基本信息
青琳森  男  硕导  中国科学院成都生物研究所
电子邮件: qingls@cib.ac.cn
通信地址: 四川省成都市人民南路四段9号 中科院成都生物所
邮政编码:

招生信息

   
招生专业
100704-药物分析学
招生方向
天然活性成分分析
天然新药开发

教育背景

2008-09--2011-06   中国科学院成都生物研究所   博士
2003-09--2006-06   四川大学华西药学院   硕士
1999-09--2003-06   华西医科大学药学院   学士

工作经历

   
工作简历
2013-07~现在, 中国科学院成都生物研究所, 副研究员
2012-08~2012-12,美国杰克逊州立大学化学系, 研究助理
2011-07~2013-06,中国科学院成都生物研究所, 博士后
2006-07~2008-08,成都地奥制药集团, 新药研发工程师
2004-06~2005-05,香港浸会大学中医药学院, 访问学者

专利与奖励

   
专利成果
[1] 青琳森, 丁立生, 杨雪锋, 彭树林, 梁健. 黄芪苷酸盐的一步制备法. CN: CN111518156B, 2021-07-27.
[2] 青琳森, 丁立生, 罗培, 彭树林, 梁健. 一种黄芪苷酸的制备方法. CN: CN111548385A, 2020-08-18.
[3] 青琳森, 罗培, 王乾龙, 黄维雪. Au@HIF-1α aptamer@Au纳米酶的制备及在隐匿型冠心病检测中的应用. CN: CN110988359A, 2020-04-10.
[4] 青琳森, 丁立生, 罗培, 谢静, 彭树林, 梁健. 黄芪苷酸及其衍生物在制备抗血栓药物中的应用. CN: CN107759654B, 2020-02-21.
[5] 青琳森, 王乾龙, 丁立生, 梁健, 饶亮明, 李兴德, 蒋立银, 帅克. 一种基于玻璃毛细管的牛血清白蛋白检测探针及其制备方法和应用. CN: CN106771226B, 2019-10-08.
[6] 青琳森, 王甜甜, 张志锋, 罗培, 梁健. 一种简易的尿糖定量检测方法以及尿糖定量检测试剂盒. CN: CN110082347A, 2019-08-02.
[7] 青琳森, 陈朝喜, 谢静, 代璐, 冯皓媛, 丁立生, 梁健, 李兴德. 黄芪甲苷人工抗原及其人工抗体的制备方法和应用. CN: CN110054681A, 2019-07-26.
[8] 青琳森, 杨雪锋, 丁立生, 梁健, 饶亮明, 李兴德, 蒋立银, 帅克. 一种伏立康唑的合成方法. CN: CN106632267B, 2019-02-22.
[9] 青琳森, 丁立生, 彭树林, 李帮经, 梁健. 一种黄芪甲苷衍生物及其制备方法和应用. 中国: CN106632572B, 2018-08-14.
[10] 青琳森, 王乾龙, 丁立生, 梁健, 饶亮明, 李兴德, 蒋立银, 帅克. 一种牛血清白蛋白检测探针及其制备方法和应用. 中国: CN106324260B, 2018-06-22.
[11] 青琳森, 廖循, 薛莹, 彭树林, 丁立生. 一种大豆及其制品中异黄酮的分析方法. 中国: CN103323557A, 2013.09.25.
[12] 青琳森, 廖循, 薛莹, 熊静, 彭树林, 丁立生. 一种表面键合黄芩苷磁性纳米粒子及其制备方法和用途. 中国: CN102463102A, 2012.05.23.
[13] 廖循, 薛莹, 青琳森, 陈志芬, 彭树林, 丁立生. 一种精制鸵鸟油的制备方法及用途. 中国: CN102277228A, 2011-12-14.

