Organic Chemistry 

Medicinal Chemistry

September 2007 – July 2012

Ph. D. (Medicinal chemistry)

Chengdu Institute of Biology, Chinese Academy of Sciences.

Ph.D. Advisor: Professor: Hua-Wu Shao

September 2007 – July 2008

Department of Chemistry,

University of Science and Technology of China (Co-training student)

September 2003 – July 2007

Bachelor of Medicine (Pharmacy)

Department of Pharmacy, Lanzhou University, China

From September 2019 

Professor 

Chengdu Institute of Biology, Chinese Academy of Sciences (CAS)

March 2016 – March 2019

Postdoctoral Associate 

School of Chemsitry, University of Brsitol, UK

Supervisor: Prof. John F. Bower

December 2012 – March 2016

Postdoctoral Associate 

Laboratoire de Chimie Organique et Médicinale, Université catholique de Louvain, Belgium

Supervisor: Prof. István. E. Markó

July 2012 – October 2012

Research Assistant

Chengdu Institute of Biology, Chinese Academy of Sciences (CAS)

Supervisor: Prof. Hua-Wu Shao

1. Amu Wang, Xiaoqi Chen, Tong Liu, Meihui Liu, Jianwei Xu, Yue Zhang, Xiaofeng Ma,^* Cu/TEMPO-Catalyzed Direct C2‑Quaternization of Pyridines with Aldehydes via Sequential N–N Bond Formation and Cleavage, ACS Catal.2026,10.1021/acscatal.6c05861

2. Zeen Qiao⁺, Lingyu Li⁺, Yuwen Sheng⁺, Jinlian Yang, Jialing Yu, Fan Wu, Minghui Ji, Ruiying Xi, Linhan Yang, Guolin Zhang, Xiaoxia Lu,* Xiaofeng Ma,* Fei Wang,* Design, Synthesis and Evaluation of Bibenzyl Analogues Against Hepatocellular Carcinoma by Targeting Pyruvate Carboxylase, J. Med. Chem. 2026, 69, 12, 14333–14364.

3. Xiaoyan Li,⁺ Peng Liang,⁺Amu Wang, Yinxiang Jian, John F. Bower,* Xiaofeng Ma,* Controllable C—N and C—C Bond Migration Rearrangements via Intramolecular Electrophilic Amination Accessing Piperidinoindolines and d-Carbolines, Nat. Commun. 2026,

4. Jian Yang⁺, Demeng Xie⁺,Xiaofeng Ma,* Streamlined Sugar Diversification via Photoredox-Catalyzed Regio-and Stereoselective 1,2-Alkylarylation of Glycals, Angew.Chem. Int. Ed. 2026, 65, e19794.

5. Li Zhang⁺, Wei Jiao⁺, Xiaofeng Ma,* Ni/Chiral Phosphoric Acid Cooperative Catalysis Enabled Radical Coupling of Carboxylic Esters/Amides to C-Acyl Glycosides, Chin. J. Chem. 2026, 44, 129−138.

6. Jian Yang, Yinxiang Jian, Demeng Xie, Jia-Xin Yan, Xiaofeng Ma,* Stereoselective Glycosylation of Amino Sugars Enabled by Thiourea/ Phosphoric Acid Dual Catalysis, Org. Lett. 2025, 27, 7673−7678.

7. Junxiu Liang, Yanchao Wu, Xiaofeng Ma,* Huijing Li,* Recent Advances in Transition Metal Catalysed Dearomatization Toward the Synthesis of Complex Cyclic Compounds, Adv. Synth. Catal. 2025, 367, e202500003.

8. Demeng Xie⁺, Wei Zeng⁺, Jian Yang, Xiaofeng Ma,* Visible-Light-Promoted Direct Desulfurization of Glycosyl Thiols to Access C-Glycosides, Nat. Commun. 2024, 15, 9187.

9. Jiangtao Li, Jiaxin Yan, Ya-Zhou Liu, Xiaofeng Ma,* Stereoselective and Controllable C3-Amination or C1,C3-Di-Amination of 2-Nitroglycals, Carbohydr. Res. 2024, 540, 109121.

