Male
Research Areas
Nanopore Single-molecule Sensing, Self-assembling Biomaterials
Education
2008.09-2011.06, Sichuan University, China (Supervisor: Prof. Dr. Xiaojun Zhao)
2005.09-2008.06, Sichuan Normal University, Research Affiliated in Sichuan Academy of Agricultural Science ( Supervisor: Prof. Dr. Guangjun Ren & Assoc. Prof. Dr. Lihua Zeng)
2001.09-2005.06, Shandong Agricultural University, China
Publications
※corresponding author
1. Xiaohan Chen, Shuo Zhou, Yunjiao Wang, Ling Zheng, Sarah Guan, Deqiang Wang, Liang Wang* and Xiyun Guan*. Nanopore single-molecule analysis of biomarkers: Providing possible clues to disease diagnosis. Trends in Analytical Chemistry. 2023. 162. 117060.
2. Shaoxia Zhang, Yunjiao Wang, Dandan Song, Sarah Guan, Daming Zhou, Linyu Gong, Liyuan Liang, Xiyun Guan* and Liang Wang*. Nanopore discrimination and sensitive plasma detection of multiple natriuretic peptides: The representative biomarker of human heart failure. Biosensors Bioelectronics. 2023. 231. 115299.
3. Dandan Song, Yunjiao Wang, Shaoxia Zhang, Lingyu Zhao, Linyu Gong, Liyuan Liang and Liang Wang*. Single-molecule Measurement of Carbonic Anhydrase in Cation Coordinated Environment Using MspA Nanopore. Chinese Journal of Chemistry. 2023. 41. 1341-1347.
4. Minghan Li, Shanchuan Chen, Yunjiao Wang, Shaoxia Zhang, Dandan Song, Rong Tian, Jia Geng, Liang Wang.* Label-free high-precise nanopore detection of endopeptidase activity of anthrax lethal factor regulated by diverse conditions. Biosensors Bioelectronics. 2023. 219. 114800.
5. Wei Li, Yunjiao Wang, Yicen Xiao, Minghan Li, Qianshan Liu, Liyuan Liang, Wanyi Xie, Deqiang Wang*, Xiyun Guan*, and Liang Wang*. Simultaneous Dual-Site Identification of 5mC/8oG in DNA Triplex Using a Nanopore Sensor. ACS Applied Materials Interfaces. 2022. 14. 32948.
6. Rong Tian, Bohua Yin, Dejin Liu, Qianshan Liu, Shanchuan Chen, Minghan Li, Liang Wang, Shuo Zhou, Deqiang Wang. Highly sensitive α-Hemolysin nanopore detection of MUC1 based on 3D DNA walker. Analytica Chimica Acta. 2022. 1223.340193.
7. Liang Wang, Han Wang, Xiaohan Chen, Shuo Zhou, Yunjiao Wang, * and Xiyun Guan*. Chemistry solutions to facilitate nanopore detection and analysis. Biosensors Bioelectronics. 2022. 213. 114448.
8. Yicen Xiao, Juansheng Ren, Yunjiao Wang, Xiaohan Chen, Shuo Zhou, Minghan Li, Fangyuan Gao, Liyuan Liang, Deqiang Wang, Guangjun Ren* and Liang Wang *. De novo Profiling of Insect-resistant Proteins of Rice via Nanopore Peptide Differentiation. Biosensors Bioelectronics. 2022. 212. 114415.
9. Ji Wu, Liyuan Liang*, Mingkun Zhang, Rui Zhu, Zhong Wang, Yajie Yin, Bohua Yin, Ting Weng, Shaoxi Fang, Wanyi Xie, Liang Wang, and Deqiang Wang. Single-Molecule Identification of the Conformations of Human C-Reactive Protein and Its Aptamer Complex with Solid-State Nanopores. ACS Appl. Mater. Interfaces 2022, 14, 10, 12077.
10. Yunjiao Wang, Zequn Wang, Liang Wang, Tianze Tong, Xiaoling Zhang, Shaoxi Fang, Wanyi Xie, Liyuan Liang, Bohua Yin, Jiahu Yuan*, Jin Zhang*, and Deqiang Wang*. Comparison Study on Single Nucleotide Transport Phenomena in Carbon Nanotubes. Nano Letters 2022, 22, 5, 2147.
11. Han Wang, Wenli Huang, Yunjiao Wang, Wei Li, qianshan liu, Bohua Yin, Liyuan Liang, Deqiang Wang, Xiyun Guan*, Liang Wang*. Enzyme hinders HIV-1 Tat viral transport and real-time measured with nanopores. ACS Sensors. 2021. 6. 3781.
12. Xiaoqing Zeng, Yang Xiang, Qianshan Liu, Liang Wang, Qianyun Ma, Wenhao Ma, Delin Zeng, Yajie Yin, Deqiang Wang. Nanopore Technology for the Application of Protein Detection. Nanomaterials. 2021. 11. 1942.
