院大学优秀毕业生, , 研究所（学校）, 2020
（4） 北京市普通高等学校优秀毕业生, 市地级, 2020
（5） 优秀员工, 研究所（学校）, 2020
（6） 中国科学院院长优秀奖, , 院级, 2019
（7） 博士研究生国家奖学金, 国家级, 2019
（8） 朱李月华奖学金, 研究所（学校）, 2019
（9） 优秀员工, 研究所（学校）, 2018
（10） 优秀员工, 研究所（学校）, 2017
（11） 优秀员工, 研究所（学校）, 2016

（ 1 ） 一种脑肿瘤靶向的仿生载药纳米颗粒及其制备方法和用途, 发明专利, 2020, 第 5 作者, 专利号: CN110859826A

（ 2 ） 一种克服肿瘤耐药的方法, 发明专利, 2020, 第 3 作者, 专利号: CN110755457A

（ 3 ） 一种改善肿瘤缺氧的新方法, 发明专利, 2020, 第 3 作者, 专利号: CN110893196A

（ 4 ） 一种纳米颗粒载药系统及其制备方法和应用, 发明专利, 2020, 第 3 作者, 专利号: CN110859817A

（ 5 ） 一种活生物自产氧光敏剂及其应用, 发明专利, 2020, 第 2 作者, 专利号: CN110812482A

（ 6 ） 一种包载免疫佐剂纳米颗粒及应用, 发明专利, 2020, 第 3 作者, 专利号: CN110755387A

（ 7 ） 金纳米笼-二氧化锰复合纳米颗粒及其制备方法和应用, 专利授权, 2020, 第 3 作者, 专利号: CN107670040B

（ 8 ） 一种用作光/声敏剂的靶向纳米颗粒及其制备方法和应用, 发明专利, 2019, 第 3 作者, 专利号: CN109568577A

（ 9 ） 一种载miRNA复合纳米颗粒及其制备方法和应用, 专利授权, 2020, 第 3 作者, 专利号: CN108210482B

（ 10 ） 复合型纳米疫苗及其制备方法, 发明专利, 2015, 第 3 作者, 专利号: CN104645349A

   