出版信息

   
发表论文
[1] TianTian Wang, XiaoFeng Huang, Hui Huang, Pei Luo, LinSen Qing. Nanomaterial-based optical- and electrochemical-biosensors for urine glucose detection: A comprehensive review. Advanced Sensor and Energy Materials[J]. 2022, 1(3): 100016-, [2] 谢静, 龚易昕悦, 丁立生, 罗培, 青琳森. 黄芪及其活性成分对脓毒症临床和药理作用的研究进展. 中草药[J]. 2021, 52(8): 2502-2510, [3] QianLong Wang, LanCong Liu, XiaoYi Chen, TianTian Wang, Hua Zhou, Hui Huang, Qing, LinSen, Luo Pei. Noninvasive prognosis of postmyocardial infarction using urinary miRNA ultratrace detection based on single-target DNA-functionalized AuNPs. ACS Applied Materials & Interfaces[J]. 2021, 14(3): 3633-3642, [4] Tang, MingQing, Xie, Jing, Rao, LiangMing, Kan, YaJie, Luo, Pei, Qing, LinSen. Advances in aptamer-based sensing assays for C-reactive protein. Analytical and Bioanalytical Chemistry[J]. 2021, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000701628800001.
[5] Xie, Jing, Wang, RunYue, Yong, Li, Gong, Yixinyue, Ding, LiSheng, Xin, Ying, Wang, HongLi, Xue, Ying, Qing, LinSen. Determination of nine nucleosides in Rhizoma Paridis by quantitative analysis of multi-components via a single marker method. Journal of Separation Science[J]. 2021, 44(9): 1875-1883, http://dx.doi.org/10.1002/jssc.202001086.
[6] Chen, Li, Chen, XiaoYi, Wang, QianLong, Yang, SiJin, Zhou, Hua, Ding, LiSheng, Qing, LinSen, Luo, Pei. Astragaloside IV Derivative (LS-102) Alleviated Myocardial Ischemia Reperfusion Injury by Inhibiting Drp1(Ser616) Phosphorylation-Mediated Mitochondrial Fission. FRONTIERS IN PHARMACOLOGY[J]. 2020, 11: https://doaj.org/article/6b77b83aeef54c579c47416a225d4f09.
[7] Chen, ChaoXi, Dai, Lu, Feng, HaoYuan, Wang, Lu, Guo, Kun, Ding, LiSheng, Qing, LinSen, Xie, Jing. A new strategy for the preparation of antibody against natural glycoside: With astragaloside IV as an example. FITOTERAPIA[J]. 2020, 142: http://dx.doi.org/10.1016/j.fitote.2020.104488.
[8] Tang, MingQing, Mao, XuHua, Gong, YiXinYue, Qing, LinSen, Xie, Jing. Research Progress of C-reactive Protein Analysis. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2020, 48(9): 1121-1130, http://dx.doi.org/10.1016/S1872-2040(20)60040-8.
[9] Wang, QianLong, Huang, WeiXue, Zhang, PuJuan, Chen, Li, Lio, ChonKit, Zhou, Hua, Qing, LinSen, Luo, Pei. Colorimetric determination of the early biomarker hypoxia-inducible factor-1 alpha (HIF-1 alpha) in circulating exosomes by using a gold seed-coated with aptamer-functionalized Au@Au core-shell peroxidase mimic. MICROCHIMICA ACTA[J]. 2020, 187(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000510867300015.
[10] 唐铭擎, 毛旭华, 龚易昕悦, 青琳森, 谢静. C反应球蛋白分析方法的研究进展. 分析化学[J]. 2020, 48(9): 1121-1130, http://lib.cqvip.com/Qikan/Article/Detail?id=7102697544.
[11] 王甜甜, 王润月, 张志锋, 青琳森. 智能手机在生化传感分析中的应用进展. 分析测试学报[J]. 2020, 39(12): 1561-1566, http://lib.cqvip.com/Qikan/Article/Detail?id=7103511696.
[12] Wang, TianTian, Lio, Chon Kit, Huang, Hui, Wang, RunYue, Zhou, Hua, Luo, Pei, Qing, LinSen. A feasible image-based colorimetric assay using a smartphone RGB camera for point-of-care monitoring of diabetes. TALANTA[J]. 2020, 206: http://dx.doi.org/10.1016/j.talanta.2019.120211.
