基本信息
李礼 男 博导 中国科学院重庆绿色智能技术研究院
电子邮件: lili@cigit.ac.cn
通信地址: 重庆市北碚区方正大道266号
邮政编码: 400714
电子邮件: lili@cigit.ac.cn
通信地址: 重庆市北碚区方正大道266号
邮政编码: 400714
招生信息
招生专业
0710J1-纳米科学与技术080502-材料学071008-发育生物学
招生方向
生物新材料巨噬细胞发育的分子调控机制
教育背景
2007-01--2011-11 香港科技大学生物化学系 博士学位2000-09--2005-06 复旦大学公共卫生学院 学士学位
工作经历
工作简历
2021-01~现在, 中国科学院重庆绿色智能技术研究院, 研究员、博士生导师2012-02~2021-01,西南大学生命科学学院, 研究员、博士生导师2011-11~2012-02,香港科技大学生物化学系, 博士后2007-01~2011-11,香港科技大学生物化学系, 博士学位2005-07~2006-08,上海市黄浦区疾病预防控制中心, 预防医师2000-09~2005-06,复旦大学公共卫生学院, 学士学位
社会兼职
2023-01-01-2026-12-31,中国细胞生物学学会第十三届理事会, 常务理事
专利与奖励
奖励信息
(1) 香港科技大学理学院最佳毕业论文奖, 研究所(学校), 2011
专利成果
( 1 ) 一种以氨基聚乙二醇为凝胶基质的抗菌凝胶的制备方法, 2022, 第 3 作者, 专利号: CN114230808A( 2 ) 一种以聚乙烯亚胺为凝胶基质的抗菌凝胶的制备方法, 2022, 第 4 作者, 专利号: CN114209877A
出版信息
发表论文
(1) Tumor microenvironment targeting for glioblastoma multiforme treatment viahybrid cell membrane coating supramolecular micelles., Journal of Control Release, 2024, (2) TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry, Nature Communications, 2024, (3) scMMT: A Multi-use Deep Learning Approach for Cell Annotation, Protein Prediction, and Embedding in Single-cell RNA-seq Data, Briefings in Bioinformatics, 2024, (4) Alterations in immune cell heterogeneities in the brain of aged zebrafish using single-cell resolution, SCIENCE CHINA-LIFE SCIENCES, 2023, 第 11 作者(5) Nrf2 dictates the neuronal survival and differentiation of embryonic zebrafish harboring compromised alanyl-tRNA synthetase, DEVELOPMENT, 2022, 第 11 作者(6) CXCR4-CXCL12 axis promotes T-cell reconstitution via efficient hematopoietic immigration, Journal of Genetics and Genomics, 2022, 第 11 作者(7) Brain milieu induces early microglial maturation through the BAX-Notch axis, NATURE COMMUNICATIONS, 2022, 第 11 作者(8) FDA-Approved Drug Screening for Compounds That Facilitate Hematopoietic Stem and Progenitor Cells (HSPCs) Expansion in Zebrafish, CELLS, 2021, 第 11 作者(9) Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 第 5 作者(10) Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish, JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021, 第 9 作者(11) Rapid orderly migration of neutrophils after traumatic brain injury depends on MMP9/13, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 第 11 作者(12) Macrophage derived IL-1�� regulates emergency myelopoiesis via the NF-��B and C/ebp�� in zebrafish, The Journal of Immunology, 2020, 第 11 作者(13) Ikzf1 regulates embryonic T lymphopoiesis via Ccr9 and Irf4 in zebrafish, JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 第 11 作者(14) Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 第 16 作者(15) The effector of Hippo signaling, Taz, is required for formation of the micropyle and fertilization in zebrafish, PLOS GENETICS, 2019, 第 7 作者(16) Caudal dorsal artery generates hematopoietic stem and progenitor cells via the endothelial-to-hematopoietic transition in zebrafish, JOURNAL OF GENETICS AND GENOMICS, 2018, 第 11 作者(17) Irf8 regulates the progression of myeloproliferative neoplasm (MPN)-like syndrome via Mertk signaling in zebrafish, Leukemia, 2018, 第 11 作者(18) Distinct regulatory networks control the development of macrophages of different origins in zebrafish, BLOOD, 2017, 第 6 作者(19) Macrophages Mediate the Repair of Brain Vascular Rupture through Direct Physical Adhesion and Mechanical Traction, IMMUNITY, 2016, 第 5 作者(20) cMyb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish, EXPERIMENTAL HEMATOLOGY, 2016, 第 10 作者(21) Il-1 beta and Reactive Oxygen Species Differentially Regulate Neutrophil Directional Migration and Basal Random Motility in a Zebrafish Injury-Induced Inflammation, JOURNAL OF IMMUNOLOGY, 2014, 第 8 作者(22) Suppression of Pu.1 function results in expanded myelopoiesis in zebrafish, LEUKEMIA, 2013, (23) Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop inhibiting Pu.1 expression, BLOOD, 2012, 第 2 作者(24) Live Imaging Reveals Differing Roles of Macrophages and Neutrophils during Zebrafish Tail Fin Regeneration, JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 第 1 作者(25) Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis, BLOOD, 2011, 第 1 作者
科研活动
科研项目
( 1 ) 造血系统发育过程中细胞类群动态变化及互作研究, 负责人, 国家任务, 2023-12--2028-11( 2 ) 儿童遗传病多组学鉴定与基因治疗技术研究, 负责人, 地方任务, 2023-09--2026-09( 3 ) 干细胞与衰老研究, 负责人, 中国科学院计划, 2023-02--2027-01( 4 ) Tango6介导RBP2入核调控造血干祖细胞扩增的机制研究, 负责人, 国家任务, 2023-01--2026-12( 5 ) 高胆固醇及致病基因对于代谢器官等发育的影响和调 控机制, 负责人, 国家任务, 2019-12--2024-11( 6 ) 发育生物学, 负责人, 国家任务, 2019-01--2021-12( 7 ) Bax调控小神经胶质细胞发育的分子机制研究, 负责人, 国家任务, 2018-01--2021-12( 8 ) 源于斑马鱼尾部主动脉的造血干细胞的谱系分化及调控机制研究, 负责人, 国家任务, 2016-01--2019-12( 9 ) 肝脏的细胞分化及再生调控, 负责人, 国家任务, 2015-05--2020-05