100706-药理学
0703Z1-化学生物学
071010-生物化学与分子生物学

化学生物学
蛋白质组学
表观遗传学

2004-09--2010-06   中国科学院上海药物研究所   理学博士
2000-09--2004-06   同济大学   理学学士

   

2019-01~现在, 中国科学院上海药物研究所, 研究员
2015-09~2019-01,美国芝加哥大学, 研究助理
2012-11~2015-08,美国芝加哥大学, 博士后
2010-08~2012-10,美国西北大学, 博士后
2004-09~2010-06,中国科学院上海药物研究所, 理学博士
2000-09~2004-06,同济大学, 理学学士

2023-03-22-今,生命过程小分子调控全国重点实验室, 副主任

   

（1） 第八届杰出青年科技创新人才, , 院级, 2022
（2） 上海市“浦江人才”, , 省级, 2019
（3） 中国科学院院长优秀奖, 院级, 2010
（4） 上海市高等学校优秀毕业生, 省级, 2010
（5） Eli Lilly亚洲优秀学位论文, 一等奖, 其他, 2010
（6） 首届中华医药澳门论坛最佳论文奖, 其他, 2009
（7） 第六届世界华人药物化学会议优秀墙报奖, 其他, 2008

（ 1 ） 一种嘧啶并咪唑类化合物及其药用组合物和应用, 2024, 第 6 作者, 专利号: CN115073467B

（ 2 ） 一类α,β-不饱和酰胺类化合物及其制备方法、药物组合物和用途, 2024, 第 7 作者, 专利号: CN117402123A

（ 3 ） 一种嘧啶并吡啶类化合物及其药用组合物和应用, 2023, 第 6 作者, 专利号: CN116410189A

（ 4 ） 一种嘧啶并咪唑类化合物及其药用组合物和应用, 2022, 第 6 作者, 专利号: CN115073467A

（ 5 ） 1－取代－4,4－二取代氨基硫脲类化合物、其制备方法以及其用途, 2008, 第 5 作者, 专利号: CN101195597A

   

