基本信息
李小双 女 博导 中国科学院新疆生态与地理研究所
电子邮件： lixs@ms.xjb.ac.cn
通信地址： 新疆乌鲁木齐新市区北京南路818号新疆生态与地理研究所
邮政编码： 830011
电子邮件： lixs@ms.xjb.ac.cn
通信地址： 新疆乌鲁木齐新市区北京南路818号新疆生态与地理研究所
邮政编码： 830011
招生信息
招生专业
071001-植物学
招生方向
植物抗逆分子机理
植物抗逆分子育种
植物逆境生理
植物抗逆分子育种
植物逆境生理
教育背景
2013-02--2014-03 美国南伊利诺伊大学 联合培养博士
2008-09--2014-07 中国科学院新疆生态与地理研究所 博士
2008-09--2014-06 新疆大学 学士
2008-09--2014-07 中国科学院新疆生态与地理研究所 博士
2008-09--2014-06 新疆大学 学士
工作经历
工作简历
2019-12~现在, 新疆生态与地理研究所, 研究员
2018-12~2019-11,中国科学院新疆生态与地理研究所, 副研究员
2014-06~2018-12,中国科学院新疆生态与地理研究所, 助理研究员
2018-12~2019-11,中国科学院新疆生态与地理研究所, 副研究员
2014-06~2018-12,中国科学院新疆生态与地理研究所, 助理研究员
社会兼职
2021-01-01-2022-12-31,中国植物生理和植物分子生物学学会会员,
2019-11-01-今,沈阳农业大学兼职教授,
2019-11-01-今,沈阳农业大学兼职教授,
教授课程
利用组学技术开展抗逆生物学研究
专利与奖励
奖励信息
（1） 新疆维吾尔自治区自然科学优秀学术论文, 三等奖, 省级, 2018
（2） 优秀女青年, 其他, 2018
（3） 新疆维吾尔自治区科学技术进步奖, 一等奖, 省级, 2017
（4） 第十三届自治区科学优秀学术论文一等奖, 一等奖, 省级, 2016
（5） 新疆维吾尔自治区科学技术进步奖, 二等奖, 省级, 2015
（2） 优秀女青年, 其他, 2018
（3） 新疆维吾尔自治区科学技术进步奖, 一等奖, 省级, 2017
（4） 第十三届自治区科学优秀学术论文一等奖, 一等奖, 省级, 2016
（5） 新疆维吾尔自治区科学技术进步奖, 二等奖, 省级, 2015
专利成果
[1] 李小双, 乔思琪, 张道远. 一种基于同化枝诱导的准噶尔无叶豆快速扩繁体系建立的方法. CN202211171215.0, 2022-09-24.
[2] 李小双, 张道远, 杨瑞瑞, 梁玉青, 杨红兰. 齿肋赤藓ScSoloist基因及其应用. CN: CN114106119A, 2022-03-01.
[3] 张道远, 周平, 刘秀瑾, 李小双, 杨红兰. BaZFP924蛋白及其相关生物材料与应用. CN202110900671.3, 2021-08-06.
[4] 张道远, 周平, 刘秀瑾, 张燕, 李小双, 杨红兰. 一种农杆菌介导的苔藓的稳定遗传转化方法. CN: CN112852864A, 2021-05-28.
[5] 张道远, 托合热·博佐罗夫, 古丽娜孜·卡哈尔, 杨红兰, 李小双. 从苹小吉丁虫幼虫肠道中提取化合物吩嗪-1-羧酸的方法及应用. CN: CN111018796A, 2020-04-17.
[6] 张道远, 张燕, 周平, 杨红兰, 李小双. 一种基于CRISPR/Cas9系统对新疆野苹果基因多靶点定点突变的方法. CN: CN110408652A, 2019-11-05.
[7] 张道远, 刘秀瑾, 杨红兰, 李小双. 齿肋赤藓早期光诱导蛋白基因ScELIP1和ScELIP2的用途. CN: CN110317827A, 2019-10-11.