[13] Qing, LinSen, Chen, TingBo, Sun, WenXia, Chen, Li, Luo, Pei, Zhang, ZhiFeng, Ding, LiSheng. Pharmacokinetics Comparison, Intestinal Absorption and Acute Toxicity Assessment of a Novel Water-Soluble Astragaloside IV Derivative (Astragalosidic Acid, LS-102). EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS[J]. 2019, 44(2): 251-259, http://dx.doi.org/10.1007/s13318-018-0515-5.
[14] Xue, Ying, Qing, LinSen, Yong, Li, Xu, XianShun, Hu, Bin, Tang, MingQing, Xie, Jing. Determination of Flavonoid Glycosides by UPLC-MS to Authenticate Commercial Lemonade. MOLECULES[J]. 2019, 24(16): https://doaj.org/article/3329e7c3d9ea4af0900c08fd1be323ca.
[15] 谢静, 王甜甜, 熊静, 丁立生, 梁健, 周璐炜, 青琳森. 分子印迹聚合物的制备及其在临床药物分析中的应用进展. 中国医院药学杂志. 2019, 407-411, http://lib.cqvip.com/Qikan/Article/Detail?id=90718990504849574852485049.
[16] Xue, Ying, Xie, Jing, Xu, XianShun, Yong, Li, Hu, Bin, Liang, Jian, Li, XingDe, Qing, LinSen. UPLC-QqQ/MS combined with similarity assessment of 17 nucleic acid constituents in 147 edible fungi from Sichuan Basin, China. FOOD RESEARCH INTERNATIONAL[J]. 2019, 120: 577-585, http://dx.doi.org/10.1016/j.foodres.2018.11.008.
[17] Wang, QianLong, Xie, Jing, Liang, Jian, Dong, GengTing, Ding, LiSheng, Luo, Pei, Qing, LinSen. Competitive Protein Binding Assay of Naproxen by Human Serum Albumin Functionalized Silicon Dioxide Nanoparticles. MOLECULES[J]. 2019, 24(14): https://doaj.org/article/cf8407d868e94e7d971367b70556b7f9.
[18] Sun WenXia, Zhang ZhiFeng, Xie Jing, He Ying, Cheng Yong, Ding LiSheng, Luo Pei, Qing LinSen. Determination of a astragaloside IV derivative LS-102 in plasma by ultra-performance liquid chromatography-tandem mass spectrometry in dog plasma and its application in a pharmacokinetic study. PHYTOMEDICINE[J]. 2019, 53: 243-251, http://dx.doi.org/10.1016/j.phymed.2018.09.019.
[19] Xie, Jing, Xiong, Jing, Ding, LiSheng, Chen, Li, Zhou, Hua, Liu, Liang, Zhang, ZhiFeng, Hu, XueMei, Luo, Pei, Qing, LinSen. A efficient method to identify cardioprotective components of Astragali Radix using a combination of molecularly imprinted polymers-based knockout extract and activity evaluation. JOURNAL OF CHROMATOGRAPHY A[J]. 2018, 1576: 10-18, http://dx.doi.org/10.1016/j.chroma.2018.09.027.
[20] Xue, Ying, Xu, XianShun, Yong, Li, Hu, Bin, Li, XingDe, Zhong, ShiHong, Li, Yi, Xie, Jing, Qing, LinSen. Optimization of Vortex-Assisted Dispersive Liquid-Liquid Microextraction for the Simultaneous Quantitation of Eleven Non-Anthocyanin Polyphenols in Commercial Blueberry Using the Multi-Objective Response Surface Methodology and Desirability Function Approach. MOLECULES[J]. 2018, 23(11): https://doaj.org/article/00ea09cd50ff43e0a9587fd340e1b399.
[21] Chen, Chu, Xue, Ying, Li, QingMiao, Wu, Yan, Liang, Jian, Qing, LinSen. Neutral Loss Scan - Based Strategy for Integrated Identification of Amorfrutin Derivatives, New Peroxisome Proliferator-Activated Receptor Gamma Agonists, from Amorpha Fruticosa by UPLC-QqQ-MS/MS and UPLC-Q-TOF-MS. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY[J]. 2018, 29(4): 685-693, https://www.webofscience.com/wos/woscc/full-record/WOS:000429431900006.
[22] Ying Xue, Wei Jin, XianShun Xu, Li Yong, Bin Hu, Jing Xiong, XueMei Hu, LinSen Qing, Jing Xie. Quality Evaluation of Tricholoma matsutake Based on the Nucleic Acid Compounds by UPLC-TOF/MS and UPLC-QqQ/MS. Molecules[J]. 2018, 24(1): [23] Fangzhu Qing, Yang Shu, Linsen Qing, Yuting Niu, He Guo, Shuyi Zhang, Chunlin Liu, Changqing Shen, Wanli Zhang, Samuel SMao, Wenjuan Zhu, Xuesong Li. A general and simple method for evaluating the electrical transport performance of graphene by the van der Pauw-Hall measurement. 科学通报:英文版. 2018, 63(22): 1521-1526, http://lib.cqvip.com/Qikan/Article/Detail?id=6100052989.