[1] Trends in Biotechnology. 2025, 第 11 作者  通讯作者  
[2] Cell Reports Physical Science. 2024, 第 10 作者  通讯作者  
[3] Chen, Huaqing, Zhang, Shengping, Fang, Quan, He, Huamei, Ren, Jian, Sun, Da, Lai, Jiazheng, Ma, Aiqing, Chen, Ze, Liu, Lanlan, Liang, Ruijing, Cai, Lintao. Biomimetic Nanosonosensitizers Combined with Noninvasive Ultrasound Actuation to Reverse Drug Resistance and Sonodynamic-Enhanced Chemotherapy against Orthotopic Glioblastoma. Acs Nano[J]. 2023, 第 10 作者  通讯作者  17(1): 421-436, http://dx.doi.org/10.1021/acsnano.2c08861.
[4] He, Huamei, Zhu, Denghui, Ma, Aiqing, Ren, Jian, Chen, Ze, Ran, Hui, Li, Zhaozhen, Qin, Ruiqing, Liang, Ruijing, Liu, Lanlan, Cai, Lintao. Reconstructing Tumor Microenvironment Using Photoresponsive Cyanobacteria to Reversal Chemoresistance for Robust Chemotherapy. Small Structures[J]. 2023, 第 10 作者  通讯作者  
[5] Lishan Zhang, baozhen zhang, Ruijing Liang, Lanlan Liu, Ma, Aiqing, Cai, Lintao. A Dual-Biomineralized Yeast Micro-/Nanorobot with Self-Driving Penetration for Gastritis Therapy and Motility Recovery. Acs Nano[J]. 2023, 第 4 作者  通讯作者  
[6] 刘兰兰, 梁锐晶, 蔡林涛. 细菌驱动的免疫调控与肿瘤精准治疗. 生命科学[J]. 2023, 第 1 作者35(3): 277-286, http://lib.cqvip.com/Qikan/Article/Detail?id=7109604447.
[7] Huang, Guojun, Liu, Lanlan, Pan, Hong, Cai, Lintao. Biomimetic Active Materials Guided Immunogenic Cell Death for Enhanced Cancer Immunotherapy. SMALL METHODS. 2022, 第 2 作者  通讯作者  7(5): 
[8] Pan, Hong, Zheng, Mingbin, Ma, Aiqing, Liu, Lanlan, Cai, Lintao. Cell/Bacteria-Based Bioactive Materials for Cancer Immune Modulation and Precision Therapy. ADVANCED MATERIALS. 2021, 第 4 作者33(50): http://dx.doi.org/10.1002/adma.202100241.
[9] Li, Wenjun, Pan, Hong, Chen, Ze, Luo, Yingmei, He, Wei, Wang, Mengmeng, Tang, Xiaofan, He, Huamei, Liu, Lanlan, Zheng, Mingbin, Jiang, Xin, Yin, Ting, Liang, Ruijing, Ma, Yifan, Cai, Lintao. Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor. BIOACTIVE MATERIALS[J]. 2021, 第 9 作者6(4): 951-962, http://dx.doi.org/10.1016/j.bioactmat.2020.09.025.
[10] Chen, Huaqing, Liu, Lanlan, Ma, Aiqing, Yin, Ting, Chen, Ze, Liang, Ruijing, Qiu, Yuzhi, Zheng, Mingbin, Cai, Lintao. Noninvasively immunogenic sonodynamic therapy with manganese protoporphyrin liposomes against triple-negative breast cancer. BIOMATERIALS[J]. 2021, 第 2 作者269: http://dx.doi.org/10.1016/j.biomaterials.2020.120639.
[11] Zhou, Haimei, He, Huamei, Liang, Ruijing, Pan, Hong, Chen, Ze, Deng, Guanjun, Zhang, Shengping, Ma, Yifan, Liu, Lanlan, Cai, Lintao. In situ poly I:C released from living cell drug nanocarriers for macrophage-mediated antitumor immunotherapy. Biomaterials[J]. 2021, 第 9 作者  通讯作者  269: http://dx.doi.org/10.1016/j.biomaterials.2021.120670.
[12] Liu, Lanlan, He, Huamei, Luo, Zhenyu, Zhou, Haimei, Liang, Ruijing, Pan, Hong, Ma, Yifan, Cai, Lintao. In Situ Photocatalyzed Oxygen Generation with Photosynthetic Bacteria to Enable Robust Immunogenic Photodynamic Therapy in Triple-Negative Breast Cancer. ADVANCED FUNCTIONAL MATERIALS[J]. 2020, 第 1 作者30(10): 
[13] He, Huamei, Liu, Lanlan, Liang, Ruijing, Zhou, Haimei, Pan, Hong, Zhang, Shengping, Cai, Lintao. Tumor-targeted nanoplatform for in situ oxygenation-boosted immunogenic phototherapy of colorectal cancer. Acta Biomaterialia[J]. 2020, 第 2 作者104: 188-197, http://dx.doi.org/10.1016/j.actbio.2020.01.012.
