基本信息
罗爽  男  硕导  中国科学院广州生物医药与健康研究院
电子邮件: luo_shuang@gibh.ac.cn
通信地址: 广东省广州市黄埔区科学城开源大道190号
邮政编码:

招生信息

   
招生专业
100701-药物化学
081701-化学工程
招生方向
药物化学,有机合成

教育背景

2005-09--2010-06   南开大学   博士
2001-09--2005-06   南开大学   学士

工作经历

   
工作简历
2013-07~2018-12,中国科学院广州生物医药与健康研究院, 副研究员
2011-04~2013-06,北京大学, 博士后
2005-09~2010-06,南开大学, 博士
2001-09~2005-06,南开大学, 学士

专利与奖励

   
专利成果
( 1 ) 有机化合物及其制备方法, 2022, 第 3 作者, 专利号: 202110022559.4

( 2 ) 多取代吲哚类化合物及其应用, 2019, 第 7 作者, 专利号: CN109665985A

出版信息

   
发表论文
(1) Palladium-Catalyzed Four-Component Cascade Imidoyl-Carbamoylation of Unactivated Alkenes, ACS Catalysis, 2022, 通讯作者
(2) Palladium-Catalyzed Tandem Heck/Carbonylation/Aminocarbonylation En Route to Chiral Heterocyclic α-Ketoamides., Organic Chemistry Frontiers, 2022, 通讯作者
(3) Inherently Chiral 6,7-Diphenyldibenzo[e,g][1,4]diazocine: Enantioselective Synthesis and Application as a Ligand Platform., CCS Chemistry, 2022, 通讯作者
(4) A New Saddle-Shaped Aza Analog of Tetraphenylene: Atroposelective Synthesis and Application as a Chiral Acylating Reagent., CCS Chemistry, 2021, 通讯作者
(5) Palladium-Catalyzed Atroposelective Coupling-Cyclization of 2-Isocyanobenzamides to Construct Axially Chiral 2-Aryl- and 2,3-Diarylquinazolinones, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, 通讯作者
(6) Palladium-Catalyzed Enantioselective 7-exo-Trig Carbopalladation/Carbonylation: Cascade Reactions To Achieve Atropisomeric Dibenzob,dazepin-6-ones, ORGANIC LETTERS, 2021, 通讯作者
(7) Pd-catalyzed imine-directed intramolecular CsbndN bond formation through C(sp3)sbndH activation: An efficient approach to multisubstituted pyrroles, Tetrahedron Letters, 2020, 通讯作者
(8) Pd-catalyzed imine-directed intramolecular C-N bond formation through C(sp(3))-H activation: An efficient approach to multisubstituted pyrroles, TETRAHEDRON LETTERS, 2020, 通讯作者
(9) Pd-Catalyzed Domino Imidoylation/Heck/C(sp(2))-H Cyclization: Isocyanide Relay Strategy toward Tricyclic-Fused Heterocycles Containing an All-Carbon Quaternary Center, ORGANIC LETTERS, 2020, 通讯作者
(10) Enantioselective Synthesis of 2-Oxindole Spirofused Lactones and Lactams by Heck/Carbonylative Cylization Sequences: Method Development and Applications, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 通讯作者
(11) Selective C-H or N-H Imidoylative Annulation of 2-(2-Isocyanophenyl)-1H-indoles Leading to Diverse Indole-fused Scaffolds, ADVANCED SYNTHESIS & CATALYSIS, 2019, 通讯作者
(12) Pd-Catalyzed C(sp(2))-H Imidoylative Annulation: A General Approach To Construct Dibenzoox(di)azepines, JOURNAL OF ORGANIC CHEMISTRY, 2019, 通讯作者
(13) Enantioselective Synthesis of Planar Chiral Pyridoferrocenes via Palladium-Catalyzed Imidoylative Cyclization Reactions, ORGANIC LETTERS, 2018, 通讯作者
(14) Stirring-controlled mono or double aminocarbonylation of 1,3-bis(2-iodoaryl)propan-2-amines, TETRAHEDRON LETTERS, 2018, 通讯作者