[8] 张道远, 张燕, 刘晓洁, 李小双, 杨红兰. 一种基于愈伤组织分化的新疆野苹果再生体系建立的方法. CN: CN109169287A, 2019-01-11.
[9] 刘晓洁, 张道远, 卓露, 杨红兰, 李小双. 一种组织培养基中受霉菌污染苔藓的恢复及复壮的方法. CN: CN106035092B, 2018-06-05.
[10] 张道远, 杨红兰, 王建成, 李小双. 极端耐干齿肋赤藓醛脱氢酶基因及其编码蛋白. CN: CN107630026A, 2018-01-26.
[11] 张道远, 李小双, 刘晓洁. 一种苹果腐烂病病原菌快速接菌及致病力快速鉴定的方法. CN: CN107517726A, 2017-12-29.
[12] 张道远, 卓露, 杨红兰, 李小双. 一种真菌和霉菌污染培养基苔藓的恢复及复壮的方法. CN: CN106035092A, 2016-10-26.
[13] 张道远, 卓露, 李小双, 杨红兰. 野生极端耐干旱植物齿肋赤藓外源基因瞬时转化方法. CN: CN104830900A, 2015-08-12.
[14] 张道远, 李小双, 李海燕, 杨红兰. 沙漠齿肋赤藓实时荧光定量PCR内参分子的筛选方法. CN: CN103866007A, 2014-06-18.
[15] 张道远, 李海燕, 李小双. 极端耐旱齿肋赤藓4个DREB转录因子及其编码基因. CN: CN103755793A, 2014-04-30.
[16] 李小双, 张道远, 杨红兰, 张元明. 准噶尔无叶豆EsDREB基因的用途. CN: CN102978238A, 2013-03-20.
[17] 张道远, 李小双, 李海燕. 适用于PCR的棉花基因组DNA快速、批量制备方法. CN: CN102925430A, 2013-02-13.
[18] 张道远, 李小双, 杨红兰, 裴金玲, 蔡明. 利用晚期胚胎发生丰富蛋白及其编码基因培育抗旱转基因棉花. CN: CN102732552A, 2012-10-17.
[19] 张道远, 杨红兰, 李小双. 利用乙醛脱氢酶及其编码基因在培育抗旱转基因棉花中的应用. CN: CN102643857A, 2012-08-22.
[20] 杨红兰, 张道远, 李小双, 张元明. 极端耐旱齿肋赤藓单株克隆系的保存、活化及快速扩繁方法. CN: CN102626050A, 2012-08-08.
[21] 李小双, 张道远, 杨红兰, 裴金玲, 蔡明, 张远明. 超旱生植物准噶尔无叶豆DREB转录因子EsDREB及编码基因和应用. CN: CN102424702A, 2012-04-25.
[22] 李小双, 张道远, 杨红兰, 裴金玲. 一种沙漠植物准噶尔无叶豆实时荧光定量PCR内参分子的筛选方法. CN: CN102321758A, 2012-01-18.
[2] 李小双, 张道远, 杨瑞瑞, 梁玉青, 杨红兰. 齿肋赤藓ScSoloist基因及其应用. CN: CN114106119A, 2022-03-01.
[3] 张道远, 周平, 刘秀瑾, 李小双, 杨红兰. BaZFP924蛋白及其相关生物材料与应用. CN202110900671.3, 2021-08-06.
[4] 张道远, 周平, 刘秀瑾, 张燕, 李小双, 杨红兰. 一种农杆菌介导的苔藓的稳定遗传转化方法. CN: CN112852864A, 2021-05-28.
[5] 张道远, 托合热·博佐罗夫, 古丽娜孜·卡哈尔, 杨红兰, 李小双. 从苹小吉丁虫幼虫肠道中提取化合物吩嗪-1-羧酸的方法及应用. CN: CN111018796A, 2020-04-17.