[24] 雨田等主编, 张志锋, 青琳森, 尚远宏. 彝药化学. 2017, 352-, http://210.75.237.14/handle/351003/28955.
[25] Li, Jie, Dastmalchi, Keyvan, Qing, Linsen, Luo, Pei. Discovery and Biological Evaluation of Natural Phenolic Antioxidants. OXIDATIVE MEDICINE AND CELLULAR LONGEVITYnull. 2017, 2017: https://doaj.org/article/4f869be56c904e43bea7ff2b064d1a38.
[26] Wang, QianLong, Li, Jie, Li, XingDe, Ding, LiSheng, Xie, Jing, Qing, LinSen. A Simple Nano-SiO2-Based ELISA Method for Residue Detection of 2,4-Dichlorophenoxyacetic Acid in Bean Sprouts. FOOD ANALYTICAL METHODS[J]. 2017, 10(5): 1500-1506, https://www.webofscience.com/wos/woscc/full-record/WOS:000399014600037.
[27] Wang, QianLong, Xie, Jing, Li, XingDe, Ding, LiSheng, Liang, Jian, Luo, Pei, Qing, LinSen. Development of a nano-SiO2 based enzyme-linked ligand binding assay for the determination of ibuprofen in human urine. TALANTA[J]. 2017, 167(2017): 617-622, http://dx.doi.org/10.1016/j.talanta.2017.03.011.
[28] Qing, LinSen, Peng, ShuLin, Liang, Jian, Ding, LiSheng. Astragalosidic Acid: A New Water-Soluble Derivative of Astragaloside IV Prepared Using Remarkably Simple TEMPO-Mediated Oxidation. MOLECULES[J]. 2017, 22(8): https://doaj.org/article/cdfc5acdb1fb44b9868189ed04bb5918.
[29] Wang, QianLong, Li, Jie, Li, XingDe, Tao, WanJun, Ding, LiSheng, Luo, Pei, Qing, LinSen. An efficient direct competitive nano-ELISA for residual BSA determination in vaccines. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2017, 409(19): 4607-4614, https://www.webofscience.com/wos/woscc/full-record/WOS:000404906800011.
[30] 宋丽华, 刘芳, 青琳森, 武勇. 基于生物碱类成分优选黄连药材的加工方法. 中国医院药学杂志. 2017, 37(22): 2248-2250, http://lib.cqvip.com/Qikan/Article/Detail?id=673926535.
[31] Xie, Jing, Li, Jie, Liang, Jian, Luo, Pei, Qing, LinSen, Ding, LiSheng. Determination of Contents of Catechins in Oolong Teas by Quantitative Analysis of Multi-components Via a Single Marker (QAMS) Method. FOOD ANALYTICAL METHODS[J]. 2017, 10(2): 363-368, https://www.webofscience.com/wos/woscc/full-record/WOS:000392379600009.
[32] 刘芳, 张浩, 青琳森, 武勇. 峨眉黄连根茎生物量积累及生物碱类成分的动态变化研究. 时珍国医国药[J]. 2015, 26(9): 2233-2235, http://210.75.237.14/handle/351003/27722.
[33] 谢静, 青芳竹, 青琳森, 黄静. 具有分子识别特性的新型大黄酸功能化树脂的制备. 华西药学杂志[J]. 2015, 30(5): 547-549, http://210.75.237.14/handle/351003/27723.
[34] 刘芳, 雷静雯, 青琳森, 武勇. 峨眉产黄连水分 灰分和浸出物的含量测定. 长治医学院学报. 2015, 29(2): 89-91, http://lib.cqvip.com/Qikan/Article/Detail?id=664769657.
[35] 刘芳, 张浩, 青琳森, 武勇. HPLC分析不同种质的黄连. 华西药学杂志[J]. 2015, 30(3): 341-344, http://210.75.237.14/handle/351003/27715.
[36] 熊静, 青琳森, 廖洪利, 蒋庆琳, 谢静. 基于专利分析的成都医学院科技创新态势分析. 西南军医. 2015, 17(5): 588-590, http://lib.cqvip.com/Qikan/Article/Detail?id=666135523.
[37] 刘芳, 张浩, 青琳森, 武勇. 及生物碱类成分的动态变化研究. 时珍国医国药[J]. 2015, 26(9): 2233-2235, [38] 刘芳, 张浩, 青琳森, 武勇. 不同生长条件下峨眉产黄连个体生物量及生物碱类成分含量的比较. 中国实验方剂学杂志[J]. 2015, 21(18): 21-25, http://210.75.237.14/handle/351003/27721.
[39] Qing, LinSen, Xue, Ying, Ding, LiSheng, Liu, YiMing, Liang, Jian, Liao, Xun. A Rapid Study of Botanical Drug-Drug Interaction with Protein by Re-ligand Fishing using Human Serum Albumin-Functionalized Magnetic Nanoparticles. NATURAL PRODUCT COMMUNICATIONS[J]. 2015, 10(12): 2161-2163, http://210.75.237.14/handle/351003/27557.
