Cell Fate Regulation and Disease Animal Modeling

2003-2007 Hubei University,  Biological Science，Bachelor

2007-2012 Guangzhou Institutes of Biomedical and Health, Chinese Academy of Sciences，Biochemical and Molecular Biology，Ph.D

Since Jan 2018, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, PI.

Jan 2013-Dec 2017,Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Associate Research Fellow.

July 2012-Dec 2012,Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Assistant Researcher.

1. Wang H, Y Li, C Yin, Z Zhang, Y Wang, Y Li, C Li, R Lin, X Zhang, J Guo, R Luo, S Li, L Zhang, Y Zhuang, A Xu, J Wan, L Xiao, B Chen, S Yu, M Kumar* and J Liu* (2026). Dose-resolved control of somatic reprogramming by Rora. Stem Cell Reports 21(4):102870.

2. Chen, Z., Y. Huang, Z. Yuan, K. Xu, Y. Guan, L. Wang, Y. Jiang, W. Deng, Y. Pan, J. Liu* and Y. Hu* (2025). "Induced pluripotent stem cells carrying novel APTX mutations presented defective neural differentiation with the accumulation of DNA single-strand breaks." Cell Death Discovery 11(1):481.

3. Guo, J., R. Lin, J. Liu, R. Liu, S. Chen, Z. Zhang, Y. Yang, H. Wang, L. Wang, S. Yu, C. Zhou, L. Xiao, R. Luo, J. Yu, L. Zeng, X. Zhang, Y. Li, H. Wu, T. Wang, Y. Li, M. Kumar*, P. Zhu* and J. Liu* (2025). "Capture primed pluripotency in guinea pig." Stem Cell Reports 20(2):102388.

4. Xiao, L., Z. Huang, Z. Wu, Y. Yang, Z. Zhang, M. Kumar, H. Wu, H. Mao, L. Lin, R. Lin, J. Long, L. Zeng, J. Guo, R. Luo, Y. Li, P. Zhu, B. Liao*, L. Wang* and J. Liu* (2024). "Reconstitution of pluripotency from mouse fibroblast through Sall4 overexpression." Nat Commun 15(1):10787.

5. Liu, Y., S. Zhang, G. Zou, J.An, Y.Li, D.Li, D.Lin, D.Wang, Y.Li, J.Chen, T.Feng, H.Li, Y.Chen, M.Zhang, M.Kumar, L.Wang*, R.Hou* and J. Liu* (2024). "Generation and characterization of giant panda induced pluripotent stem cells". Sci Adv 10(38):eadn7724.

6. Guan, T., J. Guo, R. Lin, J. Liu, R. Luo, Z. Zhang*, D. Pei* and J. Liu* (2024). "Single-cell analysis of preimplantation embryonic development in guinea pigs." BMC Genomics 25(1): 911.

7. Li, C., X. Xu, S. Chen, A. Xu, T. Guan, H. Wu*, D. Pei* and J. Liu* (2024). "Epigenetic reshaping through damage: promoting cell fate transition by BrdU and IdU incorporation." Cell Biosci 14(1): 9.

8. Lin, R., Z. Zhai, J. Kuang, C. Wu, Y. Yao, R. Shi, J. He, S. Xu, P. Li, Y. Fan, W. Li, Z. Wu, X. Li, J. Ming, J. Guo, B. Wang, D. Li, S. Cao, X. Zhang, Y. Li, D. Pei* and J. Liu* (2022). "H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition." Cell Biosci 12(1): 89.

9. Wu, H., C. Li, M. Masood, Z. Zhang, E. Gonzalez-Almela, A. Castells-Garcia, G. Zou, X. Xu, L. Wang, G. Zhao, S. Yu, P. Zhu, B. Wang, D. Qin* and J. Liu* (2022). "Static Magnetic Fields Regulate T-Type Calcium Ion Channels and Mediate Mesenchymal Stem Cells Proliferation." Cells 11(15):2460.

10. Yu, S., C. Zhou, J. He, Z. Yao, X. Huang, B. Rong, H. Zhu, S. Wang, S. Chen, X. Wang, B. Cai, G. Zhao, Y. Chen, L. Xiao, H. Liu, Y. Qin, J. Guo, H. Wu, Z. Zhang, M. Zhang, X. Zhao, F. Lan, Y. Wang, J. Chen, S. Cao*, D. Pei* and J. Liu* (2022). "BMP4 drives primed to naive transition through PGC-like state." Nat Commun 13(1): 2756.

11. Kuang, J., Z. Zhai, P. Li, R. Shi, W. Guo, Y. Yao, J. Guo, G. Zhao, J. He, S. Xu, C. Wu, S. Yu, C. Zhou, L. Wu, Y. Qin, B. Cai, W. Li, Z. Wu, X. Li, S. Chu, T. Yang, B. Wang, S. Cao, D. Li, X. Zhang, J. Chen, J. Liu* and D. Pei* (2021). "SS18 regulates pluripotent-somatic transition through phase separation." Nat Commun 12(1): 4090.

12. Liu, Y., J. He, R. Chen, H. Liu, J. Chen, Y. Liu, B. Wang, L. Guo, D. Pei, J. Wang, J. Liu* and J. Chen* (2021). "AP-1 activity is a major barrier of human somatic cell reprogramming." Cell Mol Life Sci. 78(15):5847-5863.