[6] 张道远, 张燕, 周平, 杨红兰, 李小双. 一种基于CRISPR/Cas9系统对新疆野苹果基因多靶点定点突变的方法. CN: CN110408652A, 2019-11-05.
[7] 张道远, 刘秀瑾, 杨红兰, 李小双. 齿肋赤藓早期光诱导蛋白基因ScELIP1和ScELIP2的用途. CN: CN110317827A, 2019-10-11.
[8] 张道远, 张燕, 刘晓洁, 李小双, 杨红兰. 一种基于愈伤组织分化的新疆野苹果再生体系建立的方法. CN: CN109169287A, 2019-01-11.
[9] 刘晓洁, 张道远, 卓露, 杨红兰, 李小双. 一种组织培养基中受霉菌污染苔藓的恢复及复壮的方法. CN: CN106035092B, 2018-06-05.
[10] 张道远, 杨红兰, 王建成, 李小双. 极端耐干齿肋赤藓醛脱氢酶基因及其编码蛋白. CN: CN107630026A, 2018-01-26.
[11] 张道远, 李小双, 刘晓洁. 一种苹果腐烂病病原菌快速接菌及致病力快速鉴定的方法. CN: CN107517726A, 2017-12-29.
[12] 张道远, 卓露, 杨红兰, 李小双. 一种真菌和霉菌污染培养基苔藓的恢复及复壮的方法. CN: CN106035092A, 2016-10-26.
[13] 张道远, 卓露, 李小双, 杨红兰. 野生极端耐干旱植物齿肋赤藓外源基因瞬时转化方法. CN: CN104830900A, 2015-08-12.
[14] 张道远, 李小双, 李海燕, 杨红兰. 沙漠齿肋赤藓实时荧光定量PCR内参分子的筛选方法. CN: CN103866007A, 2014-06-18.
[15] 张道远, 李海燕, 李小双. 极端耐旱齿肋赤藓4个DREB转录因子及其编码基因. CN: CN103755793A, 2014-04-30.
[16] 李小双, 张道远, 杨红兰, 张元明. 准噶尔无叶豆EsDREB基因的用途. CN: CN102978238A, 2013-03-20.
[17] 张道远, 李小双, 李海燕. 适用于PCR的棉花基因组DNA快速、批量制备方法. CN: CN102925430A, 2013-02-13.
[18] 张道远, 李小双, 杨红兰, 裴金玲, 蔡明. 利用晚期胚胎发生丰富蛋白及其编码基因培育抗旱转基因棉花. CN: CN102732552A, 2012-10-17.
[19] 张道远, 杨红兰, 李小双. 利用乙醛脱氢酶及其编码基因在培育抗旱转基因棉花中的应用. CN: CN102643857A, 2012-08-22.
[20] 杨红兰, 张道远, 李小双, 张元明. 极端耐旱齿肋赤藓单株克隆系的保存、活化及快速扩繁方法. CN: CN102626050A, 2012-08-08.
[21] 李小双, 张道远, 杨红兰, 裴金玲, 蔡明, 张远明. 超旱生植物准噶尔无叶豆DREB转录因子EsDREB及编码基因和应用. CN: CN102424702A, 2012-04-25.
[22] 李小双, 张道远, 杨红兰, 裴金玲. 一种沙漠植物准噶尔无叶豆实时荧光定量PCR内参分子的筛选方法. CN: CN102321758A, 2012-01-18.
出版信息
发表论文
[1] Environmental and Experimental Botany. 2024, 通讯作者
[2] Plant Physiology. 2024, 第 2 作者
[3] International Journal of Biological Macromolecules. 2024, 通讯作者
[4] Plants. 2023, 通讯作者
[5] Plant Cell Physiology. 2023, 通讯作者
[6] Xiujin Liu, Xiaoshuang Li, Honglan Yang, Ruirui Yang, Daoyuan Zhang. Genome-Wide Characterization and Expression Profiling of ABA Biosynthesis Genes in a Desert Moss Syntrichia caninervis. PLANTS[J]. 2023, 第 2 作者12: https://doaj.org/article/9356ec06be65422ca1178d2a12142caf.
