基本信息
赵健  男  硕导  国家纳米科学中心
电子邮件: zhaojian@nanoctr.cn
通信地址: 北京海淀中关村北一条11号
邮政编码:

招生信息

   
招生专业
0703Z1-化学生物学
0703J1-纳米科学与技术
招生方向
化学生物传感
化学生物学调控

教育背景

2013-09--2016-07   中国科学院微生物研究所   博士学历

工作经历

   
工作简历
2019-09~现在, 国家纳米科学中心, 副研究员
2016-12~2019-08,国家纳米科学中心, 博士后
2013-09~2016-07,中国科学院微生物研究所, 博士学历

出版信息

   
发表论文
(1) Enzyme Translocation-Mediated Signal Amplification for Spatially Selective Aptasensing of ATP in Inflammatory Cells, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 第 2 作者
(2) Near-infrared light triggered degradation of metal���organic frameworks for spatiotemporally-controlled protein release, NANO TODAY, 2023, 第 7 作者  通讯作者
(3) A Remotely Controlled Nanosystem for Spatiotemporally Specific Gene Regulation and Combinational Tumor Therapy, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 第 4 作者  通讯作者
(4) A DNA- Based Nanodevice for Near-Infrared Light-Controlled Drug Release and Bioimaging, Nano Today, 2023, 第 7 作者  通讯作者
(5) Mild Acidosis-Directed Signal Amplification in Tumor Microenvironment via Spatioselective Recruitment of DNA Amplifiers, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 第 3 作者
(6) Spatiotemporally Selective Molecular Imaging via Upconversion Luminescence���Controlled, DNA���Based Biosensor Technology, Angewandte Chemie International Edition, 2022, 第 1 作者
(7) Spatially Resolved in Vivo Imaging of Inflammation-Associated mRNA via Enzymatic Fluorescence Amplification in a Molecular Beacon, Nature Biomedical Engineering, 2022, 第 2 作者
(8) Spatially Selective Imaging of Mitochondrial MicroRNAs via Optically Programmable Strand Displacement Reactions, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 第 1 作者
(9) Upconversion Luminescence-Controlled DNA Computation for Spatiotemporally Resolved, Multiplexed Molecular Imaging, ANALYTICAL CHEMISTRY, 2021, 第 2 作者
(10) An Enzyme-Activatable Engineered DNAzyme Sensor for Cell-Selective Imaging of Metal Ions, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 第 2 作者
(11) Organelle-Specific Photoactivation of DNA Nanosensors for Precise Profiling of Subcellular Enzymatic Activity, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 第 2 作者
(12) A Redox-Activatable DNA Nanodevice for Spatially-Selective, AND-Gated Imaging of ATP and Glutathione in Mitochondria, Nano Letters, 2021, 第 5 作者  通讯作者
(13) An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment, SCIENCE ADVANCES, 2020, 第 3 作者
(14) A smart DNA nanodevice for ATP-activatable bioimaging and photodynamic therapy, A smart DNA nanodevice for ATP-activatable bioimaging and photodynamic therapy, SCIENCE CHINA-CHEMISTRY, 2020, 第 3 作者
(15) Time-Resolved Activation of pH Sensing and Imaging in Vivo by a Remotely Controllable DNA Nanomachine, NANO LETTERS, 2020, 第 1 作者
(16) Nd3+-Sensitized Upconversion Metal-Organic Frameworks for Mitochondria-Targeted Amplified Photodynamic Therapy, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 第 3 作者
(17) A NIR Light Gated DNA Nanodevice for Spatiotemporally Controlled Imaging of MicroRNA in Cells and Animals, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 第 1 作者
(18) Light-Activated Nanoprobes for Biosensing and Imaging, ADVANCED MATERIALS, 2019, 第 2 作者
(19) An Acidic-Microenvironment-Driven DNA Nanomachine Enables Specific ATP Imaging in the Extracellular Milieu of Tumor, ADVANCED MATERIALS, 2019, 第 2 作者
(20) Deconstructive di-functionalization of unstrained, benzo cyclic amines by C-N bond cleavage using a recyclable tungsten catalyst, ORGANIC & BIOMOLECULAR CHEMISTRY, 2019, 第 4 作者
(21) Near-Infrared Light-Initiated Hybridization Chain Reaction for Spatially and Temporally Resolved Signal Amplification, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 2 作者
(22) NIR-light-mediated spatially selective triggering of anti-tumor immunity via upconversion nanoparticle-based immunodevices, NATURE COMMUNICATIONS, 2019, 第 2 作者
(23) Trace water mediated growth of oriented single-crystalline mesoporous metal-organic frameworks on gold nanorods, CHEMICAL COMMUNICATIONS, 2018, 第 3 作者
(24) Upconversion Luminescence-Activated DNA Nanodevice for ATP Sensing in Living Cells, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 1 作者

科研活动

   
科研项目
( 1 ) 复杂生命体系分子成像, 负责人, 国家任务, 2024-01--2026-12
( 2 ) 基于DNA纳米器件的肿瘤细胞上皮-间充质转换动态可视 化鉴定研究, 负责人, 国家任务, 2023-01--2026-12
( 3 ) 构建近红外光门控的DNA纳米器件用于细胞器内多靶标microRNA精准成像, 负责人, 国家任务, 2021-01--2023-12
( 4 ) 青年创新促进会-赵健, 负责人, 中国科学院计划, 2021-01--2024-12
参与会议
(1)Upconversion Luminescence-Activated DNA Nanodevice for ATP Sensing in Living Cells   2018-10-18