基本信息
周小龙 男 博导 中国科学院分子细胞科学卓越创新中心
电子邮件: xlzhou@sibcb.ac.cn
通信地址: 上海市岳阳路320号
邮政编码:
电子邮件: xlzhou@sibcb.ac.cn
通信地址: 上海市岳阳路320号
邮政编码:
招生信息
招生专业
071010-生物化学与分子生物学
招生方向
RNA代谢与线粒体疾病
教育背景
2004-09--2009-05 中国科学院上海生命科学研究院 获得博士学位2000-09--2004-06 安徽师范大学 获得学士学位
工作经历
工作简历
2019-05~2024-04,中国科学院上海生命科学研究院生物化学与细胞生物学研究所, 任职研究组长2017-11~2024-04,中国科学院上海生命科学研究院生物化学与细胞生物学研究所, 任职研究员2009-06~2017-10,中国科学院上海生命科学研究院生物化学与细胞生物学研究所, 任职助理研究员、副研究员2004-09~2009-05,中国科学院上海生命科学研究院, 获得博士学位2000-09~2004-06,安徽师范大学, 获得学士学位
社会兼职
2019-05-01-2024-04-30,中国生物化学与分子生物学学会核酸专业委员会青年委员会, 副主任
专利与奖励
奖励信息
(1) 上海市青年科技启明星, 一等奖, 省级, 2016(2) 赛诺菲-中科院上海生命科学研究院优秀青年人才奖, 一等奖, 研究所(学校), 2012(3) 中科院卢嘉锡青年人才奖, 一等奖, 院级, 2011
出版信息
发表论文
(1) Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development., J Biol Chem, 2023, 第 11 作者(2) Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, REDOX BIOLOGY, 2023, 第 9 作者(3) Selective degradation of tRNA(Ser)(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease, NUCLEIC ACIDS RESEARCH, 2022, 第 11 作者(4) Molecular basis for human mitochondrial tRNA m(3)C modification by alternatively spliced METTL8, NUCLEIC ACIDS RESEARCH, 2022, 第 11 作者(5) Elucidating the molecular mechanisms associated with TARS2-related mitochondrial disease, HUMAN MOLECULAR GENETICS, 2022, 第 11 作者(6) RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation, NUCLEIC ACIDS RESEARCH, 2022, 第 11 作者(7) Commonality and diversity in tRNA substrate recognition in t(6)A biogenesis by eukaryotic KEOPSs, NUCLEIC ACIDS RESEARCH, 2022, 第 11 作者(8) Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis, CELL DISCOVERY, 2021, 第 11 作者(9) 多氨基酰-tRNA合成酶复合物的发生发展, The development of multiple synthetase complex(MSC), 生命科学, 2021, 第 2 作者(10) Modifications of the human tRNA anticodon loop and their associations with genetic diseases, CELLULAR AND MOLECULAR LIFE SCIENCES, 2021, 第 11 作者(11) The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases, NUCLEIC ACIDS RESEARCH, 2021, 第 11 作者(12) Mutually exclusive substrate selection strategy by human m(3)C RNA transferases METTL2A and METTL6, NUCLEIC ACIDS RESEARCH, 2021, 第 11 作者(13) Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, SCIENCE CHINA-LIFE SCIENCES, 2021, 第 11 作者(14) Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, NUCLEIC ACIDS RESEARCH, 2020, 第 11 作者(15) Molecular basis for t 6 A modification in human mitochondria, NUCLEIC ACIDS RESEARCH, 2020, 第 11 作者(16) Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNA^(Lys), Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNA(Lys), SCIENCE CHINA-LIFE SCIENCES, 2020, 第 11 作者(17) 氨基酰-tRNA合成酶与神经系统疾病, Aminoacyl-tRNA synthetase in neuropathy, 生命科学, 2020, 第 2 作者(18) The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase, NUCLEIC ACIDS RESEARCH, 2019, 第 11 作者(19) Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex, NUCLEIC ACIDS RESEARCH, 2019, 第 11 作者(20) Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria, NUCLEIC ACIDS RESEARCH, 2018, 第 2 作者(21) A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities, NUCLEIC ACIDS RESEARCH, 2018, 第 11 作者(22) A natural non-Watson-Crick base pair in human mitochondrial tRNA(Thr) causes structural and functional susceptibility to local mutations, NUCLEIC ACIDS RESEARCH, 2018, 第 11 作者(23) Mutations in KARS cause early-onset hearing loss and leukoencephalopathy: Potential pathogenic mechanism, HUMAN MUTATION, 2017, 第 1 作者(24) Translational Quality Control by Bacterial Threonyl-tRNA Synthetases, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 1 作者(25) A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 11 作者(26) C-terminal Domain of Leucyl-tRNA Synthetase from Pathogenic Candida albicans Recognizes both tRNASer and tRNALeu, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 11 作者(27) Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 第 11 作者(28) Degenerate Connective Polypeptide 1 (CP1) Domain from Human Mitochondrial Leucyl-tRNA Synthetase, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 第 6 作者(29) A minimalist mitochondrial threonyl-tRNA synthetase exhibits tRNA-isoacceptor specificity during proofreading, NUCLEIC ACIDS RESEARCH, 2014, 第 1 作者(30) Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNA(Leu) in the archaeal mode, NUCLEIC ACIDS RESEARCH, 2014, 第 11 作者
科研活动
科研项目
( 1 ) 核糖核酸高效使能的基础与应用研究, 负责人, 中国科学院计划, 2023-10--2028-09( 2 ) 人胞质tRNA第32位3-甲基胞嘧啶修饰的分子机制, 负责人, 国家任务, 2023-01--2026-12( 3 ) 全人工合成细胞, 参与, 中国科学院计划, 2022-07--2026-06( 4 ) 新型冠状病毒重塑宿主细胞关键细胞器的机制研究, 参与, 国家任务, 2021-12--2026-11( 5 ) 蛋白质生物合成, 负责人, 国家任务, 2019-01--2021-12( 6 ) 人线粒体tRNA修饰及其缺陷导致线粒体相关疾病的机理研究, 负责人, 国家任务, 2019-01--2022-12( 7 ) 线粒体tRNAThr及苏氨酰-tRNA合成酶基因突变导致线粒体脑肌病的机理研究, 负责人, 国家任务, 2017-01--2020-12
参与会议
(1)线粒体翻译紊乱导致线粒体功能障碍与疾病 中国生物化学与分子生物学会2023年全国学术会议 2023-10-20(2)氨基酰-tRNA合成酶与线粒体疾病 第10届全国核糖核酸会议 2018-06-15(3)Nitric Oxide (NO)-induced S-nitrosation inhibits aminoacylation and editing activities of human mitochondrial threonyl-tRNA synthetase 2017-10-28(4)KARS突变导致耳聋与智障的分子机理研究 第十三届全国酶学学术讨论会 2017-08-18(5)Human threonyl-tRNA synthetase and disease 全国生化大会 2016-10-20(6)Mitochondrial threonyl-tRNA synthetase and human disease 2015-10-17