(15) Palladium-catalyzed beta-selective C(sp(2))-H carboxamidation of enamides by isocyanide insertion: synthesis of N-acyl enamine amides, ORGANIC CHEMISTRY FRONTIERS, 2017, 通讯作者
(16) Palladium-catalyzed C(sp(2))-H aminoimidoylation of isocyano-containing arenes: synthesis of amino substituted N-heterocycles, ORGANIC CHEMISTRY FRONTIERS, 2017, 通讯作者
(17) Palladium-catalyzed β-selective C(sp2)–H carboxamidation of enamides by isocyanide insertion: synthesis of N-acyl enamine amides, Org. Chem. Front., 2017, 通讯作者
(18) Pd-Catalyzed C(sp(2))-H carbonylation of 2-benzylpyridines for the synthesis of pyridoisoquinolinones, CHEMICAL COMMUNICATIONS, 2016, 通讯作者
(19) Dearomative C-C and C-N bond cleavage of 2-arylindoles: transition-metal-free access to 2-aminoarylphenones, ORGANIC CHEMISTRY FRONTIERS, 2016, 通讯作者
(20) A metal-free synthesis of 2-aminobenzothiazoles through aminyl radical addition to aryl isothiocyanates, CHEMICAL COMMUNICATIONS, 2016, 第 3 作者
(21) Aminopalladation-Triggered Carbene Insertion Reaction: Synthesis of 2-(1H-Indol-3-yl)acetates, ADVANCED SYNTHESIS & CATALYSIS, 2015, 通讯作者
(22) Palladium-catalyzed intermolecular C-H amidation of indoles with sulfonyl azides, SCIENCE CHINA-CHEMISTRY, 2015, 通讯作者
(23) Palladium-Catalyzed Intramolecular C(sp(2))-H Imidoylation for the Synthesis of Six-Membered N-Heterocycles, JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 3 作者
(24) A room-temperature synthesis of 2,2 '-bisoxazoles through palladium-catalyzed oxidative coupling of alpha-isocyanoacetamides, ORGANIC CHEMISTRY FRONTIERS, 2014, 第 2 作者
(25) Copper-mediated C(sp(2))-H amination using TMSN3 as a nitrogen source: redox-neutral access to primary anilines, ORGANIC CHEMISTRY FRONTIERS, 2014, 第 4 作者
(26) Palladium-Catalyzed Imidoylative Cyclization of alpha-Isocyanoacetamides: Efficient Access to C2-Diversified Oxazoles, CHEMISTRY-A EUROPEAN JOURNAL, 2014, 第 2 作者
(27) Palladium-Catalyzed Imidoylative Cyclization of a- Isocyanoacetamides: Efficient Access to C2-Diversified Oxazoles, Chem. Eur. J., 2014, 第 1 作者
(28) Synthesis of Dibenzopyranones through Palladium-Catalyzed Directed C-H Activation/Carbonylation of 2-Arylphenols, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 第 1 作者
(29) Fe-promoted cross coupling of homobenzylic methyl ethers with Grignard reagents via sp(3) C-O bond cleavage, CHEMICAL COMMUNICATIONS, 2013, 第 1 作者

科研活动

   
科研项目
( 1 ) 钯催化的不对称亚胺基化反应研究, 负责人, 国家任务, 2018-01--2021-12
( 2 ) 碳氢键羰基化反应, 负责人, 中国科学院计划, 2015-01--2018-12
( 3 ) 过渡金属催化的双碳氢键的羰基化反应, 负责人, 国家任务, 2015-01--2017-12
( 4 ) 抗金黄色葡萄球菌的药物研发, 参与, 其他任务, 2018-12--2021-12
( 5 ) 钯催化的基于异腈插入的 不对称反应研究, 负责人, 地方任务, 2019-10--2022-09
( 6 ) 以Skp1为靶标的抗肺癌药 物分子的合成和生物活性研究, 负责人, 其他任务, 2020-01--2022-12
( 7 ) 吲哚-2-酮-3-螺噻嗪酮类化合物的抗结核活性研究, 参与, 国家任务, 2017-01--2020-12