10.Jiangtao Li, Zhengyan Fu, Zeen Qiao, Demeng Xie, Li Zhang, Ya-Zhou Liu, Jian Yang, Jia-Xin Yan, Xiaofeng Ma,* Controllable 1,3-bis-Functionalizaiton of 2-Nitroglycals with High Regioselectivity and Stereoselectivity Enabled by a H-Bond Catalyst, JACS Au 2024, 4, 974−984.

11.  Li Zhang, Wei Zeng, Demeng Xie, Jiangtao Li, Xiaofeng Ma,* Nickel and Chiral Phosphoric Acid Cocatalysis Enables Synthesis of C-Acyl Glycosides, Org. Lett. 2024, 26, 1332−1337.

12.  胡晓芳，张建刚，赵晋忠，马小锋^*，光催化二苯并噻吩的Thia-Baeyer-Villiger氧化重排反应，合成化学，32(10)，881−886.

13.  Ya-Zhou Liu⁺, Yu Chen⁺, Amu Wang, Zhongke Shen, Xueting Zhou, Jichao Zhang, Yinxiang Jian, Xiaofeng Ma,* Electron-donor-acceptor Complex Between Two Intermediates Enables a N-N Bond Cleavage Cascade Process to Access 2,3-Difunctionalized Pyridines, Green Chem. 2024, 26, 2280–2289.

14.  Yong-Qiang Wang,* Wei-Ting Chen, Xia Liu, Hua Zhu, Xuan Qiao, Yuzhi Wang, Xiaofeng Ma,* Development of a Safe, Efficient and Scalable Process for the Synthesis of Midazolam Hydrochloride, Org. Process Res. Dev. 2023, 27, 2374–2384.

15.  Xiaofang Hu, Zeen Qiao, Li Zhang, Jinzhong Zhao, Ya-Zhou Liu, Jiangang Zhang,* Xiaofeng Ma,* One-pot Cascade Synthesis of Dibenzothiophene-based Heterobiaryls from Dibenzothiophene-5-oxide, Org. Biomol. Chem. 2023, 21, 9123–9127.

16.  Junxiu Liang, Ya-Zhou Liu, Amu Wang, Yanchao Wu, Xiaofeng Ma*, Huijing Li*, Dearomatization of Halonaphthols via an Intermolecular [4+1] Spiroannulation with in situ Formed Aza-Ortho-Quinone Methides, Chin. J. Org. Chem. 2023, 43, 3888–3899.

17.  Jian Yang⁺, Shanqiao Wei⁺, Jinzhong Zhao, Wei Zeng, Huawu Shao*, Xiaofeng Ma*, An Environmentally Benign Protocol for the Synthesis of Sugar 1,2-Orthoesters in Poly(ethylene glycol) Dimethyl Ether (DMPE), Carbohydr. Res. 2023, 534, 108902.

18.  Hailong Shi⁺, Jinlian Yang⁺, Zeen Qiao⁺, Lingyu Li, Gang Liu, Qi Dai, Li Xu, Wei Jiao, Guolin Zhang, Fei Wang, Xiaoxia Lu*, Xiaofeng Ma*, Design, Synthesis and Structure–Activity Relationship Studies on Erianin Analogues as Pyruvate Carboxylase (PC)

Inhibitors Against Hepatocellular Carcinoma Cells, Org. Biomol. Chem. 2023, 21, 7005-7017.

19.  Jian Yang, Demeng Xie, Xiaofeng Ma*, Recent Advances in Chemical Synthesis of Amino Sugars, Molecules, 2023, 28, 4724.

20.  Yinxiang Jian⁺, Peng Liang⁺, Xiaoyan Li, Huawu Shao*, Xiaofeng Ma*, Controllable Transformation of Indoles Using Iodine(III) Reagent, Org. Biomol. Chem. 2023, 21, 179-186.

21.  Xiaoke Zhang, Ya-Zhou Liu, Huawu Shao*, Xiaofeng Ma*, Advances in Atroposelectively De Novo Synthesis of Axially Chiral Heterobiaryl Scaffolds Molecules 2022, 27, 8517.

