基本信息
徐咏芬  女  硕导  中国科学院上海免疫与感染研究所
电子邮件: xuyf@siii.cas.cn
通信地址: 徐汇区岳阳路320号生命科学楼B座809#
邮政编码: 200031

招生信息

   
招生专业
071005-微生物学
招生方向
抗黄病毒属病毒的药物新靶点发现;
不同免疫条件下,黄病毒属病毒感染所致脂质代谢变化谱
黄病毒科病毒引起的天然免疫反应和逃逸机制研究。

工作经历

   
社会兼职
2024-03-31-今,review editor of Microorganisms 编委,
2023-07-16-2023-11-30,Guest editor of Life | Special Issue : Arbovirus: Infection, Immunity and Antiviral Research 客座主编,
2022-06-27-今,review editor of Frontiers in cellular and infection microbiology in virology 编委,
2022-06-27-今,review editor of Frontiers in cellular and infection microbiology in Infectious Agents and Disease 编委,
2022-06-18-今,associate editor of Frontiers in cellular and infection microbiology in virus and host 副主编,
2020-09-09-2023-09-08,上海市医学会医学病毒专科分会第九届委员会青年委员会副主任委员,
2017-07-06-2020-07-06,上海市医学会医学病毒专科分会第八届委员会青年委员,

专利与奖励

   
专利成果
( 1 ) 原花青素类化合物在制备抗寨卡病毒的药物中的应用, 2019, 第 4 作者, 专利号: CN109394755A

出版信息

   
发表论文
(1) Extracellular vesicles from Zika virus-infected cells display viral E protein that binds ZIKV-neutralizing antibodies to prevent infection enhancement, EMBO JOURNAL, 2023, 第 2 作者
(2) Mouse circulating extracellular vesicles contain virus-derived siRNAs active in antiviral immunity, THEEMBOJOURNAL, 2022, 
(3) Photo-catalyzed TiO2 inactivates pathogenic viruses by attacking viral genome, CHEMICAL ENGINEERING JOURNAL, 2021, 第 7 作者
(4) Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody, Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody, CELLULAR & MOLECULAR IMMUNOLOGY, 2021, 第 14 作者
(5) TRIM26 is a critical host factor for HCV replication and contributes to host tropism, SCIENCE ADVANCES, 2021, 第 12 作者
(6) A Novel Approach To Display Structural Proteins of Hepatitis C Virus Quasispecies in Patients Reveals a Key Role of E2 HVR1 in Viral Evolution, JOURNAL OF VIROLOGY, 2020, 第 4 作者
(7) Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections, ACS INFECTIOUS DISEASES, 2020, 第 2 作者
(8) A Nanoparticle-Based Hepatitis C Virus Vaccine With Enhanced Potency, JOURNAL OF INFECTIOUS DISEASES, 2020, 第 8 作者
(9) 丙型肝炎病毒的发现及研究——从2020年度诺贝尔生理学或医学奖谈起, Discovery and research of hepatitis C virus-Thoughts from the 2020 Nobel Prize in Physiology or Medicine, CHINESE SCIENCE BULLETIN-CHINESE, 2020, 第 1 作者
(10) 丙型肝炎病毒的发现及研究——从2020年度诺贝尔生理学或医学奖谈起, Discovery and research of hepatitis C virus������Thoughts from the 2020 Nobel Prize in Physiology or Medicine, 科学通报, 2020, 第 1 作者
(11) The pre-existing cellular immunity to Japanese encephalitis virus heterotypically protects mice from Zika virus infection, SCIENCE BULLETIN, 2020, 第 2 作者
(12) IL-1 beta Enhances the Antiviral Effect of IFN-alpha on HCV Replication by Negatively Modulating ERK2 Activation, ACS INFECTIOUS DISEASES, 2020, 第 12 作者  通讯作者
(13) Japanese Encephalitis Virus Vaccination Elicits Cross-Reactive HLA-Class I-Restricted CD8 T Cell Response Against Zika Virus Infection, FRONTIERS IN IMMUNOLOGY, 2020, 第 4 作者
(14) Anti-flavivirus activity of polyoxometalate, ANTIVIRAL RESEARCH, 2020, 第 8 作者  通讯作者
(15) Antiviral effects of simeprevir on multiple viruses, ANTIVIRAL RESEARCH, 2019, 第 4 作者
(16) Construction and characterization of Genotype-3 hepatitis C virus replicon revealed critical genotype-3-specific polymorphism for drug resistance and viral fitness, ANTIVIRAL RESEARCH, 2019, 第 5 作者
(17) ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice, NATURE COMMUNICATIONS, 2019, 第 6 作者
(18) Negligible contribution of M2634V substitution to ZIKV pathogenesis in AG6 mice revealed by a bacterial promoter activity reduced infectious clone, SCIENTIFIC REPORTS, 2018, 第 2 作者
(19) Neuralized E3 Ubiquitin Protein Ligase 3 Is an Inducible Antiviral Effector That Inhibits Hepatitis C Virus Assembly by Targeting Viral E1 Glycoprotein, JOURNAL OF VIROLOGY, 2018, 第 11 作者
(20) Antiviral effects of ferric ammonium citrate, CELLDISCOVERY, 2018, 第 4 作者
(21) Genetic Analysis of Serum-Derived Defective Hepatitis C Virus Genomes Revealed Novel Viral cis Elements for Virus Replication and Assembly, JOURNAL OF VIROLOGY, 2018, 第 3 作者
(22) Pediatric Drug Nitazoxanide: A Potential Choice for Control of Zika, OPEN FORUM INFECTIOUS DISEASES, 2017, 第 2 作者
(23) Novel Stable Ebola Virus Minigenome Replicon Reveals Remarkable Stability of the Viral Genome, JOURNAL OF VIROLOGY, 2017, 第 4 作者
(24) Innate immunity against hepatitis C virus, CURRENT OPINION IN IMMUNOLOGY, 2016, 第 1 作者
(25) HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells, PLOS ONE, 2014, 第 2 作者
(26) Mycoplasma hyorhinis Activates the NLRP3 Inflammasome and Promotes Migration and Invasion of Gastric Cancer Cells, PLOS ONE, 2013, 第 1 作者
(27) Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma, Liver Int., 2012, 第 3 作者
(28) Suppression of Human Liver Cancer Cell Migration and Invasion via the GABAA Receptor, Cancer Biol Med., 2012, 第 3 作者
(29) HBsAg inhibits TLR9-mediated activation and IFN-alpha production in plasmacytoid dendritic cells, MOLECULAR IMMUNOLOGY, 2009, 第 1 作者
(30) Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients, Clin Immunol., 2008, 第 3 作者
(31) 系统性红斑狼疮外周血B 淋巴细胞激活及 TOLL 样受体9 表达, 中华风湿病学杂志, 2006, 第 3 作者