[40] Xie, Jing, Liao, Xun, Qing, FangZhu, Luo, Pei, Zhang, ZhiFeng, Huang, Jing, Qing, LinSen. A novel rhein-functionalized resin with application for the preconcentration of anthraquinones. ANALYTICAL LETTERS[J]. 2014, 47(14): 2332-2340, http://210.75.237.14/handle/351003/26702.
[41] Zhu, YuanTing, Ren, XiaoYun, Liu, YiMing, Wei, Ying, Qing, LinSen, Liao, Xun. Covalent immobilization of porcine pancreatic lipase on carboxyl-activated magnetic nanoparticles: Characterization and application for enzymatic inhibition assays. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS[J]. 2014, 38: 278-285, http://dx.doi.org/10.1016/j.msec.2014.02.011.
[42] Shi, HaiLi, Peng, ShuLin, Sun, Jun, Liu, YiMing, Zhu, YuanTing, Qing, LinSen, Liao, Xun. Selective extraction of berberine from Cortex Phellodendri using polydopamine-coated magnetic nanoparticles. JOURNAL OF SEPARATION SCIENCE[J]. 2014, 37(6): 704-710, http://210.75.237.14/handle/351003/26694.
[43] Xue, Ying, Xiong, Jing, Shi, HaiLi, Liu, YiMing, Qing, LinSen, Liao, Xun. In vitro metabolic study of Rhizoma coptidis extract using liver microsomes immobilized on magnetic nanoparticles. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2013, 405(27): 8807-8817, http://www.irgrid.ac.cn/handle/1471x/900531.
[44] Zhang, Zhifeng, Lu, Luyang, Luo, Pei, Qing, Linsen, Liu, Yuan. Two new ursolic acid saponins from Morina nepalensis var. alba Hand-Mazz. NATURAL PRODUCT RESEARCH[J]. 2013, 27(24): 2256-2262, http://www.irgrid.ac.cn/handle/1471x/900521.
[45] 刘芳, 张浩, 青琳森. 黄连HPLC数字化指纹图谱研究及7种生物碱含量测定. 中国中药杂志[J]. 2013, 38(21): 3713-3719, http://210.75.237.14/handle/351003/24041.
[46] Qing, LinSen, Xue, Ying, Liu, YiMing, Liang, Jian, Xie, Jing, Liao, Xun. Rapid Magnetic Solid-Phase Extraction for the Selective Determination of Isoflavones in Soymilk Using Baicalin-Functionalized Magnetic Nanoparticles. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2013, 61(34): 8072-8078, http://dx.doi.org/10.1021/jf402097y.
[47] 薛莹, 张剑光, 梁健, 青琳森, 丁立生, 廖循. 月季花中黄酮化合物的HPLC-MS/MS分析. 分析试验室[J]. 2012, 31(增刊): 214-215, http://210.75.237.14/handle/351003/23970.
[48] 熊静, 张剑光, 梁健, 青琳森, 廖循. 诃子提取物配体垂钓成分的ESI-MSn分析. 分析试验室[J]. 2012, 31(增刊): 207-209, http://210.75.237.14/handle/351003/23969.
[49] 任晓云, 张剑光, 青琳森, 梁健, 廖循. 独脚当归化学成分的HPLC/MSn分析. 分析试验室[J]. 2012, 31(增刊): 201-202, http://210.75.237.14/handle/351003/23968.
[50] 张剑光, 青琳森, 丁立生, 廖循, 达娃卓玛, 张志锋. 水母雪莲花中黄酮成分的ESI—MSn分析. 中国民族医药杂志. 2011, 17(7): 50-51, http://lib.cqvip.com/Qikan/Article/Detail?id=38724173.
[51] 青琳森. 用功能化磁性纳米粒子“垂钓”中药材活性成分. 2011, [52] Qing, LinSen, Xiong, Jing, Xue, Ying, Liu, YiMing, Guang, Bin, Ding, LiSheng, Liao, Xun. Using baicalin-functionalized magnetic nanoparticles for selectively extracting flavonoids from Rosa chinensis. JOURNAL OF SEPARATION SCIENCE[J]. 2011, 34(22): 3240-3245, http://www.irgrid.ac.cn/handle/1471x/517861.
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发表著作
(1) 彝药化学, 民族出版社, 2017-08, 第 2 作者

科研活动

   
科研项目
( 1 ) 基于多靶标的微循环改善创新药物LS-102的临床前药效学研究, 主持, 部委级, 2018-08--2020-12
( 2 ) 中国科学院“西部青年学者”(院内A类)项目, 主持, 部委级, 2019-01--2021-12
( 3 ) 黄芪甲苷水溶性衍生物的成药性研究, 主持, 省级, 2019-01--2020-01
( 4 ) 乌灵胶囊的二次开发, 主持, 院级, 2021-03--2024-03