将核酸编码化合库筛选技术和其他药物开发技术（计算机辅助药物设计，天然产物药物开发等）结合起来设计和合成针对特定靶点的核酸编码集中库来加快小分子药物的开发。

1. 针对特定靶点的核酸编码集中库的设计，合成和筛选

2. 和核酸相容能用于核酸编码化合物库合成的化学反应开发

3. 多功能小分子药物的设计和合成

4. 大分子的选择性化学修饰

   

100701-药物化学

小分子药物筛选， DNA Encoded Library

   

2007.9-2011.5 Brandeis University, 有机化学博士 　　

2005.9-2007.8 Brandeis University, 有机化学硕士　　

2001.9-2005.6南京大学，化学本科

博士

2017.7-至今 上海药物研究所，课题组长，研究员 　　

2016.5-2017.6葛兰素史克, 美国波士顿， Associate Fellow　　

2010.11-2016.5葛兰素史克, 美国波士顿, 研究员

2017年中组部青年****

[1] 郑明月, 陆晓杰, 刘小红, 蒋华良, 李召军. 一种基于DNA编码化合物数据库的系统及其分析方法. CN: CN110021366A, 2019-07-16.

[2] 王璇, 索延瑞, 张雨晴, 刘小红, 郑明月, 蒋华良, 陆晓杰. DNA编码化合物文库起始片段及其制备和应用. CN: CN115506036A, 2022-12-23.

[3] 温馨, 张敏敏, 段志强, 沈爱军, 耿美玉, 陆晓杰. 一种GST蛋白抑制剂、其制备方法、药用组合物及其用途. CN: CN116693515A, 2023-09-05.

[4] 凌星, 闫克念, 段志强, 岳金凤, 郑明月, 陈小华, 陆晓杰. 一种CBP/P300抑制剂、其制备方法、药用组合物及其用途. CN: CN116446054A, 2023-07-18.

1. Xiaojie Lu*, Sarah Roberts, George J. Frankline and Christopher P. Davie, “On-DNA Pd and Cu promoted C-N Cross-Coupling Reactions”, MedChemComm, in press. 

2. Xiaojie Lu*, Lijun Fan*, Christopher B. Phelps, Christopher P. Davie, and Christine P. Donahue, “Ruthenium Promoted On-DNA Ring-Closing Metathesis and Cross-Metathesis”, Bioconjugate Chem., 2017, 28, 1625–1629 (This article was highlighted by C&EN, “Making macrocyclic compounds for DNA-encoded libraries”, C&EN online July 6, 2017)

3. Baptiste Thomas, Xiaojie Lu*, William Birmingham, Kun Huang, Peter Both, Juana Reyes Martinez, Robert Young*, Christopher Davie, Sabine Flitsch*, “Application of Biocatalysis to on-DNA Carbohydrate Library Synthesis”, ChemBioChem, 2017, 18, 858-863. (This article was selected as the cover picture for special issue: DNA encoded chemistry, ChemBioChem, 2017, 18, 825.) 

4. Xiaojie Lu and Li Deng*, “Hydrogen Bonding-Mediated Cooperative Organocataoysis by Modified Cinchona Alkaloids”Cooperative Catalysis. Ed. Peters, R.. WeinheimGemany: Wiley-VCH Gmbh & Co, 2015. 145-169.

5. Lin Hu, Xiaojie Lu and Li Deng*, “Catalytic Enantioselective Peroxidation of α,β-Unsaturated Aldehydes for the Asymmetric Synthesis of Biologically Important Chiral Endoperoxides” J. Am. Chem. Soc., 2015, 137, 8400-8403.

6. Xiaojie Lu and Li Deng*, “Catalytic Asymmetric Peroxidation of α,β-Unsaturated Nitroalkenes by a Bifunctional Organic catalyst”, Org. Lett., 2014, 16, 2358-2361.  

7. Xiaojie Lu, Yan Liu, Bingfeng Sun, Brittany Cindric, and Li Deng*, “Catalytic enantioselective peroxidation of a,b-unsaturated ketones”, J. Am. Chem. Soc., 2008, 130, 8134-8135 (This communication was highlighted by JACS Select # 7 : Organocatalysis in Organic Synthesis. Guest Editor: Louis S. Hegedus J. Am. Chem. Soc., 2009, 131, 15075-15077.

8. Xiaojie Lu and Li Deng*, “Asymmetric aza-Michael reactions of a,b-unsaturated ketones with bifunctional organic catalysts”, Angew. Chem. Int. Ed. 2008, 47, 7710-7713.

9. Ravi P. Singh, Keith Bartelson, Yi Wang, Heng Su, Xiaojie Lu and Li Deng*, “Enantioselective Diels-Alder reaction of simple a,b-unsaturated ketones with a Cinchona Alkaloid catalyst”, J. Am. Chem. Soc., 2008, 130, 2422-2423.