[14] Luo, Ying, Yang, Jun, Zhang, Chi, Jin, Yan, Pan, Hong, Liu, Lanlan, Gong, Yifeng, Xia, Yu, Wang, Guobing, Zhang, Jiaosheng, Li, Chengrong, Li, Qiu. Up-regulation of miR-27a promotes monocyte-mediated inflammatory responses in Kawasaki disease by inhibiting function of B10 cells. JOURNAL OF LEUKOCYTE BIOLOGY[J]. 2020, 第 6 作者107(1): 133-144, https://www.webofscience.com/wos/woscc/full-record/WOS:000505244900013.
[15] Wang, Fangfang, Pan, Hong, Yao, Xiangjie, He, Huamei, Liu, Lanlan, Luo, Yingmei, Zhou, Haimei, Zheng, Mingbin, Zhang, Renli, Ma, Yifan, Cai, Lintao. Bioorthogonal Metabolic Labeling Utilizing Protein Biosynthesis for Dynamic Visualization of Nonenveloped Enterovirus 71 Infection. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 第 5 作者12(3): 3363-3370, https://www.webofscience.com/wos/woscc/full-record/WOS:000509428300006.
[16] Li, Ping, Yang, Xinyu, Yang, Yang, He, Huamei, Chou, ChonKit, Chen, Fengyang, Pan, Hong, Liu, Lanlan, Cai, Lintao, Ma, Yifan, Chen, Xin. Synergistic effect of all-trans-retinal and triptolide encapsulated in an inflammation-targeted nanoparticle on collagen-induced arthritis in mice. JOURNALOFCONTROLLEDRELEASE[J]. 2020, 第 8 作者319: 87-103, http://dx.doi.org/10.1016/j.jconrel.2019.12.025.
[17] He, Huamei, Liu, Lanlan, Zhang, Shengping, Zheng, Mingbin, Ma, Aiqing, Chen, Ze, Pan, Hong, Zhou, Haimei, Liang, Ruijing, Cai, Lintao. Smart gold nanocages for mild heat -triggered drug release and breaking chemoresistance. Journal of Controlled Release[J]. 2020, 第 2 作者323: 387-397, http://dx.doi.org/10.1016/j.jconrel.2020.04.029.
[18] Li, Wenjun, Pan, Hong, He, Huamei, Meng, Xiaoqing, Ren, Qian, Gong, Ping, Jiang, Xin, Liang, Zhenguo, Liu, Lanlan, Zheng, Mingbin, Shao, Ximing, Ma, Yifan, Cai, Lintao. Bio-Orthogonal T Cell Targeting Strategy for Robustly Enhancing Cytotoxicity against Tumor Cells. SMALL[J]. 2019, 第 9 作者15(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000456849600008.
[19] Hong Pan, Ping Li, Guifei Li, Wenjun Li, Bian Hu, Huamei He, Ze Chen, Fangfang Wang, Lanlan Liu, Yifeng Gong, Yutong Han, Yingmei Luo, Mingbin Zheng, Yifan Ma, Lintao Cai, Yan Jin. Glycometabolic Bioorthogonal Chemistry‐Guided Viral Transduction for Robust Human T Cell Engineering. Advanced Functional Materials[J]. 2019, 第 9 作者29(22): https://www.doi.org/10.1002/adfm.201807528.
[20] Chen, Zhikuan, Liu, Lanlan, Liang, Ruijing, Luo, Zhenyu, He, Huamei, Wu, Zhihao, Tian, Hao, Zheng, Mingbin, Ma, Yifan, Cai, Lintao. Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect. ACSNANO[J]. 2018, 第 2 作者12(8): 8633-8645, http://ir.siat.ac.cn:8080/handle/172644/14607.
[21] Liang, Ruijing, Liu, Lanlan, He, Huamei, Chen, Zhikuan, Han, Zhiqun, Luo, Zhenyu, Wu, Zhihao, Zheng, Mingbin, Ma, Yifan, Cai, Lintao. Oxygen-boosted immunogenic photodynamic therapy with gold nanocages@manganese dioxide to inhibit tumor growth and metastases. BIOMATERIALS[J]. 2018, 第 2 作者177: 149-160, http://ir.siat.ac.cn:8080/handle/172644/14596.
[22] Liu, Lanlan, He, Huamei, Liang, Ruijing, Yi, Huqiang, Meng, Xiaoqing, Chen, Zhikuan, Pan, Hong, Ma, Yifan, Cai, Lintao. ROS-Inducing Micelles Sensitize Tumor-Associated Macrophages to TLR3 Stimulation for Potent Immunotherapy. BIOMACROMOLECULES[J]. 2018, 第 1 作者19(6): 2146-2155, http://ir.siat.ac.cn:8080/handle/172644/14597.
[23] Pan, Hong, Yao, Xiangjie, Chen, Weihua, Wang, Fangfang, He, Huamei, Liu, Lanlan, He, Yaqing, Chen, Jinquan, Jiang, Puzi, Zhang, Renli, Ma, Yifan, Cai, Lintao. Dissecting complicated viral spreading of enterovirus 71 using in situ bioorthogonal fluorescent labeling. BIOMATERIALS[J]. 2018, 第 6 作者181: 199-209, http://ir.siat.ac.cn:8080/handle/172644/14610.