[7] Haron Salih, Wenwan Bai, Mingqi Zhao, Yuqing Liang, Ruirui Yang, Daoyuan Zhang, Xiaoshuang Li. Genome-Wide Characterization and Expression Analysis of Transcription Factor Families in Desert Moss Syntrichia caninervis under Abiotic Stresses. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2023, 第 7 作者24(7): https://doaj.org/article/25e1b425d7394a9d88209b2e5a8bcca0.
[8] Li, Xiaoshuang, Yang, Ruirui, Liang, Yuqing, Gao, Bei, Li, Shimin, Bai, Wenwan, Oliver, Melvin J, Zhang, Daoyuan. The ScAPD1-like gene from the desert moss Syntrichia caninervis enhances resistance to Verticillium dahliae via phenylpropanoid gene regulation. PLANT JOURNAL[J]. 2023, 第 1 作者113(1): 75-91,
[9] Shanshan Jia, Xiaojie Liu, Xuejing Wen, Abdul Waheed, Yu Ding, Gulnaz Kahar, Xiaoshuang Li, Daoyuan Zhang, Hironori Kaminaka, William Underwood. Genome-Wide Identification of bHLH Transcription Factor Family in Malus sieversii and Functional Exploration of MsbHLH155.1 Gene under Valsa Canker Infection. PLANTS[J]. 2023, 第 7 作者12(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919239/.
[10] Yang, Ruirui, Li, Xiaoshuang, Yang, Qilin, Zhao, Mingqi, Bai, Wenwan, Liang, Yuqing, Liu, Xiujin, Gao, Bei, Zhang, Daoyuan. Transcriptional profiling analysis providing insights into desiccation tolerance mechanisms of the desert moss Syntrichia caninervis. FRONTIERS IN PLANT SCIENCE[J]. 2023, 第 2 作者 通讯作者 14: http://dx.doi.org/10.3389/fpls.2023.1127541.
[11] 闫振, 牙库甫江阿西木, 刘秀瑾, 李小双, 张道远, 李进. 丁香假单胞菌在3种苔藓中的致病性研究. 云南农业大学学报:自然科学版[J]. 2023, 第 4 作者38(3): 383-391, http://lib.cqvip.com/Qikan/Article/Detail?id=7110157651.
[12] Liu, Jinyuan, Yang, Ruirui, Liang, Yuqing, Wang, Yan, Li, Xiaoshuang. The DREB A-5 Transcription Factor ScDREB5 From Syntrichia caninervis Enhanced Salt Tolerance by Regulating Jasmonic Acid Biosynthesis in Transgenic Arabidopsis. FRONTIERS IN PLANT SCIENCE[J]. 2022, 第 5 作者 通讯作者 13: http://dx.doi.org/10.3389/fpls.2022.857396.
[13] 赵明奇, 刘晓洁, 梁玉青, 杨瑞瑞, 李小双. 新疆野苹果AP2/ERF转录因子家族鉴定与响应腐烂病的表达分析. 西北植物学报. 2022, 第 5 作者42(6): 930-942, https://d.wanfangdata.com.cn/periodical/xbzwxb202206004.
[14] 杨瑞瑞, 李小双, 梁玉青, 张道远. 植物激素在苔藓生长发育与逆境响应过程中的作用机制研究进展. 西北植物学报[J]. 2022, 第 2 作者42(3): 527-540, http://lib.cqvip.com/Qikan/Article/Detail?id=7106936305.
[15] Zhao, Mingqi, Haxim, Yakupjan, Liang, Yuqing, Qiao, Siqi, Gao, Bei, Zhang, Daoyuan, Li, Xiaoshuang. Genome-wide investigation of AP2/ERF gene family in the desert legume Eremosparton songoricum: Identification, classification, evolution, and expression profiling under drought stress. FRONTIERS IN PLANT SCIENCE[J]. 2022, 第 7 作者 通讯作者 13: http://dx.doi.org/10.3389/fpls.2022.885694.