[1] Xin Wen, Xinyuan Wu, Rui Jin, Xiaojie Lu. Privileged heterocycles for DNA-encoded library design and hit-to-lead optimization. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2023, 248: http://dx.doi.org/10.1016/j.ejmech.2022.115079.
[2] Suo, Yanrui, Xu, Min, Sun, Meimei, Lu, Weiwei, Wang, Xuan, Lu, Xiaojie. Ruthenium-Mediated 2+2+2 Cyclization: A Route to Forge Indane and Isoindoline Core and Its Application in DNA-Encoded Library Technology. ORGANIC LETTERS[J]. 2022, 24(49): 9092-9096, [3] Wu, Xinyuan, Chen, Yujie, Lu, Weiwei, Jin, Rui, Lu, Xiaojie. Quantitative Validation and Application of the Photo-Cross-Linking Selection for Double-Stranded DNA-Encoded Libraries. BIOCONJUGATE CHEMISTRY[J]. 2022, 33(10): 1818-1824, http://dx.doi.org/10.1021/acs.bioconjchem.2c00421.
[4] Liu, Chenglong, Zhou, Feilong, Yan, Ziqin, Shen, Lian, Zhang, Xichen, He, Fenglian, Wang, Heng, Lu, Xiaojie, Yu, Ker, Zhao, Yujun, Zhu, Di. Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy. BRITISH JOURNAL OF PHARMACOLOGY[J]. 2021, 178(13): 2651-2670, http://dx.doi.org/10.1111/bph.15457.
[5] Liu, Sixiu, Qi, Jingjing, Lu, Weiwei, Wang, Xuan, Lu, Xiaojie. Synthetic Studies toward DNA-Encoded Heterocycles Based on the On-DNA Formation of alpha,beta-Unsaturated Ketones. ORGANIC LETTERS[J]. 2021, 23(3): 908-913, http://dx.doi.org/10.1021/acs.orglett.0c04118.
[6] Wang, Xuan, Liu, Jiaxiang, Yan, Ziqin, Liu, Xiaohong, Liu, Sixiu, Suo, Yanrui, Lu, Weiwei, Yue, Jinfeng, Chen, Kaixian, Jiang, Hualiang, Zhao, Yujun, Zheng, Mingyue, Dai, Dongcheng, Lu, Xiaojie. Diversified strategy for the synthesis of DNA-encoded oxindole libraries. CHEMICAL SCIENCE[J]. 2021, 12(8): 2841-2847, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179416/.
[7] Yang, Peng, Wang, Xuan, Li, Bo, Yang, Yixuan, Yue, Jinfeng, Suo, Yanrui, Tong, Huarong, He, Gang, Lu, Xiaojie, Chen, Gong. Streamlined construction of peptide macrocycles via palladium-catalyzed intramolecular S-arylation in solution and on DNA dagger. CHEMICAL SCIENCE[J]. 2021, 12(16): 5804-5810, http://dx.doi.org/10.1039/d1sc00789k.
[8] 陆晓杰. Divergent On-DNA Transformations from DNA-Linked Piperidones. Journal of Organic Chemistry. 2021, [9] Shan, Jinming, Ling, Xing, Liu, JiaXiang, Wang, Xuan, Lu, Xiaojie. DNA-encoded C-H functionality via photoredox-mediated hydrogen atom transformation catalysis. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2021, 42: http://dx.doi.org/10.1016/j.bmc.2021.116234.
[10] Wu, Wenting, Sun, Zhen, Wang, Xuan, Lu, Xiaojie, Dai, Dongcheng. Construction of Thiazole-Fused Dihydropyrans via Formal 4+2 Cycloaddition Reaction on DNA. ORGANIC LETTERS[J]. 2020, 22(8): 3239-3244, https://www.webofscience.com/wos/woscc/full-record/WOS:000526894000075.
[11] Li, Ke, Liu, Xiaohong, Liu, Sixiu, An, Yulong, Shen, Yanfang, Sun, Qingxia, Shi, Xiaodong, Su, Wenji, Cui, Weiren, Duan, Zhiqiang, Kuai, Letian, Yang, Hongfang, Satz, Alexander L, Chen, Kaixian, Jiang, Hualiang, Zheng, Mingyue, Peng, Xuanjia, Lu, Xiaojie. Solution-Phase DNA-Compatible Pictet-Spengler Reaction Aided by Machine Learning Building Block Filtering. ISCIENCE[J]. 2020, 23(6): http://dx.doi.org/10.1016/j.isci.2020.101142.
[12] Wen, Xin, Duan, Zhiqiang, Liu, Jiaxiang, Lu, Weiwei, Lu, Xiaojie. On-DNA Cross-Dehydrogenative Coupling Reaction toward the Synthesis of Focused DNA-Encoded Tetrahydroisoquinoline Libraries. ORGANIC LETTERS[J]. 2020, 22(15): 5721-5725, http://dx.doi.org/10.1021/acs.orglett.0c01565.