（1） Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis, Cell Metabolism, 2025, 第 17 作者  通讯作者
（2） Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1, JOURNAL OF MEDICINAL CHEMISTRY, 2024, 第 12 作者  通讯作者
（3） Controlled Reversible N-Terminal Modification of Peptides and Proteins, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 第 12 作者  通讯作者
（4） SIRT1/SIRT3 are robust lysine delactylases and SIRT1-mediated delactylation regulates glycolysis, iScience, 2024, 第 14 作者  通讯作者
（5） Exploring the Molecular Therapeutic Mechanisms of Gemcitabine through Quantitative Proteomics, JOURNAL OF PROTEOME RESEARCH, 2024, 第 10 作者  通讯作者
（6） Asymmetric macrocyclization enabled by Rh(III)-catalyzed C-H activation: Enantioenriched macrocyclic inhibitor of Zika virus infection, CHINESE CHEMICAL LETTERS, 2024, 第 11 作者  通讯作者
（7） SIRT3 differentially regulates lysine benzoylation from SIRT2 in mammalian cells, iScience, 2024, 第 8 作者  通讯作者
（8） Advancing In-Depth N-Terminomics Detection with a Cleavable 2-Pyridinecarboxyaldehyde Probe, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 第 5 作者  通讯作者
（9） Non-natural sialic acid derivatives with o-nitrobenzyl alcohol substituents for light-mediated protein conjugation and cell imaging, ORGANIC & BIOMOLECULAR CHEMISTRY, 2024, 第 7 作者  通讯作者
（10） Exploring the mechanism of contact-dependent cell-cell communication on chemosensitivity based on single-cell high-throughput drug screening platform, TALANTA, 2024, 第 7 作者  通讯作者
（11） Discovery of a potent and selective covalent threonine tyrosine kinase (TTK) inhibitor, BIOORGANIC CHEMISTRY, 2024, 第 10 作者  通讯作者
（12） Quantitative ProteomicsReveal the Role of Matrinein Regulating Lipid Metabolism, ACS OMEGA, 2024, 第 10 作者  通讯作者
（13） Oroxylin A attenuates psoriasiform skin inflammation by direct targeting p62 (sequestosome 1) via suppressing M1 macrophage polarization, British Journal of Pharmacology, 2024, 第 8 作者
（14） Discovery of a PROTAC degrader for METTL3-METTL14 complex, CELL CHEMICAL BIOLOGY, 2024, 第 10 作者
（15） HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation, CELL DISCOVERY, 2023, 第 10 作者  通讯作者
（16） Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization, CELL REPORTS, 2023, 第 8 作者  通讯作者
（17） A Ru(ii)-catalyzed C���H activation and annulation cascade for the construction of highly coumarin-fused benzo[a]quinolizin-4-ones and pyridin-2-ones, Organic Chemistry Frontiers, 2023, 第 8 作者  通讯作者
（18） Lactylome suggests novel mechanisms of metabolic adaptation in hepatocellular carcinoma, Nature Metabolism, 2023, 第 14 作者  通讯作者
（19） Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial, CELL METABOLISM, 2022, 第 19 作者  通讯作者
（20） HBO1 catalyzes lysine benzoylation in mammalian cells, ISCIENCE, 2022, 第 10 作者  通讯作者
（21） Quantitative Proteomics Analysis Expands the Roles of Lysine �� -Hydroxybutyrylation Pathway in Response to Environmental �� -Hydroxybutyrate, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2022, 第 6 作者  通讯作者
（22） The regulatory enzymes and protein substrates for the lysine beta-hydroxybutyrylation pathway, SCIENCE ADVANCES, 2021, 第 1 作者  通讯作者
（23） Metabolic regulation of gene expression by histone lactylation, NATURE, 2019, 第 3 作者
（24） Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway, CELL RESEARCH, 2018, 第 1 作者
（25） p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis, MOLECULAR CELL, 2018, 第 1 作者
（26） Lysine benzoylation is a histone mark regulated by SIRT2, NATURE COMMUNICATIONS, 2018, 第 1 作者
（27） Quantitative Crotonylome Analysis Expands the Roles of p300 in the Regulation of Lysine Crotonylation Pathway, PROTEOMICS, 2018, 第 1 作者  通讯作者
（28） Structure of p300 in complex with acyl-CoA variants, NATURE CHEMICAL BIOLOGY, 2017, 第 4 作者
（29） 2-Hydroxyisobutyrylation on histone H4K8 is regulated by glucose homeostasis in Saccharomyces cerevisiae., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 5 作者
（30） TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions, MOLECULAR CELL, 2016, 第 5 作者
（31） Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain, MOLECULAR CELL, 2016, 第 8 作者
（32） Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters, MOLECULAR CELL, 2016, 第 3 作者
（33） Metabolic Regulation of Gene Expression by Histone Lysine-X modification, Mol Cell, 2016, 第 1 作者
（34） Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, 2015, 第 7 作者
（35） Quantitative Proteomic Analysis of Histone Modifications, CHEMICAL REVIEWS, 2015, 第 1 作者
（36） Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation, MOLECULAR CELL, 2015, 第 3 作者
（37） SnapShot: Histone Modifications, CELL, 2014, 第 1 作者  通讯作者
（38） Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5, CELL METABOLISM, 2014, 第 9 作者
（39） Silverman RB. Potent and Selective Double-headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma., J Med Chem, 2014, 第 1 作者
（40） Structural and biological characterization of NOS inhibitors with antimicrobial properties, FASEB JOURNAL, 2014, 第 7 作者
（41） Arylazanyl pyrazolone derivatives as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of amyotrophic lateral sclerosis., J Med Chem, 2013, 第 1 作者
（42） Structure-guided Design of Selective Inhibitors of Neuronal Nitric Oxide Synthase, JOURNAL OF MEDICINAL CHEMISTRY, 2013, 第 1 作者
（43） Selective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics Simulations, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 第 1 作者
（44） Recent advances in the gold-catalyzed additions to C���C multiple bonds, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2011, 第 1 作者
（45） Iron deprivation caused by a novel iron chelator thiosemicarbazone-24 suppresses hepatocellular carcinoma in vitro and in vivo., Clin Cancer Res, 2011, 第 1 作者
（46） PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo, BREAST CANCER RESEARCH AND TREATMENT, 2011, 第 2 作者
（47） Synthesis of 4-Aryl-2(5H)-furanones by Gold(I)-Catalyzed Intramolecular Annulation, ADVANCED SYNTHESIS & CATALYSIS, 2011, 第 2 作者
（48） Iron Deprivation Suppresses Hepatocellular Carcinoma Growth in Experimental Studies, CLINICAL CANCER RESEARCH, 2011, 第 3 作者
（49） A Series of alpha-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase II alpha Catalytic Activity, JOURNAL OF MEDICINAL CHEMISTRY, 2010, 第 1 作者
（50） PH006, a novel and highly potent Src kinase inhibitor, suppresses tumor growth and metastasis in vitro and in vivo., Breast Cancer Res Tr, 2010, 第 1 作者
（51） Total Synthesis of Cytosporone B, CHINESE JOURNAL OF CHEMISTRY, 2010, 第 1 作者
（52） Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase, BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 第 1 作者
（53） A class of ��-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase II�� catalytic activity,, J Med Chem, 2010, 第 1 作者
（54） Metal-Free Synthesis of 2-Substituted (N, O, C) Benzothiazoles via an Intramolecular C-S Bond Formation, JOURNAL OF COMBINATORIAL CHEMISTRY, 2010, 第 2 作者
（55） Ligand-free iron/copper cocatalyzed N-arylations of aryl halides with amines under microwave irradiation, GREEN CHEMISTRY, 2010, 第 2 作者
（56） 新型Src激酶抑制剂PH006的抗肿瘤作用研究, 2009, 第 2 作者
（57） A Simple and Efficient Copper-Catalyzed Tandem Synthesis of Quinoline-2-carboxylates at Room Temperature,, J Org Chem, 2009, 第 1 作者
（58） Discovering novel quercetin-3-O-amino acid-esters as a new class of Src tyrosine kinase inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 第 1 作者
（59） 缩氨基硫脲类新化合物TSC的抗肿瘤作用及其分子机制研究, 2009, 第 2 作者
（60） A Simple and Convenient Copper-Catalyzed Tandem Synthesis of Quinoline-2-carboxylates at Room Temperature, JOURNAL OF ORGANIC CHEMISTRY, 2009, 第 1 作者
（61） Copper(I)-Catalyzed One-Pot Synthesis of 2H-1,4-Benzoxazin-3-(4H)-ones from o-Halophenols and 2-Chloroacetamides, JOURNAL OF ORGANIC CHEMISTRY, 2009, 第 2 作者
（62） Microwave-assisted synthesis of quinazolinone derivatives by efficient and rapid iron-catalyzed cyclization in water, GREEN CHEMISTRY, 2009, 第 6 作者
（63） Discovering novel 3-nitroquinolines as a new class of anticancer agents, ACTA PHARMACOLOGICA SINICA, 2008, 第 2 作者
（64） Structure-Activity Relationship and Substrate-Dependent Phenomena in Effects of Ginsenosides on Activities of Drug-Metabolizing P450 Enzymes, PLOS ONE, 2008, 第 4 作者
（65） Efficient iron/copper cocatalyzed alkynylation of aryl iodides with terminal alkynes, JOURNAL OF ORGANIC CHEMISTRY, 2008, 第 1 作者
（66） Discovering novel 3-nitroquinolines as a new class of anticancer agents, Discovering novel 3-nitroquinolines as a new class of anticancer agents, 中国药理学报：英文版, 2008, 第 2 作者
（67） Structure-Activity Relationship and Substrate-Dependent Phenomena in Effects of Ginsenosides on Activities of Drug-Metabolizing P450 Enzymes, PLOS ONE, 2008, 第 4 作者
（68） Microwave-assisted efficient and convenient synthesis of 2,4(1H,3H)-quinazolinediones and 2-thioxoquinazolines, JOURNAL OF COMBINATORIAL CHEMISTRY, 2008, 第 2 作者
（69） Efficient Iron-Catalyzed N-Arylation of Aryl Halides with Amines, ORGANIC LETTERS, 2008, 第 2 作者
（70） Rapid and efficient Pd-catalyzed sonogashira coupling of aryl chlorides, JOURNAL OF ORGANIC CHEMISTRY, 2008, 第 1 作者
（71） Microwave-assisted efficient copper-promoted N-arylation of Amines with arylboronic acids, JOURNAL OF COMBINATORIAL CHEMISTRY, 2008, 第 2 作者
（72） Efficient copper-promoted n-arylations of aryl halides with amines, JOURNAL OF COMBINATORIAL CHEMISTRY, 2008, 第 1 作者
（73） Microwave-assisted rapid synthesis of 2,6,9-substituted purines, JOURNAL OF COMBINATORIAL CHEMISTRY, 2007, 第 1 作者