[16] Zhou, Ping, Liu, Xiujin, Li, Xiaoshuang, Zhang, Daoyuan. BaZFP1, a C2H2 Subfamily Gene in Desiccation-Tolerant Moss Bryum argenteum, Positively Regulates Growth and Development in Arabidopsis and Mosses. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2022, 第 3 作者23(21): http://dx.doi.org/10.3390/ijms232112894.
[17] Zhou, Ping, Li, Xiaoshuang, Liu, Xiaojie, Wen, Xuejing, Zhang, Yan, Zhang, Daoyuan. Transcriptome profiling of Malus sieversii under freezing stress after being cold-acclimated. BMC GENOMICS[J]. 2021, 第 2 作者22(1): http://dx.doi.org/10.1186/s12864-021-07998-0.
[18] Zhang, HongXiang, Li, XiaoShuang, Wang, JianCheng, Zhang, DaoYuan. Insights into the aridification history of Central Asian Mountains and international conservation strategy from the endangered wild apple tree. JOURNAL OF BIOGEOGRAPHY[J]. 2021, 第 2 作者48(2): 332-344, http://dx.doi.org/10.1111/jbi.13999.
[19] Yang, Honglan, Bozorov, Tohir A, Chen, Xiaoping, Zhang, Dawei, Wang, Jiancheng, Li, Xiaoshuang, Gui, Dongwei, Qi, Zhiming, Zhang, Daoyuan. Yield Comparisons between Cotton Variety Xin Nong Mian 1 and Its Transgenic ScALDH21 Lines under Different Water Deficiencies in a Desert-Oasis Ecotone. AGRONOMY-BASEL[J]. 2021, 第 6 作者11(5): http://dx.doi.org/10.3390/agronomy11051019.
[20] Liu, Xiujin, Zhou, Ping, Li, Xiaoshuang, Zhang, Daoyuan. Propagation of desert moss Syntrichia caninervis in peat pellet: a method for rapidly obtaining large numbers of cloned gametophytes. PLANT METHODS[J]. 2021, 第 3 作者17(1): https://doaj.org/article/8df0e404613e4a08b5a6e6800a8e2fc7.
[21] Liang Yuqing, Li Xiaoshuang, Zhang Jing, Zhuo Lu, Liu Xiaojie, Yang Ruirui, Zhang Daoyuan. Dehydration rates impact physiological, biochemical and molecular responses in desert moss Bryum argenteum. ENVIRONMENTAL AND EXPERIMENTAL BOTANY[J]. 2021, 第 2 作者 通讯作者 183: http://dx.doi.org/10.1016/j.envexpbot.2020.104346.
[22] Liu, Xiaojie, Li, Xiaoshuang, Wen, Xuejing, Zhang, Yan, Ding, Yu, Zhang, Yiheng, Gao, Bei, Zhang, Daoyuan. PacBio full-length transcriptome of wild apple (Malus sieversii) provides insights into canker disease dynamic response. BMC GENOMICS[J]. 2021, 第 2 作者22(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809858/.
[23] Liang, Yuqing, Li, Xiaoshuang, Yang, Ruirui, Gao, Bei, Yao, Juanxia, Oliver, Melvin J, Zhang, Daoyuan. BaDBL1, a unique DREB gene from desiccation tolerant moss Bryum argenteum, confers osmotic and salt stress tolerances in transgenic Arabidopsis. PLANT SCIENCE[J]. 2021, 第 2 作者 通讯作者 313: http://dx.doi.org/10.1016/j.plantsci.2021.111047.
[24] Haxim, Yakupjan, Si, Yu, Liu, Xiaojie, Wen, Xuejing, Kahar, Gulnaz, Ding, Yu, Li, Xiaoshuang, Zhang, Daoyuan. Genome-Wide Characterization of HSP90 Gene Family in Malus sieversii and Their Potential Roles in Response to Valsa mali Infection. FORESTS[J]. 2021, 第 7 作者12(9): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000700629300001.