13. Ji Wu, Sen Wang, Liyuan Liang, Chuanqi Zhao, Yajie Yin, Ting Weng, Bohua Yin, Liang Wang, Deqiang Wang. Investigation on the competition of duplex/ G-quadruplex/ i-motif in telomere sequences and c-MYC gene with a solid-state nanopore sensor. Sensors and Actuators B: Chemical. 2021. 348.13072.
14. Minghan Li, Wei Li, Yicen Xiao, Qianshan Liu, Liyuan Liang, Deqiang Wang, Wenli Huang* and Liang Wang*. Nanopore Detects γ-Radiation Inhibited HIV-1 Protease Activity. Biosensors Bioelectronics. 2021. 194. 113602.
15. Yunjiao Wang, Min Cheng, Liang Wang, Daming Zhou, Shixuan He, Liyuan Liang, Feng Zhang, Chang Liu, Deqiang Wang and Jiahu Yuan. Nanocrystalline Graphite Nanopores for DNA Sensing. Carbon. 2021. 176. 271.
16. Wanyi Xie, Shixuan He, Shaoxi Fang, Daming Zhou, Yongna Zhang, Liyuan Liang, Liang Wang, and Deqiang Wang. The Raman band shift of suspended graphene impacted by the substrate edge and helium ion irradiation. Nano express. 2021.2.010001.
17. Qianshan Liu, Yunjiao Wang, Yaqing Liu, Han Wang, Wei Li, Peng Tang, Ting Weng, Shuo Zhou, Liyuan Liang, Jiahu Yuan*, Deqiang Wang*, and Liang Wang*. Reduction Chemistry-Assisted Nanopore Determination Method for Immunoglobulins Isotypes. Nanoscale. 2020. 12. 19711.
18. Jing Tang, Sen Wang, Ji Wu, Liyuan Liang, Liang Wang, Deqiang Wang. Applications of Photo-Responsive Molecules in Nanopore-based Devices. Chinese Journal of Analytical Chemistry. 2020. 48. 1458.
19. Yunjiao Wang, Youwen Zhang, Xiaohan Chen, Xiyun Guan*, Liang Wang*. Analytical Strategies with Biological Nanopore: On-pore, off-pore Strategies and application in Biological Fluids. Talanta. 2021. 223. 121684.
20. Youwen Zhang, Xiaohan Chen, Shaoqing Yuan, Liang Wang*, and Xiyun Guan*. Joint Entropy-assisted Graphene Oxide-based Multiplexing Biosensing Platform for Simultaneous Detection of Multiple Proteases. Analytical Chemistry. 2020. 22. 15042.
21. Yao Cai, Baocai Zhang, Liyuan Liang, Sen Wang, Lanjun Zhang, Liang Wang, Hongliang Cui, Yihua Zhou, Deqiang Wang. A Solid-State Nanopore-Based Single-Molecule Approach for Label-Free Characterization of Plant Polysaccharides. Plant Communication. 2020. 1. 100106.
22. Golbarg Mohammadi Roozbahani, Xiaohan Chen, Youwen Zhang, Liang Wang* and Xiyun Guan*. Nanopore Detection of Metal Ions: Current Status and Future Directions. Small Methods. 2020. 4. 2000266.
23. Sen Wang, Liyuan Liang, Jing Tang, Yao Cai, Chuanqi Zhao, Shaoxi Fang, Huabin Wang, Ting Weng, Liang Wang and Deqiang Wang. Label-free single-molecule identification of telomere G-quadruplexes with a solid-state nanopore sensor. RSC Advances. 2020,10, 27215-27224.
24. Bohua Yin, Shaoxi Fang, Daming Zhou, Liyuan Liang, Liang Wang, and Zuobin Wang, Deqiang Wang, Jiahu Yuan. Nanopore Fabrication via Transient High Electric Field Controlled Breakdown and Detection of Single RNA Molecules. ACS Applied Bio Materials. 2020. 3. 6368.
25. Shuo Zhou, Han Wang, Xiaohan Chen, Yunjiao Wang, Daming Zhou, Liyuan Liang, Liang Wang,* Deqiang Wang,* and Xiyun Guan*. Single-Molecule Study on Interactions between Cyclic Nonribosomal Peptides and Protein Nanopore. ACS Appl. Bio Mater. 2020, 3, 554-560.
26. Liang Wang, Xiaohan Chen, Yunjiao Wang, Shuo Zhou, Deqiang Wang, Xiyun Guan. Nanopore Determination of Nucleic Acids in Whole Blood Based on a Displacement Reaction Strategy. Biophysical J. 2020.118.3.475A.