   

（ 1 ） 自噬激酶ULK1的磷酸化底物谱及其调控乳腺癌转移的机制研究, 负责人, 地方任务, 2023-04--2026-03
（ 2 ） 肝癌演进过程中肿瘤及免疫微环境异常糖基化的动态可视化、新功能靶 标发现与特异性化学干预, 负责人, 国家任务, 2023-01--2025-12
（ 3 ） 赖氨酸苯甲酰化关键调控因子鉴定及其对乳腺癌细胞TGF-β的调控机制研究, 负责人, 国家任务, 2023-01--2026-12
（ 4 ） 降血脂症药物DC371739的临床研究, 负责人, 其他国际合作项目, 2021-12--2023-06
（ 5 ） 海外高层次人才引进计划青年项目, 负责人, 中国科学院计划, 2021-01--2023-12
（ 6 ） 基于蛋白翻译后修饰的神经退行性疾病人群精准健康研究, 负责人, 地方任务, 2020-01--2024-12
（ 7 ） 组蛋白修饰介导的抑郁症表观遗传调控机制及化学干预, 负责人, 国家任务, 2020-01--2023-12

（1）Lysine benzoylation is a new type of histone mark regulated by SIRT2   2018-06-03
（2）Quantitative Proteomic Approach Reveals Landscape of the Regulatory Elements for Lysine β-hydroxybutyrylation   2017-06-04
（3）Landscape of the Regulatory Elements for Lysine 2-Hydroxyisobutyrylation Pathway   2017-04-25
（4）Lysine β-hydroxybutyrylation is a new type of protein post-translational modification associated with diverse pathophysiology   2016-06-05