22.  Hailong Shi⁺, Jian Yang⁺, Yao Cheng, Jinlian Yang, Xiaoxia Lu*, Xiaofeng Ma*, 1, 2-trans-Stereoselective 7-O-Glycosylation of Flavonoids with Unprotected Pyranoses by Mitsunobu Reaction, Chem. Asian J. 2022, 17, e2022001.

23.  Zhongke Shen⁺, Qin Tang⁺, Wei Jiao, Huawu Shao*, Xiaofeng Ma*, One-Pot Synthesis of 2-C-Branched Glycosyl Triazoles by Integrating 1,2-Cyclopropanated Sugar Ring-Opening Azidation and CuAAC Reaction, J. Org. Chem. 2022, 87, 16736-16742.

24.  Amu Wang⁺, Ya-Zhou Liu⁺, Zhongke Shen, Zeen Qiao, Xiaofeng Ma*, Regioselective Synthesis of Pyrazolo[1,5-a]pyridine via TEMPO Mediated [3+2] Annulation-Aromatization of N-Aminopyridines and α,β-Unsaturated Compounds, Org. Lett. 2022, 24, 1454-1459.

25.  Peng Liang, Hang Zhao, Tingting Zhou, Kaiyun Zeng, Wei Jiao, Yang Pan, Yazhou Liu, Dongmei Fang, Xiaofeng Ma*, Huawu Shao*. Rapid Oxidation Indoles into 2-Oxindoles Mediated by PIFA in Combination with n-Bu₄NCl ×H₂O, Adv. Synth. Catal. 2021, 363, 3532-3538.

26.  Xiaofeng Ma*, Yazhou Liu, Le Du, Jingwei Zhou, István E. Markó. Post-functionalization of Dibenzothiophene to Functionalized Biphenyls via a Photoinduced Thia-Baeyer-Villiger Oxidation, Nat. Commun. 2020, 11, 914.

27.  Xiaofeng Ma, Ian R. Hazelden, Thomas Langer, Rachel H. Munday, John F. Bower*. Enantioselective Aza-Heck Cyclizations of N‑(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines, J. Am. Chem. Soc. 2019, 141, 3356-3360. (Highlight in Synfacts, 2019; 15, 0483).

28.  Xiaofeng Ma,* Damien F. Dewez, Le Du, Xiya Luo, István E. Markó, Kevin Lam*, Synthesis of Diketones, Ketoesters and Tetraketones by Electrochemical Oxidative Decarboxylation of Malonic Acid Derivatives: Application to the Synthesis of cis-Jasmone, J. Org. Chem. 2018, 83, 12044-12055.

29.   Xiaofeng Ma, Joshua J. Farndon, Tom A. Young, Natalie Fey, John F. Bower*, A Simple and Broadly Applicable C-N Bond Forming Dearomatization Protocol Enabled by Bifunctional Amino-Reagents, Angew. Chem. Int. Ed. 2017, 56, 14531-14535. (Highlight in Org. Process Res. Dev. 2017, 21, 1873-1883).

30.  Ian R. Hazelden,⁺ Xiaofeng Ma,⁺(⁺并列第一作者) Thomas Langer, John F. Bower*, Diverse N-Heterocyclic Ring Systems via Aza-Heck Cyclizations of N-(Pentafluorobenzoyloxy)sulfonamides, Angew. Chem. Int. Ed. 2016, 55, 11198-11202.

31.  Xiaofeng Ma, Hodney Lubin, Ágnes Simon, Enikő Ioja, Orsolya Kékesi, Ágota Apáti, Tamás I. Orbán, László Héja, Julianna Kardos, István E. Markó*, Straightforward and Effective Synthesis of γ-Aminobutyric Acid Transporter Subtype 2-Selective Acyl-Substituted Azaspiro[4.5]decanes, Bioorg.Med. Chem. Lett. 2016, 26, 417-423.

32.  Xiaofeng Ma, Xiya Luo, Simon Dochain, Charlotte Mathot, István E. Markó*, Electrochemical Oxidative Decarboxylation of Malonic Acid Derivatives: A Method for the Synthesis of Ketals and Ketones, Org. Lett.2015, 17, 4690-4693. (Featured on Organic Chemistry Portal, https://www.organic- chemistry. org/ abstracts /lit5/128.shtm)

33.  Xiaofeng Ma, Jichao Zhang, Qin Tang, Jun Ke, Wei Zou, Huawu Shao*, Stereospecific [3+2] Cycloaddition of 1,2-Cyclopropanated Sugars and Ketones Catalyzed by SnCl₄: an Efficient Synthesis of Multi-Substituted Perhydrofuro[2,3-b]furans and Perhydrofuro[2,3-b]pyrans, Chem. Commun. 2014, 50, 3505-3508.

