基本信息
岳会兰  女  硕导  中国科学院西北高原生物研究所
电子邮件: hlyue@nwipb.cas.cn
通信地址: 青海新宁路23号
邮政编码:

招生信息

   
招生专业
100800-中药学
招生方向
天然药物化学

教育背景

2008-07--2012-07   中国科学院成都生物研究所   理学博士
2005-07--2008-07   中国科学院西北高原生物研究所   理学硕士
2001-09--2005-07   淮北煤炭师范大学   学士学位

工作经历

   
工作简历
2023-05~现在, 中国科学院西北高原生物研究所, 研究员
2015-10~2023-05,中国科学院西北高原生物研究所, 副研究员
2015-03~2016-03,德国马克斯普朗克煤炭研究所, 访问学者
2012-07~2015-10,中国科学院西北高原生物研究所, 助理研究员
2008-07~2012-07,中国科学院成都生物研究所, 理学博士
2005-07~2008-07,中国科学院西北高原生物研究所, 理学硕士
2001-09~2005-07,淮北煤炭师范大学, 学士学位

专利与奖励

   
奖励信息
(1) 青海省首届青年科技奖状, 一等奖, 省级, 2020
专利成果
( 1 ) 一种白檀提取物在制备降低血糖的食品、药品或保健品中的应用, 2022, 第 1 作者, 专利号: N.102020000016591