[24] Luo, Zhenyu, Tian, Hao, Liu, Lanlan, Chen, Zhikuan, Liang, Ruijing, Chen, Ze, Wu, Zhihao, Ma, Aiqing, Zheng, Mingbin, Cai, Lintao. Tumor-targeted hybrid protein oxygen carrier to simultaneously enhance hypoxia-dampened chemotherapy and photodynamic therapy at a single dose. THERANOSTICS[J]. 2018, 第 3 作者8(13): 3584-3596, http://ir.siat.ac.cn:8080/handle/172644/14598.
[25] Tian, Hao, Luo, Zhenyu, Liu, Lanlan, Zheng, Mingbin, Chen, Ze, Ma, Aiqing, Liang, Ruijing, Han, Zhiqun, Lu, Chengyu, Cai, Lintao. Cancer Cell Membrane-Biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance. ADVANCED FUNCTIONAL MATERIALS[J]. 2017, 第 3 作者27(38): 
[26] Liu, Lanlan, Yi, Huqiang, He, Huamei, Pan, Hong, Cai, Lintao, Ma, Yifan. Tumor associated macrophage-targeted microRNA delivery with dual-responsive polypeptide nanovectors for anti-cancer therapy. BIOMATERIALS[J]. 2017, 第 1 作者134: 166-179, http://dx.doi.org/10.1016/j.biomaterials.2017.04.043.
[27] Pan, Hong, Li, Wenjun, Yao, Xiangjie, Wu, Yayun, Liu, Lanlan, He, Huamei, Zhang, Renli, Ma, Yifan, Cai, Lintao. In Situ Bioorthogonal Metabolic Labeling for Fluorescence Imaging of Virus Infection In Vivo. SMALL[J]. 2017, 第 5 作者13(17): https://www.webofscience.com/wos/woscc/full-record/WOS:000400452200013.
[28] Chen, Ze, Zhao, Pengfei, Luo, Zhenyu, Zheng, Mingbin, Tian, Hao, Gong, Ping, Gao, Guanhui, Pan, Hong, Liu, Lanlan, Ma, Aiqing, Cui, Haodong, Ma, Yifan, Cai, Lintao. Cancer Cell Membrane-Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy. ACS NANO[J]. 2016, 第 9 作者10(11): 10049-10057, https://www.webofscience.com/wos/woscc/full-record/WOS:000388913100033.
[29] Zhang, Yijuan, Li, Ping, Pan, Hong, Liu, Lanlan, Ji, Manyi, Sheng, Nan, Wang, Ce, Cai, Lintao, Ma, Yifan. Retinal-conjugated pH-sensitive micelles induce tumor senescence for boosting breast cancer chemotherapy. BIOMATERIALS[J]. 2016, 第 4 作者83: 219-232, http://dx.doi.org/10.1016/j.biomaterials.2016.01.023.
[30] Wang, Ce, Li, Ping, Liu, Lanlan, Pan, Hong, Li, Hongchang, Cai, Lintao, Ma, Yifan. Self-adjuvanted nanovaccine for cancer immunotherapy: Role of lysosomal rupture-induced ROS in MHC class I antigen presentation. BIOMATERIALS[J]. 2016, 第 3 作者79: 88-100, http://dx.doi.org/10.1016/j.biomaterials.2015.11.040.
[31] Yi, Huqiang, Liu, Lanlan, Sheng, Nan, Li, Ping, Pan, Hong, Cai, Lintao, Ma, Yifan. Synergistic Therapy of Doxorubicin and miR-129-5p with Self-Cross-Linked Bioreducible Polypeptide Nanoparticles Reverses Multidrug Resistance in Cancer Cells. BIOMACROMOLECULES[J]. 2016, 第 2 作者17(5): 1737-1747, https://www.webofscience.com/wos/woscc/full-record/WOS:000375886500019.
[32] Liu, Lanlan, Yi, Huqiang, Wang, Ce, He, Huamei, Li, Ping, Pan, Hong, Sheng, Nan, Ji, Manyi, Cai, Lintao, Ma, Yifan. Integrated Nanovaccine with MicroRNA-148a Inhibition Reprograms Tumor-Associated Dendritic Cells by Modulating miR-148a/DNMT1/SOCS1 Axis. JOURNAL OF IMMUNOLOGY[J]. 2016, 第 1 作者197(4): 1231-1241, https://www.webofscience.com/wos/woscc/full-record/WOS:000384999100023.
[33] Ji, Manyi, Li, Ping, Sheng, Nan, Liu, Lanlan, Pan, Hong, Wang, Ce, Cai, Lintao, Ma, Yifan. Sialic Acid-Targeted Nanovectors with Phenylboronic Acid-Grafted Polyethylenimine Robustly Enhance siRNA-Based Cancer Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 第 4 作者8(15): 9565-9576, https://www.webofscience.com/wos/woscc/full-record/WOS:000374812000006.
