100704-药物分析学
100706-药理学

药物代谢，药物不良反应机理，新代谢途径，反常药动学，药物代谢新技术
低辐射能量放射性同位素[14C]/[3H]标记技术在新药DMPK中的应用

2009-09--2014-07   中国科学院大学   博士
2005-09--2009-06   武汉大学   学士

   

2019-02~现在, 中国科学院上海药物研究所, 课题组长
2018-08~2019-02,美国Celgene公司, 科学家II
2016-06~2018-08,美国XenoBiotic Laboratories, 科学家I/II
2014-07~2016-06,美国国立卫生研究院（NIH）, 博士后
2009-09~2014-07,中国科学院大学, 博士
2005-09~2009-06,武汉大学, 学士

   

（1） 第4届ISSX/CSSX 联合会议演讲二等奖, 二等奖, 其他, 2013
（2） 第十届全国药物分析优秀论文评选交流会三等奖, 三等奖, 其他, 2011

   

（1） Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry, J Pharm Biomed Anal, 2019, 通讯作者
（2） New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites, Frontiers in Chemistry, 2019, 第 1 作者
（3） Metabolism of the new synthetic cannabinoid EG-018 in human hepatocytes by high-resolution mass spectrometry, Forensic Toxicol, 2018, 第 1 作者
（4） Synthetic cannabinoid BB-22 (QUCHIC): Human hepatocytes metabolism with liquid chromatography-high-resolution mass spectrometry detection, J Pharm Biomed Anal, 2018, 第 1 作者
（5） Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay, Mol Psychiatry, 2018, 第 3 作者
（6） In vitro and in vivo human metabolism of a new synthetic cannabinoid NM-2201 (CBL-2201), Forensic Toxicol, 2017, 第 1 作者
（7） Human hepatocyte metabolism of novel synthetic cannabinoids MN-18 and its 5-fluoro analog 5F-MN-18, Clin Chem, 2017, 第 1 作者
（8） In vitro metabolism of new synthetic cannabinoid SDB-006 in human hepatocytes by high-resolution mass spectrometry, Forensic Toxicol, 2017, 第 1 作者
（9） Distinguishing intake of new synthetic cannabinoids, ADB-PINACA and 5F-ADB-PINACA, with human hepatocyte metabolites and high resolution mass spectrometry, Clin Chem, 2017, 第 2 作者
（10） Approaches, challenges and advances in metabolism of new synthetic cannabinoids and identification of optimal urinary marker metabolites, Clin Pharmacol Ther, 2017, 第 1 作者
（11） Identification of new synthetic cannabinoid ADB-CHMINACA (MAB-CHMINACA) metabolites in human hepatocytes, AAPS J, 2017, 第 1 作者
（12） 25C-NBOMe and 25I-NBOMe metabolite studies in human hepatocytes, in vivo mouse and human urine with high-resolution mass spectrometry, Drug Test Anal, 2017, 第 5 作者
（13） In vitro metabolite profiling of ADB-FUBINACA, a new synthetic cannabinoid, Curr Neuropharmacol, 2017, 第 2 作者
（14） Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide, Drug Des Devel Ther, 2016, 第 5 作者
（15） First metabolic profile of PV8, a novel synthetic cathinone, in human hepatocytes and urine by high-resolution mass spectrometry, Anal Bioanal Chem, 2016, 第 4 作者
（16） Metabolic profiling of new synthetic cannabinoids AMB and 5F-AMB by human hepatocyte and liver microsome incubations and high-resolution mass spectrometry, Rapid Commun Mass Spectrom, 2016, 第 2 作者
（17） In vitro and in vivo human metabolism of synthetic cannabinoids FDU-PB-22 and FUB-PB-22, AAPS J, 2016, 第 1 作者
（18） In vitro, in vivo and in silico metabolic profiling of α-pyrrolidinopentiothiophenone, a novel thiophene stimulant, Bioanalysis, 2016, 第 5 作者
（19） 4-Methoxy-a-PVP: in silico prediction, metabolic stability, and metabolite identification by human hepatocyte incubation and high-resolution mass spectrometry, Forensic Toxicol, 2016, 第 4 作者
（20） High-resolution mass spectrometry for characterizing the metabolism of synthetic cannabinoids THJ-018 and its 5-fluoro analog THJ-2201 after incubation in human hepatocytes, Clin Chem, 2016, 第 1 作者
（21） Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry, J Chromatogr B, 2016, 第 6 作者
（22） Strategies to distinguish new synthetic cannabinoid FUBIMINA (BIM-2201) intake from its isomer THJ-2201: metabolism of FUBIMINA in human hepatocytes, Forensic Toxicol, 2016, 第 1 作者
（23） Isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-OH-NBP and 10-OH-NBP, across the rat blood-brain barrier, Acta Pharmacol Sin, 2015, 第 1 作者
（24） 醛氧化酶在药物代谢中的作用, The role of aldehyde oxidase in drug metabolism, Journal of Baoji University of Arts and Sciences (Natural Science), 2014, 第 1 作者
（25） Bioactivation of 3-n-butylphthalide via the sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase1A1, Drug Metab Dispos, 2014, 第 1 作者
（26） Simultaneous quantitation of 3-n-butylphthalide (NBP) and its four major metabolites in human plasma by LC–MS/MS using deuterated internal standards, J Pharm Biomed Anal, 2013, 第 1 作者
（27） Enantioselective determination of 3-n-butylphthalide (NBP) in human plasma by liquid chromatography on a teicoplanin-based chiral column coupled with tandem mass spectrometry, J Chromatogr B, 2013, 第 1 作者
（28） Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients, Brit J Pharmacol, 2013, 第 4 作者
（29） Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation, Drug Metab Dispos, 2013, 第 1 作者
（30） Metabolism and pharmacokinetics of morinidazole in humans: Identification of diastereoisomeric morpholine N+-glucuronides catalyzed by UDP glucuronosyltransferase, Drug Metab Dispos, 2012, 第 4 作者

   

（ 1 ） 川楝素代谢活化和肝脏毒性机理研究, 参与, 国家任务, 2013-01--2015-12
（ 2 ） “****”启动基金, 负责人, 研究所自主部署, 2019-02--2024-02
（ 3 ） 硫酸结合代谢途径介导药物不良反应的分子机制和预防策略研究, 负责人, 国家任务, 2020-01--2022-12
（ 4 ） 云端一体化视-听-触多模态交互反馈式高仿真智慧虚 拟手术关键技术研发与示范应用, 参与, 国家任务, 2022-11--2025-10

（1）如何在法医样品中根据特征性代谢物判定吸食某种新型毒品（合成类大麻）？   第七届中国生物分析论坛年会   2019-06-14
（2）Metabolism of synthetic cannabinoids THJ-018 and its 5-fluoro analog THJ-2201 following human hepatocytes Incubation and high-resolution mass spectrometry   美国法医毒理学会2015年会   2015-10-22
（3）Simultaneous determination of butylphthalide and four metabolites in human plasma by LC-MS/MS   第5届化学与药学结构分析年会   2014-04-17
（4）Insight into uncommon metabolic pathways of butylphthalide (NBP) in humans   第4届ISSX/CSSX 联合会议   2013-05-17
（5）Metabolism of 3-n-butylphthalide (NBP), an anti-celebral ischemia, in vitro and in vivo   中国第10届药物与异物代谢暨第3届ISSX/CSSX 联合会议   2012-09-23
（6）Metabolism of 3-n-butylphthalide (NBP) in humans   中国第10届药物分析会议   2011-09-16