基本信息
赖玮毅  女  硕导  中国科学院生态环境研究中心
email: wylai@rcees.ac.cn
address: 北京市海淀区双清路18号
postalCode:

招生信息

   
招生专业
083001-环境科学
招生方向
环境科学
生物分离分析

教育背景

2012-09--2018-06   中国科学院生态环境研究中心   博士
2008-09--2012-07   上海交通大学   学士

工作经历

   
工作简历
2022-02~现在, 中国科学院生态环境研究中心, 副研究员
2018-07~2022-01,中国科学院生态环境研究中心, 助理研究员
2012-09~2018-06,中国科学院生态环境研究中心, 博士
2008-09~2012-07,上海交通大学, 学士

专利与奖励

   
奖励信息
(1) 中国分析测试协会科学技术奖-CAIA 奖, 特等奖, 省级, 2020

出版信息

   
发表论文
(1) Identification and quantification of DNA N6-methyladenine modification in mammals: A challenge to modern analytical technologies, CURRENT OPINION IN CHEMICAL BIOLOGY, 2023, 第 3 作者
(2) Aberrant DNA N-6-methyladenine incorporation via adenylate kinase 1 is suppressed by ADAL deaminase-dependent 2'-deoxynucleotide pool sanitation, EMBO JOURNAL, 2023, 第 2 作者
(3) Hyperactive DNA Cutting for Unbiased UHPLC-MS/MS Quantification of Epigenetic DNA Marks by Engineering DNase I Mutants, ANALYTICAL CHEMISTRY, 2022, 第 11 作者
(4) Critical assessment of DNA adenine methylation in eukaryotes using quantitative deconvolution, SCIENCE, 2022, 第 6 作者
(5) Necrosulfonamide Selectively Induces DNA Double-Strand Breaks in Acute Myeloid Leukemia Cells, CHEMICAL RESEARCH IN TOXICOLOGY, 2022, 第 2 作者
(6) Detection and Quantification of UV-irradiation-induced DNA Damages by Liquid Chromatography-Mass Spectrometry and Immunoassay ���, PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2022, 第 1 作者
(7) Quantification of Epigenetic DNA Modifications in the Subchromatin Structure Matrix Attachment Regions by Stable Isotope Dilution UHPLC-MS/MS Analysis, ANALYTICAL CHEMISTRY, 2021, 第 11 作者
(8) The loss of RNA N-6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8(+) T cell dysfunction and tumor growth, CANCER CELL, 2021, 第 12 作者
(9) N^(6)-methyladenine is incorporated into mammalian genome by DNA polymerase, N-6-methyladenine is incorporated into mammalian genome by DNA polymerase, CELL RESEARCH, 2021, 第 2 作者
(10) DNA胞嘧啶的甲基化与去甲基化进展, Progresses in DNA Cytosine Methylation and Demethylation, 分析科学学报, 2021, 第 4 作者
(11) USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment, CELL DISCOVERY, 2020, 第 13 作者
(12) 哺乳动物基因组中由DNA聚合酶掺入的N^6-甲基腺嘌呤, 生命的化学, 2020, 第 1 作者
(13) Profiling of epigenetic DNA modifications by advanced liquid chromatography-mass spectrometry technologies, TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2019, 第 1 作者
(14) Predominance of N-6-Methyladenine-Specific DNA Fragments Enriched by Multiple Immunoprecipitation, ANALYTICAL CHEMISTRY, 2018, 第 2 作者
(15) Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1, NATURE, 2018, 第 5 作者
(16) An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C, JOURNAL OF VISUALIZED EXPERIMENTS : JOVE, 2018, 第 2 作者
(17) Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b, STEM CELL REPORTS, 2018, 第 0 作者
(18) An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2018, 第 2 作者
(19) Vertical ultrafiltration-facilitated dna digestion for rapid and sensitive uhplc-ms/ms detection of dna modifications, ANALYTICAL CHEMISTRY, 2018, 第 1 作者
(20) UHPLC-Q-TOF/MS detection of UV-induced TpT dimeric lesions in genomic DNA, JOURNAL OF CHROMATOGRAPHY B, 2018, 第 2 作者
(21) Uhplc-q-tof/ms detection of uv-induced tpt dimeric lesions in genomic dna, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2018, 第 2 作者
(22) 5-methylcytosine promotes mRNA export ��� NSUN2 as the methyltransferase and ALYREF as an m~5C reader, Cell Research, 2017, 第 6 作者
(23) Metabolically generated stable isotope-labeled deoxynucleoside code for tracing dna n-6-methyladenine in human cells, ANALYTICAL CHEMISTRY, 2017, 第 3 作者
(24) Profiling DNA and RNA Modifications Using Advanced LC-MS/MS Technologies, LC GC NORTH AMERICA, 2017, 第 2 作者
(25) Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing, MOLECULAR CELL, 2016, 第 10 作者
(26) 高效液相色谱串联电喷雾四级杆飞行时间质谱检测RNA寡核苷酸, 第二十届全国色谱学术报告会及仪器展览会, 2015, 第 1 作者

科研活动

   
科研项目
( 1 ) 基于核酸酶特异性酶解的DNA特殊结构R环的高通量分析方法, 负责人, 国家任务, 2023-01--2026-12
( 2 ) 持久性有毒污染物的生物识别调控机制/子课题, 负责人, 国家任务, 2019-07--2024-06
参与会议
(1)基于UHPLC-MS/MS的亚染色质结构DNA 表观遗传修饰分析   中国化学会第十四届全国生物医药色谱质谱及相关技术交流会   2023-05-06
(2)Quantification of DNA Modifications of Subchromatin Structure by Fractionation and UHPLC-MS/MS Analysis   BCEIA 北京分析测试学术报告会暨展览会   2021-09-27
(3)基于液质联用的RNA 5-甲基胞嘧啶分析及去甲基化酶探索   中国化学会第 22 届全国色谱学术报告会及仪器展览会   2019-04-20