[34] Wang, Ce, Liu, Peng, Zhuang, Yan, Li, Ping, Jiang, Boling, Pan, Hong, Liu, Lanlan, Cai, Lintao, Ma, Yifan. Lymphatic-targeted cationic liposomes: A robust vaccine adjuvant for promoting long-term immunological memory. JOURNAL OF CONTROLLED RELEASE. 2015, 第 7 作者213: E16-E16, http://dx.doi.org/10.1016/j.jconrel.2015.05.022.
[35] Luo, Zichao, Wang, Ce, Yi, Huqiang, Li, Ping, Pan, Hong, Liu, Lanlan, Cai, Lintao, Ma, Yifan. Co-delivery of poly I:C and STAT3 siRNA by nanovaccines effectively overcomes tumor-associated dendritic cell dysfunction and elicits anti-tumor immune response. JOURNAL OF CONTROLLED RELEASE. 2015, 第 6 作者213: E133-E134, http://dx.doi.org/10.1016/j.jconrel.2015.05.225.
[36] Luo, Zichao, Wang, Ce, Yi, Huqiang, Li, Ping, Pan, Hong, Liu, Lanlan, Cai, Lintao, Ma, Yifan. Nanovaccine loaded with poly I:C and STAT3 siRNA robustly elicits anti-tumor immune responses through modulating tumor-associated dendritic cells in vivo. BIOMATERIALS[J]. 2015, 第 6 作者38: 50-60, http://dx.doi.org/10.1016/j.biomaterials.2014.10.050.
[37] Pan, Hong, Zhang, Yijuan, Luo, Zichao, Li, Ping, Liu, Lanlan, Wang, Ce, Wang, Hanzhong, Li, Hongchang, Ma, Yifan. Autophagy mediates avian influenza H5N1 pseudotyped particle-induced lung inflammation through NF-kappa B and p38 MAPK signaling pathways. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY[J]. 2014, 第 5 作者306(2): L183-L195, http://dx.doi.org/10.1152/ajplung.00147.2013.
[38] Pan, Hong, Zhang, Pengfei, Gao, Duyang, Zhang, Yijuan, Li, Ping, Liu, Lanlan, Wang, Ce, Wang, Hanzhong, Ma, Yifan, Cai, Lintao. Noninvasive Visualization of Respiratory Viral Infection Using Bioorthogonal Conjugated Near-Infrared-Emitting Quantum Dots. ACS NANO[J]. 2014, 第 6 作者8(6): 5468-5477, https://www.webofscience.com/wos/woscc/full-record/WOS:000338089200012.
[39] Wang, Ce, Liu, Peng, Zhuang, Yan, Li, Ping, Jiang, Boling, Pan, Hong, Liu, Lanlan, Cai, Lintao, Ma, Yifan. Lymphatic-targeted cationic liposomes: A robust vaccine adjuvant for promoting long-term immunological memory. VACCINE[J]. 2014, 第 7 作者32(42): 5475-5483, http://dx.doi.org/10.1016/j.vaccine.2014.07.081.
[40] Zhang, Yijuan, Pan, Hong, Zhang, Pengfei, Gao, Ningning, Lin, Yi, Luo, Zichao, Li, Ping, Wang, Ce, Liu, Lanlan, Pang, Daiwen, Cai, Lintao, Ma, Yifan. Functionalized quantum dots induce proinflammatory responses in vitro: the role of terminal functional group-associated endocytic pathways. NANOSCALE[J]. 2013, 第 9 作者5(13): 5919-5929, https://www.webofscience.com/wos/woscc/full-record/WOS:000320398300033.
[41] Liu, Lanlan, Yang, Zhaojuan, Xu, Yingqian, Li, Jingyi, Xu, Dongxu, Zhang, Li, Sun, Jiabin, Xia, Suhua, Zou, Feiyan, Liu, Yongzhong. Inhibition of Oxidative Stress-Elicited AKT Activation Facilitates PPAR gamma Agonist-Mediated Inhibition of Stem Cell Character and Tumor Growth of Liver Cancer Cells. PLOS ONE[J]. 2013, 第 1 作者8(8): http://dx.doi.org/10.1371/journal.pone.0073038.
[42] Li, Ping, Luo, Zichao, Liu, Peng, Gao, Ningning, Zhang, Yijuan, Pan, Hong, Liu, Lanlan, Wang, Ce, Cai, Lintao, Ma, Yifan. Bioreducible alginate-poly(ethylenimine) nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune responses. JOURNAL OF CONTROLLED RELEASE[J]. 2013, 第 7 作者168(3): 271-279, http://dx.doi.org/10.1016/j.jconrel.2013.03.025.