( 2 ) 大花红景天提取物在制备抑制淀粉酶和葡萄糖苷酶活性的食品、药品或保健, 2022, 第 1 作者, 专利号: 2022/01098

出版信息

   
发表论文
(1) Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS, FOOD & FUNCTION, 2022, 通讯作者
(2) Hypoglycemic ingredients identification of Rheum tanguticum Maxim. ex Balf. by UHPLC-triple-TOF-MS/MS and interrelationships between ingredients content and glycosidase inhibitory activities, Industrial Crops & Products, 2022, 通讯作者
(3) Hypoglycemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba in vitro and in vivo and its ingredient identification by UPLC-triple- TOF/MS, Food & Function, 2022, 通讯作者
(4) Alkaloids and phenolics identification in fruit of Nitraria tangutorum Bobr. by UPLC-Q-TOF-MS/MS and their a-glucosidase inhibitory effects in vivo and in vitro, FOOD CHEMISTRY, 2021, 通讯作者
(5) A new flavonol acylglycoside from the fruits of Nitraria tangutorum Bobr, NATURAL PRODUCT RESEARCH, 2021, 通讯作者
(6) Anti-rheumatoid arthritis effects of iridoid glucosides from Lamiophlomis rotata (Benth.) kudo on adjuvant-induced arthritis in rats by OPG/RANKL/NF-κB signaling pathways, JOURNAL OF ETHNOPHARMACOLOGY, 2021, 第 8 作者
(7) Identification of phenolic compounds in fruits of Ribes stenocarpum Maxim. By UHPLC-QTOF/MS and their hypoglycemic effects in vitro and in vivo, FOOD CHEMISTRY, 2021, 通讯作者
(8) Visible-light-promoted acridine red catalyzed aerobic oxidative decarboxylative acylation of α-oxo-carboxylic acids with quinoxalin-2(1H)- ones, ORGANIC CHEMISTRY, 2020, 通讯作者
(9) Variation of anthocyanin content in fruits of wild and cultivated Lycium ruthenicum, INDUSTRIAL CROPS AND PRODUCTS, 2020, 通讯作者
(10) Ultrasonic extraction of anthocyanins from Lycium ruthenicum Murr. and its antioxidant activity, FOOD SCIENCE & NUTRITION, 2020, 通讯作者
(11) Resveratroloside Alleviates Postprandial Hyperglycemia in Diabetic Mice by Competitively Inhibiting a-Glucosidase, J. Agric. Food Chem., 2019, 
(12) Visible-light-mediated metal-free decarboxylative acylations of isocyanides with alpha-oxocarboxylic acids and water leading to alpha-ketoamides, GREEN CHEMISTRY, 2019, 通讯作者
(13) Selective assembly of N1-and N2-alkylated 1,2,3-triazoles via copper-catalyzed decarboxylative cycloaddition of alkynyl carboxylic acids with ethers and azidotrimethylsilane, ORGANIC CHEMISTRY FRONTIERS, 2019, 通讯作者
(14) Visible-Light-Enabled Construction of Thiocarbamates from Isocyanides, Thiols, and Water at Room Temperature, ORGANIC LETTERS, 2018, 通讯作者
(15) Direct synthesis of β-ketophosphine oxides via copper-catalyzed difunctionalization of alkenes with H-phosphine oxides and dioxygen, TETRAHEDRON LETTERS, 2018, 第 2 作者
(16) Antioxidants from Pedicularis longiflora var. tubiformis (Klotzsch) P. C. Tsoong, RECORDS OF NATURAL PRODUCTS, 2018, 
(17) Visible-light-enabled oxyazidation of alkenes leading to alpha-azidoketones in air, GREEN CHEMISTRY, 2018, 通讯作者
(18) Visible-Light-Promoted Difunctionalization of Olefins Leading to -Thiocyanato Ketones, SYNLETT, 2018, 通讯作者
(19) Fatty Acid and Phytosterol Composition, and Biological Activities of Lycium ruthenicum Murr. Seed Oil, JOURNAL OF FOOD SCIENCE, 2018, 通讯作者
(20) Metal-free Oxidative Coupling of Aromatic Alkenes with Thiols Leading to (E)-Vinyl Sulfones, JOURNAL OF ORGANIC CHEMISTRY, 2017, 第 2 作者
(21) Highly efficient TfOH-catalyzed head-to-tail dimerization of vinylarenes, SYNTHETIC COMMUNICATIONS, 2016, 第 1 作者
(22) Fe3O4 Nanoparticles with Ursolic Methyl Ester Induce Apoptosis of Multidrug-Resistant Leukemia KA Cell: In Vitro Evaluation, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2016, 第 1 作者
(23) Acid-Catalyzed Oxidative Addition of Thiols to Olefins and Alkynes for a One-Pot Entry to Sulfoxides, SYNLETT, 2016, 第 1 作者
(24) SEMI-PREPARATIVE SEPARATION AND PURIFICATION OF THREE FLAVONOIDS FROM PEDICULARIS LONGIFLORA VAR. TUBIFORMIS (KLOTZSCH) P. C. TSOONG BY HSCCC, JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2013, 通讯作者
(25) Separation and purification of five phenylpropanoid glycosides from Lamiophlomis rotata (Benth.) Kudo by a macroporous resin column combined with high‐speed counter‐current chromatography, JOURNAL OF SEPARATION SCIENCE, 2013, 第 1 作者
(26) Separation and purification of water-soluble iridoid glucosides by high speed counter-current chromatography combined with macroporous resin column separation, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2013, 第 1 作者
(27) INDIUM-PROMOTED ALLYLATION OF ALKYNES WITH ALLYLIC ALCOHOLS: HIGHLY REGIOSELECTIVE SYNTHESIS OF HALOGEN-SUBSTITUTED 1,4-DIENES, SYNTHETIC COMMUNICATIONS, 2013, 第 1 作者
(28) Preparative Isolation and Purification of Three Stilbene Glycosides from the Tibetan Medicinal Plant Rheum tanguticum Maxim. Ex Balf. by High-speed Counter-current Chromatography, PHYTOCHEMICAL ANALYSIS, 2013, 第 4 作者
(29) Sp3-sp2 C-C bond formation via Brønsted acid TfOH-catalyzed direct coupling reaction of alcohols and alkenes, Adv. Synth. Catal., 2011, 第 1 作者

科研活动

   
科研项目
( 1 ) 异叶青兰中抗肿瘤活性成分筛选及结构修饰制研究, 负责人, 中国科学院计划, 2012-12--2016-09
( 2 ) 独一味抗类风湿性关节炎活性物质基础及机理研究, 负责人, 地方任务, 2013-07--2015-12
( 3 ) PhlorigidosideC抗类风湿性关节炎活性及机制研究, 负责人, 地方任务, 2017-01--2019-12
( 4 ) 治疗上呼吸道感染中药巴尔巴达雾化剂关键技术研究, 负责人, 境内委托项目, 2017-09--2019-09
( 5 ) 基于α-葡萄糖苷酶靶点的白刺等植物抗糖尿病活性物质临床前研究, 负责人, 地方任务, 2019-01--2021-12
( 6 ) 唐古特白刺果实中α-葡萄糖苷酶抑制剂的发现及其降血糖作用机制研究, 负责人, 国家任务, 2020-01--2022-12
( 7 ) 大花红景天中α-葡萄糖苷酶抑制剂的发现及其降血糖作用机制研究, 负责人, 中国科学院计划, 2020-01--2024-12
( 8 ) 柴达木白刺中苯丙氨酸和色氨酸类衍生物发现及其降血糖活性研究, 负责人, 地方任务, 2022-01--2024-12
( 9 ) 高原特色植物(白刺)有效成分与生态环境相关研究, 负责人, 研究所自主部署, 2023-01--2025-12