34.  Xiaofeng Ma, Qin Tang, Jun Ke, Jichao Zhang, Xinglong Yang, Xudong Shen, Huawu Shao*, A Neighboring Group Participation Strategy: Direct and Highly Diastereoselective Synthesis of 2-Substituted and 2,2-Bisubstituted Perhydrofuro[2,3-b]pyran Derivatives, Org. Biomol. Chem. 2014, 12, 7381-7388.

35.  Xiaofeng Ma, Qin Tang, Jun Ke, Jichao Zhang, Cong Wang, Haibo Wang, Yuxue Li, Huawu Shao*, Straightforward and Highly Diastereoselective Synthesis of 2,2-Disubstituted Perhydrofuro[2,3-b]pyran (and furan) Derivatives Promoted by BiCl₃, Chem. Commun. 2013, 49, 7085-7087(Highlight in Synfacts, 2013; 9, 1212).

36.  Xiaofeng Ma, Qin Tang, Jun Ke, Xinglong Yang, Jichao Zhang, Huawu Shao*, InCl₃ Catalyzed Highly Diastereoselective [3+2] Cycloaddition of 1,2-Cyclopropanated Sugars with Aldehydes: a Straightforward Synthesis of Persubstituted Bis-Tetrahydrofurans and perhydrofuro [2,3-b]pyrans, Org. Lett. 2013, 15, 5170-5173.

37.  Xiaofeng Ma, Qin Tang, Jun Ke, Haibo Wang, Wei Zou, Huawu Shao*, A Convenient and Highly Stereoselective Method for Synthesis of Octahydropyrano[3,2-b]pyrrole Derivatives, Carbohydr. Res. 2013, 366, 55-62.

38.  Shuaibing Zhang, ⁺ Xiaofeng Ma, ⁺ (⁺并列第一作者) Xiaoqiong Pei, Jingyuan Liu, Huawu Shao, Zhongliu Wu, A Practical High-throughput Screening System for Feruloyl Esterases: Substrate Design and Evaluation, J. Mol. Catal.B-Enzym. 2012, 74, 36-40.

39.Xiaofeng Ma, Qiang Tian, Qin Tang, Huawu Shao*, A Novel and Highly Stereoselective Synthesis of 2-Substituted Perhydrofuro[2,3-b]pyran Derivatives, Org. Lett. 2011, 13, 4276-4279.

已指导学生

申忠珂  硕士研究生  078001-药物化学  

张力  博士研究生  100701-药物化学  

李江涛  博士研究生  100701-药物化学  

王阿木  硕士研究生  078001-药物化学  

李小燕  硕士研究生  086002-制药工程  

杨建  博士研究生  100701-药物化学  

简银香  硕士研究生  078001-药物化学  

曾薇  硕士研究生  078001-药物化学  

聂小康  博士研究生  100701-药物化学  

乔泽恩  博士研究生  100701-药物化学  

李雨韓  硕士研究生  086002-制药工程  

现指导学生

严佳欣  博士研究生  100701-药物化学  

刘美慧  硕士研究生  086002-制药工程  

王阿木  博士研究生  100701-药物化学  

黄福星  硕士研究生  078001-药物化学  

卢赫轩  硕士研究生  070303-有机化学  

舒采华  硕士研究生  070303-有机化学  

杨玺俊  硕士研究生  086002-制药工程  

黄艳铃  硕士研究生  086002-制药工程  

余思弦  博士研究生  070303-有机化学  

王沫  博士研究生  100701-药物化学  

黄文溢  硕士研究生  078001-药物化学  

潘志成  硕士研究生  070303-有机化学  

谭雅芯  硕士研究生  070303-有机化学  

刘桐  博士研究生  100701-药物化学  

彭超  博士研究生  070303-有机化学  

王越  博士研究生  070303-有机化学