Nanomaterials, biomaterials, tumor therapy, gene therapy, nucleic acid materials

2009-09--2014-12 Institute of Zoology, Chinese Academy of Sciences, Ph.D. 
2005-09--2009-07 Wuhan University, Bachelor

Feb 2025–Present, Institute of High Energy Physics, Chinese Academy of Sciences, Associate Researcher
Apr 2019–Jan 2025, Institute of High Energy Physics, Chinese Academy of Sciences, Assistant Researcher
Jan 2015–Mar 2019, Institute of Zoology, Chinese Academy of Sciences, Postdoctoral Researcher

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[1] Zhang, Jiayu, Gong, Jiayuan, Chen, Jun, Chen, Hanqing. Protocol for forming G-quadruplexes from double-stranded DNA during transcription. STAR PROTOCOLS. 2025, 6(1): http://dx.doi.org/10.1016/j.xpro.2025.103677.

[2] Dou, Rui, Wang, Linbang, Zhang, Jiayu, Cai, Xiaomeng, Tang, Jiaruo, Liu, Xiaoguang, Hu, Yi, Chen, Jun. Reversing Photodynamic Therapy-Induced Tumor Metabolic Symbiosis and Immune Evasion Delivers a Two-Punch Attack on Tumors. SMALL. 2025, 21(11): 2409052, http://dx.doi.org/10.1002/smll.202409052.

[3] Jiayu Zhang, Jun Chen. Targeted nucleic acid delivery for traumatic brain injury: Overcoming blood-brain barrier challenges. MOLECULAR THERAPY. NUCLEIC ACIDS. 2024, 35(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792969/.

[4] Cai, Xiaomeng, Ruan, Lifo, Wang, Dongqing, Zhang, Jiayu, Tang, Jiaruo, Guo, Chen, Dou, Rui, Zhou, Mengxue, Hu, Yi, Chen, Jun. Boosting chemotherapy of bladder cancer cells by ferroptosis using intelligent magnetic targeting nanoparticles. COLLOIDS AND SURFACES B-BIOINTERFACES. 2024, 234: http://dx.doi.org/10.1016/j.colsurfb.2023.113664.

[5] Jiayu Zhang, Xiaomeng Cai, Rui Dou, Chen Guo, Jiaruo Tang, Yi Hu, Hanqing Chen, Jun Chen. Poly(b-amino ester)s-based nanovehicles: Structural regulation and gene delivery. MOLECULAR THERAPY - NUCLEIC ACIDS. 2023, 32: 568-581, http://dx.doi.org/10.1016/j.omtn.2023.04.019.

[6] Cai, Xiaomeng, Dou, Rui, Guo, Chen, Tang, Jiaruo, Li, Xiajuan, Chen, Jun, Zhang, Jiayu. Cationic Polymers as Transfection Reagents for Nucleic Acid Delivery. PHARMACEUTICS. 2023, 15(5): https://doaj.org/article/3ebb6aaeafb840eea66cf603cfbc5b07.

[7] Ruan, Lifo, Li, Haijing, Zhang, Jiayu, Zhou, Mengxue, Huang, Hui, Dong, Juncai, Li, Jinxia, Zhao, Feng, Wu, Zhonghua, Chen, Jun, Chai, Zhifang, Hu, Yi. Chemical transformation and cytotoxicity of iron oxide nanoparticles (IONPs) accumulated in mitochondria. TALANTA. 2023, 251: 123770, http://dx.doi.org/10.1016/j.talanta.2022.123770.

[8] Zhang, Jiayu, Chen, Hanqing, Chen, Jun. Colostrum-derived exosome based system: The next-generation nucleic acid delivery system with enhanced biosafety. MOLECULAR THERAPY-NUCLEIC ACIDS. 2022, 30: 449-450, http://dx.doi.org/10.1016/j.omtn.2022.10.013.

[9] Zhang, Jiayu, Chen, Jun. Circular mRNAs: More stable RNAs lead to more persistent protein expression. MOLECULAR THERAPY NUCLEIC ACIDS. 2022, 30: 357-358, http://dx.doi.org/10.1016/j.omtn.2022.10.014.

[10] Ruan, Lifo, Chen, Jun, Du, Chuanchao, Lu, Huiru, Zhang, Jiayu, Cai, Xiaomeng, Dou, Rui, Lin, Wenchu, Chai, Zhifang, Nie, Guangjun, Hu, Yi. Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer. BIOACTIVE MATERIALS. 2022, 13: 191-199, http://dx.doi.org/10.1016/j.bioactmat.2021.10.045.

