100706-药理学
071006-神经生物学

阿片受体功能研究
成瘾的神经生物学机制
镇痛药，戒毒药开发

2005-09--2009-06   沈阳药科大学   药理学博士

   

2013-06~现在, 中国科学院上海药物研究所, 研究员
2009-09~2013-03,Temple University School of Medicine, 博士后
2005-09~2009-06,沈阳药科大学, 药理学博士

高等药理学

   

（1） 中国药理学会青年药理学家奖, 其他, 2018
（2） SA-SIBS优秀青年科技人才奖励, 其他, 2018
（3） 入选中国科学院青年创新促进会, 院级, 2017
（4） 入选中国科学院上海药物研究所“新星计划”, 研究所（学校）, 2016

（ 1 ） 四氢去甲蒂巴因衍生物及制备方法和用途, 2021, 第 4 作者, 专利号: CN112661765A

   

（1） Upregulation of dynorphin/kappa opioid receptor system in the dorsal hippocampus contributes to morphine withdrawal-induced place aversion, ACTA PHARMACOLOGICA SINICA, 2023, 第 11 作者
（2） Changes in mRNA and miRNA expression in the prelimbic cortex related to depression-like syndrome induced by chronic social defeat stress in mice, BEHAVIOURAL BRAIN RESEARCH, 2023, 第 11 作者
（3） Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion, Novel selective �� agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion, 中国药理学报:英文版, 2022, 第 11 作者
（4） Dezocine as a potent analgesic:overview of its pharmacological characterization, Dezocine as a potent analgesic: overview of its pharmacological characterization, ACTA PHARMACOLOGICA SINICA, 2022, 第 11 作者
（5） SLL-627 Is a Highly Selective and Potent ? Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity, JOURNAL OF MEDICINAL CHEMISTRY, 2022, 第 11 作者
（6） Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic, JOURNAL OF MEDICINAL CHEMISTRY, 2021, 第 11 作者
（7） Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity, MOLECULAR PSYCHIATRY, 2021, 第 2 作者
（8） Amygdalar k-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence, CELL REPORTS, 2021, 第 11 作者
（9） Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory, MOLECULAR PSYCHIATRY, 2021, 第 11 作者
（10） Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation, NEUROPHARMACOLOGY, 2020, 第 11 作者
（11） Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic, EUROPEANJOURNALOFMEDICINALCHEMISTRY, 2020, 第 11 作者
（12） Discovery of a Highly Selective and Potent �� Opioid Receptor Agonist from N -Cyclopropylmethyl-7��-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept., 2019, 第 2 作者
（13） Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a k Partial Agonist and mu Partial Agonist., Sci Rep, 2018, 第 11 作者
（14） ACC to Dorsal Medial Striatum Inputs Modulate Histaminergic Itch Sensation, JOURNAL OF NEUROSCIENCE, 2018, 第 11 作者
（15） 7��-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues, BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 第 6 作者
（16） Src���dependent phosphorylation of �����opioid receptor at Tyr336 modulates opiate withdrawal, EMBO MOLECULAR MEDICINE, 2017, 
（17） Heteromers of �� opioid and dopamine D 1 receptors modulate opioid���induced locomotor sensitization in a dopamine���independent manner, BRITISH JOURNAL OF PHARMACOLOGY, 2017, 第 8 作者
（18） Opioid receptor activation in different brain regions differentially modulate anxiety-related behaviors in mice., Neuropharmacology, 2016, 
（19） The anxiolytic- and anti-depressant-like effects of ATPM-ET, a novel k agonist and m partial agonist, in mice, Psychopharmacol, 2016, 第 11 作者
（20） Novel ��-opioid receptor agonist MB-1C-OH produces potent analgesia with less depression and sedation, ACTA PHARMACOLOGICA SINICA, 2015, 第 0 作者
（21） Role for engagement of-arrestin2 by the transactivated EGFR in agonist-specific regulation of receptor activation of ERK1/2, BRITISH JOURNAL OF PHARMACOLOGY, 2015, 第 2 作者
（22） Pharmacological characterization and therapeutic potential for the treatment of opioid abuse with ATPM-ET, an N-ethyl substituted aminothiazolomorphinan with �� agonist and �� agonist/antagonist activity, EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 第 13 作者

   

（ 1 ） Sirtuin 2调控的微管乙酰化改变在吗啡戒断引起的背侧海马突触骨架重排和负性情绪记忆形成中的作用及机制研究, 负责人, 地方任务, 2023-04--2026-03
（ 2 ） 丘脑前内侧核介导的丘脑皮层通路在痒觉中的调控作用及其机制研究, 负责人, 地方任务, 2020-07--2023-06
（ 3 ） Kappa受体激活介导谷氨酸转运体表达异常在社交逃避抑郁样行为中的作用及机制研究, 负责人, 国家任务, 2018-01--2021-12
（ 4 ） Src酪氨酸激酶在吗啡依赖中的调节作用及机制研究, 负责人, 国家任务, 2015-01--2017-12