[25] Silva, Anderson T, Gao, Bei, Fisher, Kirsten M, Mishler, Brent D, Ekwealor, Jenna T B, Stark, Lloyd R, Li, Xiaoshuang, Zhang, Daoyuan, Bowker, Matthew A, Brinda, John C, Coe, Kirsten K, Oliver, Melvin J. To dry perchance to live: Insights from the genome of the desiccation-tolerant biocrust moss Syntrichia caninervis. PLANT JOURNAL[J]. 2021, 第 7 作者105(5): 1339-1356, http://dx.doi.org/10.1111/tpj.15116.
[26] Liu, Xiaojie, Zhang, Yiheng, Zhou, Tong, Li, Xiaoshuang, Wen, Xuejing, Zhang, Daoyuan. Full-Length Transcriptome-Wide Characteristic and Functional Identification of WRKY Family in Malus sieversii during the Valsa Canker Disease Response. FORESTS[J]. 2021, 第 4 作者12(6):
[27] Zhuo, Lu, Liang, Yuqing, Yang, Honglan, Li, Xiaoshuang, Zhang, Yiheng, Zhang, Yigong, Guan, Kaiyun, Zhang, Daoyuan. Thermal tolerance of dried shoots of the moss Bryum argenteum. JOURNAL OF THERMAL BIOLOGY[J]. 2020, 第 4 作者89: http://dx.doi.org/10.1016/j.jtherbio.2019.102469.
[28] Liu, Xiaojie, Li, Xiaoshuang, Bozorov, Tohir A, Ma, Rong, Ma, Jinbiao, Zhang, Yiheng, Yang, Honglan, Li, Li, Zhang, Daoyuan. Characterization and pathogenicity of six Cytospora strains causing stem canker of wild apple in the Tianshan Forest, China. FOREST PATHOLOGY[J]. 2020, 第 2 作者50(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000517641000001.
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[56] 李小双. Overexpression of ScALDH21 gene in cotton improves drought tolerance and growth confers drought in greenhouse and filed conditions. Molecular Breeding. 2016, 第 1 作者
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[59] Li, Xiaoshuang, Zhang, Daoyuan, Li, Haiyan, Gao, Bei, Yang, Honglan, Zhang, Yuanming, Wood, Andrew J. Characterization of reference genes for RT-qPCR in the desert moss Syntrichia caninervis in response to abiotic stress and desiccation/rehydration. FRONTIERS IN PLANT SCIENCE[J]. 2015, 第 1 作者6: https://doaj.org/article/88d0b9e63fb54f31b977cfa1ad60e5b0.
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科研活动
科研项目
（ 1 ） 极端耐干藓类齿肋赤藓A-5类DREB转录因子调控耐干性分子机制研究, 主持, 国家级, 2019-01--2022-12
（ 2 ） 自治区天池****, 主持, 省级, 2018-01--2020-12
（ 3 ） 中国科学院青年促进会项目, 主持, 部委级, 2018-01--2020-12
（ 4 ） 新疆野苹果优质抗腐烂病关键基因的挖掘和应用, 主持, 部委级, 2017-01--2019-12
（ 5 ） A-5类DREB转录因子家族调控齿肋赤藓耐干分子机制研究, 主持, 部委级, 2019-09--2024-09
（ 2 ） 自治区天池****, 主持, 省级, 2018-01--2020-12
（ 3 ） 中国科学院青年促进会项目, 主持, 部委级, 2018-01--2020-12
（ 4 ） 新疆野苹果优质抗腐烂病关键基因的挖掘和应用, 主持, 部委级, 2017-01--2019-12
（ 5 ） A-5类DREB转录因子家族调控齿肋赤藓耐干分子机制研究, 主持, 部委级, 2019-09--2024-09
指导学生
现指导学生
赵明奇 硕士研究生 071001-植物学
乔思琪 硕士研究生 086000-生物与医药