[13] Qu, Yi, Liu, Sixiu, Wen, Huanan, Xu, Yanfen, An, Yulong, Li, Ke, Ni, Mengyuan, Shen, Yanfang, Shi, Xiaodong, Su, Wenji, Cui, Weiren, Kuai, Letian, Satz, Alexander L, Yang, Hongfang, Lu, Xiaojie, Peng, Xuanjia. Palladium-mediated Suzuki-Miyaura Cross-Coupling Reaction of Potassium Boc-protected aminomethyltrifluoroborate with DNA-Conjugated aryl bromides for DNA-Encoded chemical library synthesis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2020, 533(2): 209-214, http://dx.doi.org/10.1016/j.bbrc.2020.04.027.
[14] Wang, Xuan, Sun, Hui, Liu, Jiaxiang, Zhong, Wenge, Zhang, Mingqiang, Zhou, Hu, Dai, Dongcheng, Lu, Xiaojie. Palladium-Promoted DNA-Compatible Heck Reaction. ORGANIC LETTERS[J]. 2019, 21(3): 719-723, https://www.webofscience.com/wos/woscc/full-record/WOS:000457947900030.
[15] Wang, Xuan, Sun, Hui, Liu, Jiaxiang, Dai, Dongcheng, Zhang, Mingqiang, Zhou, Hu, Zhong, Wenge, Lu, Xiaojie. Ruthenium-Promoted C-H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids. ORGANIC LETTERS[J]. 2018, 20(16): 4764-4768, http://dx.doi.org/10.1021/acs.orglett.8b01837.
[16] Li, Hailong, Sun, Zhen, Wu, Wenting, Wang, Xuan, Zhang, Mingqiang, Lu, Xiaojie, Zhong, Wenge, Dai, Dongcheng. Inverse-Electron-Demand Diels-Alder Reactions for the Synthesis of Pyridazines on DNA. ORGANICLETTERS[J]. 2018, 20(22): 7186-7191, https://www.webofscience.com/wos/woscc/full-record/WOS:000451101500046.
[17] Lu, Xiaojie, Fan, Lijun, Phelps, Christopher B, Davie, Christopher P, Donahue, Christine P. Ruthenium Promoted On-DNA Ring-Closing Metathesis and Cross-Metathesis. BIOCONJUGATE CHEMISTRY[J]. 2017, 28(6): 1625-1629, https://www.webofscience.com/wos/woscc/full-record/WOS:000404090500004.
[18] Lu, Xiaojie, Roberts, Sarah E, Franklin, George J, Davie, Christopher P. On-DNA Pd and Cu promoted C-N cross-coupling reactions. MEDCHEMCOMM[J]. 2017, 8(8): 1614-1617, https://www.webofscience.com/wos/woscc/full-record/WOS:000407769400004.
[19] Thomas, Baptiste, Lu, Xiaojie, Birmingham, William R, Huang, Kun, Both, Peter, Martinez, Juana Elizabeth Reyes, Young, Robert J, Davie, Christopher P, Flitsch, Sabine L. Application of Biocatalysis to on-DNA Carbohydrate Library Synthesis. CHEMBIOCHEM[J]. 2017, 18(9): 858-863, https://www.webofscience.com/wos/woscc/full-record/WOS:000400572500007.
[20] 陆晓杰. Hydrogen Bonding-Mediated Cooperative Organocataoysis by Modified Cinchona Alkaloids. Wiley-VCH Gmbh & Co. 2015, [21] Hu, Lin, Lu, Xiaojie, Deng, Li. Catalytic Enantioselective Peroxidation of alpha,beta-Unsaturated Aldehydes for the Asymmetric Synthesis of Biologically Important Chiral Endoperoxides. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2015, 137(26): 8400-8403, https://www.webofscience.com/wos/woscc/full-record/WOS:000357964400022.
[22] Lu, Xiaojie, Deng, Li. Catalytic Asymmetric Peroxidation of alpha,beta-Unsaturated Nitroalkenes by a Bifunctional Organic Catalyst. ORGANIC LETTERS[J]. 2014, 16(9): 2358-2361, https://www.webofscience.com/wos/woscc/full-record/WOS:000335491000016.
[23] 刘. Catalytic Enantioselective Peroxidation of a,b-Unsaturated Ketones. 2008, [24] 陆晓杰. Asymmetric aza-Michael reactions of a,b-unsaturated ketones with bifunctional organic catalysts. Angew. Chem. Int. Ed. 2008, [25] 陆晓杰. Enantioselective Diels-Alder reaction of simple a,b-unsaturated ketones with a Cinchona Alkaloid catalyst. JAMCHEMSOC. 2008,