   

（ 1 ） 基于益生菌芽孢基因递送系统光控原位表达IFNγ治疗结直肠癌的研究, 负责人, 地方任务, 2024-11--2027-11
（ 2 ） 智能交互型生物-非生物杂合体系的构建及消化道肿瘤诊疗应用, 参与, 国家任务, 2023-12--2028-11
（ 3 ） 基于蓝细菌的超声驱动IL12基因递送系统光免疫治疗肿瘤研究, 负责人, 地方任务, 2022-10--2025-10
（ 4 ） 仿生纳米基因载体的构建及肿瘤精准光免疫研究, 负责人, 地方任务, 2022-01--2023-12
（ 5 ） 声-光双操控仿生基因递送系统原位表达IFNγ免疫治疗肿瘤的研究, 负责人, 地方任务, 2022-01--2026-12
（ 6 ） 新型光合微纳生物机器人的定向合成及诊疗应用研究（深圳市重点项目，250万）, 负责人, 地方任务, 2021-03--2024-02
（ 7 ） 基于工程化蓝细菌微纳仿生机器人的肿瘤微环境调控和精准治疗研究（国自然面上，56万））, 负责人, 国家任务, 2021-01--2024-12
（ 8 ） 基于光合细菌联合光动力纳米颗粒用于抗肿瘤免疫治疗的研究（深圳市自由探索，30万））, 负责人, 地方任务, 2019-04--2021-03
（ 9 ） 基于光合细菌负载纳米光敏剂的免疫光动力治疗及机制研究（国自然青基，21万）, 负责人, 国家任务, 2019-01--2021-12
（ 10 ） 靶向纳米氧载体增效光动力及其抗肿瘤免疫学机制研究（广东省自然，10万）, 负责人, 地方任务, 2018-05--2021-04

（1）基于蓝细菌光合产氧介导的抗肿瘤免疫光动力治疗   中国化学会第32届学术年会   2021-04-19
（2）Targeted oxygen-enhanced photodynamic therapy for inducing anti-tumor immunity   中美纳米医学与纳米生物技术学会   2019-08-20
（3）Targeted Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-Tumor Immunity and Abscopal Effect.   2018-08-14
（4）Integrated nanovaccine with microRNA-148a inhibition reprograms tumor-associated dendritic cells by modulating miR-148a/DNMT1/SOCS1 axis.    2016-08-25
（5）Nanovaccine-based gene-immune therapy robustly elicits anti-tumor immune response in vivo   2015-10-14
（6）复合型肿瘤疫苗调控肿瘤相关树突状细胞增强抗肿瘤免疫的研究   中国免疫学会第九届全国免疫学学术大会   2014-11-22

现指导学生

李照珍  硕士研究生  071000-生物学  

秦瑞晴  硕士研究生  086000-生物与医药  

辛峰  硕士研究生  085600-材料与化工  

杨欣欣  硕士研究生  086000-生物与医药  

何婧  硕士研究生  086000-生物与医药