27. Xiaohan Chen#, Liang Wang#, Golbarg M Roozbahani, Youwen Zhang, Jialing Xiang, Xiyun Guan，Nanopore label-free detection of single-nucleotide deletion in Baxa/BaxΔ2. Electrophoresis, 2018，39，2410-2416. (co-first author)
28. Shuo Zhou, Peng Tang, Yunjiao Wang, Liang Wang※, Deqiang Wang※, Application of nanopore sensing in detection of toxic molecules. Chinese Journal Analytical Chemistry, 2018,46(6), 826-835.
29. Liang Wang, Shuo Zhou, Xiaohan Chen, Xiyun Guan, Displacement chemistry-based nanopore analysis of nucleic acids in complicated matrices. Chemical Communication. 2018, 54，13977-13980.
Patents
US Patent：Nanoproe Stochastic Sensing of Biomarkers. (2017) Patent No.: US9828623B2
Research Interests
Nanopore Single-molecue Sensing, Self-assembling Biomaterials
Conferences
Conference Presentations
1 X. Guan, L. Wang, S. Zhou, X. Chen, “Label-free real-time measurement of protease activity by nanopore analysis,” Pacifichem 2015, Honolulu, HI, December 15-20.
2 L. Wang, S. Zhou, X. Chen, X. Guan, “Nanopore Stochastic Sensing: A Versatile Tool,” ACS Chicago Events, Chicago, IL, April 23, 2015.
3 S. Zhou, L. Wang, X. Chen, X. Guan, “Nanopore Back Titration Analysis of Dipicolinic Acid,” 249th ACS National Meeting & Exposition, Denver, CO, March 22-26, 2015.
4 X. Chen, L. Wang, S. Zhou, X. Guan, “Probe-based Nanopore Biosensor for Detection of Copper Ions,” 249th ACS National Meeting & Expositions, Denver, CO, March 22-26, 2015.
5 L. Wang, S. Zhou, X. Chen, X. Guan, “Real-time Label-free Nanopore Sensor for the Detection of Anthrax,” 249th ACS National Meeting & Expositions, Denver, CO, March 22-26, 2015.
6 S. Zhou, Y. Han, L. Wang, X. Guan, “Nanopore Stochastic Sensing of Trypsin,” 248th ACS National Meeting & Exposition, San Francisco, CA, August 10-14, 2014.
7 L. Wang, Y. Han, S. Zhou, X. Guan, “Real-time Label-free Measurement of HIV-1 Protease Activity by Nanopore Analysis,” 248th ACS National Meeting & Exposition, San Francisco, CA, August 10-14, 2014.
8 S. Zhou, L. Wang, Y. Han, G. Wang, X. Guan, “Rapid and Sensitive Detection of DPA Using a Nanopore Probe,”Pittcon 2014, Chicago, IL, March 2 -6, 2014.
9 Y. Han, L. Wang, S. Zhou, X. Guan, “Nanopore Stochastic Sensing of HIV-1 Protease.” Pittcon 2014, Chicago, IL, March 2 -6, 2014.
10 L. Wang, Y. Han, S. Zhou, X. Guan, “A Label-Free Real-Time cDNA Sensor for Infectious Diseases by Nanopore Analysis,” Pittcon 2014, Chicago, IL, March 2 -6, 2014.
11 S. Zhou, G. Wang, L. Wang, X. Guan, “Nanopore Detection of Copper and Zinc Ions,” Eastern Analytical Symposium & Exposition, Somerset, New Jersey, November 18-20, 2013.
12 X. Guan, G. Wang, L. Wang, Y. Han, S. Zhou, “Rapid and Sensitive Detection of Copper Ions by Nanopore Stochastic Sensing,” 2013 Great Lakes Regional Meeting, La Crosse, WI, June 5 -8, 2013.
13 X. Guan, G. Wang, L. Wang, Y. Han, S. Zhou, “Nanopore Detection of Biological Warfare Agents,”Advances in Microfluidics & Nanofluidics 2013, Notre Dame, IN, May 24 -26, 2013.
14 X. Guan, G. Wang, L. Wang, Y. Han, S. Zhou, “Rapid and Sensitive Detection of Metal Ions by Nanopore Analysis,” Pittcon 2013, Philadelphia, PA, March 17-21.
Honors & Distinctions
First place in poster competition of 2014 Kilpatrick Lecture, 2014 (Delivered by Nobel Laureate Prof. Roald Hoffmann @ Cornell University) Illinois Institute Technology, USA
Secondary place in poster competition of 2013 Kilpatrick Lecture, 2013 (Delivered by Creator of "Artificial Leaf", Prof. Daniel Nocera @Harvard University) Illinois Institute Technology, USA
Excellent Graduate Leader Award, Sichuan University, China
GuangHua Graduate Scholarship, Sichuan University, China