[11] Zhou, MengXue, Zhang, JiaYu, Cai, XiaoMeng, Dou, Rui, Ruan, LiFo, Yang, WenJiang, Lin, WenChu, Chen, Jun, Hu, Yi. Tumor-Penetrating and Mitochondria-Targeted Drug Delivery Overcomes Doxorubicin Resistance in Lung Cancer. CHINESE JOURNAL OF POLYMER SCIENCE. 2022.

[12] Gong Jiayuan, Wen Cuijiao, Tang Mingliang, Duan Ruifang, Chen Juannan, Zhang Jiayu, Zheng Kewei, He Yide, Hao Yuhua, Yu Qun, Ren Suping, Tan Zheng. G-QUADRUPLEX STRUCTURAL VARIATIONS IN HUMAN GENOME ASSOCIATED WITH SINGLE-NUCLEOTIDE VARIATIONS AND THEIR IMPACT ON GENE ACTIVITY. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021, 118(21): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166059/.

[13] Zhang, Jiayu, Song, Xiaofang, Xia, Miaoren, Xue, Yanan, Zhou, Mengxue, Ruan, Lifo, Lu, Huiru, Chen, Jun, Wang, Dongqi, Chai, Zhifang, Hu, Yi. The proximity of the G-quadruplex to hemin impacts the intrinsic DNAzyme activity in mitochondria. CHEMICAL COMMUNICATIONS. 2021, 57(24): 3038-3041, https://www.webofscience.com/wos/woscc/full-record/WOS:000631568300013.

[14] Ren, Weifeng, Cai, Xiaomeng, Chen, Jun, Ruan, Lifo, Lu, Huiru, Zhang, Jiayu, Hu, Yi, Gao, Jimin. GM-CSF-Loaded Nanoparticles for Photothermal-Assisted Immunotherapy against Orthotopic Bladder Cancer. ONCOLOGIE. 2021, 23(3): 359-371, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000701857100005.

[15] Du, Chuanchao, Zhou, Mengxue, Jia, Fei, Ruan, Lifo, Lu, Huiru, Zhang, Jiayu, Zhu, Bin, Liu, Xiaoguang, Chen, Jun, Chai, Zhifang, Hu, Yi. D-arginine-loaded metal-organic frameworks nanoparticles sensitize osteosarcoma to radiotherapy. BIOMATERIALS. 2021, 269: 120642, http://dx.doi.org/10.1016/j.biomaterials.2020.120642.

[16] Zheng, KeWei, Zhang, JiaYu, He, Yide, Gong, JiaYuan, Wen, CuiJiao, Chen, JuanNan, Hao, YuHua, Zhao, Yong, Tan, Zheng. Detection of genomic G-quadruplexes in living cells using a small artificial protein. NUCLEIC ACIDS RESEARCH. 2020, 48(20): 11706-11720, http://dx.doi.org/10.1093/nar/gkaa841.

[17] Wen, Cuijiao, Gong, Jiayuan, Zheng, Kewei, He, Yide, Zhang, Jiayu, Hao, Yuhua, Tan, Zheng. Targeting nucleic acids with a G-triplex-to-G-quadruplex transformation and stabilization using a peptide-PNA G-tract conjugate. CHEMICAL COMMUNICATIONS. 2020, 56(48): 6567-6570, https://www.webofscience.com/wos/woscc/full-record/WOS:000544281500020.

[18] Zhang, Jiayu, Xia, Ye, Hao, Yuhua, Tan, Zheng. DNA:RNA hybrid G-quadruplex formation upstream of transcription start site. SCIENTIFIC REPORTS. 2020, 10(1): http://dx.doi.org/10.1038/s41598-020-64117-x.

[19] Ruan, Lifo, Zhou, Mengxue, Chen, Jun, Huang, Hui, Zhang, Jiayu, Sun, Hongyan, Chai, Zhifang, Hu, Yi. Thermoresponsive drug delivery to mitochondria in vivo. CHEMICAL COMMUNICATIONS. 2019, 55(97): 14645-14648, http://dx.doi.org/10.1039/c9cc07538k.

[20] Zheng, Kewei, Zhang, Jiayu, Tan, Zheng. Characterization of Co-transcriptional Formation of G-Quadruplexes in Double-Stranded DNA. Methods in Molecular Biology 2035: 243-255. 2019.

[21] Wang, Dongqing, Zhou, Mengxue, Huang, Hui, Ruan, Lifo, Lu, Huiru, Zhang, Jiayu, Chen, Jun, Gao, Jimin, Chai, Zhifang, Hu, Yi. Gold Nanoparticle-Based Probe for Analyzing Mitochondrial Temperature in Living Cells. ACS APPLIED BIO MATERIALS. 2019, 2(8): 3178-3182.

