基本信息
谢岑  女  博导  中国科学院上海药物研究所
电子邮件: xiecen@simm.ac.cn
通信地址: 上海市浦东新区张江高科海科路501号
邮政编码:

招生信息

   
招生专业
100706-药理学
100800-中药学
招生方向
代谢疾病药理学(肝脏疾病为主)
临床中药学

教育背景

2008-09--2013-06   中国科学院大学   研究生,博士
2004-09--2008-06   浙江大学   本科,学士

工作经历

   
工作简历
2019-10~现在, 中国科学院上海药物研究所, 研究员,课题组长
2013-10~2018-10,美国国立卫生研究院, 博士后
2013-07~2013-09,中国科学院上海药物研究所, 助理研究员
2008-09~2013-06,中国科学院大学, 研究生,博士
2004-09~2008-06,浙江大学, 本科,学士

专利与奖励

   
专利成果
( 1 ) 环烯醚萜苷化合物在制备治疗DUSP9表达异常相关疾病的药物中的应用, 2021, 第 7 作者, 专利号: CN113181202A

出版信息

   
发表论文
(1) Bile acid and receptors: biology and drug discovery for nonalcoholic fatty liver disease, ACTA PHARMACOLOGICA SINICA, 2022, 通讯作者
(2) Structural Characterization of a Polysaccharide from Gastrodia elata and Its Bioactivity on Gut Microbiota, MOLECULES, 2021, 通讯作者
(3) Regulating Glucose Metabolism with Prodrug Nanoparticles for Promoting Photoimmunotherapy of Pancreatic Cancer, ADVANCED SCIENCE, 2021, 第 10 作者
(4) Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2021, 第 3 作者
(5) An Integrated LC-MS/MS Strategy for Quantifying the Oxidative-Redox Metabolome in Multiple Biological Samples, ANALYTICAL CHEMISTRY, 2020, 通讯作者
(6) Hepatocyte peroxisome proliferator-activated receptor α regulates bile acid synthesis and transport, BBA - Molecular and Cell Biology of Lipids, 2019, 通讯作者
(7) Hepatocyte peroxisome proliferator-activated receptor alpha regulates bile acid synthesis and transport, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2019, 通讯作者
(8) Metabolism of MRX-I, a Novel Antibacterial Oxazolidinone, in Humans: The Oxidative Ring Opening of 2,3-Dihydropyridin-4-One Catalyzed by Non-P450 Enzymes, DRUG METABOLISM AND DISPOSITION, 2015, 第 6 作者
(9) Chemical and Enzymatic Transformations of Nimesulide to GSH Conjugates through Reductive and Oxidative Mechanisms, CHEMICAL RESEARCH IN TOXICOLOGY, 2015, 第 3 作者
(10) Effects of Renal Impairment on the Pharmacokinetics of Morinidazole: Uptake Transporter-Mediated Renal Clearance of the Conjugated Metabolites, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 第 3 作者
(11) Bioactivation of 3-n-Butylphthalide via Sulfation of Its Major Metabolite 3-Hydroxy-NBP: Mediated Mainly by Sulfotransferase 1A1, DRUG METABOLISM AND DISPOSITION, 2014, 第 3 作者
(12) 奋乃静在人胆汁中的代谢物分析, Analysis of Perphenazine Metabolites in Human Bile, 质谱学报, 2014, 第 2 作者
(13) Metabolism and Pharmacokinetics of Allitinib in Cancer Patients: The Roles of Cytochrome P450s and Epoxide Hydrolase in its Biotransformation, DRUG METABOLISM AND DISPOSITION, 2014, 第 2 作者
(14) EFFECT OF RENAL IMPAIRMENT ON THE PHARMACOKINETICS OF MORINIDAZOLE: ALTERED UPTAKE TRANSPORTER-MEDIATED RENAL CLEARANCE?, DRUG METABOLISM REVIEWS, 2014, 第 2 作者
(15) High-Resolution Mass Spectrometry: An Ideal Analytical Tool for Drug Metabolism Studies, LC GC NORTH AMERICA, 2013, 第 1 作者
(16) High-Resolution Mass Spectrometry: An Ideal Premier Analytical Tool for Drug Metabolism Studies, LC GC EUROPE, 2013, 通讯作者
(17) Metabolism and Pharmacokinetics of 3-n-Butylphthalide (NBP) in Humans: The Role of Cytochrome P450s and Alcohol Dehydrogenase in Biotransformation, DRUG METABOLISM AND DISPOSITION, 2013, 第 3 作者
