基本信息
丁璟珒  男  博导  中国科学院生物物理研究所
电子邮件: jding@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号中国科学院生物物理研究所3403室
邮政编码:

招生信息

   
招生专业
071010-生物化学与分子生物学
招生方向
病原菌感染和天然免疫防御的结构分子机理

教育背景

2003-09--2008-06   中国科学院生物物理研究所   理学博士
1999-09--2003-06   武汉大学生命科学学院   理学学士

工作经历

   
工作简历
2018-01~现在, 中国科学院生物物理研究所, 研究员
2017-01~2017-12,中国科学院生物物理研究所, 项目研究员
2012-01~2016-12,中国科学院生物物理研究所, 副研究员
2010-11~2011-12,中国科学院生物物理研究所, 助理研究员
2008-10~2010-10,中国科学院生物物理研究所, 博士后
2003-09~2008-06,中国科学院生物物理研究所, 理学博士
1999-09~2003-06,武汉大学生命科学学院, 理学学士

出版信息

   
发表论文
(1) Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells, SCIENCE, 2020, 第 14 作者
(2) A bioorthogonal system reveals antitumour immune function of pyroptosis, NATURE, 2020, 第 3 作者
(3) Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis, CELL, 2020, 通讯作者
(4) Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector, MOLECULAR CELL, 2019, 通讯作者
(5) A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy, CELL, 2019, 第 14 作者
(6) Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose, NATURE, 2018, 第 14 作者
(7) Growing a gasdermin pore in membranes of pyroptotic cells, EMBO JOURNAL, 2018, 通讯作者
(8) Growing a gasdermin pore in membranes of pyroptotic cells, The EMBO Journal, 2018, 通讯作者
(9) Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin, NATURE, 2017, 第 4 作者
(10) SnapShot: The Noncanonical Inflammasome, CELL, 2017, 通讯作者
(11) Biochemical and structural characterization of a DNA N 6 -adenine methyltransferase from Helicobacter pylori, ONCOTARGET, 2016, 第 6 作者
(12) Pore-forming activity and structural autoinhibition of the gasdermin family, NATURE, 2016, 第 1 作者
(13) The molecular recognition between cerebral cavernous malformation 2 and mitogen-activated protein kinase kinase kinase 3, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2015, 第 6 作者
(14) Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3, STRUCTURE, 2015, 通讯作者
(15) Biochemical and Structural Insights into RNA Binding by Ssh10b, a Member of the Highly Conserved Sac10b Protein Family in Archaea, JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 
(16) Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis of Cephalosporins, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 第 2 作者
(17) Structural basis of the ultrasensitive calcium indicator GCaMP6, SCIENCE CHINA-LIFE SCIENCES, 2014, 第 1 作者
(18) Structural insights into the unique single-stranded DNA-binding mode of Helicobacter pylori DprA, NUCLEIC ACIDS RESEARCH, 2014, 
(19) Inflammatory caspases are innate immune receptors for intracellular LPS, NATURE, 2014, 
(20) Structural Basis for the Unique Heterodimeric Assembly between Cerebral Cavernous Malformation 3 and Germinal Center Kinase III, STRUCTURE, 2013, 
(21) Structural Basis of the Novel S. pneumoniae Virulence Factor, GHIP, a Glycosyl Hydrolase 25 Participating in Host-Cell Invasion, PLOS ONE, 2013, 通讯作者
(22) Structural Insights into the Pseudomonas aeruginosa Type VI Virulence Effector Tse1 Bacteriolysis and Self-protection Mechanisms, JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 
(23) Crystallization and preliminary X-ray analysis of the C-terminal domain of CCM2, part of a novel adaptor protein involved in cerebral cavernous malformations, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2012, 通讯作者
(24) 绿脓杆菌特有的Tsi2三维结构——一种全新卷曲螺旋构象的类抗毒素蛋白, Three Dimensional Structure of Pseudomonas aeruginosa Tsi2: a Novel Species-specific Antitoxin-like Protein With Coiled Coil Conformation, 生物化学与生物物理进展, 2012, 第 2 作者
(25) Three Dimensional Structure of Pseudomonas aeruginosa Tsi2: a Novel Species-specific Antitoxin-like Protein With Coiled Coil Conformation, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2012, 
(26) Crystallization and preliminary crystallographic studies of CCM3 in complex with the C-terminal domain of MST4, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2012, 通讯作者
(27) Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 
(28) Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: A novel adaptor protein involved in human cerebral cavernous malformation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 
(29) Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure, JOURNAL OF STRUCTURAL BIOLOGY, 2010, 
(30) 黄精凝集素PCL和其甘露糖复合物的晶体结构解析及结构与功能关系研究, 2008, 第 1 作者
(31) Crystallization and Preliminary X-Ray Diffraction Analysis of a Novel Mannose-Binding Lectin with Antiretroviral Properties from Polygonatum cyrtonema Hua, PROTEIN AND PEPTIDE LETTERS, 2008, 第 1 作者

科研活动

   
科研项目
( 1 ) 病原体感染和宿主天然免疫防御的结构分子机理研究, 负责人, 中国科学院计划, 2018-07--2023-06
( 2 ) 病原菌感染和宿主天然免疫防御, 负责人, 国家任务, 2020-01--2022-12