13. Fu, M., H. Chen, Z. Cai, Y. Yang, Z. Feng, M. Zeng, L. Chen, Y. Qin, B. Cai, P. Zhu, C. Zhou, S. Yu, J. Guo, J. Liu*, S. Cao* and D. Pei* (2021). "Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency." Cell Regen 10(1): 17.

14. Wu, L., G. Zhao, S. Xu, J. Kuang, J. Min, G. Wu, T. Wang, B. Wang, P. Zhu, D. Pei* and J. Liu* (2020). "The nuclear factor CECR2 promotes somatic cell reprogramming by reorganizing the chromatin structure." J Biol Chem 296:100022.

15. Yu, S., C. Zhou, S. Cao, J. He, B. Cai, K. Wu, Y. Qin, X. Huang, L. Xiao, J. Ye, S. Xu, W. Xie, J. Kuang, S. Chu, J. Guo, H. Liu, W. Pang, L. Guo, M. Zeng, X. Wang, R. Luo, C. Li, G. Zhao, B. Wang, L. Wu, J. Chen, J. Liu* and D. Pei* (2020). "BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling." Nat Cell Biol 22(6): 651-662.

16. Wang, B., L. Wu, D. Li, Y. Liu, J. Guo, C. Li, Y. Yao, Y. Wang, G. Zhao, X. Wang, M. Fu, H. Liu, S. Cao, C. Wu, S. Yu, C. Zhou, Y. Qin, J. Kuang, J. Ming, S. Chu, X. Yang, P. Zhu, G. Pan, J. Chen, J. Liu* and D. Pei* (2019). "Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4." Cell Rep 27(12): 3473-3485.

17. Cao, S., S. Yu, D. Li, J. Ye, X. Yang, C. Li, X. Wang, Y. Mai, Y. Qin, J. Wu, J. He, C. Zhou, H. Liu, B. Zhao, X. Shu, C. Wu, R. Chen, W. Chan, G. Pan, J. Chen, J. Liu* and D. Pei* (2018). "Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency." Cell Stem Cell 22(4): 529-542 .

18. Wang, B., D. Li, J. Chen, J. Liu* and D. Pei* (2018). "Mouse embryonic stem cells resist c-Jun induced differentiation when in suspension." Cell Regen 7(1): 16-21.

19. Li, D., J. Liu, X. Yang, C. Zhou, J. Guo, C. Wu, Y. Qin, L. Guo, J. He, S. Yu, H. Liu, X. Wang, F. Wu, J. Kuang, A. P. Hutchins*, J. Chen* and D. Pei* (2017). "Chromatin Accessibility Dynamics during iPSC Reprogramming." Cell Stem Cell 21(6): 819-833.

20. Cao, S., S. Yu, Y. Chen, X. Wang, C. Zhou, Y. Liu, J. Kuang, H. Liu, D. Li, J. Ye, Y. Qin, S. Chu, L. Wu, L. Guo, Y. Li, X. Shu, J. Chen, J. Liu* and D. Pei* (2017). "Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage." J Biol Chem 292(46): 19122-19132.

21. Liu, J., Q. Han, T. Peng, M. Peng, B. Wei, D. Li, X. Wang, S. Yu, J. Yang, S. Cao, K. Huang, A. P. Hutchins, H. Liu, J. Kuang, Z. Zhou, J. Chen, H. Wu, L. Guo, Y. Chen, Y. Chen, X. Li, H. Wu, B. Liao, W. He, H. Song, H. Yao, G. Pan, J. Chen* and D. Pei* (2015). "The oncogene c-Jun impedes somatic cell reprogramming." Nat Cell Biol 17(7): 856-867.

22. Ouyang, J., W. Yu, J. Liu, N. Zhang, L. Florens, J. Chen, H. Liu, M. Washburn, D. Pei and T. Xie (2015). "Cyclin-dependent kinase-mediated Sox2 phosphorylation enhances the ability of Sox2 to establish the pluripotent state." J Biol Chem 290(37): 22782-22794.

23. Chen, J., J. Liu, Y. Chen, J. Yang, J. Chen, H. Liu, X. Zhao, K. Mo, H. Song, L. Guo, S. Chu, D. Wang, K. Ding and D. Pei (2011). "Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics." Cell Res 21(6): 884-894.

24. Chen, J., J. Liu, J. Yang, Y. Chen, J. Chen, S. Ni, H. Song, L. Zeng, K. Ding and D. Pei (2011). "BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone." Cell Res 21(1): 205-212.

25. Chen, J., J. Liu, Q. Han, D. Qin, J. Xu, Y. Chen, J. Yang, H. Song, D. Yang, M. Peng, W. He, R. Li, H. Wang, Y. Gan, K. Ding, L. Zeng, L. Lai, M. A. Esteban and D. Pei (2010). "Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells." J Biol Chem 285(40): 31066-31072.

Cell fate regulation mechanism based on iPSC and PNT system;

Establishment of multispecies pluripotent stem cell lines and disease animal models;

Multidimensional data analysis and mathematical modeling of cell fate transformation process.