(18) Oxidation-sensing Regulator AbfR Regulates Oxidative Stress Responses, Bacterial Aggregation, and Biofilm Formation in Staphylococcus epidermidis, JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 第 4 作者
(19) 绿原酸和法米替尼的代谢和生物活化研究, 2013, 第 1 作者
(20) Metabolism and Pharmacokinetics of Novel Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitor Apatinib in Humans, DRUG METABOLISM AND DISPOSITION, 2013, 第 6 作者
(21) Crystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactonesignaling DWARF14, Cell Research, 2013, 第 14 作者
(22) Crystal structures of two phytohormone signal-transducing alpha/beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14, CELL RESEARCH, 2013, 第 14 作者
(23) A fragmentation-based method for the differentiation of glutathione conjugates by high-resolution mass spectrometry with electrospray ionization, ANALYTICA CHIMICA ACTA, 2013, 第 1 作者
(24) Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients, BRITISH JOURNAL OF PHARMACOLOGY, 2013, 第 1 作者
(25) 阿帕替尼在人体内的代谢、排泄和药动学研究, 2012, 第 6 作者
(26) Identification of the ortho-Benzoquinone Intermediate of 5-O-Caffeoylquinic Acid In Vitro and In Vivo: Comparison of Bioactivation under Normal and Pathological Situations, DRUG METABOLISM AND DISPOSITION, 2012, 第 1 作者
(27) Metabolism and Pharmacokinetics of Morinidazole in Humans: Identification of Diastereoisomeric Morpholine N+-Glucuronides Catalyzed by UDP Glucuronosyltransferase 1A9, DRUG METABOLISM AND DISPOSITION, 2012, 第 3 作者
(28) Recent advances in metabolite identification and quantitative bioanalysis by LC-Q-TOF MS, BIOANALYSIS, 2012, 第 1 作者
(29) 鉴定大鼠注射绿原酸后体内的代谢产物, Metabolites of injected chlorogenic acid in rats, 药学学报, 2011, 第 1 作者
(30) Investigation of Isomeric Transformations of Chlorogenic Acid in Buffers and Biological Matrixes by Ultraperformance Liquid Chromatography Coupled with Hybrid Quadrupole/Ion Mobility/Orthogonal Acceleration Time-of-Flight Mass Spectrometry, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 第 1 作者
(31) UPLC/Q-TOFMS法研究吗啉硝唑人体内外代谢, 2011, 第 3 作者
(32) 液相色谱-串联质谱法检测反应性代谢物, Applications of Liquid Chromatography-Tandem Mass Spectrometry to Detection and Characterization of Reactive Metabolites, 质谱学报, 2011, 第 1 作者
(33) UPLC/Q-TOFMS法检测和鉴定阿帕替尼在肿瘤患者血浆和尿中代谢产物, 2011, 第 3 作者
(34) Simultaneous determination of dronedarone and its active metabolite debutyldronedarone in human plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2011, 第 1 作者
(35) Metabolic Activation of Chlorogenic Acid in vitro and in vivo, DRUG METABOLISM REVIEWS, 2010, 第 2 作者
(36) 绿原酸和双黄连粉针剂致敏性比较评价, Allergenicity Assessment and Comparison between Chlorogenic Acid and Shuanghuanglian Fenzhenji, 世界科学技术(中医药现代化), 2010, 第 5 作者

科研活动

   
科研项目
( 1 ) 非酒精性脂肪肝病进程中肠源性神经酰胺代谢网络的跨器官调控机制和新药研究, 负责人, 国家任务, 2020-01--2022-12
( 2 ) 肝脏FXR-CYP8B1-胆酸代谢轴跨器官调控肠上皮损伤修复和加重肠道炎症的机制研究, 负责人, 国家任务, 2022-01--2025-12
( 3 ) 临床药物对肠道微生物介导疾病进程的调控机制研究, 负责人, 国家任务, 2021-11--2026-10
( 4 ) 以肠道菌群为靶点的新药发现技术, 负责人, 中国科学院计划, 2019-10--2020-09
( 5 ) 肠道微生态代谢调控与衰老相关神经退行性疾病, 负责人, 中国科学院计划, 2020-01--2024-12