[22] Huang, Hui, Zhou, Mengxue, Ruan, Lifo, Wang, Dongqing, Lu, Huiru, Zhang, Jiayu, Chen, Jun, Hu, Yi, Chai, Zhifang. AMPK mediates the neurotoxicity of iron oxide nanoparticles retained in mitochondria or lysosomes. METALLOMICS. 2019, 11(7): 1200-1206, https://www.webofscience.com/wos/woscc/full-record/WOS:000475799400001.

[23] Ruan, Lifo, Wang, Miao, Zhou, Mengxue, Lu, Huiru, Zhang, Jiayu, Gao, Jimin, Chen, Jun, Hu, Yi. Doxorubicin-Metal Coordinated Micellar Nanoparticles for Intracellular Codelivery and Chemo/Chemodynamic Therapy in Vitro. ACS APPLIED BIO MATERIALS. 2019, 2(11): 4703-4707.

[24] Zhao, Yang, Zhang, Jiayu, Zhang, Zongyu, Tong, Tanjun, Hao, Yuhua, Tan, Zheng. Real-Time Detection Reveals Responsive Cotranscriptional Formation of Persistent Intramolecular DNA and Intermolecular DNA:RNA Hybrid G-Quadruplexes Stabilized by R-Loop. ANALYTICAL CHEMISTRY. 2017, 89(11): 6037-6043, https://www.webofscience.com/wos/woscc/full-record/WOS:000403036800054.

[25] Li, Xinmin, Zheng, Kewei, Zhang, Jiayu, Liu, Honghe, He, Yide, Yuan, Bifeng, Hao, Yuhua, Tan, Zheng. Guanine-vacancy-bearing G-quadruplexes responsive to guanine derivatives. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015, 112(47): 14581-14586, http://dx.doi.org/10.1073/pnas.1516925112.

[26] Wu, Renyi, Zheng, Kewei, Zhang, Jiayu, Hao, Yuhua, Tan, Zheng. Formation of DNA: RNA Hybrid G-Quadruplex in Bacterial Cells and Its Dominance over the Intramolecular DNA G-Quadruplex in Mediating Transcription Termination. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2015, 54(8): 2447-2451, http://dx.doi.org/10.1002/anie.201408719.

[27] Zheng, Kewei, Wu, Renyi, He, Yide, Xiao, Shan, Zhang, Jiayu, Liu, Jiaquan, Hao, Yuhua, Tan, Zheng. A competitive formation of DNA: RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site. NUCLEIC ACIDS RESEARCH. 2014, 42(16): 10832-10844, http://dx.doi.org/10.1093/nar/gku764.

[28] Xiao, Shan, Zhang, Jiayu, Wu, Jun, Wu, Renyi, Xia, Ye, Zheng, Kewei, Hao, Yuhua, Zhou, Xiang, Tan, Zheng. Formation of DNA:RNA Hybrid G-Quadruplexes of Two G-Quartet Layers in Transcription: Expansion of the Prevalence and Diversity of G-Quadruplexes in Genomes. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2014, 53(48): 13110-13114, http://dx.doi.org/10.1002/anie.201407045.

[29] Zhang, Jiayu, Zheng, Kewei, Xiao, Shan, Hao, Yuhua, Tan, Zheng. Mechanism and Manipulation of DNA:RNA Hybrid G-Quadruplex Formation in Transcription of G-Rich DNA. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2014, 136(4): 1381-1390, http://dx.doi.org/10.1021/ja4085572.

[30] Zheng, Kewei, Xiao, Shan, Liu, Jiaquan, Zhang, Jiayu, Hao, Yuhua, Tan, Zheng. Co-transcriptional formation of DNA:RNA hybrid G-quadruplex and potential function as constitutional cis element for transcription control. NUCLEIC ACIDS RESEARCH. 2013, 41(10): 5533-5541, http://dx.doi.org/10.1093/nar/gkt264.

[31] Xiao, Shan, Zhang, Jiayu, Zheng, Kewei, Hao, Yuhua, Tan, Zheng. Bioinformatic analysis reveals an evolutional selection for DNA: RNA hybrid G-quadruplex structures as putative transcription regulatory elements in warm-blooded animals. NUCLEIC ACIDS RESEARCH. 2013, 41(22): 10379-10390, http://dx.doi.org/10.1093/nar/gkt781.

Peking University Third Hospital

Capital Medical University

Tiangong University