将核酸编码化合库筛选技术和其他药物开发技术（计算机辅助药物设计，天然产物药物开发等）结合起来设计和合成针对特定靶点的核酸编码集中库来加快小分子药物的开发。

1. 针对特定靶点的核酸编码集中库的设计，合成和筛选

2. 和核酸相容能用于核酸编码化合物库合成的化学反应开发

3. 多功能小分子药物的设计和合成

4. 大分子的选择性化学修饰

2007.9-2011.5 Brandeis University, 有机化学博士 　　

2005.9-2007.8 Brandeis University, 有机化学硕士　　

2001.9-2005.6南京大学，化学本科

博士

2017.7-至今 上海药物研究所，课题组长，研究员 　　

2016.5-2017.6葛兰素史克, 美国波士顿， Associate Fellow　　

2010.11-2016.5葛兰素史克, 美国波士顿, 研究员

2017年中组部青年****

1. Xiaojie Lu*, Sarah Roberts, George J. Frankline and Christopher P. Davie, “On-DNA Pd and Cu promoted C-N Cross-Coupling Reactions”, MedChemComm, in press. 

2. Xiaojie Lu*, Lijun Fan*, Christopher B. Phelps, Christopher P. Davie, and Christine P. Donahue, “Ruthenium Promoted On-DNA Ring-Closing Metathesis and Cross-Metathesis”, Bioconjugate Chem., 2017, 28, 1625–1629 (This article was highlighted by C&EN, “Making macrocyclic compounds for DNA-encoded libraries”, C&EN online July 6, 2017)

3. Baptiste Thomas, Xiaojie Lu*, William Birmingham, Kun Huang, Peter Both, Juana Reyes Martinez, Robert Young*, Christopher Davie, Sabine Flitsch*, “Application of Biocatalysis to on-DNA Carbohydrate Library Synthesis”, ChemBioChem, 2017, 18, 858-863. (This article was selected as the cover picture for special issue: DNA encoded chemistry, ChemBioChem, 2017, 18, 825.) 

4. Xiaojie Lu and Li Deng*, “Hydrogen Bonding-Mediated Cooperative Organocataoysis by Modified Cinchona Alkaloids”Cooperative Catalysis. Ed. Peters, R.. WeinheimGemany: Wiley-VCH Gmbh & Co, 2015. 145-169.

5. Lin Hu, Xiaojie Lu and Li Deng*, “Catalytic Enantioselective Peroxidation of α,β-Unsaturated Aldehydes for the Asymmetric Synthesis of Biologically Important Chiral Endoperoxides” J. Am. Chem. Soc., 2015, 137, 8400-8403.

6. Xiaojie Lu and Li Deng*, “Catalytic Asymmetric Peroxidation of α,β-Unsaturated Nitroalkenes by a Bifunctional Organic catalyst”, Org. Lett., 2014, 16, 2358-2361.  

7. Xiaojie Lu, Yan Liu, Bingfeng Sun, Brittany Cindric, and Li Deng*, “Catalytic enantioselective peroxidation of a,b-unsaturated ketones”, J. Am. Chem. Soc., 2008, 130, 8134-8135 (This communication was highlighted by JACS Select # 7 : Organocatalysis in Organic Synthesis. Guest Editor: Louis S. Hegedus J. Am. Chem. Soc., 2009, 131, 15075-15077.

8. Xiaojie Lu and Li Deng*, “Asymmetric aza-Michael reactions of a,b-unsaturated ketones with bifunctional organic catalysts”, Angew. Chem. Int. Ed. 2008, 47, 7710-7713.

9. Ravi P. Singh, Keith Bartelson, Yi Wang, Heng Su, Xiaojie Lu and Li Deng*, “Enantioselective Diels-Alder reaction of simple a,b-unsaturated ketones with a Cinchona Alkaloid catalyst”, J. Am. Chem. Soc., 2008, 130, 2422-2423.